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Items: 1 to 50 of 117


Chemical Ligand Space of Cereblon.

Boichenko I, Bär K, Deiss S, Heim C, Albrecht R, Lupas AN, Hernandez Alvarez B, Hartmann MD.

ACS Omega. 2018 Sep 14;3(9):11163-11171. doi: 10.1021/acsomega.8b00959. eCollection 2018 Sep 30.


Structural diversity of coiled coils in protein fibers of the bacterial cell envelope.

Hernandez Alvarez B, Bassler J, Lupas AN.

Int J Med Microbiol. 2019 Jul;309(5):351-358. doi: 10.1016/j.ijmm.2019.05.011. Epub 2019 Jun 3. Review.


Characterization of MCU-Binding Proteins MCUR1 and CCDC90B - Representatives of a Protein Family Conserved in Prokaryotes and Eukaryotic Organelles.

Adlakha J, Karamichali I, Sangwallek J, Deiss S, Bär K, Coles M, Hartmann MD, Lupas AN, Hernandez Alvarez B.

Structure. 2019 Mar 5;27(3):464-475.e6. doi: 10.1016/j.str.2018.11.004. Epub 2019 Jan 3.


Histones predate the split between bacteria and archaea.

Alva V, Lupas AN.

Bioinformatics. 2019 Jul 15;35(14):2349-2353. doi: 10.1093/bioinformatics/bty1000.


The Origin of Mitochondria-Specific Outer Membrane β-Barrels from an Ancestral Bacterial Fragment.

Pereira J, Lupas AN.

Genome Biol Evol. 2018 Oct 1;10(10):2759-2765. doi: 10.1093/gbe/evy216.


An Interface-Driven Design Strategy Yields a Novel, Corrugated Protein Architecture.

ElGamacy M, Coles M, Ernst P, Zhu H, Hartmann MD, Plückthun A, Lupas AN.

ACS Synth Biol. 2018 Sep 21;7(9):2226-2235. doi: 10.1021/acssynbio.8b00224. Epub 2018 Sep 4.


The ancestral KH peptide at the root of a domain family with three different folds.

Pereira J, Lupas AN.

Bioinformatics. 2018 Dec 1;34(23):3961-3965. doi: 10.1093/bioinformatics/bty480.


Adenylate cyclases: Receivers, transducers, and generators of signals.

Bassler J, Schultz JE, Lupas AN.

Cell Signal. 2018 Jun;46:135-144. doi: 10.1016/j.cellsig.2018.03.002. Epub 2018 Mar 18. Review.


Journal of Structural Biology - Paper of the year 2017.

Lupas AN, Steven AC.

J Struct Biol. 2018 Mar;201(3):185-186. doi: 10.1016/j.jsb.2018.01.008. Epub 2018 Jan 31. No abstract available.


A Completely Reimplemented MPI Bioinformatics Toolkit with a New HHpred Server at its Core.

Zimmermann L, Stephens A, Nam SZ, Rau D, Kübler J, Lozajic M, Gabler F, Söding J, Lupas AN, Alva V.

J Mol Biol. 2018 Jul 20;430(15):2237-2243. doi: 10.1016/j.jmb.2017.12.007. Epub 2017 Dec 16.


From ancestral peptides to designed proteins.

Alva V, Lupas AN.

Curr Opin Struct Biol. 2018 Feb;48:103-109. doi: 10.1016/ Epub 2017 Nov 28. Review.


Ribosomal proteins as documents of the transition from unstructured (poly)peptides to folded proteins.

Lupas AN, Alva V.

J Struct Biol. 2017 May;198(2):74-81. doi: 10.1016/j.jsb.2017.04.007. Epub 2017 Apr 26. Review.


Characterization of a novel signal transducer element intrinsic to class IIIa/b adenylate cyclases and guanylate cyclases.

Ziegler M, Bassler J, Beltz S, Schultz A, Lupas AN, Schultz JE.

