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Short Excited-State Lifetimes Enable Photo-Oxidatively Stable Rubrene Derivatives.

Ly J, Martin K, Thomas S, Yamashita M, Yu B, Pointer CA, Yamada H, Carter KR, Parkin S, Zhang L, Bredas JL, Young ER, Briseno AL.

J Phys Chem A. 2019 Aug 26. doi: 10.1021/acs.jpca.9b04203. [Epub ahead of print]


Process evaluation of team-based care in people aged >65 years with type 2 diabetes mellitus.

Sims Gould J, Tong C, Ly J, Vazirian S, Windt A, Khan K.

BMJ Open. 2019 Aug 2;9(8):e029965. doi: 10.1136/bmjopen-2019-029965.


Joint intracranial and carotid vessel wall imaging in 5 minutes using compressed sensing accelerated DANTE-SPACE.

Jia S, Zhang L, Ren L, Qi Y, Ly J, Zhang N, Li Y, Liu X, Zheng H, Liang D, Chung YC.

Eur Radiol. 2019 Aug 1. doi: 10.1007/s00330-019-06366-7. [Epub ahead of print]


Disruption of IRE1α through its kinase domain attenuates multiple myeloma.

Harnoss JM, Le Thomas A, Shemorry A, Marsters SA, Lawrence DA, Lu M, Chen YA, Qing J, Totpal K, Kan D, Segal E, Merchant M, Reichelt M, Ackerly Wallweber H, Wang W, Clark K, Kaufman S, Beresini MH, Laing ST, Sandoval W, Lorenzo M, Wu J, Ly J, De Bruyn T, Heidersbach A, Haley B, Gogineni A, Weimer RM, Lee D, Braun MG, Rudolph J, VanWyngarden MJ, Sherbenou DW, Gomez-Bougie P, Amiot M, Acosta-Alvear D, Walter P, Ashkenazi A.

Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16420-16429. doi: 10.1073/pnas.1906999116. Epub 2019 Aug 1.


Role of 3 Tesla MR Neurography and CT-guided Injections for Pudendal Neuralgia: Analysis of Pain Response.

Ly J, Scott K, Xi Y, Ashikyan O, Chhabra A.

Pain Physician. 2019 Jul;22(4):E333-E344.


Microbiota of newborn meconium is associated with maternal anxiety experienced during pregnancy.

Hu J, Ly J, Zhang W, Huang Y, Glover V, Peter I, Hurd YL, Nomura Y.

Dev Psychobiol. 2019 Jul;61(5):640-649. doi: 10.1002/dev.21837. Epub 2019 Mar 25.


Initial Debridement of Dorsal Hand Abscesses in the Operating Room Does Not Improve Outcomes.

Jennings JD, Vroome C, Ly JA, Thoder J.

Hand (N Y). 2019 Mar 21:1558944719836234. doi: 10.1177/1558944719836234. [Epub ahead of print]


Age-related decrease in cortical excitability circadian variations during sleep loss and its links with cognition.

Gaggioni G, Ly JQM, Muto V, Chellappa SL, Jaspar M, Meyer C, Delfosse T, Vanvinckenroye A, Dumont R, Coppieters 't Wallant D, Berthomier C, Narbutas J, Van Egroo M, Luxen A, Salmon E, Collette F, Phillips C, Schmidt C, Vandewalle G.

Neurobiol Aging. 2019 Jun;78:52-63. doi: 10.1016/j.neurobiolaging.2019.02.004. Epub 2019 Feb 13.


Stroke Severity Versus Dysphagia Screen as Driver for Post-stroke Pneumonia.

Phan TG, Kooblal T, Matley C, Singhal S, Clissold B, Ly J, Thrift AG, Srikanth V, Ma H.

Front Neurol. 2019 Jan 29;10:16. doi: 10.3389/fneur.2019.00016. eCollection 2019.


Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma.

Wang X, Blackaby W, Allen V, Chan GKY, Chang JH, Chiang PC, Diène C, Drummond J, Do S, Fan E, Harstad EB, Hodges A, Hu H, Jia W, Kofie W, Kolesnikov A, Lyssikatos JP, Ly J, Matteucci M, Moffat JG, Munugalavadla V, Murray J, Nash D, Noland CL, Del Rosario G, Ross L, Rouse C, Sharpe A, Slaga D, Sun M, Tsui V, Wallweber H, Yu SF, Ebens AJ.

