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Items: 1 to 50 of 141

1.

Targeted Inhibition of CD47-SIRPα Requires Fc-FcγR Interactions to Maximize Activity in T-cell Lymphomas.

Jain S, Van Scoyk A, Morgan EA, Matthews A, Stevenson K, Newton G, Powers F, Autio A, Louissaint A Jr, Pontini G, Aster JC, Luscinskas FW, Weinstock DM.

Blood. 2019 Aug 5. pii: blood.2019001744. doi: 10.1182/blood.2019001744. [Epub ahead of print]

PMID:
31383641
2.

Increased lymphocyte activation and atherosclerosis in CD47-deficient mice.

Engelbertsen D, Autio A, Verwilligen RAF, Depuydt MAC, Newton G, Rattik S, Levinsohn E, Saggu G, Jarolim P, Wang H, Velazquez F, Lichtman AH, Luscinskas FW.

Sci Rep. 2019 Jul 23;9(1):10608. doi: 10.1038/s41598-019-46942-x.

3.

Neutrophil Extracellular Traps Induce Endothelial Cell Activation and Tissue Factor Production Through Interleukin-1α and Cathepsin G.

Folco EJ, Mawson TL, Vromman A, Bernardes-Souza B, Franck G, Persson O, Nakamura M, Newton G, Luscinskas FW, Libby P.

Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1901-1912. doi: 10.1161/ATVBAHA.118.311150.

4.

Complement C5a Receptor is the Key Initiator of Neutrophil Adhesion Igniting Immune Complex-induced Arthritis.

Miyabe Y, Miyabe C, Murooka TT, Kim EY, Newton GA, Kim ND, Haribabu B, Luscinskas FW, Mempel TR, Luster AD.

Sci Immunol. 2017 Jan;2(7). pii: eaaj2195. doi: 10.1126/sciimmunol.aaj2195. Epub 2017 Jan 20.

5.

Defects in CD4+ T cell LFA-1 integrin-dependent adhesion and proliferation protect Cd47-/- mice from EAE.

Azcutia V, Bassil R, Herter JM, Engelbertsen D, Newton G, Autio A, Mayadas T, Lichtman AH, Khoury SJ, Parkos CA, Elyaman W, Luscinskas FW.

J Leukoc Biol. 2017 Feb;101(2):493-505. doi: 10.1189/jlb.3A1215-546RR. Epub 2016 Dec 13.

6.

A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton.

Janssen E, Tohme M, Hedayat M, Leick M, Kumari S, Ramesh N, Massaad MJ, Ullas S, Azcutia V, Goodnow CC, Randall KL, Qiao Q, Wu H, Al-Herz W, Cox D, Hartwig J, Irvine DJ, Luscinskas FW, Geha RS.

J Clin Invest. 2016 Oct 3;126(10):3837-3851. doi: 10.1172/JCI85774. Epub 2016 Sep 6.

7.

Endomucin prevents leukocyte-endothelial cell adhesion and has a critical role under resting and inflammatory conditions.

Zahr A, Alcaide P, Yang J, Jones A, Gregory M, dela Paz NG, Patel-Hett S, Nevers T, Koirala A, Luscinskas FW, Saint-Geniez M, Ksander B, D'Amore PA, Argüeso P.

Nat Commun. 2016 Feb 2;7:10363. doi: 10.1038/ncomms10363.

8.

AKAP9 regulates activation-induced retention of T lymphocytes at sites of inflammation.

Herter JM, Grabie N, Cullere X, Azcutia V, Rosetti F, Bennett P, Herter-Sprie GS, Elyaman W, Luscinskas FW, Lichtman AH, Mayadas TN.

Nat Commun. 2015 Dec 18;6:10182. doi: 10.1038/ncomms10182.

9.

Introduction for the special issue on "Tissue Barriers in Inflammation".

Luscinskas FW, Leick M, Newton G, Nusrat A.

Tissue Barriers. 2015 Feb 25;3(1-2):e1015825. doi: 10.1080/21688370.2015.1015825. eCollection 2015.

10.

Migration of myeloid cells during inflammation is differentially regulated by the cell surface receptors Slamf1 and Slamf8.

Wang G, van Driel BJ, Liao G, O'Keeffe MS, Halibozek PJ, Flipse J, Yigit B, Azcutia V, Luscinskas FW, Wang N, Terhorst C.

PLoS One. 2015 Mar 23;10(3):e0121968. doi: 10.1371/journal.pone.0121968. eCollection 2015.

11.

A Lupus-Associated Mac-1 Variant Has Defects in Integrin Allostery and Interaction with Ligands under Force.