FEBS J. 2017 Apr;284(8):1204-1217. doi: 10.1111/febs.14047. Epub 2017 Mar 20.


The Structure and Topology of α-Helical Coiled Coils.

Lupas AN, Bassler J, Dunin-Horkawicz S.

Subcell Biochem. 2017;82:95-129. doi: 10.1007/978-3-319-49674-0_4. Review.


N@a and N@d: Oligomer and Partner Specification by Asparagine in Coiled-Coil Interfaces.

Fletcher JM, Bartlett GJ, Boyle AL, Danon JJ, Rush LE, Lupas AN, Woolfson DN.

ACS Chem Biol. 2017 Feb 17;12(2):528-538. doi: 10.1021/acschembio.6b00935. Epub 2017 Jan 9.


Coiled Coils - A Model System for the 21st Century.

Lupas AN, Bassler J.

Trends Biochem Sci. 2017 Feb;42(2):130-140. doi: 10.1016/j.tibs.2016.10.007. Epub 2016 Nov 21. Review.


Origin of a folded repeat protein from an intrinsically disordered ancestor.

Zhu H, Sepulveda E, Hartmann MD, Kogenaru M, Ursinus A, Sulz E, Albrecht R, Coles M, Martin J, Lupas AN.

Elife. 2016 Sep 13;5. pii: e16761. doi: 10.7554/eLife.16761.


An endosomal tether undergoes an entropic collapse to bring vesicles together.

Murray DH, Jahnel M, Lauer J, Avellaneda MJ, Brouilly N, Cezanne A, Morales-Navarrete H, Perini ED, Ferguson C, Lupas AN, Kalaidzidis Y, Parton RG, Grill SW, Zerial M.

Nature. 2016 Sep 1;537(7618):107-111. doi: 10.1038/nature19326. Epub 2016 Aug 24.


The MPI bioinformatics Toolkit as an integrative platform for advanced protein sequence and structure analysis.

Alva V, Nam SZ, Söding J, Lupas AN.

Nucleic Acids Res. 2016 Jul 8;44(W1):W410-5. doi: 10.1093/nar/gkw348. Epub 2016 Apr 29.


The TULIP superfamily of eukaryotic lipid-binding proteins as a mediator of lipid sensing and transport.

Alva V, Lupas AN.

Biochim Biophys Acta. 2016 Aug;1861(8 Pt B):913-923. doi: 10.1016/j.bbalip.2016.01.016. Epub 2016 Jan 26. Review.


α/β coiled coils.

Hartmann MD, Mendler CT, Bassler J, Karamichali I, Ridderbusch O, Lupas AN, Hernandez Alvarez B.

Elife. 2016 Jan 15;5. pii: e11861. doi: 10.7554/eLife.11861.


Structural Basis for Toughness and Flexibility in the C-terminal Passenger Domain of an Acinetobacter Trimeric Autotransporter Adhesin.

Koiwai K, Hartmann MD, Linke D, Lupas AN, Hori K.

J Biol Chem. 2016 Feb 19;291(8):3705-24. doi: 10.1074/jbc.M115.701698. Epub 2015 Dec 23.


A vocabulary of ancient peptides at the origin of folded proteins.

Alva V, Söding J, Lupas AN.

Elife. 2015 Dec 14;4:e09410. doi: 10.7554/eLife.09410.


Some of the most interesting CASP11 targets through the eyes of their authors.

Kryshtafovych A, Moult J, Baslé A, Burgin A, Craig TK, Edwards RA, Fass D, Hartmann MD, Korycinski M, Lewis RJ, Lorimer D, Lupas AN, Newman J, Peat TS, Piepenbrink KH, Prahlad J, van Raaij MJ, Rohwer F, Segall AM, Seguritan V, Sundberg EJ, Singh AK, Wilson MA, Schwede T.

Proteins. 2016 Sep;84 Suppl 1:34-50. doi: 10.1002/prot.24942. Epub 2015 Nov 16.


STAC--A New Domain Associated with Transmembrane Solute Transport and Two-Component Signal Transduction Systems.

