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Multiple roles of lymphatic vessels in peripheral lymph node development.

Bovay E, Sabine A, Prat-Luri B, Kim S, Son K, Willrodt AH, Olsson C, Halin C, Kiefer F, Betsholtz C, Jeon NL, Luther SA, Petrova TV.

J Exp Med. 2018 Nov 5;215(11):2760-2777. doi: 10.1084/jem.20180217. Epub 2018 Oct 24.


Identification of a new subset of lymph node stromal cells involved in regulating plasma cell homeostasis.

Huang HY, Rivas-Caicedo A, Renevey F, Cannelle H, Peranzoni E, Scarpellino L, Hardie DL, Pommier A, Schaeuble K, Favre S, Vogt TK, Arenzana-Seisdedos F, Schneider P, Buckley CD, Donnadieu E, Luther SA.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6826-E6835. doi: 10.1073/pnas.1712628115. Epub 2018 Jul 2.


Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity.

Rodda LB, Lu E, Bennett ML, Sokol CL, Wang X, Luther SA, Barres BA, Luster AD, Ye CJ, Cyster JG.

Immunity. 2018 May 15;48(5):1014-1028.e6. doi: 10.1016/j.immuni.2018.04.006. Epub 2018 May 8.


Manifold Roles of CCR7 and Its Ligands in the Induction and Maintenance of Bronchus-Associated Lymphoid Tissue.

Fleige H, Bosnjak B, Permanyer M, Ristenpart J, Bubke A, Willenzon S, Sutter G, Luther SA, Förster R.

Cell Rep. 2018 Apr 17;23(3):783-795. doi: 10.1016/j.celrep.2018.03.072.


Perivascular Fibroblasts of the Developing Spleen Act as LTα1β2-Dependent Precursors of Both T and B Zone Organizer Cells.

Schaeuble K, Britschgi MR, Scarpellino L, Favre S, Xu Y, Koroleva E, Lissandrin TKA, Link A, Matloubian M, Ware CF, Nedospasov SA, Tumanov AV, Cyster JG, Luther SA.

Cell Rep. 2017 Nov 28;21(9):2500-2514. doi: 10.1016/j.celrep.2017.10.119.


A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.

Boege Y, Malehmir M, Healy ME, Bettermann K, Lorentzen A, Vucur M, Ahuja AK, Böhm F, Mertens JC, Shimizu Y, Frick L, Remouchamps C, Mutreja K, Kähne T, Sundaravinayagam D, Wolf MJ, Rehrauer H, Koppe C, Speicher T, Padrissa-Altés S, Maire R, Schattenberg JM, Jeong JS, Liu L, Zwirner S, Boger R, Hüser N, Davis RJ, Müllhaupt B, Moch H, Schulze-Bergkamen H, Clavien PA, Werner S, Borsig L, Luther SA, Jost PJ, Weinlich R, Unger K, Behrens A, Hillert L, Dillon C, Di Virgilio M, Wallach D, Dejardin E, Zender L, Naumann M, Walczak H, Green DR, Lopes M, Lavrik I, Luedde T, Heikenwalder M, Weber A.

Cancer Cell. 2017 Sep 11;32(3):342-359.e10. doi: 10.1016/j.ccell.2017.08.010.


Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis.

Dubey LK, Karempudi P, Luther SA, Ludewig B, Harris NL.

Nat Commun. 2017 Aug 28;8(1):367. doi: 10.1038/s41467-017-00504-9.


Essential role of CCL21 in establishment of central self-tolerance in T cells.

Kozai M, Kubo Y, Katakai T, Kondo H, Kiyonari H, Schaeuble K, Luther SA, Ishimaru N, Ohigashi I, Takahama Y.

J Exp Med. 2017 Jul 3;214(7):1925-1935. doi: 10.1084/jem.20161864. Epub 2017 Jun 13.


Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy.

Kallert SM, Darbre S, Bonilla WV, Kreutzfeldt M, Page N, Müller P, Kreuzaler M, Lu M, Favre S, Kreppel F, Löhning M, Luther SA, Zippelius A, Merkler D, Pinschewer DD.

Nat Commun. 2017 May 26;8:15327. doi: 10.1038/ncomms15327.


Erratum: CCL19-CCR7-dependent reverse transendothelial migration of myeloid cells clears Chlamydia muridarum from the arterial intima.

Roufaiel M, Gracey E, Siu A, Zhu SN, Lau A, Ibrahim H, Althagafi M, Tai K, Hyduk SJ, Cybulsky KO, Ensan S, Li A, Besla R, Becker HM, Xiao H, Luther SA, Inman RD, Robbins CS, Jongstra-Bilen J, Cybulsky MI.

