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Items: 1 to 50 of 201


Improvement of antibody functionality by structure-guided paratope engraftment.

Liu Q, Lai YT, Zhang P, Louder MK, Pegu A, Rawi R, Asokan M, Chen X, Shen CH, Chuang GY, Yang ES, Miao H, Wang Y, Fauci AS, Kwong PD, Mascola JR, Lusso P.

Nat Commun. 2019 Feb 13;10(1):721. doi: 10.1038/s41467-019-08658-4.


Structural Constraints at the Trimer Apex Stabilize the HIV-1 Envelope in a Closed, Antibody-Protected Conformation.

Guzzo C, Zhang P, Liu Q, Kwon AL, Uddin F, Wells AI, Schmeisser H, Cimbro R, Huang J, Doria-Rose N, Schmidt SD, Dolan MA, Connors M, Mascola JR, Lusso P.

MBio. 2018 Dec 11;9(6). pii: e00955-18. doi: 10.1128/mBio.00955-18.


Considerations on human Herpesvirus 6 reactivation after cord blood transplantation.

Phan T, Zerr DM, Boussiotis V, Lusso P, Di Luca D.

Am J Hematol. 2018 Sep;93(9):E249-E250. doi: 10.1002/ajh.25207. Epub 2018 Jul 30. No abstract available.


Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer.

Zhang P, Gorman J, Geng H, Liu Q, Lin Y, Tsybovsky Y, Go EP, Dey B, Andine T, Kwon A, Patel M, Gururani D, Uddin F, Guzzo C, Cimbro R, Miao H, McKee K, Chuang GY, Martin L, Sironi F, Malnati MS, Desaire H, Berger EA, Mascola JR, Dolan MA, Kwong PD, Lusso P.

Cell Host Microbe. 2018 Jun 13;23(6):832-844.e6. doi: 10.1016/j.chom.2018.05.002.


HHV-6B infection, T-cell reconstitution, and graft-vs-host disease after hematopoietic stem cell transplantation.

Phan TL, Pritchett JC, Leifer C, Zerr DM, Koelle DM, Di Luca D, Lusso P.

Bone Marrow Transplant. 2018 Dec;53(12):1508-1517. doi: 10.1038/s41409-018-0225-2. Epub 2018 May 24. Review.


Infection with hepatitis C virus depends on TACSTD2, a regulator of claudin-1 and occludin highly downregulated in hepatocellular carcinoma.

Sekhar V, Pollicino T, Diaz G, Engle RE, Alayli F, Melis M, Kabat J, Tice A, Pomerenke A, Altan-Bonnet N, Zamboni F, Lusso P, Emerson SU, Farci P.

PLoS Pathog. 2018 Mar 14;14(3):e1006916. doi: 10.1371/journal.ppat.1006916. eCollection 2018 Mar.


Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing.

Guzzo C, Ichikawa D, Park C, Phillips D, Liu Q, Zhang P, Kwon A, Miao H, Lu J, Rehm C, Arthos J, Cicala C, Cohen MS, Fauci AS, Kehrl JH, Lusso P.

Sci Immunol. 2017 May 12;2(11). pii: eaam7341. doi: 10.1126/sciimmunol.aam7341.


Corrigendum: Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer.

Liu Q, Acharya P, Dolan MA, Zhang P, Guzzo C, Lu J, Kwon A, Gururani D, Miao H, Bylund T, Chuang GY, Druz A, Zhou T, Rice WJ, Wigge C, Carragher B, Potter CS, Kwong PD, Lusso P.

Nat Struct Mol Biol. 2017 Jun 6;24(6):553. doi: 10.1038/nsmb0617-553b. No abstract available.


Design of HIV Coreceptor Derived Peptides That Inhibit Viral Entry at Submicromolar Concentrations.

Bobyk KD, Mandadapu SR, Lohith K, Guzzo C, Bhargava A, Lusso P, Bewley CA.

Mol Pharm. 2017 Aug 7;14(8):2681-2689. doi: 10.1021/acs.molpharmaceut.7b00155. Epub 2017 Jul 13.


Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer.

