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Evaluating the In Vivo Specificity of [18F]UCB-H for the SV2A Protein, Compared with SV2B and SV2C in Rats Using microPET.

Serrano ME, Becker G, Bahri MA, Seret A, Mestdagh N, Mercier J, Mievis F, Giacomelli F, Lemaire C, Salmon E, Luxen A, Plenevaux A.

Molecules. 2019 May 1;24(9). pii: E1705. doi: 10.3390/molecules24091705.


Age-related decrease in cortical excitability circadian variations during sleep loss and its links with cognition.

Gaggioni G, Ly JQM, Muto V, Chellappa SL, Jaspar M, Meyer C, Delfosse T, Vanvinckenroye A, Dumont R, Coppieters 't Wallant D, Berthomier C, Narbutas J, Van Egroo M, Luxen A, Salmon E, Collette F, Phillips C, Schmidt C, Vandewalle G.

Neurobiol Aging. 2019 Jun;78:52-63. doi: 10.1016/j.neurobiolaging.2019.02.004. Epub 2019 Feb 13.


Fully Automated Synthesis and Evaluation of [18 F]BPAM121: Potential of an AMPA Receptor Positive Allosteric Modulator as PET Radiotracer.

Manos-Turvey A, Becker G, Francotte P, Serrano ME, Luxen A, Pirotte B, Plenevaux A, Lemaire C.

ChemMedChem. 2019 Apr 3;14(7):788-795. doi: 10.1002/cmdc.201800816. Epub 2019 Feb 22.


Quantification of [18F]UCB-H Binding in the Rat Brain: From Kinetic Modelling to Standardised Uptake Value.

Serrano ME, Bahri MA, Becker G, Seret A, Mievis F, Giacomelli F, Lemaire C, Salmon E, Luxen A, Plenevaux A.

Mol Imaging Biol. 2018 Nov 20. doi: 10.1007/s11307-018-1301-0. [Epub ahead of print]


Progress in Lanthionine and Protected Lanthionine Synthesis.

Denoël T, Lemaire C, Luxen A.

Chemistry. 2018 Oct 17;24(58):15421-15441. doi: 10.1002/chem.201801115. Epub 2018 Aug 2. Review.


Human fronto-parietal response scattering subserves vigilance at night.

Gaggioni G, Ly JQM, Chellappa SL, Coppieters 't Wallant D, Rosanova M, Sarasso S, Luxen A, Salmon E, Middleton B, Massimini M, Schmidt C, Casali A, Phillips C, Vandewalle G.

Neuroimage. 2018 Jul 15;175:354-364. doi: 10.1016/j.neuroimage.2018.03.055. Epub 2018 Mar 28.


"NOTA-PRGD2 and NODAGA-PRGD2 : Bioconjugation, characterization, radiolabelling, and design space".

Salvé M, Avohou HT, Monbaliu JM, Lebrun P, Lemaire C, Damblon C, de Tullio P, Hubert P, Hustinx R, Luxen A.

J Labelled Comp Radiopharm. 2018 May 30;61(6):487-500. doi: 10.1002/jlcr.3613. Epub 2018 Apr 25.


Measuring brain synaptic vesicle protein 2A with positron emission tomography and [18F]UCB-H.

Bahri MA, Plenevaux A, Aerts J, Bastin C, Becker G, Mercier J, Valade A, Buchanan T, Mestdagh N, Ledoux D, Seret A, Luxen A, Salmon E.

Alzheimers Dement (N Y). 2017 Aug 30;3(4):481-486. doi: 10.1016/j.trci.2017.08.004. eCollection 2017 Nov.


Nanofitin as a New Molecular-Imaging Agent for the Diagnosis of Epidermal Growth Factor Receptor Over-Expressing Tumors.

Goux M, Becker G, Gorré H, Dammicco S, Desselle A, Egrise D, Leroi N, Lallemand F, Bahri MA, Doumont G, Plenevaux A, Cinier M, Luxen A.

Bioconjug Chem. 2017 Sep 20;28(9):2361-2371. doi: 10.1021/acs.bioconjchem.7b00374. Epub 2017 Sep 12.


Pharmacokinetic Characterization of [18F]UCB-H PET Radiopharmaceutical in the Rat Brain.

