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Items: 1 to 50 of 146

1.

Health and Aging: Unifying Concepts, Scores, Biomarkers and Pathways.

Fuellen G, Jansen L, Cohen AA, Luyten W, Gogol M, Simm A, Saul N, Cirulli F, Berry A, Antal P, Köhling R, Wouters B, Möller S.

Aging Dis. 2019 Aug 1;10(4):883-900. doi: 10.14336/AD.2018.1030. eCollection 2019 Aug. Review.

2.

Advantages and shortcomings of cell-based electrical impedance measurements as a GPCR drug discovery tool.

Doijen J, Van Loy T, Landuyt B, Luyten W, Schols D, Schoofs L.

Biosens Bioelectron. 2019 Jul 15;137:33-44. doi: 10.1016/j.bios.2019.04.041. Epub 2019 Apr 28. Review.

PMID:
31077988
3.

Isolation of Antimicrobial Compounds From Cnestis ferruginea Vahl ex. DC (Connaraceae) Leaves Through Bioassay-Guided Fractionation.

Kouakou K, Panda SK, Yang MR, Lu JG, Jiang ZH, Van Puyvelde L, Luyten W.

Front Microbiol. 2019 Apr 11;10:705. doi: 10.3389/fmicb.2019.00705. eCollection 2019.

4.

Screening of a drug repurposing library with a nematode motility assay identifies promising anthelmintic hits against Cooperia oncophora and other ruminant parasites.

Liu M, Landuyt B, Klaassen H, Geldhof P, Luyten W.

Vet Parasitol. 2019 Jan;265:15-18. doi: 10.1016/j.vetpar.2018.11.014. Epub 2018 Dec 7.

PMID:
30638515
5.

Bioassay-Guided Isolation of Anti-Candida Biofilm Compounds From Methanol Extracts of the Aerial Parts of Salvia officinalis (Annaba, Algeria).

Kerkoub N, Panda SK, Yang MR, Lu JG, Jiang ZH, Nasri H, Luyten W.

Front Pharmacol. 2018 Dec 10;9:1418. doi: 10.3389/fphar.2018.01418. eCollection 2018.

6.

Antimicrobial secondary metabolites of an endolichenic Aspergillus niger isolated from lichen thallus of Parmotrema ravum.

Padhi S, Masi M, Panda SK, Luyten W, Cimmino A, Tayung K, Evidente A.

Nat Prod Res. 2019 Jan 2:1-8. doi: 10.1080/14786419.2018.1544982. [Epub ahead of print]

PMID:
30600725
7.

Bioassay-guided isolation of anti-seizure principles from Semen Pharbitidis using a zebrafish pentylenetetrazol seizure model.

Liu M, Copmans D, Lu JG, Yang MR, Sourbron J, Ny A, Jiang ZH, de Witte PAM, Luyten W.

J Ethnopharmacol. 2019 Mar 25;232:130-134. doi: 10.1016/j.jep.2018.12.024. Epub 2018 Dec 17.

PMID:
30572093
8.

Identification of fukinolic acid from Cimicifuga heracleifolia and its derivatives as novel antiviral compounds against enterovirus A71 infection.

Ma Y, Cong W, Huang H, Sun L, Mai AH, Boonen K, Maryam W, De Borggraeve W, Luo G, Liu Q, Schoofs L, Van Kuppeveld F, Neyts J, Mirabelli C, Luyten W.

Int J Antimicrob Agents. 2019 Feb;53(2):128-136. doi: 10.1016/j.ijantimicag.2018.07.014. Epub 2018 Jul 29.

PMID:
30063999
9.

Bioassay-guided isolation of three anthelmintic compounds from Warburgia ugandensis Sprague subspecies ugandensis, and the mechanism of action of polygodial.

Liu M, Kipanga P, Mai AH, Dhondt I, Braeckman BP, De Borggraeve W, Luyten W.

Int J Parasitol. 2018 Sep;48(11):833-844. doi: 10.1016/j.ijpara.2017.11.009. Epub 2018 Jul 18.

PMID:
30031002
10.