Korycinski M, Albrecht R, Ursinus A, Hartmann MD, Coles M, Martin J, Dunin-Horkawicz S, Lupas AN.

J Mol Biol. 2015 Oct 9;427(20):3327-3339. doi: 10.1016/j.jmb.2015.08.017. Epub 2015 Aug 28.


Structural dynamics of the cereblon ligand binding domain.

Hartmann MD, Boichenko I, Coles M, Lupas AN, Hernandez Alvarez B.

PLoS One. 2015 May 29;10(5):e0128342. doi: 10.1371/journal.pone.0128342. eCollection 2015.


A domain dictionary of trimeric autotransporter adhesins.

Bassler J, Hernandez Alvarez B, Hartmann MD, Lupas AN.

Int J Med Microbiol. 2015 Feb;305(2):265-75. doi: 10.1016/j.ijmm.2014.12.010. Epub 2014 Dec 24. Review.


Structure and evolution of N-domains in AAA metalloproteases.

Scharfenberg F, Serek-Heuberger J, Coles M, Hartmann MD, Habeck M, Martin J, Lupas AN, Alva V.

J Mol Biol. 2015 Feb 27;427(4):910-923. doi: 10.1016/j.jmb.2014.12.024. Epub 2015 Jan 8.


The thalidomide-binding domain of cereblon defines the CULT domain family and is a new member of the β-tent fold.

Lupas AN, Zhu H, Korycinski M.

PLoS Comput Biol. 2015 Jan 8;11(1):e1004023. doi: 10.1371/journal.pcbi.1004023. eCollection 2015 Jan.


Protein Design. What I cannot create, I do not understand.

Lupas AN.

Science. 2014 Dec 19;346(6216):1455-6. doi: 10.1126/science.aaa2721. No abstract available.


Thalidomide mimics uridine binding to an aromatic cage in cereblon.

Hartmann MD, Boichenko I, Coles M, Zanini F, Lupas AN, Hernandez Alvarez B.

J Struct Biol. 2014 Dec;188(3):225-32. doi: 10.1016/j.jsb.2014.10.010. Epub 2014 Nov 4.


Crystallographic snapshot of the Escherichia coli EnvZ histidine kinase in an active conformation.

Ferris HU, Coles M, Lupas AN, Hartmann MD.

J Struct Biol. 2014 Jun;186(3):376-9. doi: 10.1016/j.jsb.2014.03.014. Epub 2014 Mar 26.


Axial helix rotation as a mechanism for signal regulation inferred from the crystallographic analysis of the E. coli serine chemoreceptor.

Ferris HU, Zeth K, Hulko M, Dunin-Horkawicz S, Lupas AN.

J Struct Biol. 2014 Jun;186(3):349-56. doi: 10.1016/j.jsb.2014.03.015. Epub 2014 Mar 27.


A soluble mutant of the transmembrane receptor Af1503 features strong changes in coiled-coil periodicity.

Hartmann MD, Dunin-Horkawicz S, Hulko M, Martin J, Coles M, Lupas AN.

J Struct Biol. 2014 Jun;186(3):357-66. doi: 10.1016/j.jsb.2014.02.008. Epub 2014 Feb 22.


Prokaryotic ancestry of eukaryotic protein networks mediating innate immunity and apoptosis.

Dunin-Horkawicz S, Kopec KO, Lupas AN.

J Mol Biol. 2014 Apr 3;426(7):1568-82. doi: 10.1016/j.jmb.2013.11.030. Epub 2013 Dec 9.


β-Propeller blades as ancestral peptides in protein evolution.

Kopec KO, Lupas AN.

PLoS One. 2013 Oct 15;8(10):e77074. doi: 10.1371/journal.pone.0077074. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/fee01544-ff98-4ed2-9dc9-7aea9c5fe828.


The first prokaryotic trehalose synthase complex identified in the hyperthermophilic crenarchaeon Thermoproteus tenax.