Becker G, Warnier C, Serrano ME, Bahri MA, Mercier J, Lemaire C, Salmon E, Luxen A, Plenevaux A.

Mol Pharm. 2017 Aug 7;14(8):2719-2725. doi: 10.1021/acs.molpharmaceut.7b00235. Epub 2017 Jul 13.


Regiospecific radiolabelling of Nanofitin on Ni magnetic beads with [18F]FBEM and in vivo PET studies.

Dammicco S, Goux M, Lemaire C, Becker G, Bahri MA, Plenevaux A, Cinier M, Luxen A.

Nucl Med Biol. 2017 Aug;51:33-39. doi: 10.1016/j.nucmedbio.2017.04.006. Epub 2017 Apr 27.


On the use of positron counting for radio-Assay in nuclear pharmaceutical production.

Maneuski D, Giacomelli F, Lemaire C, Pimlott S, Plenevaux A, Owens J, O'Shea V, Luxen A.

Appl Radiat Isot. 2017 Jul;125:9-14. doi: 10.1016/j.apradiso.2017.03.021. Epub 2017 Mar 24.


Comparative assessment of 6-[18 F]fluoro-L-m-tyrosine and 6-[18 F]fluoro-L-dopa to evaluate dopaminergic presynaptic integrity in a Parkinson's disease rat model.

Becker G, Bahri MA, Michel A, Hustadt F, Garraux G, Luxen A, Lemaire C, Plenevaux A.

J Neurochem. 2017 May;141(4):626-635. doi: 10.1111/jnc.14016. Epub 2017 Apr 12.


Cerebral Activity Associated with Transient Sleep-Facilitated Reduction in Motor Memory Vulnerability to Interference.

Albouy G, King BR, Schmidt C, Desseilles M, Dang-Vu TT, Balteau E, Phillips C, Degueldre C, Orban P, Benali H, Peigneux P, Luxen A, Karni A, Doyon J, Maquet P, Korman M.

Sci Rep. 2016 Oct 11;6:34948. doi: 10.1038/srep34948.


Circadian dynamics in measures of cortical excitation and inhibition balance.

Chellappa SL, Gaggioni G, Ly JQ, Papachilleos S, Borsu C, Brzozowski A, Rosanova M, Sarasso S, Luxen A, Middleton B, Archer SN, Dijk DJ, Massimini M, Maquet P, Phillips C, Moran RJ, Vandewalle G.

Sci Rep. 2016 Sep 21;6:33661. doi: 10.1038/srep33661.


Enabling Efficient Positron Emission Tomography (PET) Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) with a Robust and One-Step Radiosynthesis of a Highly Potent 18F-Labeled Ligand ([18F]UCB-H).

Warnier C, Lemaire C, Becker G, Zaragoza G, Giacomelli F, Aerts J, Otabashi M, Bahri MA, Mercier J, Plenevaux A, Luxen A.

J Med Chem. 2016 Oct 13;59(19):8955-8966. Epub 2016 Sep 20.


Local modulation of human brain responses by circadian rhythmicity and sleep debt.

Muto V, Jaspar M, Meyer C, Kussé C, Chellappa SL, Degueldre C, Balteau E, Shaffii-Le Bourdiec A, Luxen A, Middleton B, Archer SN, Phillips C, Collette F, Vandewalle G, Dijk DJ, Maquet P.

Science. 2016 Aug 12;353(6300):687-90. doi: 10.1126/science.aad2993. Erratum in: Science. 2016 Dec 23;354(6319):null.


Circadian regulation of human cortical excitability.

Ly JQM, Gaggioni G, Chellappa SL, Papachilleos S, Brzozowski A, Borsu C, Rosanova M, Sarasso S, Middleton B, Luxen A, Archer SN, Phillips C, Dijk DJ, Maquet P, Massimini M, Vandewalle G.

Nat Commun. 2016 Jun 24;7:11828. doi: 10.1038/ncomms11828.


Fully automated radiosynthesis of N(1)-[(18)F]fluoroethyl-tryptophan and study of its biological activity as a new potential substrate for indoleamine 2,3-dioxygenase PET imaging.

Henrottin J, Lemaire C, Egrise D, Zervosen A, Van den Eynde B, Plenevaux A, Franci X, Goldman S, Luxen A.