Nat Immunol. 2017 May 18;18(6):705. doi: 10.1038/ni0617-705d. No abstract available.


Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands.

Chung J, Ebens CL, Perkey E, Radojcic V, Koch U, Scarpellino L, Tong A, Allen F, Wood S, Feng J, Friedman A, Granadier D, Tran IT, Chai Q, Onder L, Yan M, Reddy P, Blazar BR, Huang AY, Brennan TV, Bishop DK, Ludewig B, Siebel CW, Radtke F, Luther SA, Maillard I.

J Clin Invest. 2017 Apr 3;127(4):1574-1588. doi: 10.1172/JCI89535. Epub 2017 Mar 20.


Stromal Fibroblasts in Tertiary Lymphoid Structures: A Novel Target in Chronic Inflammation.

Barone F, Gardner DH, Nayar S, Steinthal N, Buckley CD, Luther SA.

Front Immunol. 2016 Nov 8;7:477. eCollection 2016. Review.


CCL19-CCR7-dependent reverse transendothelial migration of myeloid cells clears Chlamydia muridarum from the arterial intima.

Roufaiel M, Gracey E, Siu A, Zhu SN, Lau A, Ibrahim H, Althagafi M, Tai K, Hyduk SJ, Cybulsky KO, Ensan S, Li A, Besla R, Becker HM, Xiao H, Luther SA, Inman RD, Robbins CS, Jongstra-Bilen J, Cybulsky MI.

Nat Immunol. 2016 Nov;17(11):1263-1272. doi: 10.1038/ni.3564. Epub 2016 Sep 26. Erratum in: Nat Immunol. 2017 May 18;18(6):705.


The aged lymphoid tissue environment fails to support naïve T cell homeostasis.

Becklund BR, Purton JF, Ramsey C, Favre S, Vogt TK, Martin CE, Spasova DS, Sarkisyan G, LeRoy E, Tan JT, Wahlus H, Bondi-Boyd B, Luther SA, Surh CD.

Sci Rep. 2016 Aug 2;6:30842. doi: 10.1038/srep30842.


Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells.

Korniotis S, Gras C, Letscher H, Montandon R, Mégret J, Siegert S, Ezine S, Fallon PG, Luther SA, Fillatreau S, Zavala F.

Nat Commun. 2016 Jul 11;7:12134. doi: 10.1038/ncomms12134.


Notch Signaling Regulates the Homeostasis of Tissue-Restricted Innate-like T Cells.

Chennupati V, Koch U, Coutaz M, Scarpellino L, Tacchini-Cottier F, Luther SA, Radtke F, Zehn D, MacDonald HR.

J Immunol. 2016 Aug 1;197(3):771-82. doi: 10.4049/jimmunol.1501675. Epub 2016 Jun 20.


Lymphotoxin-Dependent B Cell-FRC Crosstalk Promotes De Novo Follicle Formation and Antibody Production following Intestinal Helminth Infection.

Dubey LK, Lebon L, Mosconi I, Yang CY, Scandella E, Ludewig B, Luther SA, Harris NL.

Cell Rep. 2016 May 17;15(7):1527-1541. doi: 10.1016/j.celrep.2016.04.023. Epub 2016 May 5.


CD8 engineered cytotoxic T cells reprogram melanoma tumor environment.

Leignadier J, Favre S, Luther SA, Luescher IF.

Oncoimmunology. 2015 Sep 11;5(3):e1086861. eCollection 2016 Mar.


DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport.

Bernier-Latmani J, Cisarovsky C, Demir CS, Bruand M, Jaquet M, Davanture S, Ragusa S, Siegert S, Dormond O, Benedito R, Radtke F, Luther SA, Petrova TV.

J Clin Invest. 2015 Nov 3;125(12):4572-86. doi: 10.1172/JCI82045.


IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs.

Barone F, Nayar S, Campos J, Cloake T, Withers DR, Toellner KM, Zhang Y, Fouser L, Fisher B, Bowman S, Rangel-Moreno J, Garcia-Hernandez Mde L, Randall TD, Lucchesi D, Bombardieri M, Pitzalis C, Luther SA, Buckley CD.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):11024-9. doi: 10.1073/pnas.1503315112. Epub 2015 Aug 18.


Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity.

Jaworski M, Marsland BJ, Gehrig J, Held W, Favre S, Luther SA, Perroud M, Golshayan D, Gaide O, Thome M.

EMBO J. 2014 Dec 1;33(23):2765-81. doi: 10.15252/embj.201488987. Epub 2014 Oct 15.


Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses.

Fasnacht N, Huang HY, Koch U, Favre S, Auderset F, Chai Q, Onder L, Kallert S, Pinschewer DD, MacDonald HR, Tacchini-Cottier F, Ludewig B, Luther SA, Radtke F.