Liu Q, Acharya P, Dolan MA, Zhang P, Guzzo C, Lu J, Kwon A, Gururani D, Miao H, Bylund T, Chuang GY, Druz A, Zhou T, Rice WJ, Wigge C, Carragher B, Potter CS, Kwong PD, Lusso P.

Nat Struct Mol Biol. 2017 Apr;24(4):370-378. doi: 10.1038/nsmb.3382. Epub 2017 Feb 20. Erratum in: Nat Struct Mol Biol. 2017 Jun 6;24(6):553.


Tyrosine-sulfated V2 peptides inhibit HIV-1 infection via coreceptor mimicry.

Cimbro R, Peterson FC, Liu Q, Guzzo C, Zhang P, Miao H, Van Ryk D, Ambroggio X, Hurt DE, De Gioia L, Volkman BF, Dolan MA, Lusso P.

EBioMedicine. 2016 Aug;10:45-54. doi: 10.1016/j.ebiom.2016.06.037. Epub 2016 Jun 26.


HHV-8 DNA replication correlates with the clinical status in AIDS-related Kaposi's sarcoma.

Broccolo F, Tassan Din C, Viganò MG, Rutigliano T, Esposito S, Lusso P, Tambussi G, Malnati MS.

J Clin Virol. 2016 May;78:47-52. doi: 10.1016/j.jcv.2016.02.019. Epub 2016 Feb 26.


Engineering Metamorphic Chemokine Lymphotactin/XCL1 into the GAG-Binding, HIV-Inhibitory Dimer Conformation.

Fox JC, Tyler RC, Guzzo C, Tuinstra RL, Peterson FC, Lusso P, Volkman BF.

ACS Chem Biol. 2015 Nov 20;10(11):2580-8. doi: 10.1021/acschembio.5b00542. Epub 2015 Sep 2.


Chemokines and HIV: The First Close Encounter.

Lusso P.

Front Immunol. 2015 Jun 8;6:294. doi: 10.3389/fimmu.2015.00294. eCollection 2015. Review. No abstract available.


Structural Determinants for the Selective Anti-HIV-1 Activity of the All-β Alternative Conformer of XCL1.

Guzzo C, Fox JC, Miao H, Volkman BF, Lusso P.

J Virol. 2015 Sep;89(17):9061-7. doi: 10.1128/JVI.01285-15. Epub 2015 Jun 17.


Characterization of HIV-1 entry inhibitors with broad activity against R5 and X4 viral strains.

Sironi F, Malnati M, Mongelli N, Cozzi P, Guzzo C, Ghezzi S, Martínez-Romero C, García-Sastre A, Lusso P, Jabes D, Biswas P.

J Transl Med. 2015 Apr 2;13:107. doi: 10.1186/s12967-015-0461-9.


Recent developments in animal models for human herpesvirus 6A and 6B.

Horvat B, Berges BK, Lusso P.

Curr Opin Virol. 2014 Dec;9:97-103. doi: 10.1016/j.coviro.2014.09.012. Epub 2014 Oct 14. Review.


Differential responses of plasmacytoid dendritic cells to influenza virus and distinct viral pathogens.

Thomas JM, Pos Z, Reinboth J, Wang RY, Wang E, Frank GM, Lusso P, Trinchieri G, Alter HJ, Marincola FM, Thomas E.

J Virol. 2014 Sep;88(18):10758-66. doi: 10.1128/JVI.01501-14. Epub 2014 Jul 9.


Glycosylation, hypogammaglobulinemia, and resistance to viral infections.

Sadat MA, Moir S, Chun TW, Lusso P, Kaplan G, Wolfe L, Memoli MJ, He M, Vega H, Kim LJY, Huang Y, Hussein N, Nievas E, Mitchell R, Garofalo M, Louie A, Ireland DC, Grunes C, Cimbro R, Patel V, Holzapfel G, Salahuddin D, Bristol T, Adams D, Marciano BE, Hegde M, Li Y, Calvo KR, Stoddard J, Justement JS, Jacques J, Priel DAL, Murray D, Sun P, Kuhns DB, Boerkoel CF, Chiorini JA, Di Pasquale G, Verthelyi D, Rosenzweig SD.