Assessing medicinal plants traditionally used in the Chirang Reserve Forest, Northeast India for antimicrobial activity.

Panda SK, Das R, Leyssen P, Neyts J, Luyten W.

J Ethnopharmacol. 2018 Oct 28;225:220-233. doi: 10.1016/j.jep.2018.07.011. Epub 2018 Jul 11.

PMID:
30005956
11.

Bioassay-guided isolation of active substances from Semen Torreyae identifies two new anthelmintic compounds with novel mechanism of action.

Liu M, Veryser C, Lu JG, Wenseleers T, De Borggraeve WM, Jiang ZH, Luyten W.

J Ethnopharmacol. 2018 Oct 5;224:421-428. doi: 10.1016/j.jep.2018.06.026. Epub 2018 Jun 19.

PMID:
29933012
12.

Iterative Chemical Engineering of Vancomycin Leads to Novel Vancomycin Analogs With a High in Vitro Therapeutic Index.

Mishra NM, Stolarzewicz I, Cannaerts D, Schuermans J, Lavigne R, Looz Y, Landuyt B, Schoofs L, Schols D, Paeshuyse J, Hickenbotham P, Clokie M, Luyten W, Van der Eycken EV, Briers Y.

Front Microbiol. 2018 Jun 7;9:1175. doi: 10.3389/fmicb.2018.01175. eCollection 2018.

13.

Comprehensive Peptide Analysis of Mouse Brain Striatum Identifies Novel sORF-Encoded Polypeptides.

Budamgunta H, Olexiouk V, Luyten W, Schildermans K, Maes E, Boonen K, Menschaert G, Baggerman G.

Proteomics. 2018 May;18(10):e1700218. doi: 10.1002/pmic.201700218. Erratum in: Proteomics. 2018 Aug;18(15):e1870118.

PMID:
29710410
14.

Antiparasitic activity in Asteraceae with special attention to ethnobotanical use by the tribes of Odisha, India.

Panda SK, Luyten W.

Parasite. 2018;25:10. doi: 10.1051/parasite/2018008. Epub 2018 Mar 12. Review.

15.

Essential oils and their components are a class of antifungals with potent vapour-phase-mediated anti-Candida activity.

Feyaerts AF, Mathé L, Luyten W, De Graeve S, Van Dyck K, Broekx L, Van Dijck P.

Sci Rep. 2018 Mar 2;8(1):3958. doi: 10.1038/s41598-018-22395-6.

16.

Anticancer Activity Study of Chromone and Coumarin Hybrids using Electrical Impedance Spectroscopy.

Bouhenna MM, Mameri N, Pérez MV, Talhi O, Bachari K, Silva AMS, Luyten W.

Anticancer Agents Med Chem. 2018;18(6):854-864. doi: 10.2174/1871520618666180130102259.

PMID:
29380706
17.

Active principles of Tetradenia riparia. IV. Anthelmintic activity of 8(14),15-sandaracopimaradiene-7α,18-diol.

Van Puyvelde L, Liu M, Veryser C, De Borggraeve WM, Mungarulire J, Mukazayire MJ, Luyten W.

J Ethnopharmacol. 2018 Apr 24;216:229-232. doi: 10.1016/j.jep.2018.01.024. Epub 2018 Jan 31.

PMID:
29366765
18.

Antimicrobial, Anthelmintic, and Antiviral Activity of Plants Traditionally Used for Treating Infectious Disease in the Similipal Biosphere Reserve, Odisha, India.

Panda SK, Padhi L, Leyssen P, Liu M, Neyts J, Luyten W.

Front Pharmacol. 2017 Oct 23;8:658. doi: 10.3389/fphar.2017.00658. eCollection 2017.

19.

New class of early-stage enterovirus inhibitors with a novel mechanism of action.

Ma Y, Abdelnabi R, Delang L, Froeyen M, Luyten W, Neyts J, Mirabelli C.

Antiviral Res. 2017 Nov;147:67-74. doi: 10.1016/j.antiviral.2017.10.004. Epub 2017 Oct 7.

