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Items: 1 to 50 of 92

1.

Development of New Epoxy Resin Monomers - A Delicate Balance between Skin Allergy and Polymerization Properties.

Ponting DJ, Ortega MA, Niklasson IB, Karlsson I, Seifert T, Stéen J, Luthman K, Karlberg AT.

Chem Res Toxicol. 2019 Jan 22;32(1):57-66. doi: 10.1021/acs.chemrestox.8b00169. Epub 2018 Dec 31.

PMID:
30543284
2.

Can the epoxides of cinnamyl alcohol and cinnamal show new cases of contact allergy?

Hagvall L, Niklasson IB, Luthman K, Karlberg AT.

Contact Dermatitis. 2018 Jun;78(6):399-405. doi: 10.1111/cod.12992. Epub 2018 Mar 30.

PMID:
29603274
3.

Identification of the Binding Site of Chroman-4-one-Based Sirtuin 2-Selective Inhibitors using Photoaffinity Labeling in Combination with Tandem Mass Spectrometry.

Seifert T, Malo M, Lengqvist J, Sihlbom C, Jarho EM, Luthman K.

J Med Chem. 2016 Dec 8;59(23):10794-10799. Epub 2016 Nov 21.

PMID:
27933951
4.

Assessment of cross-reactivity of new less sensitizing epoxy resin monomers in epoxy resin-allergic individuals.

Hagvall L, Niklasson IB, Rudbäck J, O'Boyle NM, Niklasson E, Luthman K, Karlberg AT.

Contact Dermatitis. 2016 Sep;75(3):144-50. doi: 10.1111/cod.12624. Epub 2016 Jun 29.

PMID:
27352978
5.

Chroman-4-one and chromone based somatostatin β-turn mimetics.

Fridén-Saxin M, Seifert T, Malo M, da Silva Andersson K, Pemberton N, Dyrager C, Friberg A, Dahlén K, Wallén EA, Grøtli M, Luthman K.

Eur J Med Chem. 2016 May 23;114:59-64. doi: 10.1016/j.ejmech.2016.02.046. Epub 2016 Feb 21.

PMID:
26974375
6.

Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction.

Pettersson M, Quant M, Min J, Iconaru L, Kriwacki RW, Waddell MB, Guy RK, Luthman K, Grøtli M.

PLoS One. 2015 Oct 1;10(10):e0137867. doi: 10.1371/journal.pone.0137867. eCollection 2015.

7.

Pathogenic fungus Batrachochytrium dendrobatidis in marbled water frog Telmatobius marmoratus: first record from Lake Titicaca, Bolivia.

Cossel J Jr, Lindquist E, Craig H, Luthman K.

Dis Aquat Organ. 2014 Nov 13;112(1):83-7. doi: 10.3354/dao02778.

PMID:
25392045
8.

Chroman-4-one- and chromone-based sirtuin 2 inhibitors with antiproliferative properties in cancer cells.

Seifert T, Malo M, Kokkola T, Engen K, Fridén-Saxin M, Wallén EA, Lahtela-Kakkonen M, Jarho EM, Luthman K.

J Med Chem. 2014 Dec 11;57(23):9870-88. doi: 10.1021/jm500930h. Epub 2014 Dec 2.

PMID:
25383691
9.

Epoxyalcohols: bioactivation and conjugation required for skin sensitization.

Delaine T, Ponting DJ, Niklasson IB, Emter R, Hagvall L, Norrby PO, Natsch A, Luthman K, Karlberg AT.

Chem Res Toxicol. 2014 Oct 20;27(10):1860-70. doi: 10.1021/tx500297d. Epub 2014 Sep 22.

PMID:
25195701
10.

Epoxy resin monomers with reduced skin sensitizing potency.

O'Boyle NM, Niklasson IB, Tehrani-Bagha AR, Delaine T, Holmberg K, Luthman K, Karlberg AT.

Chem Res Toxicol. 2014 Jun 16;27(6):1002-10. doi: 10.1021/tx5000624. Epub 2014 Jun 2.

PMID:
24830866
11.

Bioactivation of cinnamic alcohol forms several strong skin sensitizers.

Niklasson IB, Ponting DJ, Luthman K, Karlberg AT.

