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Items: 1 to 50 of 142

1.

Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction.

Aarts SABM, Reiche ME, den Toom M, Beckers L, Gijbels MJJ, Gerdes N, de Winther MPJ, Lutgens E.

PLoS One. 2018 Aug 10;13(8):e0202150. doi: 10.1371/journal.pone.0202150. eCollection 2018.

2.

Cardiovascular oncology: exploring the effects of targeted cancer therapies on atherosclerosis.

Seijkens TTP, Lutgens E.

Curr Opin Lipidol. 2018 Jul 31. doi: 10.1097/MOL.0000000000000538. [Epub ahead of print]

PMID:
30074493
3.

Circulating levels of P-selectin and E-selectin relate to cardiovascular magnetic resonance-derived aortic characteristics in young adults from the general population, a cross-sectional study.

Eikendal ALM, Bots ML, Gohar A, Lutgens E, Hoefer IE, den Ruijter HM, Leiner T.

J Cardiovasc Magn Reson. 2018 Aug 2;20(1):54. doi: 10.1186/s12968-018-0473-8.

4.

Future directions for therapeutic strategies in post-ischaemic vascularization: a position paper from European Society of Cardiology Working group on Atherosclerosis and Vascular Biology.

Caporali A, Bäck M, Daemen MJ, Hoefer IE, Jones EA, Lutgens E, Matter CM, Bochaton-Piallat ML, Siekmann AF, Sluimer JC, Steffens S, Tuñón J, Vindis C, Wentzel JJ, Ylä-Herttuala S, Evans PC.

Cardiovasc Res. 2018 Jul 17. doi: 10.1093/cvr/cvy184. [Epub ahead of print]

PMID:
30016405
5.

2016 Jeffrey M. Hoeg Award Lecture: Immune Checkpoints in Atherosclerosis: Toward Immunotherapy for Atheroprotection.

Rouwet E, Lutgens E.

Arterioscler Thromb Vasc Biol. 2018 Jun 21. pii: ATVBAHA.118.307742. doi: 10.1161/ATVBAHA.118.307742. [Epub ahead of print] Review.

PMID:
29930003
6.

Commonly available hematological biomarkers are associated with the extent of coronary calcifications.

den Harder AM, de Jong PA, de Groot MCH, Wolterink JM, Budde RPJ, Iŝgum I, van Solinge WW, Ten Berg MJ, Lutgens E, Veldhuis WB, Haitjema S, Hoefer IE, Leiner T.

Atherosclerosis. 2018 Jun 12;275:166-173. doi: 10.1016/j.atherosclerosis.2018.06.017. [Epub ahead of print]

PMID:
29920437
7.

Myeloid Kdm6b deficiency results in advanced atherosclerosis.

Neele AE, Gijbels MJJ, van der Velden S, Hoeksema MA, Boshuizen MCS, Prange KHM, Chen HJ, Van den Bossche J, van Roomen CPPA, Shami A, Levels JHM, Kroon J, Lucas T, Dimmeler S, Lutgens E, de Winther MPJ.

Atherosclerosis. 2018 Jun 1;275:156-165. doi: 10.1016/j.atherosclerosis.2018.05.052. [Epub ahead of print]

8.

Interplay between hypercholesterolaemia and inflammation in atherosclerosis: Translating experimental targets into clinical practice.

Tuñón J, Bäck M, Badimón L, Bochaton-Piallat ML, Cariou B, Daemen MJ, Egido J, Evans PC, Francis SE, Ketelhuth DF, Lutgens E, Matter CM, Monaco C, Steffens S, Stroes E, Vindis C, Weber C, Hoefer IE; ESC Working Group on Atherosclerosis and Vascular Biology.

Eur J Prev Cardiol. 2018 Jun;25(9):948-955. doi: 10.1177/2047487318773384. Epub 2018 May 14.

PMID:
29759006
9.

CD40L Deficiency Protects Against Aneurysm Formation.

