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Items: 1 to 50 of 132

1.

Dynamics of pertussis toxin IgG after symptomatic pertussis in children and adults.

Jõgi P, Soeorg H, Oona M, Kaart T, Toompere K, Maskina T, Koort I, Rätsep A, Lutsar I; Pertussis study group of Estonia.

Vaccine. 2020 Mar 11. pii: S0264-410X(20)30324-8. doi: 10.1016/j.vaccine.2020.02.080. [Epub ahead of print]

PMID:
32171577
2.

Meropenem vs standard of care for treatment of neonatal late onset sepsis (NeoMero1): A randomised controlled trial.

Lutsar I, Chazallon C, Trafojer U, de Cabre VM, Auriti C, Bertaina C, Calo Carducci FI, Canpolat FE, Esposito S, Fournier I, Hallik M, Heath PT, Ilmoja ML, Iosifidis E, Kuznetsova J, Meyer L, Metsvaht T, Mitsiakos G, Pana ZD, Mosca F, Pugni L, Roilides E, Rossi P, Sarafidis K, Sanchez L, Sharland M, Usonis V, Warris A, Aboulker JP, Giaquinto C; NeoMero Consortium.

PLoS One. 2020 Mar 4;15(3):e0229380. doi: 10.1371/journal.pone.0229380. eCollection 2020.

3.

Discovery and development of safe-in-man broad-spectrum antiviral agents.

Andersen PI, Ianevski A, Lysvand H, Vitkauskiene A, Oksenych V, Bjørås M, Telling K, Lutsar I, Dumpis U, Irie Y, Tenson T, Kantele A, Kainov DE.

Int J Infect Dis. 2020 Feb 17;93:268-276. doi: 10.1016/j.ijid.2020.02.018. [Epub ahead of print] Review.

4.

Acute gastroenteritis hospitalizations after implementation of universal mass vaccination against rotavirus.

Kõivumägi K, Toompere K, Soeorg H, Kallas E, Jõgeda EL, Huik K; Rotavirus Study group, Lutsar I.

Vaccine. 2020 Mar 17;38(13):2879-2886. doi: 10.1016/j.vaccine.2020.01.098. Epub 2020 Feb 14.

PMID:
32067818
5.

Standardising neonatal and paediatric antibiotic clinical trial design and conduct: the PENTA-ID network view.

Folgori L, Lutsar I, Standing JF, Walker AS, Roilides E, Zaoutis TE, Jafri H, Giaquinto C, Turner MA, Sharland M.

BMJ Open. 2019 Dec 31;9(12):e032592. doi: 10.1136/bmjopen-2019-032592.

6.

GAPPS (Grading and Assessment of Pharmacokinetic-Pharmacodynamic Studies) a critical appraisal system for antimicrobial PKPD studies - development and application in pediatric antibiotic studies.

Gastine S, Rashed AN, Hsia Y, Jackson C, Barker CIS, Mathur S, Tomlin S, Lutsar I, Bielicki J, Standing JF, Sharland M.

Expert Rev Clin Pharmacol. 2019 Dec;12(12):1091-1098. doi: 10.1080/17512433.2019.1695600. Epub 2019 Nov 30. Review.

PMID:
31747323
7.

Medicines prescription patterns in European neonatal units.

Mesek I, Nellis G, Lass J, Metsvaht T, Varendi H, Visk H, Turner MA, Nunn AJ, Duncan J, Lutsar I.

Int J Clin Pharm. 2019 Dec;41(6):1578-1591. doi: 10.1007/s11096-019-00923-2. Epub 2019 Oct 17.

PMID:
31625122
8.

Pertussis Prevention: Reasons for Resurgence, and Differences in the Current Acellular Pertussis Vaccines.

