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Items: 25


ATP-dependent thermostabilization of human P-glycoprotein (ABCB1) is blocked by modulators.

Lusvarghi S, Ambudkar SV.

Biochem J. 2019 Nov 27. pii: BCJ20190736. doi: 10.1042/BCJ20190736. [Epub ahead of print]


ABC-transporter upregulation mediates resistance to the CDK7 inhibitors THZ1 and ICEC0942.

Sava GP, Fan H, Fisher RA, Lusvarghi S, Pancholi S, Ambudkar SV, Martin LA, Charles Coombes R, Buluwela L, Ali S.

Oncogene. 2019 Sep 17. doi: 10.1038/s41388-019-1008-y. [Epub ahead of print]


A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.

Lee TD, Lee OW, Brimacombe KR, Chen L, Guha R, Lusvarghi S, Tebase BG, Klumpp-Thomas C, Robey RW, Ambudkar SV, Shen M, Gottesman MM, Hall MD.

Mol Pharmacol. 2019 Nov;96(5):629-640. doi: 10.1124/mol.119.115964. Epub 2019 Sep 12.


Synthesis and Characterization of Bodipy-FL-Cyclosporine A as a Substrate for Multidrug Resistance-Linked P-Glycoprotein (ABCB1).

Sajid A, Raju N, Lusvarghi S, Vahedi S, Swenson RE, Ambudkar SV.

Drug Metab Dispos. 2019 Oct;47(10):1013-1023. doi: 10.1124/dmd.119.087734. Epub 2019 Aug 1.


Avapritinib: A Selective Inhibitor of KIT and PDGFRα that Reverses ABCB1 and ABCG2-Mediated Multidrug Resistance in Cancer Cell Lines.

Wu CP, Lusvarghi S, Wang JC, Hsiao SH, Huang YH, Hung TH, Ambudkar SV.

Mol Pharm. 2019 Jul 1;16(7):3040-3052. doi: 10.1021/acs.molpharmaceut.9b00274. Epub 2019 Jun 4.


Large-scale purification of functional human P-glycoprotein (ABCB1).

Nandigama K, Lusvarghi S, Shukla S, Ambudkar SV.

Protein Expr Purif. 2019 Jul;159:60-68. doi: 10.1016/j.pep.2019.03.002. Epub 2019 Mar 6.


The FLT3 inhibitor midostaurin selectively resensitizes ABCB1-overexpressing multidrug-resistant cancer cells to conventional chemotherapeutic agents.

Hsiao SH, Lusvarghi S, Huang YH, Ambudkar SV, Hsu SC, Wu CP.

Cancer Lett. 2019 Mar 31;445:34-44. doi: 10.1016/j.canlet.2019.01.001. Epub 2019 Jan 11.


Evidence for the critical role of transmembrane helices 1 and 7 in substrate transport by human P-glycoprotein (ABCB1).

Sajid A, Lusvarghi S, Chufan EE, Ambudkar SV.

PLoS One. 2018 Sep 28;13(9):e0204693. doi: 10.1371/journal.pone.0204693. eCollection 2018.


Mapping discontinuous epitopes for MRK-16, UIC2 and 4E3 antibodies to extracellular loops 1 and 4 of human P-glycoprotein.

Vahedi S, Lusvarghi S, Pluchino K, Shafrir Y, Durell SR, Gottesman MM, Ambudkar SV.

Sci Rep. 2018 Aug 24;8(1):12716. doi: 10.1038/s41598-018-30984-8.


Chemical and Biophysical Approaches for Complete Characterization of Lectin-Carbohydrate Interactions.

Lusvarghi S, Ghirlando R, Davison JR, Bewley CA.

Methods Enzymol. 2018;598:3-35. doi: 10.1016/bs.mie.2017.06.010. Epub 2017 Jul 23.


Griffithsin: An Antiviral Lectin with Outstanding Therapeutic Potential.

Lusvarghi S, Bewley CA.

Viruses. 2016 Oct 24;8(10). pii: E296. Review.


Binding Site Geometry and Subdomain Valency Control Effects of Neutralizing Lectins on HIV-1 Viral Particles.

Lusvarghi S, Lohith K, Morin-Leisk J, Ghirlando R, Hinshaw JE, Bewley CA.

ACS Infect Dis. 2016 Nov 11;2(11):882-891. Epub 2016 Oct 3.


Correction: Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability.

Mason RD, Welles HC, Adams C, Chakrabarti BK, Gorman J, Zhou T, Nguyen R, O'Dell S, Lusvarghi S, Bewley CA, Li H, Shaw GM, Sheng Z, Shapiro L, Wyatt R, Kwong PD, Mascola JR, Roederer M.