Kusters PJH, Seijkens TTP, Beckers L, Lievens D, Winkels H, de Waard V, Duijvestijn A, Lindquist Liljeqvist M, Roy J, Daugherty A, Newby A, Gerdes N, Lutgens E.

Arterioscler Thromb Vasc Biol. 2018 May;38(5):1076-1085. doi: 10.1161/ATVBAHA.117.310640. Epub 2018 Mar 8.

PMID:
29519940
10.

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis.

Seijkens TTP, van Tiel CM, Kusters PJH, Atzler D, Soehnlein O, Zarzycka B, Aarts SABM, Lameijer M, Gijbels MJ, Beckers L, den Toom M, Slütter B, Kuiper J, Duchene J, Aslani M, Megens RTA, van 't Veer C, Kooij G, Schrijver R, Hoeksema MA, Boon L, Fay F, Tang J, Baxter S, Jongejan A, Moerland PD, Vriend G, Bleijlevens B, Fisher EA, Duivenvoorden R, Gerdes N, de Winther MPJ, Nicolaes GA, Mulder WJM, Weber C, Lutgens E.

J Am Coll Cardiol. 2018 Feb 6;71(5):527-542. doi: 10.1016/j.jacc.2017.11.055.

11.

The CD40-CD40L Dyad in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis.

Aarts SABM, Seijkens TTP, van Dorst KJF, Dijkstra CD, Kooij G, Lutgens E.

Front Immunol. 2017 Dec 12;8:1791. doi: 10.3389/fimmu.2017.01791. eCollection 2017. Review.

12.

Exploring immune checkpoints as potential therapeutic targets in atherosclerosis.

Kusters PJH, Lutgens E, Seijkens TTP.

Cardiovasc Res. 2018 Mar 1;114(3):368-377. doi: 10.1093/cvr/cvx248.

PMID:
29309533
13.

Novel molecular imaging ligands targeting matrix metalloproteinases 2 and 9 for imaging of unstable atherosclerotic plaques.

Hakimzadeh N, Pinas VA, Molenaar G, de Waard V, Lutgens E, van Eck-Smit BLF, de Bruin K, Piek JJ, Eersels JLH, Booij J, Verberne HJ, Windhorst AD.

PLoS One. 2017 Nov 30;12(11):e0187767. doi: 10.1371/journal.pone.0187767. eCollection 2017.

14.

Monocyte and haematopoietic progenitor reprogramming as common mechanism underlying chronic inflammatory and cardiovascular diseases.

Hoogeveen RM, Nahrendorf M, Riksen NP, Netea MG, de Winther MPJ, Lutgens E, Nordestgaard B, Neidhart M, Stroes ESG, Catapano AL, Bekkering S.

Eur Heart J. 2017 Oct 24. doi: 10.1093/eurheartj/ehx581. [Epub ahead of print]

15.

CD27 co-stimulation increases the abundance of regulatory T cells and reduces atherosclerosis in hyperlipidaemic mice.

Winkels H, Meiler S, Lievens D, Engel D, Spitz C, Bürger C, Beckers L, Dandl A, Reim S, Ahmadsei M, Hartwig H, Holdt LM, Hristov M, Megens RTA, Schmitt MM, Biessen EA, Borst J, Faussner A, Weber C, Lutgens E, Gerdes N.

Eur Heart J. 2017 Dec 21;38(48):3590-3599. doi: 10.1093/eurheartj/ehx517.

PMID:
29045618
16.

CD40L controls obesity-associated vascular inflammation, oxidative stress, and endothelial dysfunction in high fat diet-treated and db/db mice.

Steven S, Dib M, Hausding M, Kashani F, Oelze M, Kröller-Schön S, Hanf A, Daub S, Roohani S, Gramlich Y, Lutgens E, Schulz E, Becker C, Lackner KJ, Kleinert H, Knosalla C, Niesler B, Wild PS, Münzel T, Daiber A.

Cardiovasc Res. 2018 Feb 1;114(2):312-323. doi: 10.1093/cvr/cvx197.

PMID:
29036612
17.

