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Items: 29


Analysis of longitudinal semicontinuous data using marginalized two-part model.

Jaffa MA, Gebregziabher M, Garrett SM, Luttrell DK, Lipson KE, Luttrell LM, Jaffa AA.

J Transl Med. 2018 Nov 6;16(1):301. doi: 10.1186/s12967-018-1674-5.


Plasma Connective Tissue Growth Factor (CTGF/CCN2) Levels Predict Myocardial Infarction in the Veterans Affairs Diabetes Trial (VADT) Cohort.

Hunt KJ, Jaffa MA, Garrett SM, Luttrell DK, Lipson KE, Lopes-Virella MF, Luttrell LM, Jaffa AA; VADT Investigators.

Diabetes Care. 2018 Apr;41(4):840-846. doi: 10.2337/dc17-2083. Epub 2018 Jan 30.


Multivariate Generalized Linear Mixed Models With Random Intercepts To Analyze Cardiovascular Risk Markers in Type-1 Diabetic Patients.

Jaffa MA, Gebregziabher M, Luttrell DK, Luttrell LM, Jaffa AA.

J Appl Stat. 2016;43(8):1447-1464. Epub 2015 Nov 26.


Relationship between vitamin D status and incidence of vascular events in the Veterans Affairs Diabetes Trial.

Alele JD, Luttrell LM, Hollis BW, Luttrell DK, Hunt KJ; VADT Study Group.

Atherosclerosis. 2013 Jun;228(2):502-7. doi: 10.1016/j.atherosclerosis.2013.03.024. Epub 2013 Apr 4.


Biasing the parathyroid hormone receptor: relating in vitro ligand efficacy to in vivo biological activity.

Appleton KM, Lee MH, Alele C, Alele C, Luttrell DK, Peterson YK, Morinelli TA, Luttrell LM.

Methods Enzymol. 2013;522:229-62. doi: 10.1016/B978-0-12-407865-9.00013-3.


The beta-arrestin pathway-selective type 1A angiotensin receptor (AT1A) agonist [Sar1,Ile4,Ile8]angiotensin II regulates a robust G protein-independent signaling network.

Kendall RT, Strungs EG, Rachidi SM, Lee MH, El-Shewy HM, Luttrell DK, Janech MG, Luttrell LM.

J Biol Chem. 2011 Jun 3;286(22):19880-91. doi: 10.1074/jbc.M111.233080. Epub 2011 Apr 18.


Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptors.

Abdallah RT, Keum JS, El-Shewy HM, Lee MH, Wang B, Gooz M, Luttrell DK, Luttrell LM, Jaffa AA.

J Biol Chem. 2010 Nov 5;285(45):35206-15. doi: 10.1074/jbc.M110.171769. Epub 2010 Sep 8. Erratum in: J Biol Chem. 2011 Jul 1;286(26):23620. El-Shewy, Hesham M [added].


The adiponectin receptors AdipoR1 and AdipoR2 activate ERK1/2 through a Src/Ras-dependent pathway and stimulate cell growth.

Lee MH, Klein RL, El-Shewy HM, Luttrell DK, Luttrell LM.

Biochemistry. 2008 Nov 4;47(44):11682-92. doi: 10.1021/bi801451f. Epub 2008 Oct 9.


Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor.

Harris PA, Boloor A, Cheung M, Kumar R, Crosby RM, Davis-Ward RG, Epperly AH, Hinkle KW, Hunter RN 3rd, Johnson JH, Knick VB, Laudeman CP, Luttrell DK, Mook RA, Nolte RT, Rudolph SK, Szewczyk JR, Truesdale AT, Veal JM, Wang L, Stafford JA.

J Med Chem. 2008 Aug 14;51(15):4632-40. doi: 10.1021/jm800566m. Epub 2008 Jul 12.


Role of beta-arrestin-mediated desensitization and signaling in the control of angiotensin AT1a receptor-stimulated transcription.

Lee MH, El-Shewy HM, Luttrell DK, Luttrell LM.

