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Items: 34


Mesenchymal Stem Cells Secretory Responses: Senescence Messaging Secretome and Immunomodulation Perspective.

Lunyak VV, Amaro-Ortiz A, Gaur M.

Front Genet. 2017 Dec 19;8:220. doi: 10.3389/fgene.2017.00220. eCollection 2017. Review.


Piwi Is Required to Limit Exhaustion of Aging Somatic Stem Cells.

Sousa-Victor P, Ayyaz A, Hayashi R, Qi Y, Madden DT, Lunyak VV, Jasper H.

Cell Rep. 2017 Sep 12;20(11):2527-2537. doi: 10.1016/j.celrep.2017.08.059.


Opposing activities of oncogenic MIR17HG and tumor suppressive MIR100HG clusters and their gene targets regulate replicative senescence in human adult stem cells.

Lopez MF, Niu P, Wang L, Vogelsang M, Gaur M, Krastins B, Zhao Y, Smagul A, Nussupbekova A, Akanov AA, Jordan IK, Lunyak VV.

NPJ Aging Mech Dis. 2017 Apr 20;3:7. doi: 10.1038/s41514-017-0006-y. eCollection 2017.


Adipose stem cells from obese patients show specific differences in the metabolic regulators vitamin D and Gas5.

Pérez LM, de Lucas B, Lunyak VV, Gálvez BG.

Mol Genet Metab Rep. 2017 May 27;12:51-56. doi: 10.1016/j.ymgmr.2017.05.008. eCollection 2017 Sep.


Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging.

Gaur M, Dobke M, Lunyak VV.

Int J Mol Sci. 2017 Jan 20;18(1). pii: E208. doi: 10.3390/ijms18010208. Review.


Transcriptional profiling of interleukin-2-primed human adipose derived mesenchymal stem cells revealed dramatic changes in stem cells response imposed by replicative senescence.

Niu P, Smagul A, Wang L, Sadvakas A, Sha Y, Pérez LM, Nussupbekova A, Amirbekov A, Akanov AA, Gálvez BG, Jordan IK, Lunyak VV.

Oncotarget. 2015 Jul 20;6(20):17938-57.


MIR retrotransposon sequences provide insulators to the human genome.

Wang J, Vicente-García C, Seruggia D, Moltó E, Fernandez-Miñán A, Neto A, Lee E, Gómez-Skarmeta JL, Montoliu L, Lunyak VV, Jordan IK.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4428-37. doi: 10.1073/pnas.1507253112. Epub 2015 Jul 27.


Mammalian-wide interspersed repeat (MIR)-derived enhancers and the regulation of human gene expression.

Jjingo D, Conley AB, Wang J, Mariño-Ramírez L, Lunyak VV, Jordan IK.

Mob DNA. 2014 May 5;5:14. doi: 10.1186/1759-8753-5-14. eCollection 2014.


Epigenetics components of aging in the central nervous system.

Zhao YQ, Jordan IK, Lunyak VV.

Neurotherapeutics. 2013 Oct;10(4):647-63. doi: 10.1007/s13311-013-0229-y. Review.


Compound cis-regulatory elements with both boundary and enhancer sequences in the human genome.

Jjingo D, Wang J, Conley AB, Lunyak VV, Jordan IK.

Bioinformatics. 2013 Dec 15;29(24):3109-12. doi: 10.1093/bioinformatics/btt542. Epub 2013 Oct 1.


BroadPeak: a novel algorithm for identifying broad peaks in diffuse ChIP-seq datasets.

Wang J, Lunyak VV, Jordan IK.

Bioinformatics. 2013 Feb 15;29(4):492-3. doi: 10.1093/bioinformatics/bts722. Epub 2013 Jan 7.


Depletion of nuclear histone H2A variants is associated with chronic DNA damage signaling upon drug-evoked senescence of human somatic cells.

Lopez MF, Tollervey J, Krastins B, Garces A, Sarracino D, Prakash A, Vogelsang M, Geesman G, Valderrama A, Jordan IK, Lunyak VV.

Aging (Albany NY). 2012 Nov;4(11):823-42.


Chromatin signature discovery via histone modification profile alignments.

Wang J, Lunyak VV, Jordan IK.

Nucleic Acids Res. 2012 Nov;40(21):10642-56. doi: 10.1093/nar/gks848. Epub 2012 Sep 18.


Epigenetics: judge, jury and executioner of stem cell fate.

Tollervey JR, Lunyak VV.

Epigenetics. 2012 Aug;7(8):823-40. doi: 10.4161/epi.21141. Epub 2012 Jul 18. Review.


Protein interactions with piALU RNA indicates putative participation of retroRNA in the cell cycle, DNA repair and chromatin assembly.

Blackwell BJ, Lopez MF, Wang J, Krastins B, Sarracino D, Tollervey JR, Dobke M, Jordan IK, Lunyak VV.

