Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 301

1.

Neuron-generated thrombin induces a protective astrocyte response via protease activated receptors.

Rajput PS, Lamb J, Kothari S, Pereira B, Soetkamp D, Wang Y, Tang J, Van Eyk JE, Mullins ES, Lyden PD.

Glia. 2019 Aug 27. doi: 10.1002/glia.23714. [Epub ahead of print]

PMID:
31453648
2.

Thrombolytic Therapy for Acute Ischemic Stroke.

Lyden PD.

Stroke. 2019 Sep;50(9):2597-2603. doi: 10.1161/STROKEAHA.119.025699. Epub 2019 Jul 22. No abstract available.

PMID:
31327316
3.

Neuroprotection and vasculoprotection using genetically targeted protease-ligands.

Rajput PS, Lamb JA, Fernández JÁ, Bai J, Pereira BR, Lei IF, Leung J, Griffin JH, Lyden PD.

Brain Res. 2019 Jul 15;1715:13-20. doi: 10.1016/j.brainres.2019.03.010. Epub 2019 Mar 14.

PMID:
30880117
4.

Acute neuropathological consequences of short-term mechanical ventilation in wild-type and Alzheimer's disease mice.

Lahiri S, Regis GC, Koronyo Y, Fuchs DT, Sheyn J, Kim EH, Mastali M, Van Eyk JE, Rajput PS, Lyden PD, Black KL, Ely EW, D Jones H, Koronyo-Hamaoui M.

Crit Care. 2019 Feb 22;23(1):63. doi: 10.1186/s13054-019-2356-2.

5.

Studies Targeting Stroke and Acute Myocardial Infarction.

Kurz MC, Lyden P, Dae M, Noc M.

Ther Hypothermia Temp Manag. 2019 Mar;9(1):8-12. doi: 10.1089/ther.2018.29054.mck. Epub 2019 Jan 7. No abstract available.

PMID:
30614768
6.

Differential effects of hypothermia on neurovascular unit determine protective or toxic results: Toward optimized therapeutic hypothermia.

Lyden PD, Lamb J, Kothari S, Toossi S, Boitano P, Rajput PS.

J Cereb Blood Flow Metab. 2019 Sep;39(9):1693-1709. doi: 10.1177/0271678X18814614. Epub 2018 Nov 21.

PMID:
30461327
7.

Hypothermia in acute ischemic stroke therapy.

Basto FM, Lyden P.

Handb Clin Neurol. 2018;157:823-837. doi: 10.1016/B978-0-444-64074-1.00051-3. Review.

PMID:
30459043
8.

Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke.

Lyden P, Pryor KE, Coffey CS, Cudkowicz M, Conwit R, Jadhav A, Sawyer RN Jr, Claassen J, Adeoye O, Song S, Hannon P, Rost NS, Hinduja A, Torbey M, Lee JM, Benesch C, Rippee M, Rymer M, Froehler MT, Clarke Haley E, Johnson M, Yankey J, Magee K, Qidwai J, Levy H, Mark Haacke E, Fawaz M, Davis TP, Toga AW, Griffin JH, Zlokovic BV; NeuroNEXT Clinical Trials Network NN104 Investigators.

Ann Neurol. 2019 Jan;85(1):125-136. doi: 10.1002/ana.25383. Epub 2019 Jan 7.

PMID:
30450637
9.

Differential Expression of Vascular Endothelial Growth Factor-A165 Isoforms Between Intracranial Atherosclerosis and Moyamoya Disease.

Jiang H, Toscano JF, Schiraldi M, Song SS, Schlick KH, Dumitrascu OM, Liou R, Lyden PD, Pan J, Zhan R, Saver JL, Gonzalez NR.

J Stroke Cerebrovasc Dis. 2019 Feb;28(2):360-368. doi: 10.1016/j.jstrokecerebrovasdis.2018.10.004. Epub 2018 Nov 2.

PMID:
30392834
10.

Absolute risk and predictors of the growth of acute spontaneous intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data.