Esposito S, Stefanelli P, Fry NK, Fedele G, He Q, Paterson P, Tan T, Knuf M, Rodrigo C, Weil Olivier C, Flanagan KL, Hung I, Lutsar I, Edwards K, O'Ryan M, Principi N; World Association of Infectious Diseases and Immunological Disorders (WAidid) and the Vaccine Study Group of the European Society of Clinical Microbiology and Infectious Diseases (EVASG).

Front Immunol. 2019 Jul 3;10:1344. doi: 10.3389/fimmu.2019.01344. eCollection 2019. Review.

9.

Stable level of HIV transmitted drug resistance in Estonia despite significant scale-up of antiretroviral therapy.

Soodla P, Huik K, Pauskar M, Cuypers L, Van Laethem K, Rajasaar H, Kallas E, Lepa H, Velts-Lindh A, Jõgeda EL, Lutsar I, Avi R.

Infect Genet Evol. 2019 Nov;75:103901. doi: 10.1016/j.meegid.2019.05.019. Epub 2019 May 28.

PMID:
31146045
10.

The concordance of the limiting antigen and the Bio-Rad avidity assays in persons from Estonia infected mainly with HIV-1 CRF06_cpx.

Huik K, Soodla P, Pauskar M, Owen SM, Luo W, Murphy G, Jõgeda EL, Kallas E, Rajasaar H, Avi R, Masciotra S, Lutsar I; CASCADE Collaboration in the EuroCoord.

PLoS One. 2019 May 24;14(5):e0217048. doi: 10.1371/journal.pone.0217048. eCollection 2019.

11.

Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young infants.

Jacqz-Aigrain E, Leroux S, Thomson AH, Allegaert K, Capparelli EV, Biran V, Simon N, Meibohm B, Lo YL, Marques R, Peris JE, Lutsar I, Saito J, Nakamura H, van den Anker JN, Sharland M, Zhao W.

J Antimicrob Chemother. 2019 Aug 1;74(8):2128-2138. doi: 10.1093/jac/dkz158.

12.

Low Temperature and Low UV Indexes Correlated with Peaks of Influenza Virus Activity in Northern Europe during 2010⁻2018.

Ianevski A, Zusinaite E, Shtaida N, Kallio-Kokko H, Valkonen M, Kantele A, Telling K, Lutsar I, Letjuka P, Metelitsa N, Oksenych V, Dumpis U, Vitkauskiene A, Stašaitis K, Öhrmalm C, Bondeson K, Bergqvist A, Cox RJ, Tenson T, Merits A, Kainov DE.

Viruses. 2019 Mar 1;11(3). pii: E207. doi: 10.3390/v11030207.

13.

Multidrug resistant Pseudomonas aeruginosa in Estonian hospitals.

Telling K, Laht M, Brauer A, Remm M, Kisand V, Maimets M, Tenson T, Lutsar I.

BMC Infect Dis. 2018 Oct 11;18(1):513. doi: 10.1186/s12879-018-3421-1.

14.

Genetic relatedness of Gram-negative bacteria colonizing gut and skin of neonates and mother's own milk.

Parm Ü, Štšepetova J, Eelmäe I, Merila M, Ilmoja ML, Metsvaht T, Lutsar I, Soeorg H.

J Perinatol. 2018 Nov;38(11):1503-1511. doi: 10.1038/s41372-018-0220-x. Epub 2018 Sep 11.

PMID:
30206349
15.

Higher intake of coagulase-negative staphylococci from maternal milk promotes gut colonization with mecA-negative Staphylococcus epidermidis in preterm neonates.

Soeorg H, Treumuth S, Metsvaht HK, Eelmäe I, Merila M, Ilmoja ML, Lutsar I, Metsvaht T.

J Perinatol. 2018 Oct;38(10):1344-1352. doi: 10.1038/s41372-018-0183-y. Epub 2018 Aug 3.

PMID:
30076401
16.

Association of IFNλ4 rs12979860 polymorphism with the acquisition of HCV and HIV infections among people who inject drugs.