PMID:
28993161
20.

Signaling properties of the human chemokine receptors CXCR4 and CXCR7 by cellular electric impedance measurements.

Doijen J, Van Loy T, De Haes W, Landuyt B, Luyten W, Schoofs L, Schols D.

PLoS One. 2017 Sep 25;12(9):e0185354. doi: 10.1371/journal.pone.0185354. eCollection 2017.

21.

Crystal structure of Porphyromonas gingivalis dipeptidyl peptidase 4 and structure-activity relationships based on inhibitor profiling.

Rea D, Van Elzen R, De Winter H, Van Goethem S, Landuyt B, Luyten W, Schoofs L, Van Der Veken P, Augustyns K, De Meester I, Fülöp V, Lambeir AM.

Eur J Med Chem. 2017 Oct 20;139:482-491. doi: 10.1016/j.ejmech.2017.08.024. Epub 2017 Aug 10.

PMID:
28826083
22.

Three-dimensional cell culture models for anticancer drug screening: Worth the effort?

Verjans ET, Doijen J, Luyten W, Landuyt B, Schoofs L.

J Cell Physiol. 2018 Apr;233(4):2993-3003. doi: 10.1002/jcp.26052. Epub 2017 Jul 11. Review.

PMID:
28618001
23.

Influence of serum and polystyrene plate type on stability of Candida albicans biofilms.

Kipanga PN, Luyten W.

J Microbiol Methods. 2017 Aug;139:8-11. doi: 10.1016/j.mimet.2017.04.006. Epub 2017 Apr 21.

PMID:
28434823
24.

Molecular mechanisms of LL-37-induced receptor activation: An overview.

Verjans ET, Zels S, Luyten W, Landuyt B, Schoofs L.

Peptides. 2016 Nov;85:16-26. doi: 10.1016/j.peptides.2016.09.002. Epub 2016 Sep 5. Review.

PMID:
27609777
25.

Ageing with elegans: a research proposal to map healthspan pathways.

Luyten W, Antal P, Braeckman BP, Bundy J, Cirulli F, Fang-Yen C, Fuellen G, Leroi A, Liu Q, Martorell P, Metspalu A, Perola M, Ristow M, Saul N, Schoofs L, Siems K, Temmerman L, Smets T, Wolk A, Rattan SI.

Biogerontology. 2016 Aug;17(4):771-82. doi: 10.1007/s10522-016-9644-x. Epub 2016 Apr 4.

PMID:
27040825
26.

Extracting relations from traditional Chinese medicine literature via heterogeneous entity networks.

Wan H, Moens MF, Luyten W, Zhou X, Mei Q, Liu L, Tang J.

J Am Med Inform Assoc. 2016 Mar;23(2):356-65. doi: 10.1093/jamia/ocv092. Epub 2015 Jul 29.

PMID:
26224335
27.

Evaluation of the antibacterial and antibiofilm activities of novel CRAMP-vancomycin conjugates with diverse linkers.

Mishra NM, Briers Y, Lamberigts C, Steenackers H, Robijns S, Landuyt B, Vanderleyden J, Schoofs L, Lavigne R, Luyten W, Van der Eycken EV.

Org Biomol Chem. 2015 Jul 21;13(27):7477-86. doi: 10.1039/c5ob00830a.

PMID:
26068402
28.

Derivatives of the mouse cathelicidin-related antimicrobial peptide (CRAMP) inhibit fungal and bacterial biofilm formation.

De Brucker K, Delattin N, Robijns S, Steenackers H, Verstraeten N, Landuyt B, Luyten W, Schoofs L, Dovgan B, Fröhlich M, Michiels J, Vanderleyden J, Cammue BP, Thevissen K.

Antimicrob Agents Chemother. 2014 Sep;58(9):5395-404. doi: 10.1128/AAC.03045-14. Epub 2014 Jun 30.

29.

Combining in silico prediction and ribosome profiling in a genome-wide search for novel putatively coding sORFs.

Crappé J, Van Criekinge W, Trooskens G, Hayakawa E, Luyten W, Baggerman G, Menschaert G.