Constitutive CD40 Signaling in Dendritic Cells Limits Atherosclerosis by Provoking Inflammatory Bowel Disease and Ensuing Cholesterol Malabsorption.

Kusters P, Seijkens T, Bürger C, Legein B, Winkels H, Gijbels M, Barthels C, Bennett R, Beckers L, Atzler D, Biessen E, Brocker T, Weber C, Gerdes N, Lutgens E.

Am J Pathol. 2017 Dec;187(12):2912-2919. doi: 10.1016/j.ajpath.2017.08.016. Epub 2017 Sep 19.

PMID:
28935569
18.

Helminth antigens counteract a rapid high-fat diet-induced decrease in adipose tissue eosinophils.

van den Berg SM, van Dam AD, Kusters PJH, Beckers L, den Toom M, van der Velden S, Van den Bossche J, van Die I, Boon MR, Rensen PCN, Lutgens E, de Winther MPJ.

J Mol Endocrinol. 2017 Oct;59(3):245-255. doi: 10.1530/JME-17-0112. Epub 2017 Jul 10.

PMID:
28694301
19.

Microvesicles in vascular homeostasis and diseases. Position Paper of the European Society of Cardiology (ESC) Working Group on Atherosclerosis and Vascular Biology.

Ridger VC, Boulanger CM, Angelillo-Scherrer A, Badimon L, Blanc-Brude O, Bochaton-Piallat ML, Boilard E, Buzas EI, Caporali A, Dignat-George F, Evans PC, Lacroix R, Lutgens E, Ketelhuth DFJ, Nieuwland R, Toti F, Tunon J, Weber C, Hoefer IE.

Thromb Haemost. 2017 Jun 28;117(7):1296-1316. doi: 10.1160/TH16-12-0943. Epub 2017 Jun 1. Review.

20.

Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation.

Aarts SABM, Seijkens TTP, Kusters PJH, van der Pol SMA, Zarzycka B, Heijnen PDAM, Beckers L, den Toom M, Gijbels MJJ, Boon L, Weber C, de Vries HE, Nicolaes GAF, Dijkstra CD, Kooij G, Lutgens E.

J Neuroinflammation. 2017 May 12;14(1):105. doi: 10.1186/s12974-017-0875-9.

21.

Hyaluronan Nanoparticles Selectively Target Plaque-Associated Macrophages and Improve Plaque Stability in Atherosclerosis.

Beldman TJ, Senders ML, Alaarg A, Pérez-Medina C, Tang J, Zhao Y, Fay F, Deichmöller J, Born B, Desclos E, van der Wel NN, Hoebe RA, Kohen F, Kartvelishvily E, Neeman M, Reiner T, Calcagno C, Fayad ZA, de Winther MPJ, Lutgens E, Mulder WJM, Kluza E.

ACS Nano. 2017 Jun 27;11(6):5785-5799. doi: 10.1021/acsnano.7b01385. Epub 2017 May 15.

22.

Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity: Evidence From Mouse and Human Studies.

Döring Y, Noels H, van der Vorst EPC, Neideck C, Egea V, Drechsler M, Mandl M, Pawig L, Jansen Y, Schröder K, Bidzhekov K, Megens RTA, Theelen W, Klinkhammer BM, Boor P, Schurgers L, van Gorp R, Ries C, Kusters PJH, van der Wal A, Hackeng TM, Gäbel G, Brandes RP, Soehnlein O, Lutgens E, Vestweber D, Teupser D, Holdt LM, Rader DJ, Saleheen D, Weber C.

Circulation. 2017 Jul 25;136(4):388-403. doi: 10.1161/CIRCULATIONAHA.117.027646. Epub 2017 Apr 27.

23.

Erratum: CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis.

Barthels C, Ogrinc A, Steyer V, Meier S, Simon F, Wimmer M, Blutke A, Straub T, Zimber-Strobl U, Lutgens E, Marconi P, Ohnmacht C, Garzetti D, Stecher B, Brocker T.

