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Items: 39


Remote Actuation of Apoptosis in Liver Cancer Cells via Magneto-Mechanical Modulation of Iron Oxide Nanoparticles.

Lunov O, Uzhytchak M, Smolková B, Lunova M, Jirsa M, Dempsey NM, Dias AL, Bonfim M, Hof M, Jurkiewicz P, Petrenko Y, Kubinová Š, Dejneka A.

Cancers (Basel). 2019 Nov 26;11(12). pii: E1873. doi: 10.3390/cancers11121873.


Light-induced modulation of the mitochondrial respiratory chain activity: possibilities and limitations.

Lunova M, Smolková B, Uzhytchak M, Janoušková KŽ, