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Gastric bypass surgery in lean adolescent mice prevents diet-induced obesity later in life.

Mumphrey MB, Hao Z, Leigh Townsend R, Qualls-Creekmore E, Yu S, Lutz TA, Münzberg H, Morrison CD, Berthoud HR.

Sci Rep. 2019 May 27;9(1):7881. doi: 10.1038/s41598-019-44344-7.


Significant changes in hepatic transcriptome and circulating miRNAs are associated with diet-induced metabolic syndrome in apoE3L.CETP mice.

Nasias D, Evangelakos I, Nidris V, Vassou D, Tarasco E, Lutz TA, Kardassis D.

J Cell Physiol. 2019 Apr 23. doi: 10.1002/jcp.28649. [Epub ahead of print]


Endogenous amylin contributes to birth of microglial cells in arcuate nucleus of hypothalamus and area postrema during fetal development.

Lutz TA, Le Foll C.

Am J Physiol Regul Integr Comp Physiol. 2019 Jun 1;316(6):R791-R801. doi: 10.1152/ajpregu.00004.2019. Epub 2019 Apr 3.


Diabetic cats have decreased gut microbial diversity and a lack of butyrate producing bacteria.

Kieler IN, Osto M, Hugentobler L, Puetz L, Gilbert MTP, Hansen T, Pedersen O, Reusch CE, Zini E, Lutz TA, Bjørnvad CR.

Sci Rep. 2019 Mar 18;9(1):4822. doi: 10.1038/s41598-019-41195-0.


High-throughput screening for selective appetite modulators: A multibehavioral and translational drug discovery strategy.

Jordi J, Guggiana-Nilo D, Bolton AD, Prabha S, Ballotti K, Herrera K, Rennekamp AJ, Peterson RT, Lutz TA, Engert F.

Sci Adv. 2018 Oct 31;4(10):eaav1966. doi: 10.1126/sciadv.aav1966. eCollection 2018 Oct.


Rodent models of leptin receptor deficiency are less sensitive to amylin.

Duffy S, Lutz TA, Boyle CN.

Am J Physiol Regul Integr Comp Physiol. 2018 Oct 1;315(4):R856-R865. doi: 10.1152/ajpregu.00179.2018. Epub 2018 Aug 22.


RYGB increases the satiating effect of intrajejunal lipid infusions in female rats.

Bächler T, Geary N, Bueter M, Leeners B, Rehfeld JF, Lutz TA, Asarian L.

Appetite. 2018 Dec 1;131:94-99. doi: 10.1016/j.appet.2018.08.020. Epub 2018 Aug 14.


Phenotypical heterogeneity in responder and nonresponder male ApoE*3Leiden.CETP mice.

Tarasco E, Pellegrini G, Whiting L, Lutz TA.

Am J Physiol Gastrointest Liver Physiol. 2018 Oct 1;315(4):G602-G617. doi: 10.1152/ajpgi.00081.2018. Epub 2018 Jul 5.


New horizons for future research - Critical issues to consider for maximizing research excellence and impact.

Langhans W, Adan R, Arnold M, Banks WA, Card JP, Dailey MJ, Daniels D, de Kloet AD, de Lartigue G, Dickson S, Fedele S, Grill HJ, Jansson JO, Kaufman S, Kolar G, Krause E, Lee SJ, Le Foll C, Levin BE, Lutz TA, Mansouri A, Moran TH, Pacheco-López G, Ramachandran D, Raybould H, Rinaman L, Samson WK, Sanchez-Watts G, Seeley RJ, Skibicka KP, Small D, Spector AC, Tamashiro KL, Templeton B, Trapp S, Tso P, Watts AG, Weissfeld N, Williams D, Wolfrum C, Yosten G, Woods SC.

Mol Metab. 2018 Aug;14:53-59. doi: 10.1016/j.molmet.2018.05.007. Epub 2018 May 12. No abstract available.


Sensitive quantification of the somatostatin analog AP102 in plasma by ultra-high pressure liquid chromatography-tandem mass spectrometry and application to a pharmacokinetic study in rats.

Eugster PJ, Boyle CN, Prod'hom S, Tarasco E, Buclin T, Lutz TA, Harris AG, Grouzmann E.

Drug Test Anal. 2018 Sep;10(9):1448-1457. doi: 10.1002/dta.2400. Epub 2018 May 29.


Glucose concentrations after insulin-induced hypoglycemia and glycemic variability in healthy and diabetic cats.

Zini E, Salesov E, Dupont P, Moretto L, Contiero B, Lutz TA, Reusch CE.

J Vet Intern Med. 2018 May;32(3):978-985. doi: 10.1111/jvim.15134. Epub 2018 Mar 30.


Amylin Selectively Signals Onto POMC Neurons in the Arcuate Nucleus of the Hypothalamus.

Lutz TA, Coester B, Whiting L, Dunn-Meynell AA, Boyle CN, Bouret SG, Levin BE, Le Foll C.

Diabetes. 2018 May;67(5):805-817. doi: 10.2337/db17-1347. Epub 2018 Feb 21.


Considering our methods: Methodological issues with rodent models of appetite and obesity research.

Lutz TA.

Physiol Behav. 2018 Aug 1;192:182-187. doi: 10.1016/j.physbeh.2018.02.026. Epub 2018 Feb 14. Review.


Comparison of the pharmacodynamics of protamine zinc insulin and insulin degludec and validation of the continuous glucose monitoring system iPro2 in healthy cats.

Salesov E, Zini E, Riederer A, Lutz TA, Reusch CE.

Res Vet Sci. 2018 Jun;118:79-85. doi: 10.1016/j.rvsc.2018.01.019. Epub 2018 Jan 31.


Establishment of a protocol for the isolation of feline pancreatic islets.

Brandão IR, Zini E, Reusch CE, Lutz TA, Osto M.

Physiol Behav. 2018 Mar 15;186:79-81. doi: 10.1016/j.physbeh.2018.01.012. Epub 2018 Jan 31.


Involvement of Amylin and Leptin in the Development of Projections from the Area Postrema to the Nucleus of the Solitary Tract.

Abegg K, Hermann A, Boyle CN, Bouret SG, Lutz TA, Riediger T.

Front Endocrinol (Lausanne). 2017 Nov 28;8:324. doi: 10.3389/fendo.2017.00324. eCollection 2017.


Brainstem GLP-1 signalling contributes to cancer anorexia-cachexia syndrome in the rat.

Borner T, Liberini CG, Lutz TA, Riediger T.

Neuropharmacology. 2018 Mar 15;131:282-290. doi: 10.1016/j.neuropharm.2017.12.024. Epub 2017 Dec 13.


Amylin - Its role in the homeostatic and hedonic control of eating and recent developments of amylin analogs to treat obesity.

Boyle CN, Lutz TA, Le Foll C.

Mol Metab. 2018 Feb;8:203-210. doi: 10.1016/j.molmet.2017.11.009. Epub 2017 Nov 23. Review.


Inhibition of Vascular c-Jun N-Terminal Kinase 2 Improves Obesity-Induced Endothelial Dysfunction After Roux-en-Y Gastric Bypass.

Doytcheva P, Bächler T, Tarasco E, Marzolla V, Engeli M, Pellegrini G, Stivala S, Rohrer L, Tona F, Camici GG, Vanhoutte PM, Matter CM, Lutz TA, Lüscher TF, Osto E.

J Am Heart Assoc. 2017 Nov 14;6(11). pii: e006441. doi: 10.1161/JAHA.117.006441.


Pharmacotherapy for Weight Loss.

Lutz TA, Asarian L.

In: Harris RBS, editor. Appetite and Food Intake: Central Control. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2017. Chapter 13.


Effect of AP102, a subtype 2 and 5 specific somatostatin analog, on glucose metabolism in rats.

Tarasco E, Seebeck P, Pfundstein S, Daly AF, Eugster PJ, Harris AG, Grouzmann E, Lutz TA, Boyle CN.

Endocrine. 2017 Oct;58(1):124-133. doi: 10.1007/s12020-017-1386-2. Epub 2017 Aug 18.


Gut hormones such as amylin and GLP-1 in the control of eating and energy expenditure.

Lutz TA.

Int J Obes Suppl. 2016 Dec;6(Suppl 1):S15-S21. doi: 10.1038/ijosup.2016.4. Epub 2016 Nov 16. Review.


Ghrelin receptor inverse agonists as a novel therapeutic approach against obesity-related metabolic disease.

Abegg K, Bernasconi L, Hutter M, Whiting L, Pietra C, Giuliano C, Lutz TA, Riediger T.

Diabetes Obes Metab. 2017 Dec;19(12):1740-1750. doi: 10.1111/dom.13020. Epub 2017 Jul 13.


Role of the area postrema in the hypophagic effects of oleoylethanolamide.

Romano A, Gallelli CA, Koczwara JB, Braegger FE, Vitalone A, Falchi M, Micioni Di Bonaventura MV, Cifani C, Cassano T, Lutz TA, Gaetani S.

Pharmacol Res. 2017 Aug;122:20-34. doi: 10.1016/j.phrs.2017.05.017. Epub 2017 May 20.


Oral Treatment with the Ghrelin Receptor Agonist HM01 Attenuates Cachexia in Mice Bearing Colon-26 (C26) Tumors.

Villars FO, Pietra C, Giuliano C, Lutz TA, Riediger T.

Int J Mol Sci. 2017 May 5;18(5). pii: E986. doi: 10.3390/ijms18050986.


The area postrema (AP) and the parabrachial nucleus (PBN) are important sites for salmon calcitonin (sCT) to decrease evoked phasic dopamine release in the nucleus accumbens (NAc).

Whiting L, McCutcheon JE, Boyle CN, Roitman MF, Lutz TA.

Physiol Behav. 2017 Jul 1;176:9-16. doi: 10.1016/j.physbeh.2017.03.023. Epub 2017 Mar 22.


Estrogenic suppression of binge-like eating elicited by cyclic food restriction and frustrative-nonreward stress in female rats.

Micioni Di Bonaventura MV, Lutz TA, Romano A, Pucci M, Geary N, Asarian L, Cifani C.

Int J Eat Disord. 2017 Jun;50(6):624-635. doi: 10.1002/eat.22687. Epub 2017 Feb 23.


Use of an implantable pump for controlled subcutaneous insulin delivery in healthy cats.

Zini E, Padrutt I, Macha K, Riederer A, Pesaresi M, Lutz TA, Reusch CE.

Vet J. 2017 Jan;219:60-64. doi: 10.1016/j.tvjl.2016.12.006. Epub 2016 Dec 15.


Anorexia-cachexia syndrome in hepatoma tumour-bearing rats requires the area postrema but not vagal afferents and is paralleled by increased MIC-1/GDF15.

Borner T, Arnold M, Ruud J, Breit SN, Langhans W, Lutz TA, Blomqvist A, Riediger T.

J Cachexia Sarcopenia Muscle. 2017 Jun;8(3):417-427. doi: 10.1002/jcsm.12169. Epub 2016 Dec 26.


Amylin and Leptin: Co-Regulators of Energy Homeostasis and Neuronal Development.

Levin BE, Lutz TA.

Trends Endocrinol Metab. 2017 Feb;28(2):153-164. doi: 10.1016/j.tem.2016.11.004. Epub 2016 Dec 6. Review.


The brain needs interleukin-6 (IL-6) to maintain a "healthy" energy balance. Focus on "IL-6 ameliorates defective leptin sensitivity in DIO ventromedial hypothalamic nucleus neurons".

Lutz TA.

Am J Physiol Regul Integr Comp Physiol. 2016 Dec 1;311(6):R989-R991. doi: 10.1152/ajpregu.00426.2016. Epub 2016 Oct 12. No abstract available.


The satiating hormone amylin enhances neurogenesis in the area postrema of adult rats.

Liberini CG, Borner T, Boyle CN, Lutz TA.

Mol Metab. 2016 Jul 5;5(10):834-843. doi: 10.1016/j.molmet.2016.06.015. eCollection 2016 Oct.


Effect of Roux-en-Y gastric bypass and diet-induced weight loss on diabetic kidney disease in the Zucker diabetic fatty rat.

Neff KJ, Elliott JA, Corteville C, Abegg K, Boza C, Lutz TA, Docherty NG, le Roux CW.

Surg Obes Relat Dis. 2017 Jan;13(1):21-27. doi: 10.1016/j.soard.2016.08.026. Epub 2016 Aug 18.


Early postnatal amylin treatment enhances hypothalamic leptin signaling and neural development in the selectively bred diet-induced obese rat.

Johnson MD, Bouret SG, Dunn-Meynell AA, Boyle CN, Lutz TA, Levin BE.

Am J Physiol Regul Integr Comp Physiol. 2016 Dec 1;311(6):R1032-R1044. doi: 10.1152/ajpregu.00326.2016. Epub 2016 Sep 14.


Effects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery.

Ratner C, Skov LJ, Raida Z, Bächler T, Bellmann-Sickert K, Le Foll C, Sivertsen B, Dalbøge LS, Hartmann B, Beck-Sickinger AG, Madsen AN, Jelsing J, Holst JJ, Lutz TA, Andrews ZB, Holst B.

Endocrinology. 2016 Sep;157(9):3482-92. doi: 10.1210/en.2016-1329. Epub 2016 Jul 20.


The Use of Rat and Mouse Models in Bariatric Surgery Experiments.

Lutz TA, Bueter M.

Front Nutr. 2016 Aug 5;3:25. doi: 10.3389/fnut.2016.00025. eCollection 2016. Review.


The ghrelin receptor agonist HM01 mimics the neuronal effects of ghrelin in the arcuate nucleus and attenuates anorexia-cachexia syndrome in tumor-bearing rats.

Borner T, Loi L, Pietra C, Giuliano C, Lutz TA, Riediger T.