J Med Chem. 2019 Feb 28;62(4):2140-2153. doi: 10.1021/acs.jmedchem.8b01857. Epub 2019 Feb 20.


Impact of infarct location on functional outcome following endovascular therapy for stroke.

Rosso C, Blanc R, Ly J, Samson Y, Lehéricy S, Gory B, Marnat G, Mazighi M, Consoli A, Labreuche J, Saleme S, Costalat V, Bracard S, Desal H, Piotin M, Lapergue B; ASTER Trial and Pitié-Salpêtrière Investigators.

J Neurol Neurosurg Psychiatry. 2019 Mar;90(3):313-319. doi: 10.1136/jnnp-2018-318869. Epub 2018 Nov 13.


Efficient Electron Mobility in an All-Acceptor Napthalenediimide-Bithiazole Polymer Semiconductor with Large Backbone Torsion.

Ly JT, Burnett EK, Thomas S, Aljarb A, Liu Y, Park S, Rosa S, Yi Y, Lee H, Emrick T, Russell TP, Brédas JL, Briseno AL.

ACS Appl Mater Interfaces. 2018 Nov 21;10(46):40070-40077. doi: 10.1021/acsami.8b11234. Epub 2018 Nov 12.


Preclinical assessment of the ADME, efficacy and drug-drug interaction potential of a novel NAMPT inhibitor.

Liederer BM, Cheong J, Chou KJ, Dragovich PS, Le H, Liang X, Ly J, Mukadam S, Oeh J, Sampath D, Wang L, Wong S.

Xenobiotica. 2019 Sep;49(9):1063-1077. doi: 10.1080/00498254.2018.1528407. Epub 2019 Jan 17.


Training on the Use of Technology to Collect Patient-Reported Outcome Data Electronically in Clinical Trials: Best Practice Recommendations from the ePRO Consortium.

Ly JJ, Crescioni M, Eremenco S, Bodart S, Donoso M, Butler AJ, Dallabrida SM.

Ther Innov Regul Sci. 2019 Jul;53(4):431-440. doi: 10.1177/2168479018796206. Epub 2018 Sep 16.


Conserved transcriptional activity and ligand responsiveness of avian PPARs: Potential role in regulating lipid metabolism in mirgratory birds.

Hamilton A, Ly J, Robinson JR, Corder KR, DeMoranville KJ, Schaeffer PJ, Huss JM.

Gen Comp Endocrinol. 2018 Nov 1;268:110-120. doi: 10.1016/j.ygcen.2018.08.009. Epub 2018 Aug 13.


Deactivation of Implantable Cardioverter-Defibrillators in Heart Failure: A Systematic Review.

Herman M, Horner K, Ly J, Vayl Y.

J Hosp Palliat Nurs. 2018 Feb;20(1):63-71. doi: 10.1097/NJH.0000000000000399.


[Clinical management of acute stroke].

Ly J, Maquet P.

Rev Med Liege. 2018 May;73(5-6):333-337. Review. French.


Unremarkable impact of Oatp inhibition on the liver concentration of fluvastatin, lovastatin and pitavastatin in wild-type and Oatp1a/1b knockout mouse.

Chang JH, Zhang X, Messick K, Chen YC, Chen E, Cheong J, Ly J.

Xenobiotica. 2019 May;49(5):602-610. doi: 10.1080/00498254.2018.1478167. Epub 2018 Jun 6.


Attention Measures of Accuracy, Variability, and Fatigue Detect Early Response to Donepezil in Alzheimer's Disease: A Randomized, Double-blind, Placebo-Controlled Pilot Trial.

Vila-Castelar C, Ly JJ, Kaplan L, Van Dyk K, Berger JT, Macina LO, Stewart JL, Foldi NS.

Arch Clin Neuropsychol. 2019 May 1;34(3):277-289. doi: 10.1093/arclin/acy032.


Nano-assemblies of cationic mPEG brush block copolymers with gadolinium polyoxotungstate [Gd(W5O18)2]9- form stable, high relaxivity MRI contrast agents.

