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Migratory DCs activate TGF-β to precondition naïve CD8+ T cells for tissue-resident memory fate.

Mani V, Bromley SK, Äijö T, Mora-Buch R, Carrizosa E, Warner RD, Hamze M, Sen DR, Chasse AY, Lorant A, Griffith JW, Rahimi RA, McEntee CP, Jeffrey KL, Marangoni F, Travis MA, Lacy-Hulbert A, Luster AD, Mempel TR.

Science. 2019 Oct 11;366(6462). pii: eaav5728. doi: 10.1126/science.aav5728.


Monocyte-derived dendritic cells in malaria.

Hirako IC, Assis PA, Galvão-Filho B, Luster AD, Antonelli LR, Gazzinelli RT.

Curr Opin Microbiol. 2019 Sep 18;52:139-150. doi: 10.1016/j.mib.2019.08.002. [Epub ahead of print] Review.


Dectin-2-induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis.

Miyabe C, Miyabe Y, Bricio-Moreno L, Lian J, Rahimi RA, Miura NN, Ohno N, Iwakura Y, Kawakami T, Luster AD.

J Clin Invest. 2019 Jun 6;130:3610-3624. doi: 10.1172/JCI123778.


Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy.

Chow MT, Ozga AJ, Servis RL, Frederick DT, Lo JA, Fisher DE, Freeman GJ, Boland GM, Luster AD.

Immunity. 2019 Jun 18;50(6):1498-1512.e5. doi: 10.1016/j.immuni.2019.04.010. Epub 2019 May 13.


Atypical complement receptor C5aR2 transports C5a to initiate neutrophil adhesion and inflammation.

Miyabe Y, Miyabe C, Mani V, Mempel TR, Luster AD.

Sci Immunol. 2019 May 10;4(35). pii: eaav5951. doi: 10.1126/sciimmunol.aav5951.


Introduction: Global positioning by chemokines and other mediators.

Luster AD.

Immunol Rev. 2019 May;289(1):5-8. doi: 10.1111/imr.12763. No abstract available.


Quantitative assessment of airway remodelling and response to allergen in asthma.

Adams DC, Miller AJ, Applegate MB, Cho JL, Hamilos DL, Chee A, Holz JA, Szabari MV, Hariri LP, Harris RS, Griffith JW, Luster AD, Medoff BD, Suter MJ.

Respirology. 2019 Nov;24(11):1073-1080. doi: 10.1111/resp.13521. Epub 2019 Mar 7.


CXCR3 regulates CD4+ T cell cardiotropism in pressure overload-induced cardiac dysfunction.

Ngwenyama N, Salvador AM, Velázquez F, Nevers T, Levy A, Aronovitz M, Luster AD, Huggins GS, Alcaide P.

JCI Insight. 2019 Apr 4;4(7). pii: 125527. doi: 10.1172/jci.insight.125527. eCollection 2019 Apr 4.


HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis.

Corleis B, Bucsan AN, Deruaz M, Vrbanac VD, Lisanti-Park AC, Gates SJ, Linder AH, Paer JM, Olson GS, Bowman BA, Schiff AE, Medoff BD, Tager AM, Luster AD, Khader SA, Kaushal D, Kwon DS.

Cell Rep. 2019 Feb 5;26(6):1409-1418.e5. doi: 10.1016/j.celrep.2019.01.021.


HIV-1 Balances the Fitness Costs and Benefits of Disrupting the Host Cell Actin Cytoskeleton Early after Mucosal Transmission.

Usmani SM, Murooka TT, Deruaz M, Koh WH, Sharaf RR, Di Pilato M, Power KA, Lopez P, Hnatiuk R, Vrbanac VD, Tager AM, Allen TM, Luster AD, Mempel TR.

Cell Host Microbe. 2019 Jan 9;25(1):73-86.e5. doi: 10.1016/j.chom.2018.12.008.


The Chemokine Receptor CCR8 Promotes the Migration of Dendritic Cells into the Lymph Node Parenchyma to Initiate the Allergic Immune Response.

Sokol CL, Camire RB, Jones MC, Luster AD.

Immunity. 2018 Sep 18;49(3):449-463.e6. doi: 10.1016/j.immuni.2018.07.012. Epub 2018 Aug 28.


Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity.

Rodda LB, Lu E, Bennett ML, Sokol CL, Wang X, Luther SA, Barres BA, Luster AD, Ye CJ, Cyster JG.

Immunity. 2018 May 15;48(5):1014-1028.e6. doi: 10.1016/j.immuni.2018.04.006. Epub 2018 May 8.


Chemokines: Critical Regulators of Memory T Cell Development, Maintenance, and Function.

Rahimi RA, Luster AD.