Nucl Med Biol. 2016 Jun;43(6):379-89. doi: 10.1016/j.nucmedbio.2016.03.001. Epub 2016 Mar 11.


Improved Aptamers for the Diagnosis and Potential Treatment of HER2-Positive Cancer.

Gijs M, Penner G, Blackler GB, Impens NR, Baatout S, Luxen A, Aerts AM.

Pharmaceuticals (Basel). 2016 May 19;9(2). pii: E29. doi: 10.3390/ph9020029.


Seasonality in human cognitive brain responses.

Meyer C, Muto V, Jaspar M, Kussé C, Lambot E, Chellappa SL, Degueldre C, Balteau E, Luxen A, Middleton B, Archer SN, Collette F, Dijk DJ, Phillips C, Maquet P, Vandewalle G.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3066-71. doi: 10.1073/pnas.1518129113. Epub 2016 Feb 8.


Aptamers as radiopharmaceuticals for nuclear imaging and therapy.

Gijs M, Aerts A, Impens N, Baatout S, Luxen A.

Nucl Med Biol. 2016 Apr;43(4):253-71. doi: 10.1016/j.nucmedbio.2015.09.005. Epub 2015 Sep 28. Review.


Gallium-68-labelled NOTA-oligonucleotides: an optimized method for their preparation.

Gijs M, Dammicco S, Warnier C, Aerts A, Impens NR, D'Huyvetter M, Léonard M, Baatout S, Luxen A.

J Labelled Comp Radiopharm. 2016 Feb;59(2):63-71. doi: 10.1002/jlcr.3363. Epub 2015 Dec 29.


Continuous-flow thermolysis for the preparation of vinylglycine derivatives.

Lamborelle N, Simon JF, Luxen A, Monbaliu JC.

Org Biomol Chem. 2015 Dec 28;13(48):11602-6. doi: 10.1039/c5ob02036k. Epub 2015 Nov 10.


Neural correlates of successful memory retrieval in aging: Do executive functioning and task difficulty matter?

Angel L, Bastin C, Genon S, Salmon E, Fay S, Balteau E, Maquet P, Luxen A, Isingrini M, Collette F.

Brain Res. 2016 Jan 15;1631:53-71. doi: 10.1016/j.brainres.2015.10.009. Epub 2015 Nov 2.


Monte Carlo simulations of the dose from imaging with GE eXplore 120 micro-CT using GATE.

Bretin F, Bahri MA, Luxen A, Phillips C, Plenevaux A, Seret A.

Med Phys. 2015 Oct;42(10):5711-9. doi: 10.1118/1.4930056.


Automated production at the curie level of no-carrier-added 6-[(18)F]fluoro-L-dopa and 2-[(18)F]fluoro-L-tyrosine on a FASTlab synthesizer.

Lemaire C, Libert L, Franci X, Genon JL, Kuci S, Giacomelli F, Luxen A.

J Labelled Comp Radiopharm. 2015 Jun 15;58(7):281-90. doi: 10.1002/jlcr.3291. Epub 2015 May 26.


N (1)-Fluoroalkyltryptophan Analogues: Synthesis and in vitro Study as Potential Substrates for Indoleamine 2,3-Dioxygenase.

Henrottin J, Zervosen A, Lemaire C, Sapunaric F, Laurent S, Van den Eynde B, Goldman S, Plenevaux A, Luxen A.

ACS Med Chem Lett. 2015 Jan 25;6(3):260-5. doi: 10.1021/ml500385d. eCollection 2015 Mar 12.


Biodistribution and Radiation Dosimetry for the Novel SV2A Radiotracer [(18)F]UCB-H: First-in-Human Study.

Bretin F, Bahri MA, Bernard C, Warnock G, Aerts J, Mestdagh N, Buchanan T, Otoul C, Koestler F, Mievis F, Giacomelli F, Degueldre C, Hustinx R, Luxen A, Seret A, Plenevaux A, Salmon E.

Mol Imaging Biol. 2015 Aug;17(4):557-64. doi: 10.1007/s11307-014-0820-6.


Enantioselective synthesis of α-benzylated lanthionines and related tripeptides for biological incorporation into E. coli peptidoglycan.

Denoël T, Zervosen A, Lemaire C, Joris B, Hervé M, Blanot D, Zaragoza G, Luxen A.

