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Items: 1 to 50 of 160

1.

Effect of Omeprazole and Dextromethorphan on the Urinary Metabolic Ratio of Flurbiprofen.

Vogl S, Steinfath M, Lutz WK, Schönfelder G.

Basic Clin Pharmacol Toxicol. 2016 Jun;118(6):496-8. doi: 10.1111/bcpt.12536. Epub 2016 Jan 14. No abstract available.

2.

Correction: CYP2C9 genotype vs. metabolic phenotype for individual drug dosing--a correlation analysis using flurbiprofen as probe drug.

Vogl S, Lutz RW, Schönfelder G, Lutz WK.

PLoS One. 2015 Apr 13;10(4):e0126329. doi: 10.1371/journal.pone.0126329. eCollection 2015. No abstract available.

3.

CYP2C9 genotype vs. metabolic phenotype for individual drug dosing--a correlation analysis using flurbiprofen as probe drug.

Vogl S, Lutz RW, Schönfelder G, Lutz WK.

PLoS One. 2015 Mar 16;10(3):e0120403. doi: 10.1371/journal.pone.0120403. eCollection 2015. Erratum in: PLoS One. 2015;10(4):e0126329.

4.

Drug interactions with mitotane by induction of CYP3A4 metabolism in the clinical management of adrenocortical carcinoma.

Kroiss M, Quinkler M, Lutz WK, Allolio B, Fassnacht M.

Clin Endocrinol (Oxf). 2011 Nov;75(5):585-91. doi: 10.1111/j.1365-2265.2011.04214.x. Review.

PMID:
21883349
5.

Strategies in case of positive in vivo results in genotoxicity testing.

Thybaud V, Macgregor JT, Müller L, Crebelli R, Dearfield K, Douglas G, Farmer PB, Gocke E, Hayashi M, Lovell DP, Lutz WK, Marzin D, Moore M, Nohmi T, Phillips DH, Van Benthem J.

Mutat Res. 2011 Aug 16;723(2):121-8. doi: 10.1016/j.mrgentox.2010.09.002. Epub 2010 Sep 17.

PMID:
20854927
6.

Quantification of cortisol and 6 beta-hydroxycortisol in human urine by LC-MS/MS, and gender-specific evaluation of the metabolic ratio as biomarker of CYP3A activity.

Lutz U, Bittner N, Ufer M, Lutz WK.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Jan 1;878(1):97-101. doi: 10.1016/j.jchromb.2009.11.023.

PMID:
19959402
7.

The Viracept (nelfinavir)--ethyl methanesulfonate case: a threshold risk assessment for human exposure to a genotoxic drug contamination?

Lutz WK.

Toxicol Lett. 2009 Nov 12;190(3):239-42. doi: 10.1016/j.toxlet.2009.07.032. Epub 2009 Aug 18.

PMID:
19695319
8.

Biological significance of DNA adducts: comparison of increments over background for various biomarkers of genotoxicity in L5178Y tk(+/-) mouse lymphoma cells treated with hydrogen peroxide and cumene hydroperoxide.

Brink A, Richter I, Lutz U, Wanek P, Stopper H, Lutz WK.

Mutat Res. 2009 Aug;678(2):123-8. doi: 10.1016/j.mrgentox.2009.06.001. Epub 2009 Jun 16.

PMID:
19539047
9.

Statistical model to estimate a threshold dose and its confidence limits for the analysis of sublinear dose-response relationships, exemplified for mutagenicity data.

Lutz WK, Lutz RW.

Mutat Res. 2009 Aug;678(2):118-22. doi: 10.1016/j.mrgentox.2009.05.010. Epub 2009 May 27.

PMID:
19477296
10.

Dose-response relationship for the pharmacokinetic interaction of grapefruit juice with dextromethorphan investigated by human urinary metabolite profiles.

Strauch K, Lutz U, Bittner N, Lutz WK.

Food Chem Toxicol. 2009 Aug;47(8):1928-35. doi: 10.1016/j.fct.2009.05.004. Epub 2009 May 13.

PMID:
19445995
11.

Pivotal role for two electron reduction in 2,3-dimethoxy-1,4-naphthoquinone and 2-methyl-1,4-naphthoquinone metabolism and kinetics in vivo that prevents liver redox stress.

Parry JD, Pointon AV, Lutz U, Teichert F, Charlwood JK, Chan PH, Athersuch TJ, Taylor EL, Singh R, Luo J, Phillips KM, Vetillard A, Lyon JJ, Keun HC, Lutz WK, Gant TW.

Chem Res Toxicol. 2009 Apr;22(4):717-25. doi: 10.1021/tx800472z.

PMID:
19338340
12.

Tests for genotoxicity and mutagenicity of furan and its metabolite cis-2-butene-1,4-dial in L5178Y tk+/- mouse lymphoma cells.

Kellert M, Brink A, Richter I, Schlatter J, Lutz WK.

Mutat Res. 2008 Dec 8;657(2):127-32. doi: 10.1016/j.mrgentox.2008.08.014. Epub 2008 Aug 28.

PMID:
18804178
13.

Metabolite profiling in human urine by LC-MS/MS: method optimization and application for glucuronides from dextromethorphan metabolism.

Lutz U, Bittner N, Lutz RW, Lutz WK.

J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Aug 15;871(2):349-56. doi: 10.1016/j.jchromb.2008.04.018. Epub 2008 May 3.

PMID:
18458004
14.

Dose-response relationships for cancer incidence reflect susceptibility distributions.

Lutz WK, Gaylor DW.

Chem Res Toxicol. 2008 May;21(5):971-2; author reply 972-3. doi: 10.1021/tx800090a. Epub 2008 Apr 23. No abstract available.

