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Checkpoint inhibition of origin firing prevents DNA topological stress.

Morafraile EC, Hänni C, Allen G, Zeisner T, Clarke C, Johnson MC, Santos MM, Carroll L, Minchell NE, Baxter J, Banks P, Lydall D, Zegerman P.

Genes Dev. 2019 Nov 1;33(21-22):1539-1554. doi: 10.1101/gad.328682.119. Epub 2019 Oct 17.


Overlapping open reading frames strongly reduce human and yeast STN1 gene expression and affect telomere function.

Torrance V, Lydall D.

PLoS Genet. 2018 Aug 1;14(8):e1007523. doi: 10.1371/journal.pgen.1007523. eCollection 2018 Aug.


The contribution of non-essential Schizosaccharomyces pombe genes to fitness in response to altered nutrient supply and target of rapamycin activity.

Lie S, Banks P, Lawless C, Lydall D, Petersen J.

Open Biol. 2018 May;8(5). pii: 180015. doi: 10.1098/rsob.180015.


Vps74 Connects the Golgi Apparatus and Telomeres in Saccharomyces cerevisiae.

Rodrigues J, Banks P, Lydall D.

G3 (Bethesda). 2018 May 4;8(5):1807-1816. doi: 10.1534/g3.118.200172.


Cis and trans interactions between genes encoding PAF1 complex and ESCRT machinery components in yeast.

Rodrigues J, Lydall D.

Curr Genet. 2018 Oct;64(5):1105-1116. doi: 10.1007/s00294-018-0828-6. Epub 2018 Mar 22.


A Critical Role for Dna2 at Unwound Telomeres.

Markiewicz-Potoczny M, Lisby M, Lydall D.

Genetics. 2018 May;209(1):129-141. doi: 10.1534/genetics.118.300809. Epub 2018 Mar 20.


Paf1 and Ctr9, core components of the PAF1 complex, maintain low levels of telomeric repeat containing RNA.

Rodrigues J, Lydall D.

Nucleic Acids Res. 2018 Jan 25;46(2):621-634. doi: 10.1093/nar/gkx1131.


Genome-Wide Quantitative Fitness Analysis (QFA) of Yeast Cultures.

Holstein EM, Lawless C, Banks P, Lydall D.

Methods Mol Biol. 2018;1672:575-597. doi: 10.1007/978-1-4939-7306-4_38.


A Functional Link Between Bir1 and the Saccharomyces cerevisiae Ctf19 Kinetochore Complex Revealed Through Quantitative Fitness Analysis.

Makrantoni V, Ciesiolka A, Lawless C, Fernius J, Marston A, Lydall D, Stark MJR.

G3 (Bethesda). 2017 Sep 7;7(9):3203-3215. doi: 10.1534/g3.117.300089.


Systematic Analysis of the DNA Damage Response Network in Telomere Defective Budding Yeast.

Holstein EM, Ngo G, Lawless C, Banks P, Greetham M, Wilkinson D, Lydall D.

G3 (Bethesda). 2017 Jul 5;7(7):2375-2389. doi: 10.1534/g3.117.042283.


Costs, benefits and redundant mechanisms of adaption to chronic low-dose stress in yeast.

Markiewicz-Potoczny M, Lydall D.

Cell Cycle. 2016 Oct 17;15(20):2732-41. doi: 10.1080/15384101.2016.1218104. Epub 2016 Aug 11.


Pho4 mediates phosphate acquisition in Candida albicans and is vital for stress resistance and metal homeostasis.

Ikeh MA, Kastora SL, Day AM, Herrero-de-Dios CM, Tarrant E, Waldron KJ, Banks AP, Bain JM, Lydall D, Veal EA, MacCallum DM, Erwig LP, Brown AJ, Quinn J.

Mol Biol Cell. 2016 Sep 1;27(17):2784-801. doi: 10.1091/mbc.E16-05-0266. Epub 2016 Jul 6.


Bayesian hierarchical modelling for inferring genetic interactions in yeast.

Heydari J, Lawless C, Lydall DA, Wilkinson DJ.

J R Stat Soc Ser C Appl Stat. 2016 Apr;65(3):367-393. Epub 2015 Oct 29.


Rif1 and Exo1 regulate the genomic instability following telomere losses.

Xue Y, Marvin ME, Ivanova IG, Lydall D, Louis EJ, Maringele L.

Aging Cell. 2016 Jun;15(3):553-62. doi: 10.1111/acel.12466. Epub 2016 Mar 22.


Genetic Networks Required to Coordinate Chromosome Replication by DNA Polymerases α, δ, and ε in Saccharomyces cerevisiae.

Dubarry M, Lawless C, Banks AP, Cockell S, Lydall D.