BMC Genomics. 2013 Sep 23;14:648. doi: 10.1186/1471-2164-14-648.

30.

Improving the identification rate of endogenous peptides using electron transfer dissociation and collision-induced dissociation.

Hayakawa E, Menschaert G, De Bock PJ, Luyten W, Gevaert K, Baggerman G, Schoofs L.

J Proteome Res. 2013 Dec 6;12(12):5410-21. doi: 10.1021/pr400446z. Epub 2013 Oct 3.

PMID:
24032530
31.

Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models.

Buenafe OE, Orellana-Paucar A, Maes J, Huang H, Ying X, De Borggraeve W, Crawford AD, Luyten W, Esguerra CV, de Witte P.

ACS Chem Neurosci. 2013 Nov 20;4(11):1479-87. doi: 10.1021/cn400140e. Epub 2013 Sep 6.

32.

PIUS: peptide identification by unbiased search.

Costa EP, Menschaert G, Luyten W, De Grave K, Ramon J.

Bioinformatics. 2013 Aug 1;29(15):1913-4. doi: 10.1093/bioinformatics/btt298. Epub 2013 May 24.

PMID:
23709496
33.

A comprehensive summary of LL-37, the factotum human cathelicidin peptide.

Vandamme D, Landuyt B, Luyten W, Schoofs L.

Cell Immunol. 2012 Nov;280(1):22-35. doi: 10.1016/j.cellimm.2012.11.009. Epub 2012 Nov 29. Review.

PMID:
23246832
34.

Peptidomic analysis of human reflex tear fluid.

Hayakawa E, Landuyt B, Baggerman G, Cuyvers R, Lavigne R, Luyten W, Schoofs L.

Peptides. 2013 Apr;42:63-9. doi: 10.1016/j.peptides.2012.11.018. Epub 2012 Dec 8.

PMID:
23228955
35.

Antifungal activity in plants from Chinese traditional and folk medicine.

Liu Q, Luyten W, Pellens K, Wang Y, Wang W, Thevissen K, Liang Q, Cammue BP, Schoofs L, Luo G.

J Ethnopharmacol. 2012 Oct 11;143(3):772-8. doi: 10.1016/j.jep.2012.06.019. Epub 2012 Jul 31.

PMID:
22867635
36.

Insights on biology and pathology of HIF-1α/-2α, TGFβ/BMP, Wnt/β-catenin, and NF-κB pathways in osteoarthritis.

Wu L, Huang X, Li L, Huang H, Xu R, Luyten W.

Curr Pharm Des. 2012;18(22):3293-312. Review.

PMID:
22646092
37.

AMIGO2 mRNA expression in hippocampal CA2 and CA3a.

Laeremans A, Nys J, Luyten W, D'Hooge R, Paulussen M, Arckens L.

Brain Struct Funct. 2013 Jan;218(1):123-30.

PMID:
22314660
38.

Comparison of extraction methods for peptidomics analysis of mouse brain tissue.

Van Dijck A, Hayakawa E, Landuyt B, Baggerman G, Van Dam D, Luyten W, Schoofs L, De Deyn PP.

J Neurosci Methods. 2011 Apr 30;197(2):231-7. doi: 10.1016/j.jneumeth.2011.02.023. Epub 2011 Mar 2.

PMID:
21376080
39.

The dipeptidyl peptidase IV (CD26, EC 3.4.14.5) inhibitor vildagliptin is a potent antihyperalgesic in rats by promoting endomorphin-2 generation in the spinal cord.

Király K, Lambeir AM, Szalai J, Szentirmay A, Luyten W, Barna I, Puskár Z, Kozsurek M, Rónai AZ.

Eur J Pharmacol. 2011 Jan 10;650(1):195-9. doi: 10.1016/j.ejphar.2010.09.060. Epub 2010 Oct 15.

PMID:
20940010
40.

Peptidomics coming of age: a review of contributions from a bioinformatics angle.

Menschaert G, Vandekerckhove TT, Baggerman G, Schoofs L, Luyten W, Van Criekinge W.