Al-Shahi Salman R, Frantzias J, Lee RJ, Lyden PD, Battey TWK, Ayres AM, Goldstein JN, Mayer SA, Steiner T, Wang X, Arima H, Hasegawa H, Oishi M, Godoy DA, Masotti L, Dowlatshahi D, Rodriguez-Luna D, Molina CA, Jang DK, Davalos A, Castillo J, Yao X, Claassen J, Volbers B, Kazui S, Okada Y, Fujimoto S, Toyoda K, Li Q, Khoury J, Delgado P, Sabín JÁ, Hernández-Guillamon M, Prats-Sánchez L, Cai C, Kate MP, McCourt R, Venkatasubramanian C, Diringer MN, Ikeda Y, Worthmann H, Ziai WC, d'Esterre CD, Aviv RI, Raab P, Murai Y, Zazulia AR, Butcher KS, Seyedsaadat SM, Grotta JC, Martí-Fàbregas J, Montaner J, Broderick J, Yamamoto H, Staykov D, Connolly ES, Selim M, Leira R, Moon BH, Demchuk AM, Di Napoli M, Fujii Y, Anderson CS, Rosand J; VISTA-ICH Collaboration; ICH Growth Individual Patient Data Meta-analysis Collaborators.

Lancet Neurol. 2018 Oct;17(10):885-894. doi: 10.1016/S1474-4422(18)30253-9. Epub 2018 Aug 14. Erratum in: Lancet Neurol. 2018 Sep 19;:.

11.

Unique Uses of Cooling Strategies.

Lyden P, Paul J, Yokobori S, Cuschieri J.

Ther Hypothermia Temp Manag. 2018 Sep;8(3):126-130. doi: 10.1089/ther.2018.29047.pjl. Epub 2018 Aug 10. No abstract available.

PMID:
30096262
12.

Can an anticoagulant reduce brain hemorrhage: Invited comment on "Dabigatran reduces endothelial permeability through inhibition of thrombin-induced cytoskeleton reorganization".

Lyden PD.

Thromb Res. 2018 Jun 12. pii: S0049-3848(18)30379-7. doi: 10.1016/j.thromres.2018.06.005. [Epub ahead of print] No abstract available.

PMID:
29935770
13.

Cerebral microemboli detection for monitoring structural cardiac disease.

Shafie M, Song S, Nezhad M, Lamberti J, Cocalis M, Cavallaro M, Rinsky B, Lyden P.

Neurol Clin Pract. 2017 Oct;7(5):409-412. doi: 10.1212/CPJ.0000000000000330. No abstract available.

14.

Treatment Modality and Quality Benchmarks of Aneurysmal Subarachnoid Hemorrhage at a Comprehensive Stroke Center.

Yu W, Kavi T, Majic T, Alva K, Moheet A, Lyden P, Schievink W, Lekovic G, Alexander M.

Front Neurol. 2018 Mar 15;9:152. doi: 10.3389/fneur.2018.00152. eCollection 2018.

15.

Retinal Microvascular Abnormalities as Surrogate Markers of Cerebrovascular Ischemic Disease: A Meta-Analysis.

Dumitrascu OM, Demaerschalk BM, Valencia Sanchez C, Almader-Douglas D, O'Carroll CB, Aguilar MI, Lyden PD, Kumar G.

J Stroke Cerebrovasc Dis. 2018 Jul;27(7):1960-1968. doi: 10.1016/j.jstrokecerebrovasdis.2018.02.041. Epub 2018 Mar 20. Review.

PMID:
29571764
16.

When less is more (brain)-comment on "Rivaroxaban plasma levels in acute ischemic stroke and intracerebral hemorrhage".

Lyden PD.

Ann Neurol. 2018 Mar;83(3):446-448. doi: 10.1002/ana.25163. Epub 2018 Mar 3. No abstract available.

17.

Local to Systemic Use of Hypothermia.

Kurz M, Lyden P, Lundbye J, Rajguru S.

Ther Hypothermia Temp Manag. 2018 Mar;8(1):4-8. doi: 10.1089/ther.2018.29041.mjk. Epub 2018 Jan 23. No abstract available.

PMID:
29360005
18.

Lack of Early Improvement Predicts Poor Outcome Following Acute Intracerebral Hemorrhage.

Yogendrakumar V, Smith EE, Demchuk AM, Aviv RI, Rodriguez-Luna D, Molina CA, Silva Blas Y, Dzialowski I, Kobayashi A, Boulanger JM, Lum C, Gubitz G, Padma V, Roy J, Kase CS, Bhatia R, Ali M, Lyden P, Hill MD, Dowlatshahi D; Prediction of haematoma growth and outcome in patients with intracerebral haemorrhage using the CT-angiography spot sign [PREDICT]/Sunnybrook ICH CTA Study Group and the Virtual International Stroke Trials Archive (VISTA)-ICH Collaborators.

Crit Care Med. 2018 Apr;46(4):e310-e317. doi: 10.1097/CCM.0000000000002962.

PMID:
29303797
19.

Effects of alteplase for acute stroke according to criteria defining the European Union and United States marketing authorizations: Individual-patient-data meta-analysis of randomized trials.