Jõgeda EL, Avi R, Pauskar M, Kallas E, Karki T, Des Jarlais D, Uusküla A, Toompere K, Lutsar I, Huik K.

J Med Virol. 2018 Nov;90(11):1779-1783. doi: 10.1002/jmv.25258. Epub 2018 Aug 16.

17.

Novel activities of safe-in-human broad-spectrum antiviral agents.

Ianevski A, Zusinaite E, Kuivanen S, Strand M, Lysvand H, Teppor M, Kakkola L, Paavilainen H, Laajala M, Kallio-Kokko H, Valkonen M, Kantele A, Telling K, Lutsar I, Letjuka P, Metelitsa N, Oksenych V, Bjørås M, Nordbø SA, Dumpis U, Vitkauskiene A, Öhrmalm C, Bondeson K, Bergqvist A, Aittokallio T, Cox RJ, Evander M, Hukkanen V, Marjomaki V, Julkunen I, Vapalahti O, Tenson T, Merits A, Kainov D.

Antiviral Res. 2018 Jun;154:174-182. doi: 10.1016/j.antiviral.2018.04.016. Epub 2018 Apr 23. Review.

PMID:
29698664
18.

Plasma and CSF pharmacokinetics of meropenem in neonates and young infants: results from the NeoMero studies.

Germovsek E, Lutsar I, Kipper K, Karlsson MO, Planche T, Chazallon C, Meyer L, Trafojer UMT, Metsvaht T, Fournier I, Sharland M, Heath P, Standing JF; NeoMero Consortium.

J Antimicrob Chemother. 2018 Jul 1;73(7):1908-1916. doi: 10.1093/jac/dky128.

19.

Genetic Relatedness of Staphylococcus haemolyticus in Gut and Skin of Preterm Neonates and Breast Milk of Their Mothers.

Soeorg H, Metsvaht HK, Keränen EE, Eelmäe I, Merila M, Ilmoja ML, Metsvaht T, Lutsar I.

Pediatr Infect Dis J. 2019 Mar;38(3):308-313. doi: 10.1097/INF.0000000000002056.

PMID:
29613973
20.

Pharmacokinetics of Penicillin G in Preterm and Term Neonates.

Padari H, Metsvaht T, Germovsek E, Barker CI, Kipper K, Herodes K, Standing JF, Oselin K, Tasa T, Soeorg H, Lutsar I.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e02238-17. doi: 10.1128/AAC.02238-17. Print 2018 May.

21.

Evaluating Safety Reporting in Paediatric Antibiotic Trials, 2000-2016: A Systematic Review and Meta-Analysis.

Pansa P, Hsia Y, Bielicki J, Lutsar I, Walker AS, Sharland M, Folgori L.

Drugs. 2018 Feb;78(2):231-244. doi: 10.1007/s40265-017-0850-x.

PMID:
29218501
22.

Pertussis and parapertussis in children and adults with a persistent cough: an observational study.

Jõgi P, Oona M, Kaart T, Toompere K, Maskina T, Koort I, Rätsep A, Lutsar I.

Infection. 2018 Feb;46(1):83-91. doi: 10.1007/s15010-017-1095-z. Epub 2017 Nov 1.

PMID:
29094317
23.

DosOpt: A Tool for Personalized Bayesian Dose Adjustment of Vancomycin in Neonates.

Tasa T, Metsvaht T, Kalamees R, Vilo J, Lutsar I.

Ther Drug Monit. 2017 Dec;39(6):604-613. doi: 10.1097/FTD.0000000000000456.

PMID:
29084032
24.

Global shortage of neonatal and paediatric antibiotic trials: rapid review.

Thompson G, Barker CI, Folgori L, Bielicki JA, Bradley JS, Lutsar I, Sharland M.

BMJ Open. 2017 Oct 13;7(10):e016293. doi: 10.1136/bmjopen-2017-016293. Review.

25.

Age-Appropriate Formulations Including Pharmaceutical Excipients in Neonatal Medicines.