Org Biomol Chem. 2014 Dec 28;12(48):9853-63. doi: 10.1039/c4ob01476f.


Stereoselective synthesis of lanthionine derivatives in aqueous solution and their incorporation into the peptidoglycan of Escherichia coli.

Denoël T, Zervosen A, Gerards T, Lemaire C, Joris B, Blanot D, Luxen A.

Bioorg Med Chem. 2014 Sep 1;22(17):4621-8. doi: 10.1016/j.bmc.2014.07.023. Epub 2014 Jul 23.


Biased binomial assessment of cross-validated estimation of classification accuracies illustrated in diagnosis predictions.

Noirhomme Q, Lesenfants D, Gomez F, Soddu A, Schrouff J, Garraux G, Luxen A, Phillips C, Laureys S.

Neuroimage Clin. 2014 Apr 13;4:687-94. doi: 10.1016/j.nicl.2014.04.004. eCollection 2014.


Evaluation of 18F-UCB-H as a novel PET tracer for synaptic vesicle protein 2A in the brain.

Warnock GI, Aerts J, Bahri MA, Bretin F, Lemaire C, Giacomelli F, Mievis F, Mestdagh N, Buchanan T, Valade A, Mercier J, Wood M, Gillard M, Seret A, Luxen A, Salmon E, Plenevaux A.

J Nucl Med. 2014 Aug;55(8):1336-41. doi: 10.2967/jnumed.113.136143. Epub 2014 Jun 16.


Memory reactivation during rapid eye movement sleep promotes its generalization and integration in cortical stores.

Sterpenich V, Schmidt C, Albouy G, Matarazzo L, Vanhaudenhuyse A, Boveroux P, Degueldre C, Leclercq Y, Balteau E, Collette F, Luxen A, Phillips C, Maquet P.

Sleep. 2014 Jun 1;37(6):1061-75, 1075A-1075B. doi: 10.5665/sleep.3762.


Photic memory for executive brain responses.

Chellappa SL, Ly JQ, Meyer C, Balteau E, Degueldre C, Luxen A, Phillips C, Cooper HM, Vandewalle G.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):6087-91. doi: 10.1073/pnas.1320005111. Epub 2014 Mar 10.


Biological carrier molecules of radiopharmaceuticals for molecular cancer imaging and targeted cancer therapy.

Aerts A, Impens NR, Gijs M, D'Huyvetter M, Vanmarcke H, Ponsard B, Lahoutte T, Luxen A, Baatout S.

Curr Pharm Des. 2014;20(32):5218-44. Review.


Automated analysis of background EEG and reactivity during therapeutic hypothermia in comatose patients after cardiac arrest.

Noirhomme Q, Lehembre R, Lugo Zdel R, Lesenfants D, Luxen A, Laureys S, Oddo M, Rossetti AO.

Clin EEG Neurosci. 2014 Jan;45(1):6-13. doi: 10.1177/1550059413509616. Epub 2014 Jan 22.


Der p 1 is the primary activator of Der p 3, Der p 6 and Der p 9 the proteolytic allergens produced by the house dust mite Dermatophagoides pteronyssinus.

Herman J, Thelen N, Smargiasso N, Mailleux AC, Luxen A, Cloes M, De Pauw E, Chevigné A, Galleni M, Dumez ME.

Biochim Biophys Acta. 2014 Mar;1840(3):1117-24. doi: 10.1016/j.bbagen.2013.11.017. Epub 2013 Nov 27.


Hybrid microPET imaging for dosimetric applications in mice: improvement of activity quantification in dynamic microPET imaging for accelerated dosimetry applied to 6-[18 F]fluoro-L-DOPA and 2-[18 F]fluoro-L-tyrosine.

Bretin F, Mauxion T, Warnock G, Bahri MA, Libert L, Lemaire C, Luxen A, Bardiès M, Seret A, Plenevaux A.

Mol Imaging Biol. 2014 Jun;16(3):383-94. doi: 10.1007/s11307-013-0706-z.


Multiclass classification of FDG PET scans for the distinction between Parkinson's disease and atypical parkinsonian syndromes.

Garraux G, Phillips C, Schrouff J, Kreisler A, Lemaire C, Degueldre C, Delcour C, Hustinx R, Luxen A, Destée A, Salmon E.