Hacke W, Lyden P, Emberson J, Baigent C, Blackwell L, Albers G, Bluhmki E, Brott T, Cohen G, Davis SM, Donnan GA, Grotta JC, Howard G, Kaste M, Koga M, von Kummer R, Lansberg MG, Lindley RI, Olivot JM, Parsons M, Sandercock PA, Toni D, Toyoda K, Wahlgren N, Wardlaw JM, Whiteley WN, Del Zoppo G, Lees KR; Stroke Thrombolysis Trialists’ Collaborators Group.

Int J Stroke. 2018 Feb;13(2):175-189. doi: 10.1177/1747493017744464. Epub 2017 Nov 24. Erratum in: Int J Stroke. 2018 Feb;13(2):NP3.

PMID:
29171359
20.

Perspectives on Temperature Management.

Lyden P, Rittenberger J, Rincon F.

Ther Hypothermia Temp Manag. 2017 Dec;7(4):188-192. doi: 10.1089/ther.2017.29035.pjl. Epub 2017 Oct 13. No abstract available.

PMID:
29027874
21.

2018: The Beginning of a New Era.

Chen J, Dijkhuizen R, Herscovitch P, Xi G, Lyden P.

J Cereb Blood Flow Metab. 2017 Oct;37(10):3273-3275. doi: 10.1177/0271678X17722341. No abstract available.

22.

Translational Stroke Research: Vision and Opportunities.

Bosetti F, Koenig JI, Ayata C, Back SA, Becker K, Broderick JP, Carmichael ST, Cho S, Cipolla MJ, Corbett D, Corriveau RA, Cramer SC, Ferguson AR, Finklestein SP, Ford BD, Furie KL, Hemmen TM, Iadecola C, Jakeman LB, Janis S, Jauch EC, Johnston KC, Kochanek PM, Kohn H, Lo EH, Lyden PD, Mallard C, McCullough LD, McGavern LM, Meschia JF, Moy CS, Perez-Pinzon MA, Ramadan I, Savitz SI, Schwamm LH, Steinberg GK, Stenzel-Poore MP, Tymianski M, Warach S, Wechsler LR, Zhang JH, Koroshetz W.

Stroke. 2017 Sep;48(9):2632-2637. doi: 10.1161/STROKEAHA.117.017112. Epub 2017 Jul 27. Review. No abstract available.

23.

Rethinking Training and Distribution of Vascular Neurology Interventionists in the Era of Thrombectomy.

Grotta JC, Lyden P, Brott T.

Stroke. 2017 Aug;48(8):2313-2317. doi: 10.1161/STROKEAHA.116.016416. Epub 2017 Jul 13. No abstract available.

PMID:
28706124
24.

Brain Transforming Growth Factor-β Resists Hypertension Via Regulating Microglial Activation.

Li Y, Shen XZ, Li L, Zhao TV, Bernstein KE, Johnson AK, Lyden P, Fang J, Shi P.

Stroke. 2017 Sep;48(9):2557-2564. doi: 10.1161/STROKEAHA.117.017370. Epub 2017 Jul 11.

25.

Cerebral Pulsatility Index Is Elevated in Patients with Elevated Right Atrial Pressure.

Lahiri S, Schlick KH, Padrick MM, Rinsky B, Gonzalez N, Jones H, Mayer SA, Lyden PD.

J Neuroimaging. 2018 Jan;28(1):95-98. doi: 10.1111/jon.12456. Epub 2017 Jul 3.

PMID:
28670797
26.

Intracerebral Hemorrhagic Expansion Occurs in Patients Using Non-Vitamin K Antagonist Oral Anticoagulants Comparable with Patients Using Warfarin.

Melmed KR, Lyden P, Gellada N, Moheet A.

J Stroke Cerebrovasc Dis. 2017 Aug;26(8):1874-1882. doi: 10.1016/j.jstrokecerebrovasdis.2017.04.025. Epub 2017 Jun 21.

PMID:
28647419
27.

Temperature Management in Neurological and Neurosurgical Intensive Care Unit.

Lyden P, Mayer SA, Lurie K, Schmutzhard E.

Ther Hypothermia Temp Manag. 2017 Jun;7(2):70-74. doi: 10.1089/ther.2017.29029.pjl. Epub 2017 Jun 6. No abstract available.

PMID:
28586295
28.

Paradoxical cerebrovascular hemodynamic changes with nicardipine.

Lahiri S, Nezhad M, Schlick KH, Rinsky B, Rosengart A, Mayer SA, Lyden PD.

J Neurosurg. 2018 Apr;128(4):1015-1019. doi: 10.3171/2016.11.JNS161992. Epub 2017 Apr 21.