PMID:
18429623
15.

Biomarkers of furan exposure by metabolic profiling of rat urine with liquid chromatography-tandem mass spectrometry and principal component analysis.

Kellert M, Wagner S, Lutz U, Lutz WK.

Chem Res Toxicol. 2008 Mar;21(3):761-8. doi: 10.1021/tx7004212. Epub 2008 Feb 13.

PMID:
18269250
17.

Ochratoxin A: 13-week oral toxicity and cell proliferation in male F344/n rats.

Rached E, Hard GC, Blumbach K, Weber K, Draheim R, Lutz WK, Ozden S, Steger U, Dekant W, Mally A.

Toxicol Sci. 2007 Jun;97(2):288-98. Epub 2007 Mar 6.

PMID:
17344223
18.

Comparison of lanosterol-14 alpha-demethylase (CYP51) of human and Candida albicans for inhibition by different antifungal azoles.

Trösken ER, Adamska M, Arand M, Zarn JA, Patten C, Völkel W, Lutz WK.

Toxicology. 2006 Nov 10;228(1):24-32. Epub 2006 Aug 12.

20.

Increased brain levels of 4-hydroxy-2-nonenal glutathione conjugates in severe Alzheimer's disease.

Völkel W, Sicilia T, Pähler A, Gsell W, Tatschner T, Jellinger K, Leblhuber F, Riederer P, Lutz WK, Götz ME.

Neurochem Int. 2006 Jun;48(8):679-86. Epub 2006 Feb 17.

PMID:
16483694
21.

Time-dependent effects of sodium arsenite on DNA breakage and apoptosis observed in the comet assay.

Brink A, Schulz B, Kobras K, Lutz WK, Stopper H.

Mutat Res. 2006 Feb 28;603(2):121-8. Epub 2005 Dec 27.

PMID:
16384727
22.
23.
24.

Oxidative stress related DNA adducts in the liver of female rats fed with sunflower-, rapeseed-, olive- or coconut oil supplemented diets.

Eder E, Wacker M, Lutz U, Nair J, Fang X, Bartsch H, Beland FA, Schlatter J, Lutz WK.

Chem Biol Interact. 2006 Feb 1;159(2):81-9. Epub 2005 Oct 27.

PMID:
16256967
25.

Dose-incidence modeling: consequences of linking quantal measures of response to depletion of critical tissue targets.

Andersen ME, Lutz RW, Liao KH, Lutz WK.

Toxicol Sci. 2006 Jan;89(1):331-7. Epub 2005 Oct 19.

PMID:
16237194
26.
27.

Population variability in biological adaptive responses to DNA damage and the shapes of carcinogen dose-response curves.

Conolly RB, Gaylor DW, Lutz WK.

Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):570-5. Review.

PMID:
15996697
28.
29.
30.

LC-MS/MS analysis of dextromethorphan metabolism in human saliva and urine to determine CYP2D6 phenotype and individual variability in N-demethylation and glucuronidation.

Lutz U, Völkel W, Lutz RW, Lutz WK.

J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Dec 25;813(1-2):217-25.

PMID:
15556536
31.

Comparative assessment of the inhibition of recombinant human CYP19 (aromatase) by azoles used in agriculture and as drugs for humans.

Trösken ER, Scholz K, Lutz RW, Völkel W, Zarn JA, Lutz WK.

Endocr Res. 2004 Aug;30(3):387-94.

PMID:
15554355
32.
33.

Nonmonotonic dose-response relationships: mechanistic basis, kinetic modeling, and implications for risk assessment.

Conolly RB, Lutz WK.

Toxicol Sci. 2004 Jan;77(1):151-7. Epub 2003 Nov 4. Erratum in: Toxicol Sci. 2004 Feb;77(2):following table of contents.

PMID:
14600281
34.
35.

Waddell's representation of the tumor incidence data of the ED01 study is strongly misleading.

Lutz WK.

Toxicol Sci. 2003 Sep;75(1):223; author reply 223-4. No abstract available.

PMID:
12923302
38.

Chemoimmunotherapy for melanoma with dacarbazine and 2,4-dinitrochlorobenzene elicits a specific T cell-dependent immune response.

Wack C, Kirst A, Becker JC, Lutz WK, Bröcker EB, Fischer WH.

Cancer Immunol Immunother. 2002 Oct;51(8):431-9. Epub 2002 Jul 25.

PMID:
12202904
39.

Expression of functional kappa-opioid receptors on murine dendritic cells.

Kirst A, Wack C, Lutz WK, Eggert A, Kämpgen E, Fischer WH.

Immunol Lett. 2002 Oct 21;84(1):41-8.

PMID:
12161282
40.
44.

Scientific analysis of the proposed uses of the T25 dose descriptor in chemical carcinogen regulation.

Roberts RA, Crump KS, Lutz WK, Wiegand HJ, Williams GM, Harrison PT, Purchase IF.

Arch Toxicol. 2001 Nov;75(9):507-12.

PMID:
11760810
46.

Chemoimmunotherapy for melanoma with dacarbazine and 2,4-dinitrochlorobenzene: results from a murine tumour model.

Wack C, Becker JC, Bröcker EB, Lutz WK, Fischer WH.

Melanoma Res. 2001 Jun;11(3):247-53.

PMID:
11468513
47.
48.
50.

Occurrence of emodin, chrysophanol and physcion in vegetables, herbs and liquors. Genotoxicity and anti-genotoxicity of the anthraquinones and of the whole plants.

Mueller SO, Schmitt M, Dekant W, Stopper H, Schlatter J, Schreier P, Lutz WK.

Food Chem Toxicol. 1999 May;37(5):481-91.

PMID:
10456676

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