Ly J, Li Y, Vu MN, Moffat BA, Jack KS, Quinn JF, Whittaker MR, Davis TP.

Nanoscale. 2018 Apr 19;10(15):7270-7280. doi: 10.1039/c8nr01544a.


Human fronto-parietal response scattering subserves vigilance at night.

Gaggioni G, Ly JQM, Chellappa SL, Coppieters 't Wallant D, Rosanova M, Sarasso S, Luxen A, Salmon E, Middleton B, Massimini M, Schmidt C, Casali A, Phillips C, Vandewalle G.

Neuroimage. 2018 Jul 15;175:354-364. doi: 10.1016/j.neuroimage.2018.03.055. Epub 2018 Mar 28.


Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling.

Chen H, Volgraf M, Do S, Kolesnikov A, Shore DG, Verma VA, Villemure E, Wang L, Chen Y, Hu B, Lu AJ, Wu G, Xu X, Yuen PW, Zhang Y, Erickson SD, Dahl M, Brotherton-Pleiss C, Tay S, Ly JQ, Murray LJ, Chen J, Amm D, Lange W, Hackos DH, Reese RM, Shields SD, Lyssikatos JP, Safina BS, Estrada AA.

J Med Chem. 2018 Apr 26;61(8):3641-3659. doi: 10.1021/acs.jmedchem.8b00117. Epub 2018 Apr 12.


Exploratory Use of Decision Tree Analysis in Classification of Outcome in Hypoxic-Ischemic Brain Injury.

Phan TG, Chen J, Singhal S, Ma H, Clissold BB, Ly J, Beare R.

Front Neurol. 2018 Mar 6;9:126. doi: 10.3389/fneur.2018.00126. eCollection 2018.


Toward miniaturized analysis of chemical identity and purity of radiopharmaceuticals via microchip electrophoresis.

Ly J, Ha NS, Cheung S, van Dam RM.

Anal Bioanal Chem. 2018 Mar;410(9):2423-2436. doi: 10.1007/s00216-018-0924-y. Epub 2018 Feb 22.


Diacerein orphan drug development for epidermolysis bullosa simplex: A phase 2/3 randomized, placebo-controlled, double-blind clinical trial.

Wally V, Hovnanian A, Ly J, Buckova H, Brunner V, Lettner T, Ablinger M, Felder TK, Hofbauer P, Wolkersdorfer M, Lagler FB, Hitzl W, Laimer M, Kitzmüller S, Diem A, Bauer JW.

J Am Acad Dermatol. 2018 May;78(5):892-901.e7. doi: 10.1016/j.jaad.2018.01.019. Epub 2018 Feb 2.


Multifocal intradural extramedullary anaplastic ependymoma of the spine.

Chakravorty A, Frydenberg E, Shein TT, Ly J, Earls P, Steel T.

J Spine Surg. 2017 Dec;3(4):727-731. doi: 10.21037/jss.2017.11.10.


Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300.

Lai KW, Romero FA, Tsui V, Beresini MH, de Leon Boenig G, Bronner SM, Chen K, Chen Z, Choo EF, Crawford TD, Cyr P, Kaufman S, Li Y, Liao J, Liu W, Ly J, Murray J, Shen W, Wai J, Wang F, Zhu C, Zhu X, Magnuson S.

Bioorg Med Chem Lett. 2018 Jan 1;28(1):15-23. doi: 10.1016/j.bmcl.2017.11.025. Epub 2017 Nov 14.


A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors.

Bronner SM, Murray J, Romero FA, Lai KW, Tsui V, Cyr P, Beresini MH, de Leon Boenig G, Chen Z, Choo EF, Clark KR, Crawford TD, Jayaram H, Kaufman S, Li R, Li Y, Liao J, Liang X, Liu W, Ly J, Maher J, Wai J, Wang F, Zheng A, Zhu X, Magnuson S.

J Med Chem. 2017 Dec 28;60(24):10151-10171. doi: 10.1021/acs.jmedchem.7b01372. Epub 2017 Dec 11.


Using Serum IgE Antibodies to Predict Esophageal Eosinophilia in Children.