Chem Res Toxicol. 2014 Apr 21;27(4):568-75. doi: 10.1021/tx400428f. Epub 2014 Feb 7.

PMID:
24460212
12.

Development of 7TM receptor-ligand complex models using ligand-biased, semi-empirical helix-bundle repacking in torsion space: application to the agonist interaction of the human dopamine D2 receptor.

Malo M, Persson R, Svensson P, Luthman K, Brive L.

J Comput Aided Mol Des. 2013 Mar;27(3):277-91. doi: 10.1007/s10822-013-9640-z. Epub 2013 Apr 4.

13.

Skin sensitization of epoxyaldehydes: importance of conjugation.

Delaine T, Hagvall L, Rudbäck J, Luthman K, Karlberg AT.

Chem Res Toxicol. 2013 May 20;26(5):674-84. doi: 10.1021/tx300465h. Epub 2013 Apr 23. Erratum in: Chem Res Toxicol. 2014 Feb 17;27(2):309.

PMID:
23534857
14.

Cinnamyl alcohol oxidizes rapidly upon air exposure.

Niklasson IB, Delaine T, Islam MN, Karlsson R, Luthman K, Karlberg AT.

Contact Dermatitis. 2013 Mar;68(3):129-38. doi: 10.1111/cod.12009.

PMID:
23421457
15.

Analogues of the epoxy resin monomer diglycidyl ether of bisphenol F: effects on contact allergenic potency and cytotoxicity.

O'Boyle NM, Delaine T, Luthman K, Natsch A, Karlberg AT.

Chem Res Toxicol. 2012 Nov 19;25(11):2469-78. doi: 10.1021/tx300305k. Epub 2012 Oct 9.

PMID:
22998141
16.

Synthesis and evaluation of substituted chroman-4-one and chromone derivatives as sirtuin 2-selective inhibitors.

Fridén-Saxin M, Seifert T, Landergren MR, Suuronen T, Lahtela-Kakkonen M, Jarho EM, Luthman K.

J Med Chem. 2012 Aug 23;55(16):7104-13. doi: 10.1021/jm3005288. Epub 2012 Aug 7.

17.

3-aminopiperidine-based peptide analogues as the first selective noncovalent inhibitors of the bacterial cysteine protease IdeS.

Berggren K, Vindebro R, Bergström C, Spoerry C, Persson H, Fex T, Kihlberg J, von Pawel-Rammingen U, Luthman K.

J Med Chem. 2012 Mar 22;55(6):2549-60. doi: 10.1021/jm201517a. Epub 2012 Mar 14.

18.

Investigation of D₁ receptor-agonist interactions and D₁/D₂ agonist selectivity using a combination of pharmacophore and receptor homology modeling.

Malo M, Brive L, Luthman K, Svensson P.

ChemMedChem. 2012 Mar 5;7(3):483-94, 338. doi: 10.1002/cmdc.201100546. Epub 2012 Feb 7.

19.

Investigation of D₂ receptor-agonist interactions using a combination of pharmacophore and receptor homology modeling.

Malo M, Brive L, Luthman K, Svensson P.

ChemMedChem. 2012 Mar 5;7(3):471-82, 338. doi: 10.1002/cmdc.201100545. Epub 2012 Feb 7.

20.

Structure--activity relationship between the in vivo skin sensitizing potency of analogues of phenyl glycidyl ether and the induction of Nrf2-dependent luciferase activity in the KeratinoSens in vitro assay.

Delaine T, Niklasson IB, Emter R, Luthman K, Karlberg AT, Natsch A.

Chem Res Toxicol. 2011 Aug 15;24(8):1312-8. doi: 10.1021/tx200196s. Epub 2011 Jul 22.

PMID:
21751775
21.

Inhibitors and promoters of tubulin polymerization: synthesis and biological evaluation of chalcones and related dienones as potential anticancer agents.

Dyrager C, Wickström M, Fridén-Saxin M, Friberg A, Dahlén K, Wallén EA, Gullbo J, Grøtli M, Luthman K.

Bioorg Med Chem. 2011 Apr 15;19(8):2659-65. doi: 10.1016/j.bmc.2011.03.005. Epub 2011 Mar 10.

PMID:
21459004
22.

Impact of a heteroatom in a structure-activity relationship study on analogues of phenyl glycidyl ether (PGE) from epoxy resin systems.

