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Items: 1 to 50 of 73

1.

Influence of local epidemiology on the performance of common colistin drug susceptibility testing methods.

Asar L, Pfefferle S, Lütgehetmann M, Hoffmann A, Katchanov J, Aepfelbacher M, Rohde H, Maurer FP.

PLoS One. 2019 Jun 6;14(6):e0217468. doi: 10.1371/journal.pone.0217468. eCollection 2019.

2.

T cell receptor grafting allows virological control of Hepatitis B virus infection.

Wisskirchen K, Kah J, Malo A, Asen T, Volz T, Allweiss L, Wettengel JM, Lütgehetmann M, Urban S, Bauer T, Dandri M, Protzer U.

J Clin Invest. 2019 Apr 30;130. pii: 120228. doi: 10.1172/JCI120228.

3.

Clinical evaluation of multiplex RT-PCR assays for the detection of influenza A/B and respiratory syncytial virus using a high throughput system.

Eigner U, Reucher S, Hefner N, Staffa-Peichl S, Kolb M, Betz U, Holfelder M, Spier G, Pfefferle S, Lütgehetmann M.

J Virol Methods. 2019 Jul;269:49-54. doi: 10.1016/j.jviromet.2019.03.015. Epub 2019 Apr 1.

PMID:
30946852
4.

Chronic Hepatitis E in Rheumatology and Internal Medicine Patients: A Retrospective Multicenter European Cohort Study.

Pischke S, Peron JM, von Wulffen M, von Felden J, Höner Zu Siederdissen C, Fournier S, Lütgehetmann M, Iking-Konert C, Bettinger D, Par G, Thimme R, Cantagrel A, Lohse AW, Wedemeyer H, de Man R, Mallet V.

Viruses. 2019 Feb 22;11(2). pii: E186. doi: 10.3390/v11020186.

5.

Changes in the composition of the upper respiratory tract microbial community in granulomatosis with polyangiitis.

Lamprecht P, Fischer N, Huang J, Burkhardt L, Lütgehetmann M, Arndt F, Rolfs I, Kerstein A, Iking-Konert C, Laudien M.

J Autoimmun. 2019 Feb;97:29-39. doi: 10.1016/j.jaut.2018.10.005. Epub 2018 Nov 9.

6.

Potential Role for Urine Polymerase Chain Reaction in the Diagnosis of Whipple's Disease.

Moter A, Janneck M, Wolters M, Iking-Konert C, Wiessner A, Loddenkemper C, Hartleben B, Lütgehetmann M, Schmidt J, Langbehn U, Janssen S, Geelhaar-Karsch A, Schneider T, Moos V, Rohde H, Kikhney J, Wiech T.

Clin Infect Dis. 2018 Oct 22. doi: 10.1093/cid/ciy664. [Epub ahead of print]

7.

Epidemiology, clinical and laboratory features of 24 consecutive cases of leptospirosis at a German infectious disease center.

Brehm TT, Schulze Zur Wiesch J, Lütgehetmann M, Tappe D, Eisermann P, Lohse AW, Addo MM, Schmiedel S.

Infection. 2018 Dec;46(6):847-853. doi: 10.1007/s15010-018-1181-x. Epub 2018 Jul 17.

PMID:
30019313
8.

Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection.

Winer BY, Shirvani-Dastgerdi E, Bram Y, Sellau J, Low BE, Johnson H, Huang T, Hrebikova G, Heller B, Sharon Y, Giersch K, Gerges S, Seneca K, Pais MA, Frankel AS, Chiriboga L, Cullen J, Nahass RG, Lutgehetmann M, Toettcher JE, Wiles MV, Schwartz RE, Ploss A.

Sci Transl Med. 2018 Jun 27;10(447). pii: eaap9328. doi: 10.1126/scitranslmed.aap9328.

PMID:
29950446
9.

Course of HEV viremia and anti-HEV IgM/IgG response in asymptomatic blood donors.

Kraef C, Schlein C, Hiller J, Westhölter D, Denzer U, Horvatits T, Peine S, Lohse AW, Lütgehetmann M, Polywka S, Pischke S.

J Clin Virol. 2018 Aug;105:26-30. doi: 10.1016/j.jcv.2018.05.013. Epub 2018 May 29.

PMID:
29860111
10.

Lack of evidence for human serum albumin as major source of HEV infections.

Horvatits T, Westhölter D, Peine S, Schulze Zur Wiesch J, Lohse AW, Lütgehetmann M, Pischke S.