Erwin EA, Rhoda DA, Redmond M, Ly JB, Russo JM, Hill ID, Platts-Mills TAE.

J Pediatr Gastroenterol Nutr. 2017 Nov;65(5):520-525. doi: 10.1097/MPG.0000000000001553.


GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).

Romero FA, Murray J, Lai KW, Tsui V, Albrecht BK, An L, Beresini MH, de Leon Boenig G, Bronner SM, Chan EW, Chen KX, Chen Z, Choo EF, Clagg K, Clark K, Crawford TD, Cyr P, de Almeida Nagata D, Gascoigne KE, Grogan JL, Hatzivassiliou G, Huang W, Hunsaker TL, Kaufman S, Koenig SG, Li R, Li Y, Liang X, Liao J, Liu W, Ly J, Maher J, Masui C, Merchant M, Ran Y, Taylor AM, Wai J, Wang F, Wei X, Yu D, Zhu BY, Zhu X, Magnuson S.

J Med Chem. 2017 Nov 22;60(22):9162-9183. doi: 10.1021/acs.jmedchem.7b00796. Epub 2017 Sep 21.


Acute caffeine ingestion affects surround suppression of perceived contrast.

Nguyen BN, Hew SA, Ly J, Shin HY, Wong JC, Yeung E, McKendrick AM.

J Psychopharmacol. 2018 Jan;32(1):81-88. doi: 10.1177/0269881117725684. Epub 2017 Sep 7.


Novel volumetric method for highly repeatable injection in microchip electrophoresis.

Ha NS, Ly J, Jones J, Cheung S, van Dam RM.

Anal Chim Acta. 2017 Sep 8;985:129-140. doi: 10.1016/j.aca.2017.05.037. Epub 2017 Jun 19.


Characterizing the in vitro species differences in N-glucuronidation of a potent pan-PIM inhibitor GNE-924 containing a 3,5-substituted 6-azaindazole.

Lin M, Ly J, Takahashi R, Chen J, Deese A, Robinson SJ, Kolesnikov A, Wong S, Wang X, Chang JH.

Xenobiotica. 2018 Oct;48(10):1021-1027. doi: 10.1080/00498254.2017.1373312. Epub 2017 Sep 29.


Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer.

Jin L, Garcia J, Chan E, de la Cruz C, Segal E, Merchant M, Kharbanda S, Raisner R, Haverty PM, Modrusan Z, Ly J, Choo E, Kaufman S, Beresini MH, Romero FA, Magnuson S, Gascoigne KE.

Cancer Res. 2017 Oct 15;77(20):5564-5575. doi: 10.1158/0008-5472.CAN-17-0314. Epub 2017 Aug 17.


Predicting Disability after Ischemic Stroke Based on Comorbidity Index and Stroke Severity-From the Virtual International Stroke Trials Archive-Acute Collaboration.

Phan TG, Clissold BB, Ma H, Ly JV, Srikanth V.

Front Neurol. 2017 May 19;8:192. doi: 10.3389/fneur.2017.00192. eCollection 2017.


Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability.

Wang X, Kolesnikov A, Tay S, Chan G, Chao Q, Do S, Drummond J, Ebens AJ, Liu N, Ly J, Harstad E, Hu H, Moffat J, Munugalavadla V, Murray J, Slaga D, Tsui V, Volgraf M, Wallweber H, Chang JH.

J Med Chem. 2017 May 25;60(10):4458-4473. doi: 10.1021/acs.jmedchem.7b00418. Epub 2017 May 5.


A comparison of the cost of primary closure or rectus abdominis myocutaneous flap closure of the perineum after abdominoperineal excision.

Woodfield J, Hulme-Moir M, Ly J.

Colorectal Dis. 2017 Oct;19(10):934-941. doi: 10.1111/codi.13690.


Restoring Cytokine Balance in HIV-Positive Individuals with Low CD4 T Cell Counts.

Valdivia A, Ly J, Gonzalez L, Hussain P, Saing T, Islamoglu H, Pearce D, Ochoa C, Venketaraman V.

AIDS Res Hum Retroviruses. 2017 Sep;33(9):905-918. doi: 10.1089/AID.2016.0303. Epub 2017 May 10.