Adv Immunol. 2018;138:71-98. doi: 10.1016/ Epub 2018 Mar 26. Review.


CXCL10 stabilizes T cell-brain endothelial cell adhesion leading to the induction of cerebral malaria.

Sorensen EW, Lian J, Ozga AJ, Miyabe Y, Ji SW, Bromley SK, Mempel TR, Luster AD.

JCI Insight. 2018 Apr 19;3(8). pii: 98911. doi: 10.1172/jci.insight.98911. eCollection 2018 Apr 19.


Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis.

Angelini A, Miyabe Y, Newsted D, Kwan BH, Miyabe C, Kelly RL, Jamy MN, Luster AD, Wittrup KD.

Nat Commun. 2018 Apr 13;9(1):1461. doi: 10.1038/s41467-018-03687-x.


The critical role of C5a as an initiator of neutrophil-mediated autoimmune inflammation of the joint and skin.

Sadik CD, Miyabe Y, Sezin T, Luster AD.

Semin Immunol. 2018 Jun;37:21-29. doi: 10.1016/j.smim.2018.03.002. Epub 2018 Mar 27. Review.


Automated segmentation and quantification of airway mucus with endobronchial optical coherence tomography.

Adams DC, Pahlevaninezhad H, Szabari MV, Cho JL, Hamilos DL, Kesimer M, Boucher RC, Luster AD, Medoff BD, Suter MJ.

Biomed Opt Express. 2017 Sep 26;8(10):4729-4741. doi: 10.1364/BOE.8.004729. eCollection 2017 Oct 1.


LTB4 and BLT1 in inflammatory arthritis.

Miyabe Y, Miyabe C, Luster AD.

Semin Immunol. 2017 Oct;33:52-57. doi: 10.1016/j.smim.2017.09.009. Review.


Targeting CXCR4-dependent immunosuppressive Ly6Clow monocytes improves antiangiogenic therapy in colorectal cancer.

Jung K, Heishi T, Incio J, Huang Y, Beech EY, Pinter M, Ho WW, Kawaguchi K, Rahbari NN, Chung E, Kim JK, Clark JW, Willett CG, Yun SH, Luster AD, Padera TP, Jain RK, Fukumura D.

Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):10455-10460. doi: 10.1073/pnas.1710754114. Epub 2017 Sep 12.


Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy.

Jung K, Heishi T, Khan OF, Kowalski PS, Incio J, Rahbari NN, Chung E, Clark JW, Willett CG, Luster AD, Yun SH, Langer R, Anderson DG, Padera TP, Jain RK, Fukumura D.

J Clin Invest. 2017 Aug 1;127(8):3039-3051. doi: 10.1172/JCI93182. Epub 2017 Jul 10.


Complement C5a Receptor is the Key Initiator of Neutrophil Adhesion Igniting Immune Complex-induced Arthritis.

Miyabe Y, Miyabe C, Murooka TT, Kim EY, Newton GA, Kim ND, Haribabu B, Luscinskas FW, Mempel TR, Luster AD.

Sci Immunol. 2017 Jan;2(7). pii: eaaj2195. doi: 10.1126/sciimmunol.aaj2195. Epub 2017 Jan 20.


Optimal CD4 T cell priming after LPS-based adjuvanticity with CD134 costimulation relies on CXCL9 production.

Shinde P, Liu W, Ménoret A, Luster AD, Vella AT.

J Leukoc Biol. 2017 Jul;102(1):57-69. doi: 10.1189/jlb.1A0616-261RR. Epub 2017 Apr 21.


Chemoattractant-mediated leukocyte trafficking enables HIV dissemination from the genital mucosa.

Deruaz M, Murooka TT, Ji S, Gavin MA, Vrbanac VD, Lieberman J, Tager AM, Mempel TR, Luster AD.

JCI Insight. 2017 Apr 6;2(7):e88533. doi: 10.1172/jci.insight.88533.


Antibody Neutralization of CXCL10 in Vivo Is Dependent on Binding to Free and Not Endothelial-bound Chemokine: IMPLICATIONS FOR THE DESIGN OF A NEW GENERATION OF ANTI-CHEMOKINE THERAPEUTIC ANTIBODIES.

Bonvin P, Gueneau F, Buatois V, Charreton-Galby M, Lasch S, Messmer M, Christen U, Luster AD, Johnson Z, Ferlin W, Kosco-Vilbois M, Proudfoot A, Fischer N.

J Biol Chem. 2017 Mar 10;292(10):4185-4197. doi: 10.1074/jbc.M116.745877. Epub 2017 Jan 30.


A sphingosine 1-phosphate receptor agonist ameliorates animal model of vasculitis.