G3 (Bethesda). 2015 Aug 21;5(10):2187-97. doi: 10.1534/g3.115.021493.


The Telomere Binding Protein Cdc13 and the Single-Stranded DNA Binding Protein RPA Protect Telomeric DNA from Resection by Exonucleases.

Greetham M, Skordalakes E, Lydall D, Connolly BA.

J Mol Biol. 2015 Sep 25;427(19):3023-30. doi: 10.1016/j.jmb.2015.08.002. Epub 2015 Aug 8.


Quantitative Fitness Analysis Identifies exo1∆ and Other Suppressors or Enhancers of Telomere Defects in Schizosaccharomyces pombe.

Narayanan S, Dubarry M, Lawless C, Banks AP, Wilkinson DJ, Whitehall SK, Lydall D.

PLoS One. 2015 Jul 13;10(7):e0132240. doi: 10.1371/journal.pone.0132240. eCollection 2015.


The 9-1-1 checkpoint clamp coordinates resection at DNA double strand breaks.

Ngo GH, Lydall D.

Nucleic Acids Res. 2015 May 26;43(10):5017-32. doi: 10.1093/nar/gkv409. Epub 2015 Apr 29.


The 9-1-1 checkpoint clamp stimulates DNA resection by Dna2-Sgs1 and Exo1.

Ngo GH, Balakrishnan L, Dubarry M, Campbell JL, Lydall D.

Nucleic Acids Res. 2014;42(16):10516-28. doi: 10.1093/nar/gku746. Epub 2014 Aug 13.


Fast Bayesian parameter estimation for stochastic logistic growth models.

Heydari J, Lawless C, Lydall DA, Wilkinson DJ.

Biosystems. 2014 Aug;122:55-72. doi: 10.1016/j.biosystems.2014.05.002. Epub 2014 Jun 4.


Interplay between nonsense-mediated mRNA decay and DNA damage response pathways reveals that Stn1 and Ten1 are the key CST telomere-cap components.

Holstein EM, Clark KR, Lydall D.

Cell Rep. 2014 May 22;7(4):1259-69. doi: 10.1016/j.celrep.2014.04.017. Epub 2014 May 15.


The yeast copper response is regulated by DNA damage.

Dong K, Addinall SG, Lydall D, Rutherford JC.

Mol Cell Biol. 2013 Oct;33(20):4041-50. doi: 10.1128/MCB.00116-13. Epub 2013 Aug 19.


Pentose phosphate pathway function affects tolerance to the G-quadruplex binder TMPyP4.

Andrew EJ, Merchan S, Lawless C, Banks AP, Wilkinson DJ, Lydall D.

PLoS One. 2013 Jun 12;8(6):e66242. doi: 10.1371/journal.pone.0066242. Print 2013.


Simple, non-radioactive measurement of single-stranded DNA at telomeric, sub-telomeric, and genomic loci in budding yeast.

Dewar JM, Lydall D.

Methods Mol Biol. 2012;920:341-8. doi: 10.1007/978-1-61779-998-3_24.


Quantitative amplification of single-stranded DNA.

Holstein EM, Lydall D.

Methods Mol Biol. 2012;920:323-39. doi: 10.1007/978-1-61779-998-3_23.


A quantitative fitness analysis workflow.

Banks AP, Lawless C, Lydall DA.

J Vis Exp. 2012 Aug 13;(66). pii: 4018. doi: 10.3791/4018.


Genome-wide analysis to identify pathways affecting telomere-initiated senescence in budding yeast.

Chang HY, Lawless C, Addinall SG, Oexle S, Taschuk M, Wipat A, Wilkinson DJ, Lydall D.

G3 (Bethesda). 2011 Aug;1(3):197-208. doi: 10.1534/g3.111.000216. Epub 2011 Aug 1.


Similarities and differences between "uncapped" telomeres and DNA double-strand breaks.

Dewar JM, Lydall D.

Chromosoma. 2012 Apr;121(2):117-30. doi: 10.1007/s00412-011-0357-2. Epub 2011 Dec 28. Review.


Quantitative fitness analysis shows that NMD proteins and many other protein complexes suppress or enhance distinct telomere cap defects.

Addinall SG, Holstein EM, Lawless C, Yu M, Chapman K, Banks AP, Ngo HP, Maringele L, Taschuk M, Young A, Ciesiolka A, Lister AL, Wipat A, Wilkinson DJ, Lydall D.

PLoS Genet. 2011 Apr;7(4):e1001362. doi: 10.1371/journal.pgen.1001362. Epub 2011 Apr 7.


Customizable views on semantically integrated networks for systems biology.

Weile J, Pocock M, Cockell SJ, Lord P, Dewar JM, Holstein EM, Wilkinson D, Lydall D, Hallinan J, Wipat A.