Am J Physiol Regul Integr Comp Physiol. 2016 Jul 1;311(1):R89-96. doi: 10.1152/ajpregu.00044.2016. Epub 2016 May 4.


Alterations in energy expenditure in Roux-en-Y gastric bypass rats persist at thermoneutrality.

Abegg K, Corteville C, Bueter M, Lutz TA.

Int J Obes (Lond). 2016 Aug;40(8):1215-21. doi: 10.1038/ijo.2016.55. Epub 2016 Apr 22.


Influence of Roux-en-Y gastric bypass on plasma bile acid profiles: a comparative study between rats, pigs and humans.

Spinelli V, Lalloyer F, Baud G, Osto E, Kouach M, Daoudi M, Vallez E, Raverdy V, Goossens JF, Descat A, Doytcheva P, Hubert T, Lutz TA, Lestavel S, Staels B, Pattou F, Tailleux A.

Int J Obes (Lond). 2016 Aug;40(8):1260-7. doi: 10.1038/ijo.2016.46. Epub 2016 Mar 22.


Glucagon-like peptide-1, glucagon-like peptide-2, and lipid metabolism.

Lutz TA, Osto E.

Curr Opin Lipidol. 2016 Jun;27(3):257-63. doi: 10.1097/MOL.0000000000000293. Review.


Amylin receptor components and the leptin receptor are co-expressed in single rat area postrema neurons.

Liberini CG, Boyle CN, Cifani C, Venniro M, Hope BT, Lutz TA.

Eur J Neurosci. 2016 Mar;43(5):653-61. doi: 10.1111/ejn.13163. Epub 2016 Feb 5.


RYGB progressively increases avidity for a low-energy, artificially sweetened diet in female rats.

Geary N, Bächler T, Whiting L, Lutz TA, Asarian L.

Appetite. 2016 Mar 1;98:133-41. doi: 10.1016/j.appet.2015.11.029. Epub 2015 Dec 17.


Effect of the Glucagon-like Peptide-1 Analogue Exenatide Extended Release in Cats with Newly Diagnosed Diabetes Mellitus.

Riederer A, Zini E, Salesov E, Fracassi F, Padrutt I, Macha K, Stöckle TM, Lutz TA, Reusch CE.

J Vet Intern Med. 2016 Jan-Feb;30(1):92-100. doi: 10.1111/jvim.13817. Epub 2015 Dec 24.


Endogenous VMH amylin signaling is required for full leptin signaling and protection from diet-induced obesity.

Dunn-Meynell AA, Le Foll C, Johnson MD, Lutz TA, Hayes MR, Levin BE.

Am J Physiol Regul Integr Comp Physiol. 2016 Feb 15;310(4):R355-65. doi: 10.1152/ajpregu.00462.2015. Epub 2015 Dec 16.


Exocrine Pancreas in Cats With Diabetes Mellitus.

Zini E, Ferro S, Lunardi F, Zanetti R, Heller RS, Coppola LM, Guscetti F, Osto M, Lutz TA, Cavicchioli L, Reusch CE.

Vet Pathol. 2016 Jan;53(1):145-52. doi: 10.1177/0300985815603434. Epub 2015 Aug 28.


Amylin at the interface between metabolic and neurodegenerative disorders.

Lutz TA, Meyer U.

Front Neurosci. 2015 Jun 16;9:216. doi: 10.3389/fnins.2015.00216. eCollection 2015. Review.


Endocrine Pancreas in Cats With Diabetes Mellitus.

Zini E, Lunardi F, Zanetti R, Heller RS, Coppola LM, Ferro S, Guscetti F, Osto M, Lutz TA, Reusch CE, Cavicchioli L.

Vet Pathol. 2016 Jan;53(1):136-44. doi: 10.1177/0300985815591078. Epub 2015 Jun 25.


Amylin: Pharmacology, Physiology, and Clinical Potential.

Hay DL, Chen S, Lutz TA, Parkes DG, Roth JD.

Pharmacol Rev. 2015 Jul;67(3):564-600. doi: 10.1124/pr.115.010629. Review.


Longitudinal evaluation of serum pancreatic enzymes and ultrasonographic findings in diabetic cats without clinically relevant pancreatitis at diagnosis.

Zini E, Hafner M, Kook P, Lutz TA, Ohlerth S, Reusch CE.

J Vet Intern Med. 2015 Mar-Apr;29(2):589-96. doi: 10.1111/jvim.12565.


Translational value of animal models of obesity-Focus on dogs and cats.

Osto M, Lutz TA.

Eur J Pharmacol. 2015 Jul 15;759:240-52. doi: 10.1016/j.ejphar.2015.03.036. Epub 2015 Mar 23. Review.


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