Rosetti F, Chen Y, Sen M, Thayer E, Azcutia V, Herter JM, Luscinskas FW, Cullere X, Zhu C, Mayadas TN.

Cell Rep. 2015 Mar 17;10(10):1655-1664. doi: 10.1016/j.celrep.2015.02.037. Epub 2015 Mar 12.

12.

NF-κB directs dynamic super enhancer formation in inflammation and atherogenesis.

Brown JD, Lin CY, Duan Q, Griffin G, Federation A, Paranal RM, Bair S, Newton G, Lichtman A, Kung A, Yang T, Wang H, Luscinskas FW, Croce K, Bradner JE, Plutzky J.

Mol Cell. 2014 Oct 23;56(2):219-231. doi: 10.1016/j.molcel.2014.08.024. Epub 2014 Sep 25.

13.

Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing.

Massaad MJ, Oyoshi MK, Kane J, Koduru S, Alcaide P, Nakamura F, Ramesh N, Luscinskas FW, Hartwig J, Geha RS.

Mol Cell Biol. 2014 Dec 1;34(23):4343-54. doi: 10.1128/MCB.00533-14. Epub 2014 Sep 22.

14.

Introduction for the special issue on new paradigms in leukocyte trafficking, lessons for therapeutics.

Luscinskas FW, Imhof BA.

Semin Immunopathol. 2014 Mar;36(2):133-6. doi: 10.1007/s00281-014-0422-z. Epub 2014 Apr 9. No abstract available.

15.

Leukocyte recruitment in inflammation: basic concepts and new mechanistic insights based on new models and microscopic imaging technologies.

Leick M, Azcutia V, Newton G, Luscinskas FW.

Cell Tissue Res. 2014 Mar;355(3):647-56. doi: 10.1007/s00441-014-1809-9. Epub 2014 Feb 23. Review.

16.

Neutrophil recruitment: perivascular macrophages 'duke it out' with Staphylococcus aureus.

Luscinskas FW.

Nat Immunol. 2014 Jan;15(1):10-1. doi: 10.1038/ni.2793. No abstract available.

PMID:
24352318
17.

CXCL1 excess stops neutrophils in their tracks.

Luscinskas FW.

Blood. 2013 Nov 28;122(23):3708-10. doi: 10.1182/blood-2013-10-531905. No abstract available.

18.

Functional vascular endothelium derived from human induced pluripotent stem cells.

Adams WJ, Zhang Y, Cloutier J, Kuchimanchi P, Newton G, Sehrawat S, Aird WC, Mayadas TN, Luscinskas FW, García-Cardeña G.

Stem Cell Reports. 2013 Jul 25;1(2):105-13. doi: 10.1016/j.stemcr.2013.06.007. eCollection 2013.

19.

CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions.

Azcutia V, Routledge M, Williams MR, Newton G, Frazier WA, Manica A, Croce KJ, Parkos CA, Schmider AB, Turman MV, Soberman RJ, Luscinskas FW.

Mol Biol Cell. 2013 Nov;24(21):3358-68. doi: 10.1091/mbc.E13-01-0063. Epub 2013 Sep 4.

20.

Novel role of CD47 in rat microvascular endothelium: signaling and regulation of T-cell transendothelial migration.

Martinelli R, Newton G, Carman CV, Greenwood J, Luscinskas FW.

Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):2566-76. doi: 10.1161/ATVBAHA.113.301903. Epub 2013 Aug 29.

21.

Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-β autocrine signaling to promote monocyte recruitment.

Venkatesh D, Ernandez T, Rosetti F, Batal I, Cullere X, Luscinskas FW, Zhang Y, Stavrakis G, García-Cardeña G, Horwitz BH, Mayadas TN.

Immunity. 2013 May 23;38(5):1025-37. doi: 10.1016/j.immuni.2013.01.012. Epub 2013 Apr 25.

22.

Signaling lymphocyte activation molecule regulates development of colitis in mice.

van Driel B, Liao G, Romero X, O'Keeffe MS, Wang G, Faubion WA, Berger SB, Magelky EM, Manocha M, Azcutia V, Grisham M, Luscinskas FW, Mizoguchi E, de Waal Malefyt R, Reinecker HC, Bhan AK, Wang N, Terhorst C.

Gastroenterology. 2012 Dec;143(6):1544-1554.e7. doi: 10.1053/j.gastro.2012.08.042. Epub 2012 Sep 6.

23.

Statins suppress apolipoprotein CIII-induced vascular endothelial cell activation and monocyte adhesion.