Transfus Med. 2018 Dec;28(6):470-471. doi: 10.1111/tme.12536. Epub 2018 Apr 30. No abstract available.

PMID:
29707836
11.

Hepatitis E seroprevalence in the Americas: A systematic review and meta-analysis.

Horvatits T, Ozga AK, Westhölter D, Hartl J, Manthey CF, Lütgehetmann M, Rauch G, Kriston L, Lohse AW, Bendall R, Wedemeyer H, Dalton HR, Pischke S.

Liver Int. 2018 Nov;38(11):1951-1964. doi: 10.1111/liv.13859. Epub 2018 May 3.

PMID:
29660259
12.

Hepatitis E: Still Waters Run Deep.

von Wulffen M, Westhölter D, Lütgehetmann M, Pischke S.

J Clin Transl Hepatol. 2018 Mar 28;6(1):40-47. doi: 10.14218/JCTH.2017.00030. Epub 2017 Sep 21. Review.

13.

HEV-positive blood donations represent a relevant infection risk for immunosuppressed recipients.

Westhölter D, Hiller J, Denzer U, Polywka S, Ayuk F, Rybczynski M, Horvatits T, Gundlach S, Blöcker J, Schulze Zur Wiesch J, Fischer N, Addo MM, Peine S, Göke B, Lohse AW, Lütgehetmann M, Pischke S.

J Hepatol. 2018 Jul;69(1):36-42. doi: 10.1016/j.jhep.2018.02.031. Epub 2018 Mar 15.

PMID:
29551705
14.

Comprehensive Molecular Approach for Characterization of Hepatitis E Virus Genotype 3 Variants.

Wang B, Harms D, Papp CP, Niendorf S, Jacobsen S, Lütgehetmann M, Pischke S, Wedermeyer H, Hofmann J, Bock CT.

J Clin Microbiol. 2018 Apr 25;56(5). pii: e01686-17. doi: 10.1128/JCM.01686-17. Print 2018 May.

15.

Multi-color RGB marking enables clonality assessment of liver tumors in a murine xenograft model.

Thomaschewski M, Riecken K, Unrau L, Volz T, Cornils K, Ittrich H, Heim D, Wege H, Akgün E, Lütgehetmann M, Dieckhoff J, Köpke M, Dandri M, Benten D, Fehse B.

Oncotarget. 2017 Dec 14;8(70):115582-115595. doi: 10.18632/oncotarget.23312. eCollection 2017 Dec 29.

16.

A humanized mouse model of liver fibrosis following expansion of transplanted hepatic stellate cells.

Benten D, Kluwe J, Wirth JW, Thiele ND, Follenzi A, Bhargava KK, Palestro CJ, Koepke M, Tjandra R, Volz T, Lutgehetmann M, Gupta S.

Lab Invest. 2018 Apr;98(4):525-536. doi: 10.1038/s41374-017-0010-7. Epub 2018 Jan 19.

17.

Hepatitis delta virus persists during liver regeneration and is amplified through cell division both in vitro and in vivo.

Giersch K, Bhadra OD, Volz T, Allweiss L, Riecken K, Fehse B, Lohse AW, Petersen J, Sureau C, Urban S, Dandri M, Lütgehetmann M.

Gut. 2019 Jan;68(1):150-157. doi: 10.1136/gutjnl-2017-314713. Epub 2017 Dec 7.

PMID:
29217749
18.

Efficacy of NVR 3-778, Alone and In Combination With Pegylated Interferon, vs Entecavir In uPA/SCID Mice With Humanized Livers and HBV Infection.

Klumpp K, Shimada T, Allweiss L, Volz T, Lütgehetmann M, Hartman G, Flores OA, Lam AM, Dandri M.

Gastroenterology. 2018 Feb;154(3):652-662.e8. doi: 10.1053/j.gastro.2017.10.017. Epub 2017 Oct 24.

PMID:
29079518
19.

A novel orally available small molecule that inhibits hepatitis B virus expression.

Mueller H, Wildum S, Luangsay S, Walther J, Lopez A, Tropberger P, Ottaviani G, Lu W, Parrott NJ, Zhang JD, Schmucki R, Racek T, Hoflack JC, Kueng E, Point F, Zhou X, Steiner G, Lütgehetmann M, Rapp G, Volz T, Dandri M, Yang S, Young JAT, Javanbakht H.

J Hepatol. 2018 Mar;68(3):412-420. doi: 10.1016/j.jhep.2017.10.014. Epub 2017 Oct 25.