Mob Genet Elements. 2012 Jan 1;2(1):26-35.


Do human transposable element small RNAs serve primarily as genome defenders or genome regulators?

Lee KJ, Conley AB, Lunyak VV, Jordan IK.

Mob Genet Elements. 2012 Jan 1;2(1):19-25.


On the presence and role of human gene-body DNA methylation.

Jjingo D, Conley AB, Yi SV, Lunyak VV, Jordan IK.

Oncotarget. 2012 Apr;3(4):462-74.


Adult stem cells: simply a tool for regenerative medicine or an additional piece in the puzzle of human aging?

Tollervey JR, Lunyak VV.

Cell Cycle. 2011 Dec 15;10(24):4173-6. doi: 10.4161/cc.10.24.18832. Epub 2011 Dec 15.


Genome-wide prediction and analysis of human chromatin boundary elements.

Wang J, Lunyak VV, Jordan IK.

Nucleic Acids Res. 2012 Jan;40(2):511-29. doi: 10.1093/nar/gkr750. Epub 2011 Sep 19.


Genomic relationship between SINE retrotransposons, Pol III-Pol II transcription, and chromatin organization: the journey from junk to jewel.

Lunyak VV, Atallah M.

Biochem Cell Biol. 2011 Oct;89(5):495-504. doi: 10.1139/o11-046. Epub 2011 Sep 14. Review.


Inhibition of activated pericentromeric SINE/Alu repeat transcription in senescent human adult stem cells reinstates self-renewal.

Wang J, Geesman GJ, Hostikka SL, Atallah M, Blackwell B, Lee E, Cook PJ, Pasaniuc B, Shariat G, Halperin E, Dobke M, Rosenfeld MG, Jordan IK, Lunyak VV.

Cell Cycle. 2011 Sep 1;10(17):3016-30. Epub 2011 Sep 1.


Aged worms erase epigenetic history.

Lunyak VV, Kennedy BK.

Cell Metab. 2011 Aug 3;14(2):147-8. doi: 10.1016/j.cmet.2011.07.008.


A Gibbs sampling strategy applied to the mapping of ambiguous short-sequence tags.

Wang J, Huda A, Lunyak VV, Jordan IK.

Bioinformatics. 2010 Oct 15;26(20):2501-8. doi: 10.1093/bioinformatics/btq460. Epub 2010 Sep 24.


Epigenetic regulation of stem cell fate.

Lunyak VV, Rosenfeld MG.

Hum Mol Genet. 2008 Apr 15;17(R1):R28-36. doi: 10.1093/hmg/ddn149. Review.


Boundaries. Boundaries...Boundaries???

Lunyak VV.

Curr Opin Cell Biol. 2008 Jun;20(3):281-7. doi: 10.1016/ Epub 2008 Jun 2. Review.


Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis.

Lunyak VV, Prefontaine GG, Núñez E, Cramer T, Ju BG, Ohgi KA, Hutt K, Roy R, García-Díaz A, Zhu X, Yung Y, Montoliu L, Glass CK, Rosenfeld MG.

Science. 2007 Jul 13;317(5835):248-51.


A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription.

Ju BG, Lunyak VV, Perissi V, Garcia-Bassets I, Rose DW, Glass CK, Rosenfeld MG.

Science. 2006 Jun 23;312(5781):1798-802. Erratum in: Science. 2011 May 6;332(6030):664. Science. 2014 Feb 21;343(6173):839.


No rest for REST: REST/NRSF regulation of neurogenesis.

Lunyak VV, Rosenfeld MG.

Cell. 2005 May 20;121(4):499-501. doi: 10.1016/j.cell.2005.05.003. Review.


REST and peace for the neuronal-specific transcriptional program.

Lunyak VV, Prefontaine GG, Rosenfeld MG.

Ann N Y Acad Sci. 2004 Apr;1014:110-20. Review.


Developmental changes in the Sciara II/9A initiation zone for DNA replication.

Lunyak VV, Ezrokhi M, Smith HS, Gerbi SA.

Mol Cell Biol. 2002 Dec;22(24):8426-37.


Corepressor-dependent silencing of chromosomal regions encoding neuronal genes.

Lunyak VV, Burgess R, Prefontaine GG, Nelson C, Sze SH, Chenoweth J, Schwartz P, Pevzner PA, Glass C, Mandel G, Rosenfeld MG.

Science. 2002 Nov 29;298(5599):1747-52. Epub 2002 Oct 24. Erratum in: Science. 2003 Mar 14;299(5613):1663.


An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation.

Klappacher GW, Lunyak VV, Sykes DB, Sawka-Verhelle D, Sage J, Brard G, Ngo SD, Gangadharan D, Jacks T, Kamps MP, Rose DW, Rosenfeld MG, Glass CK.

Cell. 2002 Apr 19;109(2):169-80.

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