Nat Commun. 2017 Apr 24;8:15439. doi: 10.1038/ncomms15439. No abstract available.

24.

Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells.

Garg G, Nikolouli E, Hardtke-Wolenski M, Toker A, Ohkura N, Beckstette M, Miyao T, Geffers R, Floess S, Gerdes N, Lutgens E, Osterloh A, Hori S, Sakaguchi S, Jaeckel E, Huehn J.

Oncotarget. 2017 May 30;8(22):35542-35557. doi: 10.18632/oncotarget.16221.

25.

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.

von Hundelshausen P, Agten SM, Eckardt V, Blanchet X, Schmitt MM, Ippel H, Neideck C, Bidzhekov K, Leberzammer J, Wichapong K, Faussner A, Drechsler M, Grommes J, van Geffen JP, Li H, Ortega-Gomez A, Megens RT, Naumann R, Dijkgraaf I, Nicolaes GA, Döring Y, Soehnlein O, Lutgens E, Heemskerk JW, Koenen RR, Mayo KH, Hackeng TM, Weber C.

Sci Transl Med. 2017 Apr 5;9(384). pii: eaah6650. doi: 10.1126/scitranslmed.aah6650.

PMID:
28381538
26.

Macrophage Kdm6b controls the pro-fibrotic transcriptome signature of foam cells.

Neele AE, Prange KH, Hoeksema MA, van der Velden S, Lucas T, Dimmeler S, Lutgens E, Van den Bossche J, de Winther MP.

Epigenomics. 2017 Apr;9(4):383-391. doi: 10.2217/epi-2016-0152. Epub 2017 Mar 21.

PMID:
28322580
27.

CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis.

Barthels C, Ogrinc A, Steyer V, Meier S, Simon F, Wimmer M, Blutke A, Straub T, Zimber-Strobl U, Lutgens E, Marconi P, Ohnmacht C, Garzetti D, Stecher B, Brocker T.

Nat Commun. 2017 Mar 9;8:14715. doi: 10.1038/ncomms14715.

28.

Atherosclerosis: cell biology and lipoproteins focus on epigenetic modification and macrophage biology.

Ferrari E, Lutgens E, Weber C, Gerdes N.

Curr Opin Lipidol. 2017 Apr;28(2):220-221. doi: 10.1097/MOL.0000000000000405. No abstract available.

PMID:
28272157
29.

Inflammation, but not recruitment, of adipose tissue macrophages requires signalling through Mac-1 (CD11b/CD18) in diet-induced obesity (DIO).

Wolf D, Bukosza N, Engel D, Poggi M, Jehle F, Anto Michel N, Chen YC, Colberg C, Hoppe N, Dufner B, Boon L, Blankenbach H, Hilgendorf I, von Zur Muhlen C, Reinöhl J, Sommer B, Marchini T, Febbraio MA, Weber C, Bode C, Peter K, Lutgens E, Zirlik A.

Thromb Haemost. 2017 Jan 26;117(2):325-338. doi: 10.1160/TH16-07-0553. Epub 2016 Nov 17.

PMID:
27853810
30.

Immune Modulation of Brown(ing) Adipose Tissue in Obesity.

van den Berg SM, van Dam AD, Rensen PC, de Winther MP, Lutgens E.

Endocr Rev. 2017 Feb 1;38(1):46-68. doi: 10.1210/er.2016-1066. Review.

PMID:
27849358
31.

CD70 limits atherosclerosis and promotes macrophage function.

Winkels H, Meiler S, Smeets E, Lievens D, Engel D, Spitz C, Bürger C, Rinne P, Beckers L, Dandl A, Reim S, Ahmadsei M, Van den Bossche J, Holdt LM, Megens RT, Schmitt M, de Winther M, Biessen EA, Borst J, Faussner A, Weber C, Lutgens E, Gerdes N.

Thromb Haemost. 2017 Jan 5;117(1):164-175. doi: 10.1160/TH16-04-0318. Epub 2016 Oct 27.

PMID:
27786334
32.