Zheng C, Azcutia V, Aikawa E, Figueiredo JL, Croce K, Sonoki H, Sacks FM, Luscinskas FW, Aikawa M.

Eur Heart J. 2013 Feb;34(8):615-24. doi: 10.1093/eurheartj/ehs271. Epub 2012 Aug 26.

24.

Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo.

Azcutia V, Stefanidakis M, Tsuboi N, Mayadas T, Croce KJ, Fukuda D, Aikawa M, Newton G, Luscinskas FW.

J Immunol. 2012 Sep 1;189(5):2553-62. doi: 10.4049/jimmunol.1103606. Epub 2012 Jul 18.

25.

p120-Catenin prevents neutrophil transmigration independently of RhoA inhibition by impairing Src dependent VE-cadherin phosphorylation.

Alcaide P, Martinelli R, Newton G, Williams MR, Adam A, Vincent PA, Luscinskas FW.

Am J Physiol Cell Physiol. 2012 Aug 15;303(4):C385-95. doi: 10.1152/ajpcell.00126.2012. Epub 2012 May 30.

26.

IL-17 and TNF-α sustain neutrophil recruitment during inflammation through synergistic effects on endothelial activation.

Griffin GK, Newton G, Tarrio ML, Bu DX, Maganto-Garcia E, Azcutia V, Alcaide P, Grabie N, Luscinskas FW, Croce KJ, Lichtman AH.

J Immunol. 2012 Jun 15;188(12):6287-99. doi: 10.4049/jimmunol.1200385. Epub 2012 May 7.

27.

FAK and PAX-illin get involved in leukocyte diapedesis.

Luscinskas FW.

Eur J Immunol. 2012 Feb;42(2):296-8. doi: 10.1002/eji.201142342.

28.

Difference in Th1 and Th17 lymphocyte adhesion to endothelium.

Alcaide P, Maganto-Garcia E, Newton G, Travers R, Croce KJ, Bu DX, Luscinskas FW, Lichtman AH.

J Immunol. 2012 Feb 1;188(3):1421-30. doi: 10.4049/jimmunol.1101647. Epub 2012 Jan 4.

29.

Foxp3+-inducible regulatory T cells suppress endothelial activation and leukocyte recruitment.

Maganto-García E, Bu DX, Tarrio ML, Alcaide P, Newton G, Griffin GK, Croce KJ, Luscinskas FW, Lichtman AH, Grabie N.

J Immunol. 2011 Oct 1;187(7):3521-9. doi: 10.4049/jimmunol.1003947. Epub 2011 Aug 26.

30.

Emerging mechanisms of neutrophil recruitment across endothelium.

Williams MR, Azcutia V, Newton G, Alcaide P, Luscinskas FW.

Trends Immunol. 2011 Oct;32(10):461-9. doi: 10.1016/j.it.2011.06.009. Epub 2011 Aug 11. Review.

31.

Leukocyte rolling and adhesion via ICAM-1 signals to endothelial permeability. Focus on "Leukocyte rolling and adhesion both contribute to regulation of microvascular permeability to albumin via ligation of ICAM-1".

Williams MR, Luscinskas FW.

Am J Physiol Cell Physiol. 2011 Oct;301(4):C777-9. doi: 10.1152/ajpcell.00250.2011. Epub 2011 Jul 20. No abstract available.

32.

Regulation of endothelial cell adhesion molecule expression by mast cells, macrophages, and neutrophils.

Zhang J, Alcaide P, Liu L, Sun J, He A, Luscinskas FW, Shi GP.

PLoS One. 2011 Jan 14;6(1):e14525. doi: 10.1371/journal.pone.0014525.

33.

Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking.

Koduru S, Kumar L, Massaad MJ, Ramesh N, Le Bras S, Ozcan E, Oyoshi MK, Kaku M, Fujiwara Y, Kremer L, King S, Fuhlbrigge R, Rodig S, Sage P, Carman C, Alcaide P, Luscinskas FW, Geha RS.

Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16252-6. doi: 10.1073/pnas.1002747107. Epub 2010 Aug 30.

34.

Neutrophil CD44 rafts and rolls.

Luscinskas FW.

Blood. 2010 Jul 22;116(3):314-5. doi: 10.1182/blood-2010-04-276410. No abstract available.

35.

Inflammation determines the pro-adhesive properties of high extracellular d-glucose in human endothelial cells in vitro and rat microvessels in vivo.

Azcutia V, Abu-Taha M, Romacho T, Vázquez-Bella M, Matesanz N, Luscinskas FW, Rodríguez-Mañas L, Sanz MJ, Sánchez-Ferrer CF, Peiró C.