Miyabe C, Miyabe Y, Komiya T, Shioya H, Miura NN, Takahashi K, Ohno N, Tsuboi R, Luster AD, Kawai S, Miyasaka N, Nanki T.

Inflamm Res. 2017 Apr;66(4):335-340. doi: 10.1007/s00011-016-1018-y. Epub 2016 Dec 10.


An expanded population of pathogenic regulatory T cells in giant cell arteritis is abrogated by IL-6 blockade therapy.

Miyabe C, Miyabe Y, Strle K, Kim ND, Stone JH, Luster AD, Unizony S.

Ann Rheum Dis. 2017 May;76(5):898-905. doi: 10.1136/annrheumdis-2016-210070. Epub 2016 Dec 7.


Lysophosphatidic acid signaling through its receptor initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor.

Sakai N, Chun J, Duffield JS, Lagares D, Wada T, Luster AD, Tager AM.

Kidney Int. 2017 Mar;91(3):628-641. doi: 10.1016/j.kint.2016.09.030. Epub 2016 Dec 4.


Splenic differentiation and emergence of CCR5+CXCL9+CXCL10+ monocyte-derived dendritic cells in the brain during cerebral malaria.

Hirako IC, Ataide MA, Faustino L, Assis PA, Sorensen EW, Ueta H, Araújo NM, Menezes GB, Luster AD, Gazzinelli RT.

Nat Commun. 2016 Nov 3;7:13277. doi: 10.1038/ncomms13277.


Gamma Interferon-Regulated Chemokines in Leishmania donovani Infection in the Liver.

Murray HW, Luster AD, Zheng H, Ma X.

Infect Immun. 2016 Dec 29;85(1). pii: e00824-16. doi: 10.1128/IAI.00824-16. Print 2017 Jan.


Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation.

Cho JL, Ling MF, Adams DC, Faustino L, Islam SA, Afshar R, Griffith JW, Harris RS, Ng A, Radicioni G, Ford AA, Han AK, Xavier R, Kwok WW, Boucher R, Moon JJ, Hamilos DL, Kesimer M, Suter MJ, Medoff BD, Luster AD.

Sci Transl Med. 2016 Oct 5;8(359):359ra132.


Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo.

Adams DC, Hariri LP, Miller AJ, Wang Y, Cho JL, Villiger M, Holz JA, Szabari MV, Hamilos DL, Scott Harris R, Griffith JW, Bouma BE, Luster AD, Medoff BD, Suter MJ.

Sci Transl Med. 2016 Oct 5;8(359):359ra131.


Keratinocyte-Derived Chemokines Orchestrate T-Cell Positioning in the Epidermis during Vitiligo and May Serve as Biomarkers of Disease.

Richmond JM, Bangari DS, Essien KI, Currimbhoy SD, Groom JR, Pandya AG, Youd ME, Luster AD, Harris JE.

J Invest Dermatol. 2017 Feb;137(2):350-358. doi: 10.1016/j.jid.2016.09.016. Epub 2016 Sep 26.


Unlocking tumor vascular barriers with CXCR3: Implications for cancer immunotherapy.

Mikucki ME, Skitzki JJ, Frelinger JG, Odunsi K, Gajewski TF, Luster AD, Evans SS.

Oncoimmunology. 2016 Feb 11;5(5):e1116675. doi: 10.1080/2162402X.2015.1116675. eCollection 2016 May.


Chemoattractant Receptors BLT1 and CXCR3 Regulate Antitumor Immunity by Facilitating CD8+ T Cell Migration into Tumors.

Chheda ZS, Sharma RK, Jala VR, Luster AD, Haribabu B.

J Immunol. 2016 Sep 1;197(5):2016-26. doi: 10.4049/jimmunol.1502376. Epub 2016 Jul 27.


Protection of Humanized Mice From Repeated Intravaginal HIV Challenge by Passive Immunization: A Model for Studying the Efficacy of Neutralizing Antibodies In Vivo.

Deruaz M, Moldt B, Le KM, Power KA, Vrbanac VD, Tanno S, Ghebremichael MS, Allen TM, Tager AM, Burton DR, Luster AD.

J Infect Dis. 2016 Aug 15;214(4):612-6. doi: 10.1093/infdis/jiw203. Epub 2016 Jun 29.


Studying Neutrophil Migration In Vivo Using Adoptive Cell Transfer.

Miyabe Y, Kim ND, Miyabe C, Luster AD.

Methods Mol Biol. 2016;1407:179-94. doi: 10.1007/978-1-4939-3480-5_14.


TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized Mice.

Wheeler LA, Trifonova RT, Vrbanac V, Barteneva NS, Liu X, Bollman B, Onofrey L, Mulik S, Ranjbar S, Luster AD, Tager AM, Lieberman J.