Inhibition of NET Release Fails to Reduce Adipose Tissue Inflammation in Mice.

Braster Q, Silvestre Roig C, Hartwig H, Beckers L, den Toom M, Döring Y, Daemen MJ, Lutgens E, Soehnlein O.

PLoS One. 2016 Oct 4;11(10):e0163922. doi: 10.1371/journal.pone.0163922. eCollection 2016.

33.

Alterations in systemic levels of Th1, Th2, and Th17 cytokines in overweight adolescents and obese mice.

Jung C, Lichtenauer M, Strodthoff D, Winkels H, Wernly B, Bürger C, Kamchybekov U, Lutgens E, Figulla HR, Gerdes N.

Pediatr Diabetes. 2017 Dec;18(8):714-721. doi: 10.1111/pedi.12435. Epub 2016 Sep 6.

PMID:
27597513
34.

Constitutive GITR Activation Reduces Atherosclerosis by Promoting Regulatory CD4+ T-Cell Responses-Brief Report.

Meiler S, Smeets E, Winkels H, Shami A, Pascutti MF, Nolte MA, Beckers L, Weber C, Gerdes N, Lutgens E.

Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1748-52. doi: 10.1161/ATVBAHA.116.307354. Epub 2016 Jul 21.

PMID:
27444204
35.

Resveratrol Inhibits Aortic Root Dilatation in the Fbn1C1039G/+ Marfan Mouse Model.

Hibender S, Franken R, van Roomen C, Ter Braake A, van der Made I, Schermer EE, Gunst Q, van den Hoff MJ, Lutgens E, Pinto YM, Groenink M, Zwinderman AH, Mulder BJ, de Vries CJ, de Waard V.

Arterioscler Thromb Vasc Biol. 2016 Aug;36(8):1618-26. doi: 10.1161/ATVBAHA.116.307841. Epub 2016 Jun 9. Erratum in: Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):e81.

36.

BCG lowers plasma cholesterol levels and delays atherosclerotic lesion progression in mice.

van Dam AD, Bekkering S, Crasborn M, van Beek L, van den Berg SM, Vrieling F, Joosten SA, van Harmelen V, de Winther MPJ, Lütjohann D, Lutgens E, Boon MR, Riksen NP, Rensen PCN, Berbée JFP.

Atherosclerosis. 2016 Aug;251:6-14. doi: 10.1016/j.atherosclerosis.2016.05.031. Epub 2016 May 19.

37.

CD40 in coronary artery disease: a matter of macrophages?

Jansen MF, Hollander MR, van Royen N, Horrevoets AJ, Lutgens E.

Basic Res Cardiol. 2016 Jul;111(4):38. doi: 10.1007/s00395-016-0554-5. Epub 2016 May 4. Review.

38.

Atherosclerosis: cell biology and lipoproteins-focus on interleukin-18 signaling, chemotactic heteromers, and microRNAs.

Meiler S, Lutgens E, Weber C, Gerdes N.

Curr Opin Lipidol. 2016 Jun;27(3):308-9. doi: 10.1097/MOL.0000000000000305. No abstract available.

PMID:
27145104
39.

Atherosclerosis: the interplay between lipids and immune cells.

Schaftenaar F, Frodermann V, Kuiper J, Lutgens E.

Curr Opin Lipidol. 2016 Jun;27(3):209-15. doi: 10.1097/MOL.0000000000000302. Review.

PMID:
27031276
40.

Liposomal prednisolone promotes macrophage lipotoxicity in experimental atherosclerosis.

van der Valk FM, Schulte DM, Meiler S, Tang J, Zheng KH, Van den Bossche J, Seijkens T, Laudes M, de Winther M, Lutgens E, Alaarg A, Metselaar JM, Dallinga-Thie GM, Mulder WJ, Stroes ES, Hamers AA.

Nanomedicine. 2016 Aug;12(6):1463-70. doi: 10.1016/j.nano.2016.02.022. Epub 2016 Mar 23.

PMID:
27015770
41.