Niklasson IB, Delaine T, Luthman K, Karlberg AT.

Chem Res Toxicol. 2011 Apr 18;24(4):542-8. doi: 10.1021/tx100417r. Epub 2011 Mar 29.

PMID:
21370839
23.

Synthesis of orthogonally protected disulfide bridge mimetics.

Tadd AC, Meinander K, Luthman K, Wallén EA.

J Org Chem. 2011 Jan 21;76(2):673-5. doi: 10.1021/jo1018427. Epub 2010 Dec 22.

PMID:
21175147
24.

Optimization of isochromanone based urotensin II receptor agonists.

Lehmann F, Currier EA, Olsson R, Ma JN, Burstein ES, Hacksell U, Luthman K.

Bioorg Med Chem. 2010 Jul 1;18(13):4844-54. doi: 10.1016/j.bmc.2010.04.041. Epub 2010 Jun 1.

PMID:
20570157
25.

KHMDS enhanced SmI(2)-mediated reformatsky type alpha-cyanation.

Ankner T, Fridén-Saxin M, Pemberton N, Seifert T, Grøtli M, Luthman K, Hilmersson G.

Org Lett. 2010 May 21;12(10):2210-3. doi: 10.1021/ol100424y.

PMID:
20429501
26.

Selective pharmacophore models of dopamine D(1) and D(2) full agonists based on extended pharmacophore features.

Malo M, Brive L, Luthman K, Svensson P.

ChemMedChem. 2010 Feb 1;5(2):232-46. doi: 10.1002/cmdc.200900398.

PMID:
20077461
27.

Reduced sensitizing capacity of epoxy resin systems: a structure-activity relationship study.

Niklasson IB, Broo K, Jonsson C, Luthman K, Karlberg AT.

Chem Res Toxicol. 2009 Nov;22(11):1787-94. doi: 10.1021/tx900193s.

PMID:
19725531
28.

2,6,8-Trisubstituted 3-hydroxychromone derivatives as fluorophores for live-cell imaging.

Dyrager C, Friberg A, Dahlén K, Fridén-Saxin M, Börjesson K, Wilhelmsson LM, Smedh M, Grøtli M, Luthman K.

Chemistry. 2009 Sep 21;15(37):9417-23. doi: 10.1002/chem.200900279.

PMID:
19670192
29.

Novel and potent small-molecule urotensin II receptor agonists.

Lehmann F, Currier EA, Clemons B, Hansen LK, Olsson R, Hacksell U, Luthman K.

Bioorg Med Chem. 2009 Jul 1;17(13):4657-65. doi: 10.1016/j.bmc.2009.04.062. Epub 2009 May 3.

PMID:
19481466
30.

Synthesis and biological evaluation of reversible inhibitors of IdeS, a bacterial cysteine protease and virulence determinant.

Berggren K, Johansson B, Fex T, Kihlberg J, Björck L, Luthman K.

Bioorg Med Chem. 2009 May 1;17(9):3463-70. doi: 10.1016/j.bmc.2009.03.026. Epub 2009 Mar 19.

PMID:
19362485
31.

Synthesis of 2-alkyl-substituted chromone derivatives using microwave irradiation.

Fridén-Saxin M, Pemberton N, Andersson Kda S, Dyrager C, Friberg A, Grøtli M, Luthman K.

J Org Chem. 2009 Apr 3;74(7):2755-9. doi: 10.1021/jo802783z.

PMID:
19323574
32.

Drug permeability across a phospholipid vesicle-based barrier 4. The effect of tensides, co-solvents and pH changes on barrier integrity and on drug permeability.

Flaten GE, Luthman K, Vasskog T, Brandl M.

Eur J Pharm Sci. 2008 Jul 3;34(2-3):173-80. doi: 10.1016/j.ejps.2008.04.001. Epub 2008 Apr 15.

PMID:
18499410
33.

Synthesis and evaluation of novel pyridine based PLG tripeptidomimetics.

Saitton S, Del Tredici AL, Saxin M, Stenström T, Kihlberg J, Luthman K.

Org Biomol Chem. 2008 May 7;6(9):1647-54. doi: 10.1039/b718058f. Epub 2008 Mar 17.

PMID:
18421399
34.