PMID:
28430036
29.

Subclinical leaflet thrombosis in surgical and transcatheter bioprosthetic aortic valves: an observational study.

Chakravarty T, Søndergaard L, Friedman J, De Backer O, Berman D, Kofoed KF, Jilaihawi H, Shiota T, Abramowitz Y, Jørgensen TH, Rami T, Israr S, Fontana G, de Knegt M, Fuchs A, Lyden P, Trento A, Bhatt DL, Leon MB, Makkar RR; RESOLVE; SAVORY Investigators.

Lancet. 2017 Jun 17;389(10087):2383-2392. doi: 10.1016/S0140-6736(17)30757-2. Epub 2017 Mar 19.

PMID:
28330690
30.

Migraine and the Risk of Carotid Artery Dissection in the IPSYS Registry: Are They Related?

Lyden PD.

JAMA Neurol. 2017 May 1;74(5):503-504. doi: 10.1001/jamaneurol.2016.6008. No abstract available.

PMID:
28264078
31.

Clinical Studies Targeting Stroke and Ischemic Insults.

Lundbye J, Lyden PD, Polderman KH, Schwab S.

Ther Hypothermia Temp Manag. 2017 Mar;7(1):12-15. doi: 10.1089/ther.2016.29022.jjl. No abstract available.

PMID:
28253089
32.

Clinical Studies Targeting Stroke and Ischemic Insults.

Lundbye J, Lyden PD, Polderman KH, Schwab S.

Ther Hypothermia Temp Manag. 2017 Jan 20. doi: 10.1089/ther.2016.29022.jjl.rev. [Epub ahead of print] No abstract available.

PMID:
28106522
33.

Using the National Institutes of Health Stroke Scale: A Cautionary Tale.

Lyden P.

Stroke. 2017 Feb;48(2):513-519. doi: 10.1161/STROKEAHA.116.015434. Epub 2017 Jan 11. Review. No abstract available.

PMID:
28077454
34.

Meta-Analysis of Pre-Clinical Trials of Therapeutic Hypothermia for Intracerebral Hemorrhage.

Melmed KR, Lyden PD.

Ther Hypothermia Temp Manag. 2017 Sep;7(3):141-146. doi: 10.1089/ther.2016.0033. Epub 2016 Dec 1. Review.

35.

In Response.

Lahiri S, Lyden PD.

J Stroke Cerebrovasc Dis. 2017 Feb;26(2):454. doi: 10.1016/j.jstrokecerebrovasdis.2016.10.022. Epub 2016 Nov 22. No abstract available.

PMID:
27887790
36.

Results of the ICTuS 2 Trial (Intravascular Cooling in the Treatment of Stroke 2).

Lyden P, Hemmen T, Grotta J, Rapp K, Ernstrom K, Rzesiewicz T, Parker S, Concha M, Hussain S, Agarwal S, Meyer B, Jurf J, Altafullah I, Raman R; Collaborators.

Stroke. 2016 Dec;47(12):2888-2895. Epub 2016 Nov 10.

37.

Temperature Management in Neurological and Neurosurgical Intensive Care Unit.

Lyden P, Brophy GM, Deye N, Horn CM.

Ther Hypothermia Temp Manag. 2016 Dec;6(4):164-168. Epub 2016 Nov 9. No abstract available.

PMID:
27828761
38.

Selecting Patients for Intra-Arterial Therapy in the Context of a Clinical Trial for Neuroprotection.

Lyden P, Weymer S, Coffey C, Cudkowicz M, Berg S, O'Brien S, Fisher M, Haley EC, Khatri P, Saver J, Levine S, Levy H, Rymer M, Wechsler L, Jadhav A, McNeil E, Waddy S, Pryor K.

Stroke. 2016 Dec;47(12):2979-2985. Epub 2016 Nov 1.

39.

Transcranial Doppler Changes in Patients Treated with Extracorporeal Membrane Oxygenation.

Kavi T, Esch M, Rinsky B, Rosengart A, Lahiri S, Lyden PD.

J Stroke Cerebrovasc Dis. 2016 Dec;25(12):2882-2885. doi: 10.1016/j.jstrokecerebrovasdis.2016.07.050. Epub 2016 Aug 26.

PMID:
27576213
40.

Optimizing Outcomes for Mechanically Ventilated Patients in an Era of Endovascular Acute Ischemic Stroke Therapy.

Lahiri S, Schlick K, Kavi T, Song S, Moheet AM, Yusufali T, Rosengart A, Alexander MJ, Lyden PD.