PLoS Pathog. 2016 May 24;12(5):e1005674. doi: 10.1371/journal.ppat.1005674. eCollection 2016 May.


Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability.

Mason RD, Welles HC, Adams C, Chakrabarti BK, Gorman J, Zhou T, Nguyen R, O'Dell S, Lusvarghi S, Bewley CA, Li H, Shaw GM, Sheng Z, Shapiro L, Wyatt R, Kwong PD, Mascola JR, Roederer M.

PLoS Pathog. 2016 Apr 11;12(4):e1005537. doi: 10.1371/journal.ppat.1005537. eCollection 2016 Apr. Erratum in: PLoS Pathog. 2016 May;12(5):e1005674.


Design and synthesis of small molecule-sulfotyrosine mimetics that inhibit HIV-1 entry.

Dogo-Isonagie C, Lee SL, Lohith K, Liu H, Mandadapu SR, Lusvarghi S, O'Connor RD, Bewley CA.

Bioorg Med Chem. 2016 Apr 15;24(8):1718-28. doi: 10.1016/j.bmc.2016.02.044. Epub 2016 Mar 3.


Novel Biochemical Tools for Probing HIV RNA Structure.

Rausch JW, Sztuba-Solinska J, Lusvarghi S, Le Grice SF.

Methods Mol Biol. 2016;1354:91-117. doi: 10.1007/978-1-4939-3046-3_7.


Glycopeptide mimetics recapitulate high-mannose-type oligosaccharide binding and function.

Lusvarghi S, Ghirlando R, Wong CH, Bewley CA.

Angew Chem Int Ed Engl. 2015 May 4;54(19):5603-8. doi: 10.1002/anie.201500157. Epub 2015 Mar 16.


HIV-1 gp120 as a therapeutic target: navigating a moving labyrinth.

Acharya P, Lusvarghi S, Bewley CA, Kwong PD.

Expert Opin Ther Targets. 2015 Jun;19(6):765-83. doi: 10.1517/14728222.2015.1010513. Epub 2015 Feb 27. Review.


RNA secondary structure prediction using high-throughput SHAPE.

Lusvarghi S, Sztuba-Solinska J, Purzycka KJ, Rausch JW, Le Grice SF.

J Vis Exp. 2013 May 31;(75):e50243. doi: 10.3791/50243.


The HIV-2 Rev-response element: determining secondary structure and defining folding intermediates.

Lusvarghi S, Sztuba-Solinska J, Purzycka KJ, Pauly GT, Rausch JW, Grice SF.

Nucleic Acids Res. 2013 Jul;41(13):6637-49. doi: 10.1093/nar/gkt353. Epub 2013 May 2.


Retrotransposon Ty1 RNA contains a 5'-terminal long-range pseudoknot required for efficient reverse transcription.

Huang Q, Purzycka KJ, Lusvarghi S, Li D, Legrice SF, Boeke JD.

RNA. 2013 Mar;19(3):320-32. doi: 10.1261/rna.035535.112. Epub 2013 Jan 17.


Exploring Ty1 retrotransposon RNA structure within virus-like particles.

Purzycka KJ, Legiewicz M, Matsuda E, Eizentstat LD, Lusvarghi S, Saha A, Le Grice SF, Garfinkel DJ.

Nucleic Acids Res. 2013 Jan 7;41(1):463-73. doi: 10.1093/nar/gks983. Epub 2012 Oct 23.


Loop and backbone modifications of peptide nucleic acid improve g-quadruplex binding selectivity.

Lusvarghi S, Murphy CT, Roy S, Tanious FA, Sacui I, Wilson WD, Ly DH, Armitage BA.

J Am Chem Soc. 2009 Dec 30;131(51):18415-24. doi: 10.1021/ja907250j.


Synthesis, stereoelectronic characterization and antiparasitic activity of new 1-benzenesulfonyl-2-methyl-1,2,3,4-tetrahydroquinolines.

Pagliero RJ, Lusvarghi S, Pierini AB, Brun R, Mazzieri MR.

Bioorg Med Chem. 2010 Jan 1;18(1):142-50. doi: 10.1016/j.bmc.2009.11.010. Epub 2009 Nov 10.


Refined multivalent display of bacterial spore-binding peptides.

Lusvarghi S, Kim JM, Creeger Y, Armitage BA.

Org Biomol Chem. 2009 May 7;7(9):1815-20. doi: 10.1039/b820013k. Epub 2009 Mar 10.


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