J Biol Chem. 2008 Jan 25;283(4):2088-97. Epub 2007 Nov 15.


Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity.

Kumar R, Knick VB, Rudolph SK, Johnson JH, Crosby RM, Crouthamel MC, Hopper TM, Miller CG, Harrington LE, Onori JA, Mullin RJ, Gilmer TM, Truesdale AT, Epperly AH, Boloor A, Stafford JA, Luttrell DK, Cheung M.

Mol Cancer Ther. 2007 Jul;6(7):2012-21.


Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors.

Harris PA, Cheung M, Hunter RN 3rd, Brown ML, Veal JM, Nolte RT, Wang L, Liu W, Crosby RM, Johnson JH, Epperly AH, Kumar R, Luttrell DK, Stafford JA.

J Med Chem. 2005 Mar 10;48(5):1610-9.


Not so strange bedfellows: G-protein-coupled receptors and Src family kinases.

Luttrell DK, Luttrell LM.

Oncogene. 2004 Oct 18;23(48):7969-78.


Antitumour efficacy of VEGFR2 tyrosine kinase inhibitor correlates with expression of VEGF and its receptor VEGFR2 in tumour models.

Dev IK, Dornsife RE, Hopper TM, Onori JA, Miller CG, Harrington LE, Dold KM, Mullin RJ, Johnson JH, Crosby RM, Truesdale AT, Epperly AH, Hinkle KW, Cheung M, Stafford JA, Luttrell DK, Kumar R.

Br J Cancer. 2004 Oct 4;91(7):1391-8.


Signaling in time and space: G protein-coupled receptors and mitogen-activated protein kinases.

Luttrell DK, Luttrell LM.

Assay Drug Dev Technol. 2003 Apr;1(2):327-38. Review.


Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.

Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ, Lin F, Kawakatsu H, Owada K, Luttrell DK, Caron MG, Lefkowitz RJ.

Science. 1999 Jan 29;283(5402):655-61.


Regulation of mitogen-activated protein kinase pathways by catecholamine receptors.

Luttrell LM, van Biesen T, Hawes BE, Della Rocca GJ, Luttrell DK, Lefkowitz RJ.

Adv Pharmacol. 1998;42:466-70. No abstract available.


Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases.

Luttrell LM, Hawes BE, van Biesen T, Luttrell DK, Lansing TJ, Lefkowitz RJ.

J Biol Chem. 1996 Aug 9;271(32):19443-50.


Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway.

van Biesen T, Hawes BE, Luttrell DK, Krueger KM, Touhara K, Porfiri E, Sakaue M, Luttrell LM, Lefkowitz RJ.

Nature. 1995 Aug 31;376(6543):781-4.


Involvement of pp60c-src with two major signaling pathways in human breast cancer.

Luttrell DK, Lee A, Lansing TJ, Crosby RM, Jung KD, Willard D, Luther M, Rodriguez M, Berman J, Gilmer TM.

Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):83-7.


Overexpression of pp60c-src is associated with altered regulation of adenylyl cyclase.

Luttrell DK, Hausdorff WP, Moyers JE, Gilmer TM, Parsons SJ, Caron MG, Lefkowitz RJ.

Cell Signal. 1992 Sep;4(5):531-41.


Tyrosine phosphorylation of G protein alpha subunits by pp60c-src.

Hausdorff WP, Pitcher JA, Luttrell DK, Linder ME, Kurose H, Parsons SJ, Caron MG, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5720-4.


Overexpression of c-src enhances beta-adrenergic-induced cAMP accumulation.

Bushman WA, Wilson LK, Luttrell DK, Moyers JS, Parsons SJ.

Proc Natl Acad Sci U S A. 1990 Oct;87(19):7462-6.


Insulin and phorbol ester induce distinct phosphorylations of pp60c-src in the BC3H-1 murine myocyte cell line.

Luttrell LM, Luttrell DK, Parsons SJ, Rogol AD.

Oncogene. 1989 Mar;4(3):317-24.


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