N Engl J Med. 2014 Apr 24;370(17):1615-1625. doi: 10.1056/NEJMoa1302846. Epub 2014 Apr 9.


Tyrosine sulfation in the second variable loop (V2) of HIV-1 gp120 stabilizes V2-V3 interaction and modulates neutralization sensitivity.

Cimbro R, Gallant TR, Dolan MA, Guzzo C, Zhang P, Lin Y, Miao H, Van Ryk D, Arthos J, Gorshkova I, Brown PH, Hurt DE, Lusso P.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3152-7. doi: 10.1073/pnas.1314718111. Epub 2014 Feb 3.


The CD8-derived chemokine XCL1/lymphotactin is a conformation-dependent, broad-spectrum inhibitor of HIV-1.

Guzzo C, Fox J, Lin Y, Miao H, Cimbro R, Volkman BF, Fauci AS, Lusso P.

PLoS Pathog. 2013;9(12):e1003852. doi: 10.1371/journal.ppat.1003852. Epub 2013 Dec 26.


Protein-based HIV-1 microbicides.

Dey B, Lagenaur LA, Lusso P.

Curr HIV Res. 2013 Oct;11(7):576-94. Review.


Sialic acid-binding Ig-like lectin-7 interacts with HIV-1 gp120 and facilitates infection of CD4pos T cells and macrophages.

Varchetta S, Lusso P, Hudspeth K, Mikulak J, Mele D, Paolucci S, Cimbro R, Malnati M, Riva A, Maserati R, Mondelli MU, Mavilio D.

Retrovirology. 2013 Dec 13;10:154. doi: 10.1186/1742-4690-10-154.


Classification of HHV-6A and HHV-6B as distinct viruses.

Ablashi D, Agut H, Alvarez-Lafuente R, Clark DA, Dewhurst S, DiLuca D, Flamand L, Frenkel N, Gallo R, Gompels UA, Höllsberg P, Jacobson S, Luppi M, Lusso P, Malnati M, Medveczky P, Mori Y, Pellett PE, Pritchett JC, Yamanishi K, Yoshikawa T.

Arch Virol. 2014 May;159(5):863-70. doi: 10.1007/s00705-013-1902-5. Epub 2013 Nov 6. Review.


Immunomodulation and immunosuppression by human herpesvirus 6A and 6B.

Dagna L, Pritchett JC, Lusso P.

Future Virol. 2013 Mar;8(3):273-287.


Selective reactivation of human herpesvirus 6 in patients with autoimmune connective tissue diseases.

Broccolo F, Drago F, Cassina G, Fava A, Fusetti L, Matteoli B, Ceccherini-Nelli L, Sabbadini MG, Lusso P, Parodi A, Malnati MS.

J Med Virol. 2013 Nov;85(11):1925-34. doi: 10.1002/jmv.23670.


Calibrated real-time polymerase chain reaction for specific quantitation of HHV-6A and HHV-6B in clinical samples.

Cassina G, Russo D, De Battista D, Broccolo F, Lusso P, Malnati MS.

J Virol Methods. 2013 Apr;189(1):172-9. doi: 10.1016/j.jviromet.2013.01.018. Epub 2013 Feb 4.


Enhancement of anti-HIV-1 activity by hot spot evolution of RANTES-derived peptides.

Secchi M, Longhi R, Vassena L, Sironi F, Grzesiek S, Lusso P, Vangelista L.

Chem Biol. 2012 Dec 21;19(12):1579-88. doi: 10.1016/j.chembiol.2012.10.007.


Molecular study of human herpesvirus 6 and 8 involvement in coronary atherosclerosis and coronary instability.

Magnoni M, Malnati M, Cristell N, Coli S, Russo D, Ruotolo G, Cianflone D, Alfieri O, Lusso P, Maseri A.

J Med Virol. 2012 Dec;84(12):1961-6. doi: 10.1002/jmv.23355.


Inhibition of HIV-1 infection by human α-defensin-5, a natural antimicrobial peptide expressed in the genital and intestinal mucosae.

