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Items: 15


Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.

Bulman ZP, Ly NS, Lenhard JR, Holden PN, Bulitta JB, Tsuji BT.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e00096-16. doi: 10.1128/AAC.00096-16. Print 2017 Apr.


Polymyxin B in combination with meropenem against carbapenemase-producing Klebsiella pneumoniae: pharmacodynamics and morphological changes.

Sharma R, Patel S, Abboud C, Diep J, Ly NS, Pogue JM, Kaye KS, Li J, Rao GG.

Int J Antimicrob Agents. 2017 Feb;49(2):224-232. doi: 10.1016/j.ijantimicag.2016.10.025. Epub 2016 Dec 23.


Population Pharmacokinetics and Target Attainment of Ertapenem in Plasma and Tissue Assessed via Microdialysis in Morbidly Obese Patients after Laparoscopic Visceral Surgery.

Wittau M, Paschke S, Kurlbaum M, Scheele J, Ly NS, Hemper E, Kornmann M, Henne-Bruns D, Bulitta JB.

Antimicrob Agents Chemother. 2016 Dec 27;61(1). pii: e00952-16. doi: 10.1128/AAC.00952-16. Print 2017 Jan.


Polymyxin B in combination with doripenem against heteroresistant Acinetobacter baumannii: pharmacodynamics of new dosing strategies.

Rao GG, Ly NS, Bulitta JB, Soon RL, San Roman MD, Holden PN, Landersdorfer CB, Nation RL, Li J, Forrest A, Tsuji BT.

J Antimicrob Chemother. 2016 Nov;71(11):3148-3156. Epub 2016 Aug 3.


Combinatorial pharmacodynamics of polymyxin B and tigecycline against heteroresistant Acinetobacter baumannii.

Rao GG, Ly NS, Diep J, Forrest A, Bulitta JB, Holden PN, Nation RL, Li J, Tsuji BT.

Int J Antimicrob Agents. 2016 Sep;48(3):331-6. doi: 10.1016/j.ijantimicag.2016.06.006. Epub 2016 Jul 12.


Optimization of Polymyxin B in Combination with Doripenem To Combat Mutator Pseudomonas aeruginosa.

Ly NS, Bulman ZP, Bulitta JB, Baron C, Rao GG, Holden PN, Li J, Sutton MD, Tsuji BT.

Antimicrob Agents Chemother. 2016 Apr 22;60(5):2870-80. doi: 10.1128/AAC.02377-15. Print 2016 May.


Emergence of polymyxin B resistance influences pathogenicity in Pseudomonas aeruginosa mutators.

Bulman ZP, Sutton MD, Ly NS, Bulitta JB, Holden PN, Nation RL, Li J, Tsuji BT.

Antimicrob Agents Chemother. 2015 Jul;59(7):4343-6. doi: 10.1128/AAC.04629-14. Epub 2015 Apr 27.


Colistin and doripenem combinations against Pseudomonas aeruginosa: profiling the time course of synergistic killing and prevention of resistance.

Ly NS, Bulitta JB, Rao GG, Landersdorfer CB, Holden PN, Forrest A, Bergen PJ, Nation RL, Li J, Tsuji BT.

J Antimicrob Chemother. 2015 May;70(5):1434-42. doi: 10.1093/jac/dku567. Epub 2015 Feb 23.


Two mechanisms of killing of Pseudomonas aeruginosa by tobramycin assessed at multiple inocula via mechanism-based modeling.

Bulitta JB, Ly NS, Landersdorfer CB, Wanigaratne NA, Velkov T, Yadav R, Oliver A, Martin L, Shin BS, Forrest A, Tsuji BT.

Antimicrob Agents Chemother. 2015 Apr;59(4):2315-27. doi: 10.1128/AAC.04099-14. Epub 2015 Feb 2.


New dosing strategies for an old antibiotic: pharmacodynamics of front-loaded regimens of colistin at simulated pharmacokinetics in patients with kidney or liver disease.

Rao GG, Ly NS, Haas CE, Garonzik S, Forrest A, Bulitta JB, Kelchlin PA, Holden PN, Nation RL, Li J, Tsuji BT.

Antimicrob Agents Chemother. 2014;58(3):1381-8. doi: 10.1128/AAC.00327-13. Epub 2013 Dec 16.


Quantifying subpopulation synergy for antibiotic combinations via mechanism-based modeling and a sequential dosing design.

Landersdorfer CB, Ly NS, Xu H, Tsuji BT, Bulitta JB.

Antimicrob Agents Chemother. 2013 May;57(5):2343-51. doi: 10.1128/AAC.00092-13. Epub 2013 Mar 11.


Pharmacodynamic variability beyond that explained by MICs.

Soon RL, Ly NS, Rao G, Wollenberg L, Yang K, Tsuji B, Forrest A.

Antimicrob Agents Chemother. 2013 Apr;57(4):1730-5. doi: 10.1128/AAC.01224-12. Epub 2013 Jan 28.


Impact of two-component regulatory systems PhoP-PhoQ and PmrA-PmrB on colistin pharmacodynamics in Pseudomonas aeruginosa.

Ly NS, Yang J, Bulitta JB, Tsuji BT.

Antimicrob Agents Chemother. 2012 Jun;56(6):3453-6. doi: 10.1128/AAC.06380-11. Epub 2012 Apr 2.


Attenuation of colistin bactericidal activity by high inoculum of Pseudomonas aeruginosa characterized by a new mechanism-based population pharmacodynamic model.

Bulitta JB, Yang JC, Yohonn L, Ly NS, Brown SV, D'Hondt RE, Jusko WJ, Forrest A, Tsuji BT.

Antimicrob Agents Chemother. 2010 May;54(5):2051-62. doi: 10.1128/AAC.00881-09. Epub 2010 Mar 8.


Development and qualification of a pharmacodynamic model for the pronounced inoculum effect of ceftazidime against Pseudomonas aeruginosa.

Bulitta JB, Ly NS, Yang JC, Forrest A, Jusko WJ, Tsuji BT.

Antimicrob Agents Chemother. 2009 Jan;53(1):46-56. doi: 10.1128/AAC.00489-08. Epub 2008 Oct 13.

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