J Exp Med. 2014 Oct 20;211(11):2265-79. doi: 10.1084/jem.20132528. Epub 2014 Oct 13.


Conditional deletion of ferritin h in mice reduces B and T lymphocyte populations.

Vanoaica L, Richman L, Jaworski M, Darshan D, Luther SA, Kühn LC.

PLoS One. 2014 Feb 21;9(2):e89270. doi: 10.1371/journal.pone.0089270. eCollection 2014.


Trapping of naive lymphocytes triggers rapid growth and remodeling of the fibroblast network in reactive murine lymph nodes.

Yang CY, Vogt TK, Favre S, Scarpellino L, Huang HY, Tacchini-Cottier F, Luther SA.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E109-18. doi: 10.1073/pnas.1312585111. Epub 2013 Dec 23.


Notch signaling regulates follicular helper T cell differentiation.

Auderset F, Schuster S, Fasnacht N, Coutaz M, Charmoy M, Koch U, Favre S, Wilson A, Trottein F, Alexander J, Luther SA, MacDonald HR, Radtke F, Tacchini-Cottier F.

J Immunol. 2013 Sep 1;191(5):2344-50. doi: 10.4049/jimmunol.1300643. Epub 2013 Aug 5.


DL4-mediated Notch signaling is required for the development of fetal αβ and γδ T cells.

Ferrero I, Koch U, Claudinot S, Favre S, Radtke F, Luther SA, MacDonald HR.

Eur J Immunol. 2013 Nov;43(11):2845-53. doi: 10.1002/eji.201343527. Epub 2013 Aug 25.


Inducible gene expression in fetal thymic epithelium: a new BAC transgenic model.

Fiorini E, Ferrero I, Poisson C, Scarpellino L, Luther SA, MacDonald HR.

Genesis. 2013 Oct;51(10):717-24. doi: 10.1002/dvg.22414. Epub 2013 Aug 7.


Innate signaling promotes formation of regulatory nitric oxide-producing dendritic cells limiting T-cell expansion in experimental autoimmune myocarditis.

Kania G, Siegert S, Behnke S, Prados-Rosales R, Casadevall A, Lüscher TF, Luther SA, Kopf M, Eriksson U, Blyszczuk P.

Circulation. 2013 Jun 11;127(23):2285-94. doi: 10.1161/CIRCULATIONAHA.112.000434. Epub 2013 May 13.


Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity.

Chai Q, Onder L, Scandella E, Gil-Cruz C, Perez-Shibayama C, Cupovic J, Danuser R, Sparwasser T, Luther SA, Thiel V, Rülicke T, Stein JV, Hehlgans T, Ludewig B.

Immunity. 2013 May 23;38(5):1013-24. doi: 10.1016/j.immuni.2013.03.012. Epub 2013 Apr 25.


Interstitial dendritic cell guidance by haptotactic chemokine gradients.

Weber M, Hauschild R, Schwarz J, Moussion C, de Vries I, Legler DF, Luther SA, Bollenbach T, Sixt M.

Science. 2013 Jan 18;339(6117):328-32. doi: 10.1126/science.1228456.


Positive and negative regulation of T cell responses by fibroblastic reticular cells within paracortical regions of lymph nodes.

Siegert S, Luther SA.

Front Immunol. 2012 Sep 11;3:285. doi: 10.3389/fimmu.2012.00285. eCollection 2012.


Expression and function of interleukin-7 in secondary and tertiary lymphoid organs.

Huang HY, Luther SA.

Semin Immunol. 2012 Jun;24(3):175-89. doi: 10.1016/j.smim.2012.02.008. Epub 2012 Mar 22. Review.


Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide.

Siegert S, Huang HY, Yang CY, Scarpellino L, Carrie L, Essex S, Nelson PJ, Heikenwalder M, Acha-Orbea H, Buckley CD, Marsland BJ, Zehn D, Luther SA.

PLoS One. 2011;6(11):e27618. doi: 10.1371/journal.pone.0027618. Epub 2011 Nov 14.


Destruction of lymphoid organ architecture and hepatitis caused by CD4+ T cells.

Matter MS, Hilmenyuk T, Claus C, Marone R, Schürch C, Tinguely M, Terracciano L, Luther SA, Ochsenbein AF.

PLoS One. 2011;6(9):e24772. doi: 10.1371/journal.pone.0024772. Epub 2011 Sep 23.


Association of T-zone reticular networks and conduits with ectopic lymphoid tissues in mice and humans.

Link A, Hardie DL, Favre S, Britschgi MR, Adams DH, Sixt M, Cyster JG, Buckley CD, Luther SA.