Furci L, Tolazzi M, Sironi F, Vassena L, Lusso P.

PLoS One. 2012;7(9):e45208. doi: 10.1371/journal.pone.0045208. Epub 2012 Sep 27.


HHV-6 encephalitis in umbilical cord blood transplantation: a systematic review and meta-analysis.

Scheurer ME, Pritchett JC, Amirian ES, Zemke NR, Lusso P, Ljungman P.

Bone Marrow Transplant. 2013 Apr;48(4):574-80. doi: 10.1038/bmt.2012.180. Epub 2012 Sep 24. Review.


IL-7 induces expression and activation of integrin α4β7 promoting naive T-cell homing to the intestinal mucosa.

Cimbro R, Vassena L, Arthos J, Cicala C, Kehrl JH, Park C, Sereti I, Lederman MM, Fauci AS, Lusso P.

Blood. 2012 Sep 27;120(13):2610-9. Epub 2012 Aug 14.


Identification of the platelet-derived chemokine CXCL4/PF-4 as a broad-spectrum HIV-1 inhibitor.

Auerbach DJ, Lin Y, Miao H, Cimbro R, Difiore MJ, Gianolini ME, Furci L, Biswas P, Fauci AS, Lusso P.

Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9569-74. doi: 10.1073/pnas.1207314109. Epub 2012 May 29.


Treatment with IL-7 prevents the decline of circulating CD4+ T cells during the acute phase of SIV infection in rhesus macaques.

Vassena L, Miao H, Cimbro R, Malnati MS, Cassina G, Proschan MA, Hirsch VM, Lafont BA, Morre M, Fauci AS, Lusso P.

PLoS Pathog. 2012;8(4):e1002636. doi: 10.1371/journal.ppat.1002636. Epub 2012 Apr 12.


Development of a human herpesvirus 6 species-specific immunoblotting assay.

Higashimoto Y, Ohta A, Nishiyama Y, Ihira M, Sugata K, Asano Y, Peterson DL, Ablashi DV, Lusso P, Yoshikawa T.

J Clin Microbiol. 2012 Apr;50(4):1245-51. doi: 10.1128/JCM.05834-11. Epub 2012 Jan 25.


Intraprotomer masking of third variable loop (V3) epitopes by the first and second variable loops (V1V2) within the native HIV-1 envelope glycoprotein trimer.

Liu L, Cimbro R, Lusso P, Berger EA.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20148-53. doi: 10.1073/pnas.1104840108. Epub 2011 Nov 29.


Chromosomally integrated human herpesvirus 6: questions and answers.

Pellett PE, Ablashi DV, Ambros PF, Agut H, Caserta MT, Descamps V, Flamand L, Gautheret-Dejean A, Hall CB, Kamble RT, Kuehl U, Lassner D, Lautenschlager I, Loomis KS, Luppi M, Lusso P, Medveczky PG, Montoya JG, Mori Y, Ogata M, Pritchett JC, Rogez S, Seto E, Ward KN, Yoshikawa T, Razonable RR.

Rev Med Virol. 2012 May;22(3):144-55. doi: 10.1002/rmv.715. Epub 2011 Nov 4. Review.


A new antigen scanning strategy for monitoring HIV-1 specific T-cell immune responses.

Malnati MS, Heltai S, Cosma A, Reitmeir P, Allgayer S, Glashoff RH, Liebrich W, Vardas E, Imami N, Westrop S, Nozza S, Tambussi G, Buttò S, Fanales-Belasio E, Ensoli B, Ensoli F, Tripiciano A, Fortis C, Lusso P, Poli G, Erfle V, Holmes H.

J Immunol Methods. 2012 Jan 31;375(1-2):46-56. doi: 10.1016/j.jim.2011.09.005. Epub 2011 Sep 22.


A multiplex calibrated real-time PCR assay for quantitation of DNA of EBV-1 and 2.

Gatto F, Cassina G, Broccolo F, Morreale G, Lanino E, Di Marco E, Vardas E, Bernasconi D, Buttò S, Principi N, Esposito S, Scarlatti G, Lusso P, Malnati MS.