Zaparty M, Hagemann A, Bräsen C, Hensel R, Lupas AN, Brinkmann H, Siebers B.

PLoS One. 2013 Apr 23;8(4):e61354. doi: 10.1371/journal.pone.0061354. Print 2013.


Complete fiber structures of complex trimeric autotransporter adhesins conserved in enterobacteria.

Hartmann MD, Grin I, Dunin-Horkawicz S, Deiss S, Linke D, Lupas AN, Hernandez Alvarez B.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20907-12. doi: 10.1073/pnas.1211872110. Epub 2012 Dec 3.


The archaeal proteasome is regulated by a network of AAA ATPases.

Forouzan D, Ammelburg M, Hobel CF, Ströh LJ, Sessler N, Martin J, Lupas AN.

J Biol Chem. 2012 Nov 9;287(46):39254-62. doi: 10.1074/jbc.M112.386458. Epub 2012 Sep 19.


The structure of proteins.

Lupas AN, Russell RB.

J Struct Biol. 2012 Sep;179(3):251. doi: 10.1016/j.jsb.2012.05.012. Epub 2012 May 26. No abstract available.


Mechanism of regulation of receptor histidine kinases.

Ferris HU, Dunin-Horkawicz S, Hornig N, Hulko M, Martin J, Schultz JE, Zeth K, Lupas AN, Coles M.

Structure. 2012 Jan 11;20(1):56-66. doi: 10.1016/j.str.2011.11.014.


Evolutionary relationships of microbial aromatic prenyltransferases.

Bonitz T, Alva V, Saleh O, Lupas AN, Heide L.

PLoS One. 2011;6(11):e27336. doi: 10.1371/journal.pone.0027336. Epub 2011 Nov 30.


Bioinformatics of the TULIP domain superfamily.

Kopec KO, Alva V, Lupas AN.

Biochem Soc Trans. 2011 Aug;39(4):1033-8. doi: 10.1042/BST0391033. Review.


Structure and function of tripeptidyl peptidase II, a giant cytosolic protease.

Rockel B, Kopec KO, Lupas AN, Baumeister W.

Biochim Biophys Acta. 2012 Jan;1824(1):237-45. doi: 10.1016/j.bbapap.2011.07.002. Epub 2011 Jul 13. Review.


The structure of E. coli IgG-binding protein D suggests a general model for bending and binding in trimeric autotransporter adhesins.

Leo JC, Lyskowski A, Hattula K, Hartmann MD, Schwarz H, Butcher SJ, Linke D, Lupas AN, Goldman A.

Structure. 2011 Jul 13;19(7):1021-30. doi: 10.1016/j.str.2011.03.021.


The mechanisms of HAMP-mediated signaling in transmembrane receptors.

Ferris HU, Dunin-Horkawicz S, Mondéjar LG, Hulko M, Hantke K, Martin J, Schultz JE, Zeth K, Lupas AN, Coles M.

Structure. 2011 Mar 9;19(3):378-85. doi: 10.1016/j.str.2011.01.006.


SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay.

Kashima I, Jonas S, Jayachandran U, Buchwald G, Conti E, Lupas AN, Izaurralde E.

Genes Dev. 2010 Nov 1;24(21):2440-50. doi: 10.1101/gad.604610. Epub 2010 Oct 7.


Crystal structure of a dimeric archaeal cleavage and polyadenylation specificity factor.

Mir-Montazeri B, Ammelburg M, Forouzan D, Lupas AN, Hartmann MD.

J Struct Biol. 2011 Jan;173(1):191-5. doi: 10.1016/j.jsb.2010.09.013. Epub 2010 Sep 17.


The use of FLP-mediated recombination for the functional analysis of an effector gene family in the biotrophic smut fungus Ustilago maydis.

Khrunyk Y, Münch K, Schipper K, Lupas AN, Kahmann R.

New Phytol. 2010 Sep;187(4):957-68. doi: 10.1111/j.1469-8137.2010.03413.x. Epub 2010 Jun 18.

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