PLoS One. 2010 Apr 8;5(4):e10091. doi: 10.1371/journal.pone.0010091.

36.

Mucin AgC10 from Trypanosoma cruzi Interferes with L-selectin-mediated monocyte adhesion.

Alcaide P, Lim YC, Luscinskas FW, Fresno M.

Infect Immun. 2010 Mar;78(3):1260-8. doi: 10.1128/IAI.00794-09. Epub 2010 Jan 11.

37.

Assays of transendothelial migration in vitro.

Muller WA, Luscinskas FW.

Methods Enzymol. 2008;443:155-76. doi: 10.1016/S0076-6879(08)02009-0.

38.

Neutrophil recruitment under shear flow: it's all about endothelial cell rings and gaps.

Alcaide P, Auerbach S, Luscinskas FW.

Microcirculation. 2009 Jan;16(1):43-57. doi: 10.1080/10739680802273892. Review. Erratum in: Microcirculation. 2009 Nov;16(8):782.

39.

p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation.

Alcaide P, Newton G, Auerbach S, Sehrawat S, Mayadas TN, Golan DE, Yacono P, Vincent P, Kowalczyk A, Luscinskas FW.

Blood. 2008 Oct 1;112(7):2770-9. doi: 10.1182/blood-2008-03-147181. Epub 2008 Jul 18.

40.

Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro.

Stefanidakis M, Newton G, Lee WY, Parkos CA, Luscinskas FW.

Blood. 2008 Aug 15;112(4):1280-9. doi: 10.1182/blood-2008-01-134429. Epub 2008 Jun 4.

41.

ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury.

Noma K, Rikitake Y, Oyama N, Yan G, Alcaide P, Liu PY, Wang H, Ahl D, Sawada N, Okamoto R, Hiroi Y, Shimizu K, Luscinskas FW, Sun J, Liao JK.

J Clin Invest. 2008 May;118(5):1632-44. doi: 10.1172/JCI29226.

42.

Mechanical forces induced by the transendothelial migration of human neutrophils.

Rabodzey A, Alcaide P, Luscinskas FW, Ladoux B.

Biophys J. 2008 Aug;95(3):1428-38. doi: 10.1529/biophysj.107.119156. Epub 2008 Apr 4.

43.

Early response of endothelial cells to flow is mediated by VE-cadherin.

Rabodzey A, Yao Y, Luscinskas FW, Shaw SK, Dewey CF Jr.

Cell Commun Adhes. 2007 Sep-Oct;14(5):195-209.

PMID:
18163230
44.

Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion.

Ghandour H, Cullere X, Alvarez A, Luscinskas FW, Mayadas TN.

Blood. 2007 Nov 15;110(10):3682-90. Epub 2007 Aug 16.

45.

Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall.

Rao RM, Yang L, Garcia-Cardena G, Luscinskas FW.

Circ Res. 2007 Aug 3;101(3):234-47. Review.

PMID:
17673684
46.

JAM-C regulates unidirectional monocyte transendothelial migration in inflammation.

Bradfield PF, Scheiermann C, Nourshargh S, Ody C, Luscinskas FW, Rainger GE, Nash GB, Miljkovic-Licina M, Aurrand-Lions M, Imhof BA.

Blood. 2007 Oct 1;110(7):2545-55. Epub 2007 Jul 11.

47.

Neutrophil transmigration under shear flow conditions in vitro is junctional adhesion molecule-C independent.

Sircar M, Bradfield PF, Aurrand-Lions M, Fish RJ, Alcaide P, Yang L, Newton G, Lamont D, Sehrawat S, Mayadas T, Liang TW, Parkos CA, Imhof BA, Luscinskas FW.

J Immunol. 2007 May 1;178(9):5879-87.

48.

The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo.

Alcaide P, King SL, Dimitroff CJ, Lim YC, Fuhlbrigge RC, Luscinskas FW.

J Invest Dermatol. 2007 Aug;127(8):1964-72. Epub 2007 Mar 29.

49.

Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue.

Alcaide P, Jones TG, Lord GM, Glimcher LH, Hallgren J, Arinobu Y, Akashi K, Paterson AM, Gurish MA, Luscinskas FW.

J Exp Med. 2007 Feb 19;204(2):431-9. Epub 2007 Feb 12.

50.

CD99 is a key mediator of the transendothelial migration of neutrophils.

Lou O, Alcaide P, Luscinskas FW, Muller WA.

J Immunol. 2007 Jan 15;178(2):1136-43.

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