J Virol Methods. 2011 Dec;178(1-2):98-105. doi: 10.1016/j.jviromet.2011.08.022. Epub 2011 Aug 27.


Broad-spectrum inhibition of HIV-1 by a monoclonal antibody directed against a gp120-induced epitope of CD4.

Burastero SE, Frigerio B, Lopalco L, Sironi F, Breda D, Longhi R, Scarlatti G, Canevari S, Figini M, Lusso P.

PLoS One. 2011;6(7):e22081. doi: 10.1371/journal.pone.0022081. Epub 2011 Jul 19.


Clinical significance of HIV-1 coreceptor usage.

Schuitemaker H, van 't Wout AB, Lusso P.

J Transl Med. 2011 Jan 27;9 Suppl 1:S5. doi: 10.1186/1479-5876-9-S1-S5. Review.


Molecular engineering of RANTES peptide mimetics with potent anti-HIV-1 activity.

Lusso P, Vangelista L, Cimbro R, Secchi M, Sironi F, Longhi R, Faiella M, Maglio O, Pavone V.

FASEB J. 2011 Apr;25(4):1230-43. doi: 10.1096/fj.10-167627. Epub 2011 Jan 3.


Nef-specific CD45RA+ CD8+ T cells secreting MIP-1beta but not IFN-gamma are associated with nonprogressive HIV-1 infection.

Dembek CJ, Kutscher S, Heltai S, Allgayer S, Biswas P, Ghezzi S, Vicenzi E, Hoffmann D, Reitmeir P, Tambussi G, Bogner JR, Lusso P, Stellbrink HJ, Santagostino E, Vollbrecht T, Goebel FD, Protzer U, Draenert R, Tinelli M, Poli G, Erfle V, Malnati M, Cosma A.

AIDS Res Ther. 2010 Jul 2;7:20. doi: 10.1186/1742-6405-7-20.


Engineering of Lactobacillus jensenii to secrete RANTES and a CCR5 antagonist analogue as live HIV-1 blockers.

Vangelista L, Secchi M, Liu X, Bachi A, Jia L, Xu Q, Lusso P.

Antimicrob Agents Chemother. 2010 Jul;54(7):2994-3001. doi: 10.1128/AAC.01492-09. Epub 2010 May 17.


Protective versus pathogenic anti-CD4 immunity: insights from the study of natural resistance to HIV infection.

Burastero SE, Figini M, Frigerio B, Lusso P, Mollica L, Lopalco L.

J Transl Med. 2009 Nov 28;7:101. doi: 10.1186/1479-5876-7-101. Review.


The superior folding of a RANTES analogue expressed in lactobacilli as compared to mammalian cells reveals a promising system to screen new RANTES mutants.

Secchi M, Xu Q, Lusso P, Vangelista L.

Protein Expr Purif. 2009 Nov;68(1):34-41. doi: 10.1016/j.pep.2009.06.018. Epub 2009 Jun 30.


Evolution of SIV toward RANTES resistance in macaques rapidly progressing to AIDS upon coinfection with HHV-6A.

Biancotto A, Grivel JC, Lisco A, Vanpouille C, Markham PD, Gallo RC, Margolis LB, Lusso P.

Retrovirology. 2009 Jul 2;6:61. doi: 10.1186/1742-4690-6-61.


Reactivation of human herpesvirus 6 (HHV-6) infection in patients with connective tissue diseases.

Broccolo F, Drago F, Paolino S, Cassina G, Gatto F, Fusetti L, Matteoli B, Zaccaria E, Parodi A, Lusso P, Ceccherini-Nelli L, Malnati MS.

J Clin Virol. 2009 Sep;46(1):43-6. doi: 10.1016/j.jcv.2009.05.010. Epub 2009 Jun 9.


Biological and physical characterization of the X4 HIV-1 suppressive factor secreted by LPS-stimulated human macrophages.

Mikulak J, Gianolini M, Versmisse P, Pancino G, Lusso P, Verani A.

Virology. 2009 Jul 20;390(1):37-44. doi: 10.1016/j.virol.2009.04.005. Epub 2009 May 17.

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