20.

Two-tier approach combining molecular and culture-based techniques for optimized detection of vancomycin-resistant enterococci.

Both A, Franke GC, Mirwald N, Lütgehetmann M, Christner M, Klupp EM, Belmar Campos C, Büttner H, Aepfelbacher M, Rohde H.

Diagn Microbiol Infect Dis. 2017 Dec;89(4):253-257. doi: 10.1016/j.diagmicrobio.2017.08.009. Epub 2017 Aug 24.

PMID:
28974396
21.

Lymphocytes transiently expressing virus-specific T cell receptors reduce hepatitis B virus infection.

Kah J, Koh S, Volz T, Ceccarello E, Allweiss L, Lütgehetmann M, Bertoletti A, Dandri M.

J Clin Invest. 2017 Aug 1;127(8):3177-3188. doi: 10.1172/JCI93024. Epub 2017 Jul 24.

22.

Both interferon alpha and lambda can reduce all intrahepatic HDV infection markers in HBV/HDV infected humanized mice.

Giersch K, Homs M, Volz T, Helbig M, Allweiss L, Lohse AW, Petersen J, Buti M, Pollicino T, Sureau C, Dandri M, Lütgehetmann M.

Sci Rep. 2017 Jun 16;7(1):3757. doi: 10.1038/s41598-017-03946-9.

23.

Dose-dependent T-cell Dynamics and Cytokine Cascade Following rVSV-ZEBOV Immunization.

Dahlke C, Kasonta R, Lunemann S, Krähling V, Zinser ME, Biedenkopf N, Fehling SK, Ly ML, Rechtien A, Stubbe HC, Olearo F, Borregaard S, Jambrecina A, Stahl F, Strecker T, Eickmann M, Lütgehetmann M, Spohn M, Schmiedel S, Lohse AW, Becker S, Addo MM; VEBCON Consortium.

EBioMedicine. 2017 May;19:107-118. doi: 10.1016/j.ebiom.2017.03.045. Epub 2017 Apr 5.

24.

Proliferation of primary human hepatocytes and prevention of hepatitis B virus reinfection efficiently deplete nuclear cccDNA in vivo.

Allweiss L, Volz T, Giersch K, Kah J, Raffa G, Petersen J, Lohse AW, Beninati C, Pollicino T, Urban S, Lütgehetmann M, Dandri M.

Gut. 2018 Mar;67(3):542-552. doi: 10.1136/gutjnl-2016-312162. Epub 2017 Apr 20.

PMID:
28428345
25.

High clinical manifestation rate in an imported outbreak of hepatitis E genotype 1 infection in a German group of travellers returning from India.

Pischke S, Schulze-Zur-Wiesch J, Lütgehetmann M, Kreuels B, Lueth S, Kapaun P, Benten D, Schmiedel S, Sterneck M, Lohse AW, Polywka S.

Ann Hepatol. 2017 Jan-Feb;16(1):57-62. doi: 10.5604/16652681.1226815.

26.

High Clinical Manifestation Rate in an Imported Outbreak of Hepatitis E Genotype 1 Infection in a German Group of Travellers Returning from India.

Pischke S, Schulze-Zur-Wiesch J, Lütgehetmann M, Kreuels B, Lueth S, Kapaun P, Benten D, Schmiedel S, Sterneck M, Lohse AW, Polywka S.

Ann Hepatol. 2017 Jan - Feb;16(1):57-62. doi: 10.5604/16652681.1226815.

27.

Haem oxygenase-1 polymorphisms can affect HCV replication and treatment responses with different efficacy in humanized mice.

Kah J, Volz T, Lütgehetmann M, Groth A, Lohse AW, Tiegs G, Sass G, Dandri M.

Liver Int. 2017 Aug;37(8):1128-1137. doi: 10.1111/liv.13347. Epub 2017 Jan 25.

PMID:
27992676
28.
29.

Serum HBV pgRNA as a clinical marker for cccDNA activity.

Giersch K, Allweiss L, Volz T, Dandri M, Lütgehetmann M.

J Hepatol. 2017 Feb;66(2):460-462. doi: 10.1016/j.jhep.2016.09.028. Epub 2016 Nov 5. No abstract available.

PMID:
27826059
30.

Kinetics of HIV-1 Latency Reversal Quantified on the Single-Cell Level Using a Novel Flow-Based Technique.

Martrus G, Niehrs A, Cornelis R, Rechtien A, García-Beltran W, Lütgehetmann M, Hoffmann C, Altfeld M.