J Proteome Res. 2010 May 7;9(5):2051-61. doi: 10.1021/pr900929m. Review.

PMID:
20377245
41.

Identification and relative quantification of neuropeptides from the endocrine tissues.

Boonen K, Husson SJ, Landuyt B, Baggerman G, Hayakawa E, Luyten WH, Schoofs L.

Methods Mol Biol. 2010;615:191-206. doi: 10.1007/978-1-60761-535-4_15.

PMID:
20013210
42.

A hybrid, de novo based, genome-wide database search approach applied to the sea urchin neuropeptidome.

Menschaert G, Vandekerckhove TT, Baggerman G, Landuyt B, Sweedler JV, Schoofs L, Luyten W, Van Criekinge W.

J Proteome Res. 2010 Feb 5;9(2):990-6. doi: 10.1021/pr900885k.

43.

Spectral clustering in peptidomics studies helps to unravel modification profile of biologically active peptides and enhances peptide identification rate.

Menschaert G, Vandekerckhove TT, Landuyt B, Hayakawa E, Schoofs L, Luyten W, Van Criekinge W.

Proteomics. 2009 Sep;9(18):4381-8. doi: 10.1002/pmic.200900248.

PMID:
19658089
44.

Thymosin beta 4 mRNA and peptide expression in phagocytic cells of different mouse tissues.

Paulussen M, Landuyt B, Schoofs L, Luyten W, Arckens L.

Peptides. 2009 Oct;30(10):1822-32. doi: 10.1016/j.peptides.2009.07.010. Epub 2009 Jul 23.

PMID:
19631707
45.

Central administration of obestatin fails to show inhibitory effects on food and water intake in mice.

Van Dijck A, Van Dam D, Vergote V, De Spiegeleer B, Luyten W, Schoofs L, De Deyn PP.

Regul Pept. 2009 Aug 7;156(1-3):77-82. doi: 10.1016/j.regpep.2009.04.014. Epub 2009 May 5. Erratum in: Regul Pept. 2010 Aug 9;163(1-3):143. Annemie, Van Dijck [corrected to Van Dijck, Annemie]; Debby, Van Dam [corrected to Van Dam, Debby] Valentijn, Vergote [corrected to Vergote, Valentijn]; Bart, De Spiegeleer [corrected to De Spiegeleer, Bart]; Walter, Luyten [corrected to Luyten, Walter]; L.

PMID:
19422857
46.

Bioinformatics solutions for MS/MS interpretation tailored to the peptidomics field.

Menschaert G, Vandekerckhove TT, Baggerman G, Landuyt B, Schoofs L, Luyten W, Van Criekinge W.

Commun Agric Appl Biol Sci. 2009;74(4):67-73. No abstract available.

PMID:
20420225
47.

The hepatocarcinoma cell line HepG2 does not express a GHS-R1a-type ghrelin receptor.

Thielemans L, Peeters PJ, Jonckheere H, Luyten W, de Hoogt R, Coulie B, Aerssens J.

J Recept Signal Transduct Res. 2007;27(4):309-22.

PMID:
17885924
48.

Discovering H-bonding rules in crystals with inductive logic programming.

Ando HY, Dehaspe L, Luyten W, Van Craenenbroeck E, Vandecasteele H, Van Meervelt L.

Mol Pharm. 2006 Nov-Dec;3(6):665-74.

PMID:
17140254
49.

Obestatin does not activate orphan G protein-coupled receptor GPR39.

Lauwers E, Landuyt B, Arckens L, Schoofs L, Luyten W.

Biochem Biophys Res Commun. 2006 Dec 8;351(1):21-5. Epub 2006 Oct 19.

PMID:
17054911
50.

p53-independent regulation of p21Waf1/Cip1 expression and senescence by Chk2.

Aliouat-Denis CM, Dendouga N, Van den Wyngaert I, Goehlmann H, Steller U, van de Weyer I, Van Slycken N, Andries L, Kass S, Luyten W, Janicot M, Vialard JE.

Mol Cancer Res. 2005 Nov;3(11):627-34.

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