Kogermann K, Lass J, Nellis G, Metsvaht T, Lutsar I.

Curr Pharm Des. 2017;23(38):5779-5789. doi: 10.2174/1381612823666170926122613. Review.

PMID:
28950820
26.

HIV incidence in the Estonian population in 2013 determined using the HIV-1 limiting antigen avidity assay.

Soodla P, Simmons R, Huik K, Pauskar M, Jõgeda EL, Rajasaar H, Kallaste E, Maimets M, Avi R, Murphy G, Porter K, Lutsar I; Concerted Action on SeroConversion to AIDS and Death in Europe (CASCADE) Collaboration in EuroCoord.

HIV Med. 2018 Jan;19(1):33-41. doi: 10.1111/hiv.12535. Epub 2017 Aug 1.

27.

EAN consensus review on prevention, diagnosis and management of tick-borne encephalitis.

Taba P, Schmutzhard E, Forsberg P, Lutsar I, Ljøstad U, Mygland Å, Levchenko I, Strle F, Steiner I.

Eur J Neurol. 2017 Oct;24(10):1214-e61. doi: 10.1111/ene.13356. Epub 2017 Aug 1. Review.

PMID:
28762591
28.

The role of breast milk in the colonization of neonatal gut and skin with coagulase-negative staphylococci.

Soeorg H, Metsvaht T, Eelmäe I, Merila M, Treumuth S, Huik K, Jürna-Ellam M, Ilmoja ML, Lutsar I.

Pediatr Res. 2017 Nov;82(5):759-767. doi: 10.1038/pr.2017.150. Epub 2017 Aug 2.

PMID:
28665928
29.

Coagulase-Negative Staphylococci in Human Milk From Mothers of Preterm Compared With Term Neonates.

Soeorg H, Metsvaht T, Eelmäe I, Metsvaht HK, Treumuth S, Merila M, Ilmoja ML, Lutsar I.

J Hum Lact. 2017 May;33(2):329-340. doi: 10.1177/0890334417691505. Epub 2017 Mar 10.

PMID:
28418807
30.

A highly sensitive method for the simultaneous UHPLC-MS/MS analysis of clonidine, morphine, midazolam and their metabolites in blood plasma using HFIP as the eluent additive.

Veigure R, Aro R, Metsvaht T, Standing JF, Lutsar I, Herodes K, Kipper K; CloSed Consortium.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 May 1;1052:150-157. doi: 10.1016/j.jchromb.2017.03.007. Epub 2017 Mar 10.

PMID:
28388512
31.

Coagulase negative staphylococcal sepsis in neonates: do we need to adapt vancomycin dose or target?

Padari H, Oselin K, Tasa T, Metsvaht T, Lõivukene K, Lutsar I.

BMC Pediatr. 2016 Dec 8;16(1):206.

32.

Molecular epidemiology of Staphylococcus epidermidis in neonatal intensive care units.

Soeorg H, Huik K, Parm Ü, Ilmoja ML, Metsvaht T, Lutsar I.

APMIS. 2017 Jan;125(1):63-73. doi: 10.1111/apm.12637. Epub 2016 Nov 16.

PMID:
27859778
33.

People living with HIV in Estonia: engagement in HIV care in 2013.

Laisaar KT, Raag M, Lutsar I, Uusküla A.

Euro Surveill. 2016 Oct 27;21(43). doi: 10.2807/1560-7917.ES.2016.21.43.30380.

34.

Prevalence and genotypes of GBV-C and its associations with HIV infection among persons who inject drugs in Eastern Europe.

Jõgeda EL, Huik K, Pauskar M, Kallas E, Karki T, Des Jarlais D, Uusküla A, Lutsar I, Avi R.

J Med Virol. 2017 Apr;89(4):632-638. doi: 10.1002/jmv.24683. Epub 2016 Sep 16.

PMID:
27603233
35.