Am J Pathol. 2011 Apr;178(4):1662-75. doi: 10.1016/j.ajpath.2010.12.039.


Guiding blind T cells and dendritic cells: A closer look at fibroblastic reticular cells found within lymph node T zones.

Luther SA, Vogt TK, Siegert S.

Immunol Lett. 2011 Jul;138(1):9-11. doi: 10.1016/j.imlet.2011.02.006. Epub 2011 Feb 17. Review.


Definition of key variables for the induction of optimal NY-ESO-1-specific T cells in HLA transgene mice.

Johannsen A, Genolet R, Legler DF, Luther SA, Luescher IF.

J Immunol. 2010 Sep 15;185(6):3445-55. doi: 10.4049/jimmunol.1001397. Epub 2010 Aug 23.


Plasma cell precursors: long-distance travelers looking for a home.

Luther SA.

Immunity. 2010 Jul 23;33(1):9-11. doi: 10.1016/j.immuni.2010.07.010.


CCL21 is sufficient to mediate DC migration, maturation and function in the absence of CCL19.

Britschgi MR, Favre S, Luther SA.

Eur J Immunol. 2010 May;40(5):1266-71. doi: 10.1002/eji.200939921.


Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies.

Fiorini E, Merck E, Wilson A, Ferrero I, Jiang W, Koch U, Auderset F, Laurenti E, Tacchini-Cottier F, Pierres M, Radtke F, Luther SA, Macdonald HR.

J Immunol. 2009 Dec 1;183(11):7212-22. doi: 10.4049/jimmunol.0902432. Epub 2009 Nov 13.


Fluid flow regulates stromal cell organization and CCL21 expression in a tissue-engineered lymph node microenvironment.

Tomei AA, Siegert S, Britschgi MR, Luther SA, Swartz MA.

J Immunol. 2009 Oct 1;183(7):4273-83. doi: 10.4049/jimmunol.0900835. Epub 2009 Sep 4.


Novel function for interleukin-7 in dendritic cell development.

Vogt TK, Link A, Perrin J, Finke D, Luther SA.

Blood. 2009 Apr 23;113(17):3961-8. doi: 10.1182/blood-2008-08-176321. Epub 2009 Feb 25.


Cutting edge: thymic crosstalk regulates delta-like 4 expression on cortical epithelial cells.

Fiorini E, Ferrero I, Merck E, Favre S, Pierres M, Luther SA, MacDonald HR.

J Immunol. 2008 Dec 15;181(12):8199-203.


Dynamic modulation of CCR7 expression and function on naive T lymphocytes in vivo.

Britschgi MR, Link A, Lissandrin TK, Luther SA.

J Immunol. 2008 Dec 1;181(11):7681-8.


Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone.

Scandella E, Bolinger B, Lattmann E, Miller S, Favre S, Littman DR, Finke D, Luther SA, Junt T, Ludewig B.

Nat Immunol. 2008 Jun;9(6):667-75. doi: 10.1038/ni.1605. Epub 2008 Apr 20.


Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells.

Link A, Vogt TK, Favre S, Britschgi MR, Acha-Orbea H, Hinz B, Cyster JG, Luther SA.

Nat Immunol. 2007 Nov;8(11):1255-65. Epub 2007 Sep 23.


Inpatient and follow-up cardiology care and mortality for acute coronary syndrome patients in the Veterans Health Administration.

Ho PM, Luther SA, Masoudi FA, Gupta I, Lowy E, Maynard C, Sales AE, Peterson ED, Fihn SD, Rumsfeld JS.

Am Heart J. 2007 Sep;154(3):489-94.


Recirculating CD4 memory T cells mount rapid secondary responses without major contributions from follicular CD4 effectors and B cells.

Luther SA, Serre K, Cunningham AF, Khan M, Acha-Orbea H, MacLennan IC, Toellner KM.

Eur J Immunol. 2007 Jun;37(6):1476-84.


The relationship between B-type natriuretic peptide and health status in patients with heart failure.

Luther SA, McCullough PA, Havranek EP, Rumsfeld JS, Jones PG, Heidenreich PA, Peterson ED, Rathore SS, Krumholz HM, Weintraub WS, Spertus JA, Masoudi FA; Cardiovascular Outcomes Research Consortium.

J Card Fail. 2005 Aug;11(6):414-21.


Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease.

Lang KS, Recher M, Junt T, Navarini AA, Harris NL, Freigang S, Odermatt B, Conrad C, Ittner LM, Bauer S, Luther SA, Uematsu S, Akira S, Hengartner H, Zinkernagel RM.

Nat Med. 2005 Feb;11(2):138-45. Epub 2005 Jan 16. Erratum in: Nat Med. 2005 Nov;11(11):1256.


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