Bioinformatics. 2011 May 1;27(9):1299-306. doi: 10.1093/bioinformatics/btr134. Epub 2011 Mar 16.


Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncapping.

Dewar JM, Lydall D.

EMBO J. 2010 Dec 1;29(23):4020-34. doi: 10.1038/emboj.2010.267. Epub 2010 Nov 2.


Survival and growth of yeast without telomere capping by Cdc13 in the absence of Sgs1, Exo1, and Rad9.

Ngo HP, Lydall D.

PLoS Genet. 2010 Aug 19;6(8):e1001072. doi: 10.1371/journal.pgen.1001072.


Telomere replication: Mre11 leads the way.

Dewar JM, Lydall D.

Mol Cell. 2010 Jun 25;38(6):777-9. doi: 10.1016/j.molcel.2010.06.003.


Colonyzer: automated quantification of micro-organism growth characteristics on solid agar.

Lawless C, Wilkinson DJ, Young A, Addinall SG, Lydall DA.

BMC Bioinformatics. 2010 May 28;11:287. doi: 10.1186/1471-2105-11-287.


Taming the tiger by the tail: modulation of DNA damage responses by telomeres.

Lydall D.

EMBO J. 2009 Aug 5;28(15):2174-87. doi: 10.1038/emboj.2009.176. Epub 2009 Jul 23. Review.


Telomere maintenance and survival in saccharomyces cerevisiae in the absence of telomerase and RAD52.

Lebel C, Rosonina E, Sealey DC, Pryde F, Lydall D, Maringele L, Harrington LA.

Genetics. 2009 Jul;182(3):671-84. doi: 10.1534/genetics.109.102939. Epub 2009 Apr 20.


A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae.

Addinall SG, Downey M, Yu M, Zubko MK, Dewar J, Leake A, Hallinan J, Shaw O, James K, Wilkinson DJ, Wipat A, Durocher D, Lydall D.

Genetics. 2008 Dec;180(4):2251-66. doi: 10.1534/genetics.108.092577. Epub 2008 Oct 9.


A genome wide analysis of the response to uncapped telomeres in budding yeast reveals a novel role for the NAD+ biosynthetic gene BNA2 in chromosome end protection.

Greenall A, Lei G, Swan DC, James K, Wang L, Peters H, Wipat A, Wilkinson DJ, Lydall D.

Genome Biol. 2008 Oct 1;9(10):R146. doi: 10.1186/gb-2008-9-10-r146.


Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response.

Morin I, Ngo HP, Greenall A, Zubko MK, Morrice N, Lydall D.

EMBO J. 2008 Sep 17;27(18):2400-10. doi: 10.1038/emboj.2008.171. Epub 2008 Aug 28.


Histone methyltransferase Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeres.

Lazzaro F, Sapountzi V, Granata M, Pellicioli A, Vaze M, Haber JE, Plevani P, Lydall D, Muzi-Falconi M.

EMBO J. 2008 May 21;27(10):1502-12. doi: 10.1038/emboj.2008.81. Epub 2008 Apr 17.


Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1.

Tsolou A, Lydall D.

DNA Repair (Amst). 2007 Nov;6(11):1607-17. Epub 2007 Jul 6.


Modelling the checkpoint response to telomere uncapping in budding yeast.

Proctor CJ, Lydall DA, Boys RJ, Gillespie CS, Shanley DP, Wilkinson DJ, Kirkwood TB.

J R Soc Interface. 2007 Feb 22;4(12):73-90.


Linear chromosome maintenance in the absence of essential telomere-capping proteins.

Zubko MK, Lydall D.

Nat Cell Biol. 2006 Jul;8(7):734-40. Epub 2006 Jun 11.


MRX protects telomeric DNA at uncapped telomeres of budding yeast cdc13-1 mutants.

Foster SS, Zubko MK, Guillard S, Lydall D.

DNA Repair (Amst). 2006 Jul 13;5(7):840-51. Epub 2006 Jun 12.


A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator.

Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D.

Cell. 2006 Mar 24;124(6):1155-68.


Pulsed-field gel electrophoresis of budding yeast chromosomes.

Maringele L, Lydall D.

Methods Mol Biol. 2006;313:65-73.


Chromatin and the DNA damage response.

Lydall D, Whitehall S.

DNA Repair (Amst). 2005 Sep 28;4(10):1195-207. Review.


The PAL-mechanism of chromosome maintenance: causes and consequences.

Maringele L, Lydall D.

Cell Cycle. 2005 Jun;4(6):747-51. Epub 2005 Jun 11.


Telomerase- and recombination-independent immortalization of budding yeast.

Maringele L, Lydall D.

Genes Dev. 2004 Nov 1;18(21):2663-75. Epub 2004 Oct 15.

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