Cathelicidin regulates myeloid cell accumulation in adipose tissue and promotes insulin resistance during obesity.

Braster Q, Silvestre-Roig C, Hartwig H, Kusters P, Aarts S, den Toom M, Gallo RL, Weber C, Lutgens E, Soehnlein O.

Thromb Haemost. 2016 Jun 2;115(6):1237-9. doi: 10.1160/TH16-02-0112. Epub 2016 Mar 3. No abstract available.

PMID:
26939624
42.

Platelet CD40 Exacerbates Atherosclerosis by Transcellular Activation of Endothelial Cells and Leukocytes.

Gerdes N, Seijkens T, Lievens D, Kuijpers MJ, Winkels H, Projahn D, Hartwig H, Beckers L, Megens RT, Boon L, Noelle RJ, Soehnlein O, Heemskerk JW, Weber C, Lutgens E.

Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):482-90. doi: 10.1161/ATVBAHA.115.307074. Epub 2016 Jan 28.

PMID:
26821950
43.

Diet-induced obesity in mice diminishes hematopoietic stem and progenitor cells in the bone marrow.

van den Berg SM, Seijkens TT, Kusters PJ, Beckers L, den Toom M, Smeets E, Levels J, de Winther MP, Lutgens E.

FASEB J. 2016 May;30(5):1779-88. doi: 10.1096/fj.201500175. Epub 2016 Jan 26.

PMID:
26813974
44.

Regulatory T cells in atherosclerosis: critical immune regulatory function and therapeutic potential.

Spitz C, Winkels H, Bürger C, Weber C, Lutgens E, Hansson GK, Gerdes N.

Cell Mol Life Sci. 2016 Mar;73(5):901-22. doi: 10.1007/s00018-015-2080-2. Epub 2015 Oct 30. Review.

PMID:
26518635
45.

Atherosclerotic Plaque Destabilization in Mice: A Comparative Study.

Hartwig H, Silvestre-Roig C, Hendrikse J, Beckers L, Paulin N, Van der Heiden K, Braster Q, Drechsler M, Daemen MJ, Lutgens E, Soehnlein O.

PLoS One. 2015 Oct 22;10(10):e0141019. doi: 10.1371/journal.pone.0141019. eCollection 2015.

46.

Ablation of CD8α(+) dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice.

Legein B, Janssen EM, Theelen TL, Gijbels MJ, Walraven J, Klarquist JS, Hennies CM, Wouters K, Seijkens TT, Wijnands E, Sluimer JC, Lutgens E, Zenke M, Hildner K, Biessen EA, Temmerman L.

Sci Rep. 2015 Oct 21;5:15414. doi: 10.1038/srep15414.

47.

Cytokines and Immune Responses in Murine Atherosclerosis.

Kusters PJ, Lutgens E.

Methods Mol Biol. 2015;1339:17-40. doi: 10.1007/978-1-4939-2929-0_2. Review.

PMID:
26445779
48.

Interferon-β promotes macrophage foam cell formation by altering both cholesterol influx and efflux mechanisms.

Boshuizen MC, Hoeksema MA, Neele AE, van der Velden S, Hamers AA, Van den Bossche J, Lutgens E, de Winther MP.

Cytokine. 2016 Jan;77:220-6. doi: 10.1016/j.cyto.2015.09.016. Epub 2015 Oct 1.

PMID:
26427927
49.

An inflammatory link in atherosclerosis and obesity. Co-stimulatory molecules.

Zirlik A, Lutgens E.

Hamostaseologie. 2015;35(3):272-8. doi: 10.5482/HAMO-14-12-0079. Review.

PMID:
26225729
50.

Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction.

Yamano T, Nedjic J, Hinterberger M, Steinert M, Koser S, Pinto S, Gerdes N, Lutgens E, Ishimaru N, Busslinger M, Brors B, Kyewski B, Klein L.

Immunity. 2015 Jun 16;42(6):1048-61. doi: 10.1016/j.immuni.2015.05.013. Epub 2015 Jun 9.

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