Neuroimage Clin. 2013 Jun 14;2:883-93. doi: 10.1016/j.nicl.2013.06.004. eCollection 2013.


The proline-rich motif of the proDer p 3 allergen propeptide is crucial for protease-protease interaction.

Dumez ME, Herman J, Campisi V, Bouaziz A, Rosu F, Luxen A, Vandenberghe I, de Pauw E, Frère JM, Matagne A, Chevigné A, Galleni M.

PLoS One. 2013 Sep 20;8(9):e68014. doi: 10.1371/journal.pone.0068014. eCollection 2013.


In vivo PET/CT in a human glioblastoma chicken chorioallantoic membrane model: a new tool for oncology and radiotracer development.

Warnock G, Turtoi A, Blomme A, Bretin F, Bahri MA, Lemaire C, Libert LC, Seret AE, Luxen A, Castronovo V, Plenevaux AR.

J Nucl Med. 2013 Oct;54(10):1782-8. doi: 10.2967/jnumed.112.117150. Epub 2013 Aug 22.


Synthesis and biological evaluation of potential threonine synthase inhibitors: Rhizocticin A and Plumbemycin A.

Gahungu M, Arguelles-Arias A, Fickers P, Zervosen A, Joris B, Damblon C, Luxen A.

Bioorg Med Chem. 2013 Sep 1;21(17):4958-67. doi: 10.1016/j.bmc.2013.06.064. Epub 2013 Jul 8.


Concurrent synaptic and systems memory consolidation during sleep.

Mascetti L, Foret A, Schrouff J, Muto V, Dideberg V, Balteau E, Degueldre C, Phillips C, Luxen A, Collette F, Bours V, Maquet P.

J Neurosci. 2013 Jun 12;33(24):10182-90. doi: 10.1523/JNEUROSCI.0284-13.2013.


Benevolent sexism alters executive brain responses.

Dardenne B, Dumont M, Sarlet M, Phillips C, Balteau E, Degueldre C, Luxen A, Salmon E, Maquet P, Collette F.

Neuroreport. 2013 Jul 10;24(10):572-7. doi: 10.1097/WNR.0b013e3283625b5b.


Production at the Curie level of no-carrier-added 6-18F-fluoro-L-dopa.

Libert LC, Franci X, Plenevaux AR, Ooi T, Maruoka K, Luxen AJ, Lemaire CF.

J Nucl Med. 2013 Jul;54(7):1154-61. doi: 10.2967/jnumed.112.112284. Epub 2013 May 8.


Preclinical radiation dosimetry for the novel SV2A radiotracer [18F]UCB-H.

Bretin F, Warnock G, Bahri MA, Aerts J, Mestdagh N, Buchanan T, Valade A, Mievis F, Giacomelli F, Lemaire C, Luxen A, Salmon E, Seret A, Plenevaux A.

EJNMMI Res. 2013 May 7;3(1):35. doi: 10.1186/2191-219X-3-35.


Interaction between hippocampal and striatal systems predicts subsequent consolidation of motor sequence memory.

Albouy G, Sterpenich V, Vandewalle G, Darsaud A, Gais S, Rauchs G, Desseilles M, Boly M, Dang-Vu T, Balteau E, Degueldre C, Phillips C, Luxen A, Maquet P.

PLoS One. 2013;8(3):e59490. doi: 10.1371/journal.pone.0059490. Epub 2013 Mar 22.


Exploration of the mechanisms underlying the ISPC effect: evidence from behavioral and neuroimaging data.

Grandjean J, D'Ostilio K, Fias W, Phillips C, Balteau E, Degueldre C, Luxen A, Maquet P, Salmon E, Collette F.

Neuropsychologia. 2013 May;51(6):1040-9. doi: 10.1016/j.neuropsychologia.2013.02.015. Epub 2013 Mar 6.


The impact of visual perceptual learning on sleep and local slow-wave initiation.

Mascetti L, Muto V, Matarazzo L, Foret A, Ziegler E, Albouy G, Sterpenich V, Schmidt C, Degueldre C, Leclercq Y, Phillips C, Luxen A, Vandewalle G, Vogels R, Maquet P, Balteau E.

J Neurosci. 2013 Feb 20;33(8):3323-31. doi: 10.1523/JNEUROSCI.0763-12.2013.

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