J Virol. 2016 Sep 29;90(20):9018-28. doi: 10.1128/JVI.01448-16. Print 2016 Oct 15.

31.

Attenuated viral hepatitis in Trem1-/- mice is associated with reduced inflammatory activity of neutrophils.

Kozik JH, Trautmann T, Carambia A, Preti M, Lütgehetmann M, Krech T, Wiegard C, Heeren J, Herkel J.

Sci Rep. 2016 Jun 22;6:28556. doi: 10.1038/srep28556.

32.

Changes in HIV-1 Capsid Stability Induced by Common Cytotoxic-T-Lymphocyte-Driven Viral Sequence Mutations.

Schommers P, Martrus G, Matschl U, Sirignano M, Lütgehetmann M, Richert L, Hope TJ, Fätkenheuer G, Altfeld M.

J Virol. 2016 Jul 27;90(16):7579-7586. doi: 10.1128/JVI.00867-16. Print 2016 Aug 15.

33.

Blood-borne Hepatitis E Virus Transmission: A Relevant Risk for Immunosuppressed Patients.

Pischke S, Hiller J, Lütgehetmann M, Polywka S, Rybczynski M, Ayuk F, Lohse AW.

Clin Infect Dis. 2016 Aug 15;63(4):569-70. doi: 10.1093/cid/ciw309. Epub 2016 May 13. No abstract available.

PMID:
27178472
34.

Primary Human Hepatocytes Repopulate Livers of Mice After In Vitro Culturing and Lentiviral-Mediated Gene Transfer.

Bierwolf J, Volz T, Lütgehetmann M, Allweiss L, Riecken K, Warlich M, Fehse B, Kalff JC, Dandri M, Pollok JM.

Tissue Eng Part A. 2016 May;22(9-10):742-53. doi: 10.1089/ten.TEA.2015.0427.

35.

Human liver chimeric mice as a new model of chronic hepatitis E virus infection and preclinical drug evaluation.

Allweiss L, Gass S, Giersch K, Groth A, Kah J, Volz T, Rapp G, Schöbel A, Lohse AW, Polywka S, Pischke S, Herker E, Dandri M, Lütgehetmann M.

J Hepatol. 2016 May;64(5):1033-1040. doi: 10.1016/j.jhep.2016.01.011. Epub 2016 Jan 22.

PMID:
26805671
36.

Variability in long-term hepatitis B virus dynamics under antiviral therapy.

Murray JM, Stancevic O, Lütgehetmann M, Wursthorn K, Petersen J, Dandri M.

J Theor Biol. 2016 Feb 21;391:74-80. doi: 10.1016/j.jtbi.2015.12.005. Epub 2015 Dec 23.

PMID:
26723531
37.

Evaluation of Unbiased Next-Generation Sequencing of RNA (RNA-seq) as a Diagnostic Method in Influenza Virus-Positive Respiratory Samples.

Fischer N, Indenbirken D, Meyer T, Lütgehetmann M, Lellek H, Spohn M, Aepfelbacher M, Alawi M, Grundhoff A.

J Clin Microbiol. 2015 Jul;53(7):2238-50. doi: 10.1128/JCM.02495-14. Epub 2015 May 13.

38.

Association of hepatitis E virus and essential cryoglobulinemia?

Pischke S, Polywka S, Haag F, Iking-Konert C, Sterneck M, Lütgehetmann M, Dammermann W, Lüth S, Schirmer JH.

J Clin Virol. 2015 Jun;67:23-4. doi: 10.1016/j.jcv.2015.03.020. Epub 2015 Mar 28. No abstract available.

PMID:
25959152
39.

Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody.

Mailly L, Xiao F, Lupberger J, Wilson GK, Aubert P, Duong FHT, Calabrese D, Leboeuf C, Fofana I, Thumann C, Bandiera S, Lütgehetmann M, Volz T, Davis C, Harris HJ, Mee CJ, Girardi E, Chane-Woon-Ming B, Ericsson M, Fletcher N, Bartenschlager R, Pessaux P, Vercauteren K, Meuleman P, Villa P, Kaderali L, Pfeffer S, Heim MH, Neunlist M, Zeisel MB, Dandri M, McKeating JA, Robinet E, Baumert TF.

Nat Biotechnol. 2015 May;33(5):549-554. doi: 10.1038/nbt.3179. Epub 2015 Mar 23.

40.

Hepatitis Delta co-infection in humanized mice leads to pronounced induction of innate immune responses in comparison to HBV mono-infection.