J Intensive Care Med. 2017 Sep;32(8):467-472. doi: 10.1177/0885066616663168. Epub 2016 Aug 19. Review.

PMID:
27543141
41.

Effects of Alteplase for Acute Stroke on the Distribution of Functional Outcomes: A Pooled Analysis of 9 Trials.

Lees KR, Emberson J, Blackwell L, Bluhmki E, Davis SM, Donnan GA, Grotta JC, Kaste M, von Kummer R, Lansberg MG, Lindley RI, Lyden P, Murray GD, Sandercock PA, Toni D, Toyoda K, Wardlaw JM, Whiteley WN, Baigent C, Hacke W, Howard G; Stroke Thrombolysis Trialists’ Collaborators Group.

Stroke. 2016 Sep;47(9):2373-9. doi: 10.1161/STROKEAHA.116.013644. Epub 2016 Aug 9.

42.

Risk of intracerebral haemorrhage with alteplase after acute ischaemic stroke: a secondary analysis of an individual patient data meta-analysis.

Whiteley WN, Emberson J, Lees KR, Blackwell L, Albers G, Bluhmki E, Brott T, Cohen G, Davis S, Donnan G, Grotta J, Howard G, Kaste M, Koga M, von Kummer R, Lansberg MG, Lindley RI, Lyden P, Olivot JM, Parsons M, Toni D, Toyoda K, Wahlgren N, Wardlaw J, Del Zoppo GJ, Sandercock P, Hacke W, Baigent C; Stroke Thrombolysis Trialists' Collaboration.

Lancet Neurol. 2016 Aug;15(9):925-933. doi: 10.1016/S1474-4422(16)30076-X. Epub 2016 Jun 8.

PMID:
27289487
43.

Activated protein C promotes neuroprotection: mechanisms and translation to the clinic.

Griffin JH, Fernández JA, Lyden PD, Zlokovic BV.

Thromb Res. 2016 May;141 Suppl 2:S62-4. doi: 10.1016/S0049-3848(16)30368-1. Review.

44.

Novel method for inducing rapid, controllable therapeutic hypothermia in rats using a perivascular implanted closed-loop cooling circuit.

Lamb JA, Rajput PS, Lyden PD.

J Neurosci Methods. 2016 Jul 15;267:55-61. doi: 10.1016/j.jneumeth.2016.04.011. Epub 2016 Apr 21.

PMID:
27090948
45.

Still cooling after all these years: Meta-analysis of pre-clinical trials of therapeutic hypothermia for acute ischemic stroke.

Dumitrascu OM, Lamb J, Lyden PD.

J Cereb Blood Flow Metab. 2016 Jul;36(7):1157-64. doi: 10.1177/0271678X16645112. Epub 2016 Apr 18. Review.

46.

Current Advances in the Use of Therapeutic Hypothermia.

Lyden PD, Lopez-de-Sa E, Nichol G, Kiragu AW.

Ther Hypothermia Temp Manag. 2016 Mar;6(1):2-5. doi: 10.1089/ther.2016.29010.pdl. Epub 2016 Feb 1. No abstract available.

PMID:
26829471
47.

Clinical Studies Targeting Stroke and In-Hospital Cardiac Arrest.

Kurz M, Lundbye J, Lyden PD.

Ther Hypothermia Temp Manag. 2016 Mar;6(1):6-8. doi: 10.1089/ther.2016.29008.mjk. Epub 2016 Jan 22. No abstract available.

PMID:
26799665
48.

Troubleshooting the NIHSS: question-and-answer session with one of the designers.

Martin-Schild S, Siegler JE, Kumar AD, Lyden P.

Int J Stroke. 2015 Dec;10(8):1284-6. doi: 10.1111/ijs.12196. No abstract available.

PMID:
26745704
49.

Online Tool to Improve Stratification of Adverse Events in Stroke Clinical Trials.

Hesse K, MacIsaac RL, Abdul-Rahim AH, Lyden PD, Bluhmki E, Lees KR; VISTA Collaborators.

Stroke. 2016 Mar;47(3):882-5. doi: 10.1161/STROKEAHA.115.011930. Epub 2016 Jan 7.

PMID:
26742798
50.

Letter by Lahiri et al Regarding Article, "Endovascular Thrombectomy for Anterior Circulation Stroke: Systematic Review and Meta-Analysis".

Lahiri S, Nuño M, Lyden PD.

Stroke. 2015 Dec;46(12):e258. doi: 10.1161/STROKEAHA.115.011677. Epub 2015 Nov 3. No abstract available.

PMID:
26534970

Supplemental Content

Support Center