Cell Rep. 2016 May 24;15(8):1715-27. doi: 10.1016/j.celrep.2016.04.048. Epub 2016 May 12.


Allergen-Specific CD4(+) T Cells in Human Asthma.

Ling MF, Luster AD.

Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S25-30. doi: 10.1513/AnnalsATS.201507-431MG. Review.


ACKR4 on Stromal Cells Scavenges CCL19 To Enable CCR7-Dependent Trafficking of APCs from Inflamed Skin to Lymph Nodes.

Bryce SA, Wilson RA, Tiplady EM, Asquith DL, Bromley SK, Luster AD, Graham GJ, Nibbs RJ.

J Immunol. 2016 Apr 15;196(8):3341-53. doi: 10.4049/jimmunol.1501542. Epub 2016 Mar 14.


Studying Chemokine Control of Neutrophil Migration In Vivo in a Murine Model of Inflammatory Arthritis.

Miyabe Y, Kim ND, Miyabe C, Luster AD.

Methods Enzymol. 2016;570:207-31. doi: 10.1016/bs.mie.2015.11.002. Epub 2016 Jan 6.


Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary.

Akkina R, Allam A, Balazs AB, Blankson JN, Burnett JC, Casares S, Garcia JV, Hasenkrug KJ, Kashanchi F, Kitchen SG, Klein F, Kumar P, Luster AD, Poluektova LY, Rao M, Sanders-Beer BE, Shultz LD, Zack JA.

AIDS Res Hum Retroviruses. 2016 Feb;32(2):109-19. doi: 10.1089/AID.2015.0258.


Allergic Non-Asthmatic Adults Have Regional Pulmonary Responses to Segmental Allergen Challenge.

Kelly VJ, Winkler T, Venegas JG, Kone M, Hamilos DL, Afshar R, Cho JL, Luster AD, Medoff BD, Harris RS.

PLoS One. 2015 Dec 7;10(12):e0143976. doi: 10.1371/journal.pone.0143976. eCollection 2015.


The role of tissue resident cells in neutrophil recruitment.

Kim ND, Luster AD.

Trends Immunol. 2015 Sep;36(9):547-55. doi: 10.1016/ Epub 2015 Aug 18. Review.


Anti-CD3/Anti-CXCL10 Antibody Combination Therapy Induces a Persistent Remission of Type 1 Diabetes in Two Mouse Models.

Lasch S, Müller P, Bayer M, Pfeilschifter JM, Luster AD, Hintermann E, Christen U.

Diabetes. 2015 Dec;64(12):4198-211. doi: 10.2337/db15-0479. Epub 2015 Aug 20.


Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints.

Mikucki ME, Fisher DT, Matsuzaki J, Skitzki JJ, Gaulin NB, Muhitch JB, Ku AW, Frelinger JG, Odunsi K, Gajewski TF, Luster AD, Evans SS.

Nat Commun. 2015 Jun 25;6:7458. doi: 10.1038/ncomms8458.


IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection.

Adoro S, Cubillos-Ruiz JR, Chen X, Deruaz M, Vrbanac VD, Song M, Park S, Murooka TT, Dudek TE, Luster AD, Tager AM, Streeck H, Bowman B, Walker BD, Kwon DS, Lazarevic V, Glimcher LH.

Nat Commun. 2015 Jun 25;6:7562. doi: 10.1038/ncomms8562.


Chemokine-guided cell positioning in the lymph node orchestrates the generation of adaptive immune responses.

Lian J, Luster AD.

Curr Opin Cell Biol. 2015 Oct;36:1-6. doi: 10.1016/ Epub 2015 Jun 8. Review.


Crystalline silica-induced leukotriene B4-dependent inflammation promotes lung tumour growth.

Satpathy SR, Jala VR, Bodduluri SR, Krishnan E, Hegde B, Hoyle GW, Fraig M, Luster AD, Haribabu B.

Nat Commun. 2015 Apr 29;6:7064. doi: 10.1038/ncomms8064.


The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity.

Ramirez-Ortiz ZG, Prasad A, Griffith JW, Pendergraft WF 3rd, Cowley GS, Root DE, Tai M, Luster AD, El Khoury J, Hacohen N, Means TK.

Nat Immunol. 2015 May;16(5):495-504. doi: 10.1038/ni.3143. Epub 2015 Apr 6.


Chemokine-mediated immune responses in the female genital tract mucosa.

Deruaz M, Luster AD.

Immunol Cell Biol. 2015 Apr;93(4):347-54. doi: 10.1038/icb.2015.20. Epub 2015 Mar 17. Review.


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