Plasmid with Colistin Resistance Gene mcr-1 in Extended-Spectrum-β-Lactamase-Producing Escherichia coli Strains Isolated from Pig Slurry in Estonia.

Brauer A, Telling K, Laht M, Kalmus P, Lutsar I, Remm M, Kisand V, Tenson T.

Antimicrob Agents Chemother. 2016 Oct 21;60(11):6933-6936. doi: 10.1128/AAC.00443-16. Print 2016 Nov.

36.

T Cell Distribution in Relation to HIV/HBV/HCV Coinfections and Intravenous Drug Use.

Kallas E, Huik K, Türk S, Pauskar M, Jõgeda EL, Šunina M, Karki T, Des Jarlais D, Uusküla A, Avi R, Lutsar I.

Viral Immunol. 2016 Oct;29(8):464-470. Epub 2016 Aug 26.

37.

Harmonisation in study design and outcomes in paediatric antibiotic clinical trials: a systematic review.

Folgori L, Bielicki J, Ruiz B, Turner MA, Bradley JS, Benjamin DK Jr, Zaoutis TE, Lutsar I, Giaquinto C, Rossi P, Sharland M.

Lancet Infect Dis. 2016 Sep;16(9):e178-e189. doi: 10.1016/S1473-3099(16)00069-4. Epub 2016 Jun 30. Review.

PMID:
27375212
38.

A CCL5 Haplotype Is Associated with Low Seropositivity Rate of HCV Infection in People Who Inject Drugs.

Huik K, Avi R, Pauskar M, Kallas E, Jõgeda EL, Karki T, Rüütel K, Talu A, Abel-Ollo K, Uusküla A, Carrillo A, Ahuja SK, He W, Lutsar I.

PLoS One. 2016 Jun 15;11(6):e0156850. doi: 10.1371/journal.pone.0156850. eCollection 2016.

39.

Development and Evaluation of a Gentamicin Pharmacokinetic Model That Facilitates Opportunistic Gentamicin Therapeutic Drug Monitoring in Neonates and Infants.

Germovsek E, Kent A, Metsvaht T, Lutsar I, Klein N, Turner MA, Sharland M, Nielsen EI, Heath PT, Standing JF.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4869-77. doi: 10.1128/AAC.00577-16. Print 2016 Aug.

40.

Human T-lymphotropic virus types 1 and 2 are rare among intravenous drug users in Eastern Europe.

Jõgeda EL, Avi R, Pauskar M, Kallas E, Karki T, Des Jarlais D, Uusküla A, Lutsar I, Huik K.

Infect Genet Evol. 2016 Sep;43:83-5. doi: 10.1016/j.meegid.2016.05.022. Epub 2016 May 17.

41.

Product Substitution as a Way Forward in Avoiding Potentially Harmful Excipients in Neonates.

Nellis G, Metsvaht T, Varendi H, Lass J, Duncan J, Nunn AJ, Turner MA, Lutsar I.

Paediatr Drugs. 2016 Jun;18(3):221-30. doi: 10.1007/s40272-016-0173-5.

PMID:
27099961
42.

Differences in T cell distribution and CCR5 expression in HIV-positive and HIV-exposed seronegative persons who inject drugs.

Kallas E, Huik K, Türk S, Pauskar M, Jõgeda EL, Šunina M, Karki T, Des Jarlais D, Uusküla A, Avi R, Lutsar I.

Med Microbiol Immunol. 2016 Jun;205(3):231-9. doi: 10.1007/s00430-015-0444-8. Epub 2015 Dec 22.

PMID:
26696529
43.

The impact of transient combination antiretroviral treatment in early HIV infection on viral suppression and immunologic response in later treatment.

Pantazis N, Touloumi G, Meyer L, Olson A, Costagliola D, Kelleher AD, Lutsar I, Chaix ML, Fisher M, Moreno S, Porter K; CASCADE Collaboration in EuroCoord.

AIDS. 2016 Mar 27;30(6):879-88. doi: 10.1097/QAD.0000000000000991.