Giersch K, Allweiss L, Volz T, Helbig M, Bierwolf J, Lohse AW, Pollok JM, Petersen J, Dandri M, Lütgehetmann M.

J Hepatol. 2015 Aug;63(2):346-53. doi: 10.1016/j.jhep.2015.03.011. Epub 2015 Mar 17.

PMID:
25795587
41.

New foe treated with old guns - supportive role of steroids in the treatment of acute severe hepatitis E.

Sebode M, Pischke S, Lütgehetmann M, Polywka S, Quaas A, Lohse AW, Wege H.

BMC Gastroenterol. 2014 Nov 15;14:191. doi: 10.1186/s12876-014-0191-0.

42.

Relevance of a full-length genomic RNA standard and a thermal-shock step for optimal hepatitis delta virus quantification.

Homs M, Giersch K, Blasi M, Lütgehetmann M, Buti M, Esteban R, Dandri M, Rodriguez-Frias F.

J Clin Microbiol. 2014 Sep;52(9):3334-8. doi: 10.1128/JCM.00940-14. Epub 2014 Jul 2.

43.

Rapid metagenomic diagnostics for suspected outbreak of severe pneumonia.

Fischer N, Rohde H, Indenbirken D, Günther T, Reumann K, Lütgehetmann M, Meyer T, Kluge S, Aepfelbacher M, Alawi M, Grundhoff A.

Emerg Infect Dis. 2014 Jun;20(6):1072-5. doi: 10.3201/eid2006.131526. No abstract available.

44.

Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of bile acid metabolism.

Oehler N, Volz T, Bhadra OD, Kah J, Allweiss L, Giersch K, Bierwolf J, Riecken K, Pollok JM, Lohse AW, Fehse B, Petersen J, Urban S, Lütgehetmann M, Heeren J, Dandri M.

Hepatology. 2014 Nov;60(5):1483-93. doi: 10.1002/hep.27159. Epub 2014 May 19.

PMID:
24711282
45.

Mouse models of hepatitis B and delta virus infection.

Dandri M, Lütgehetmann M.

J Immunol Methods. 2014 Aug;410:39-49. doi: 10.1016/j.jim.2014.03.002. Epub 2014 Mar 12.

PMID:
24631647
46.

Improved detection of bacterial central nervous system infections by use of a broad-range PCR assay.

Meyer T, Franke G, Polywka SK, Lütgehetmann M, Gbadamosi J, Magnus T, Aepfelbacher M.

J Clin Microbiol. 2014 May;52(5):1751-3. doi: 10.1128/JCM.00469-14. Epub 2014 Mar 12.

47.

Immune cell responses are not required to induce substantial hepatitis B virus antigen decline during pegylated interferon-alpha administration.

Allweiss L, Volz T, Lütgehetmann M, Giersch K, Bornscheuer T, Lohse AW, Petersen J, Ma H, Klumpp K, Fletcher SP, Dandri M.

J Hepatol. 2014 Mar;60(3):500-7. doi: 10.1016/j.jhep.2013.10.021. Epub 2013 Oct 26.

PMID:
24398036
48.

Persistent hepatitis D virus mono-infection in humanized mice is efficiently converted by hepatitis B virus to a productive co-infection.

Giersch K, Helbig M, Volz T, Allweiss L, Mancke LV, Lohse AW, Polywka S, Pollok JM, Petersen J, Taylor J, Dandri M, Lütgehetmann M.

J Hepatol. 2014 Mar;60(3):538-44. doi: 10.1016/j.jhep.2013.11.010. Epub 2013 Nov 23.

PMID:
24280293
49.

Herpes simplex virus-1 encephalitis can trigger anti-NMDA receptor encephalitis: case report.

Leypoldt F, Titulaer MJ, Aguilar E, Walther J, Bönstrup M, Havemeister S, Teegen B, Lütgehetmann M, Rosenkranz M, Magnus T, Dalmau J.

Neurology. 2013 Oct 29;81(18):1637-9. doi: 10.1212/WNL.0b013e3182a9f531. Epub 2013 Oct 2. No abstract available.

50.

The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus.

Volz T, Allweiss L, Ben MBarek M, Warlich M, Lohse AW, Pollok JM, Alexandrov A, Urban S, Petersen J, Lütgehetmann M, Dandri M.

J Hepatol. 2013 May;58(5):861-7. doi: 10.1016/j.jhep.2012.12.008. Epub 2012 Dec 13.

PMID:
23246506

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