Oximes: metabolic activation and structure-allergenic activity relationships.

Bergström MA, Andersson SI, Broo K, Luthman K, Karlberg AT.

J Med Chem. 2008 Apr 24;51(8):2541-50. doi: 10.1021/jm701092n. Epub 2008 Mar 28.

PMID:
18370375
35.

Allergic contact dermatitis--formation, structural requirements, and reactivity of skin sensitizers.

Karlberg AT, Bergström MA, Börje A, Luthman K, Nilsson JL.

Chem Res Toxicol. 2008 Jan;21(1):53-69. Epub 2007 Dec 4. Review.

PMID:
18052130
36.

Beta- and gamma-di- and tripeptides as potential substrates for the oligopeptide transporter hPepT1.

Hubatsch I, Arvidsson PI, Seebach D, Luthman K, Artursson P.

J Med Chem. 2007 Oct 18;50(21):5238-42. Epub 2007 Sep 21.

PMID:
17887660
37.

CYP2C9 structure-metabolism relationships: optimizing the metabolic stability of COX-2 inhibitors.

Ahlström MM, Ridderström M, Zamora I, Luthman K.

J Med Chem. 2007 Sep 6;50(18):4444-52. Epub 2007 Aug 14.

PMID:
17696334
38.

Metabolic epoxidation of an alpha,beta-unsaturated oxime generates sensitizers of extreme potency. Are nitroso intermediates responsible?

Bergström MA, Luthman K, Karlberg AT.

Chem Res Toxicol. 2007 Jun;20(6):927-36. Epub 2007 May 19.

PMID:
17511479
39.
40.

Synthesis of 3-aminomethyl-2-aryl- 8-bromo-6-chlorochromones.

Wallén EA, Dahlén K, Grøtli M, Luthman K.

Org Lett. 2007 Feb 1;9(3):389-91.

PMID:
17249769
42.

Synthesis of functionalized, unsymmetrical 1,3,4,6-tetrasubstituted 2,5-diketopiperazines.

Tullberg M, Grøtli M, Luthman K.

J Org Chem. 2007 Jan 5;72(1):195-9.

PMID:
17194099
43.

Design, parallel synthesis and SAR of novel urotensin II receptor agonists.

Lehmann F, Lake L, Currier EA, Olsson R, Hacksell U, Luthman K.

Eur J Med Chem. 2007 Feb;42(2):276-85. Epub 2006 Nov 15.

PMID:
17112638
44.

Microwave-assisted solid-phase synthesis of 2,5-diketopiperazines: solvent and resin dependence.

Tullberg M, Luthman K, Grøtli M.

J Comb Chem. 2006 Nov-Dec;8(6):915-22.

PMID:
17096581
45.

Synthesis of 2,3,6,8-tetrasubstituted chromone scaffolds.

Dahlén K, Wallén EA, Grøtli M, Luthman K.

J Org Chem. 2006 Sep 1;71(18):6863-71.

PMID:
16930039
46.

Role of the subunit composition of central nicotinic acetylcholine receptors for the stimulatory and dopamine-enhancing effects of ethanol.

Jerlhag E, Grøtli M, Luthman K, Svensson L, Engel JA.

Alcohol Alcohol. 2006 Sep-Oct;41(5):486-93. Epub 2006 Jun 23.

PMID:
16799162
47.
48.

Drug permeability across a phospholipid vesicle-based barrier 2. Characterization of barrier structure, storage stability and stability towards pH changes.

Flaten GE, Bunjes H, Luthman K, Brandl M.

Eur J Pharm Sci. 2006 Jul;28(4):336-43. Epub 2006 Apr 18.

PMID:
16697561
49.

Novel potent and efficacious nonpeptidic urotensin II receptor agonists.

Lehmann F, Pettersen A, Currier EA, Sherbukhin V, Olsson R, Hacksell U, Luthman K.

J Med Chem. 2006 Apr 6;49(7):2232-40.

PMID:
16570919
50.

Drug permeability across a phospholipid vesicle based barrier: a novel approach for studying passive diffusion.

Flaten GE, Dhanikula AB, Luthman K, Brandl M.

Eur J Pharm Sci. 2006 Jan;27(1):80-90. Epub 2005 Oct 24.

PMID:
16246536

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