44.

Comment on Pharmacokinetic Studies in Neonates: The Utility of an Opportunistic Sampling Design.

Standing JF, Anderson BJ, Holford NH, Lutsar I, Metsvaht T.

Clin Pharmacokinet. 2015 Dec;54(12):1287-8. doi: 10.1007/s40262-015-0344-5. No abstract available.

PMID:
26547309
45.

Prevalence of drug resistance mutations in HAART patients infected with HIV-1 CRF06_cpx in Estonia.

Avi R, Pauskar M, Karki T, Kallas E, Jõgeda EL, Margus T, Huik K, Lutsar I.

J Med Virol. 2016 Mar;88(3):448-54. doi: 10.1002/jmv.24361. Epub 2015 Sep 21.

PMID:
26291050
46.

Estimated and reported incidence of pertussis in Estonian adults: A seroepidemiological study.

Jõgi P, Oona M, Toompere K, Lutsar I.

Vaccine. 2015 Sep 11;33(38):4756-61. doi: 10.1016/j.vaccine.2015.08.007. Epub 2015 Aug 13.

PMID:
26277068
47.

Design and structure of the Estonian HIV Cohort Study (E-HIV).

Soodla P, Rajasaar H, Avi R, Zilmer K, Kink K, Novikova L, Huik K, Maimets M, Lutsar I.

Infect Dis (Lond). 2015;47(11):768-75. doi: 10.3109/23744235.2015.1061203. Epub 2015 Jul 8.

PMID:
26153824
48.

Correction: Geographic and Temporal Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted HIV-1 Drug Resistance: An Individual-Patient- and Sequence-Level Meta-Analysis.

Rhee SY, Blanco JL, Jordan MR, Taylor J, Lemey P, Varghese V, Hamers RL, Bertagnolio S, de Wit TF, Aghokeng AF, Albert J, Avi R, Avila-Rios S, Bessong PO, Brooks JI, Boucher CA, Brumme ZL, Busch MP, Bussmann H, Chaix ML, Chin BS, D'Aquin TT, De Gascun CF, Derache A, Descamps D, Deshpande AK, Djoko CF, Eshleman SH, Fleury H, Frange P, Fujisaki S, Harrigan PR, Hattori J, Holguin A, Hunt GM, Ichimura H, Kaleebu P, Katzenstein D, Kiertiburanakul S, Kim JH, Kim SS, Li Y, Lutsar I, Morris L, Ndembi N, Kee PN, Paranjape RS, Peeters M, Poljak M, Price MA, Ragonnet-Cronin ML, Reyes-Terán G, Rolland M, Sirivichayakul S, Smith DM, Soares MA, Soriano VV, Ssemwanga D, Stanojevic M, Stefani MA, Sugiura W, Sungkanuparph S, Tanuri A, Tee KK, Truong HM, van de Vijver DA, Vidal N, Yang C, Yang R, Yebra G, Ioannidis JP, Vandamme AM, Shafer RW.

PLoS Med. 2015 Jun 1;12(6):e1001845. doi: 10.1371/journal.pmed.1001845. eCollection 2015 Jun. No abstract available.

49.

Gut colonization by aerobic microorganisms is associated with route and type of nutrition in premature neonates.

Parm Ü, Metsvaht T, Ilmoja ML, Lutsar I.

Nutr Res. 2015 Jun;35(6):496-503. doi: 10.1016/j.nutres.2015.04.006. Epub 2015 Apr 16.

PMID:
25922115
50.

High variability in the dosing of commonly used antibiotics revealed by a Europe-wide point prevalence study: implications for research and dissemination.

Metsvaht T, Nellis G, Varendi H, Nunn AJ, Graham S, Rieutord A, Storme T, McElnay J, Mulla H, Turner MA, Lutsar I.

BMC Pediatr. 2015 Apr 16;15:41. doi: 10.1186/s12887-015-0359-y.

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