Googling Service Boundaries for Endovascular Clot Retrieval Hub Hospitals in a Metropolitan Setting: Proof-of-Concept Study.

Phan TG, Beare R, Chen J, Clissold B, Ly J, Singhal S, Ma H, Srikanth V.

Stroke. 2017 May;48(5):1353-1361. doi: 10.1161/STROKEAHA.116.015323. Epub 2017 Mar 29.


Utility of CYP3A4 and PXR-CAR-CYP3A4/3A7 Transgenic Mouse Models To Assess the Magnitude of CYP3A4 Mediated Drug-Drug Interactions.

Ly JQ, Messick K, Qin A, Takahashi RH, Choo EF.

Mol Pharm. 2017 May 1;14(5):1754-1759. doi: 10.1021/acs.molpharmaceut.7b00006. Epub 2017 Apr 7.


Classification of Different Degrees of Disability Following Intracerebral Hemorrhage: A Decision Tree Analysis from VISTA-ICH Collaboration.

Phan TG, Chen J, Beare R, Ma H, Clissold B, Van Ly J, Srikanth V; VISTA-ICH Collaboration.

Front Neurol. 2017 Feb 28;8:64. doi: 10.3389/fneur.2017.00064. eCollection 2017.


Examining Subcortical Infarcts in the Era of Acute Multimodality CT Imaging.

Tan MY, Singhal S, Ma H, Chandra RV, Cheong J, Clissold BB, Ly J, Srikanth V, Phan TG.

Front Neurol. 2016 Dec 5;7:220. eCollection 2016.


Arthroscopic Double-Row Suture Anchor Repair of Acute Posterior Bony Bankart Lesion.

Ly JA, Coleman EM, Kropf EJ.

Arthrosc Tech. 2016 Aug 8;5(4):e839-e843. eCollection 2016 Aug.


Prevalence of Brain MRI Markers of Hemorrhagic Risk in Patients with Stroke and Atrial Fibrillation.

Karayiannis C, Soufan C, Chandra RV, Phan TG, Wong K, Singhal S, Slater LA, Ly J, Moran C, Srikanth V.

Front Neurol. 2016 Sep 20;7:151. eCollection 2016.


Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.

Crawford TD, Romero FA, Lai KW, Tsui V, Taylor AM, de Leon Boenig G, Noland CL, Murray J, Ly J, Choo EF, Hunsaker TL, Chan EW, Merchant M, Kharbanda S, Gascoigne KE, Kaufman S, Beresini MH, Liao J, Liu W, Chen KX, Chen Z, Conery AR, Côté A, Jayaram H, Jiang Y, Kiefer JR, Kleinheinz T, Li Y, Maher J, Pardo E, Poy F, Spillane KL, Wang F, Wang J, Wei X, Xu Z, Xu Z, Yen I, Zawadzke L, Zhu X, Bellon S, Cummings R, Cochran AG, Albrecht BK, Magnuson S.

J Med Chem. 2016 Dec 8;59(23):10549-10563. Epub 2016 Sep 28.


Circadian dynamics in measures of cortical excitation and inhibition balance.

Chellappa SL, Gaggioni G, Ly JQ, Papachilleos S, Borsu C, Brzozowski A, Rosanova M, Sarasso S, Luxen A, Middleton B, Archer SN, Dijk DJ, Massimini M, Maquet P, Phillips C, Moran RJ, Vandewalle G.

Sci Rep. 2016 Sep 21;6:33661. doi: 10.1038/srep33661.


Unrecognized osteoid osteoma of the proximal femur with associated cam impingement.

Ly JA, Coleman EM, Cohen GS, Kropf EJ.

J Hip Preserv Surg. 2016 Jun 1;3(3):236-7. doi: 10.1093/jhps/hnw002. eCollection 2016 Aug. Review.


Rifampin-Mediated Induction of Tamoxifen Metabolism in a Humanized PXR-CAR-CYP3A4/3A7-CYP2D6 Mouse Model.

Chang JH, Chen J, Liu L, Messick K, Ly J.

Drug Metab Dispos. 2016 Nov;44(11):1736-1741. Epub 2016 Aug 18.


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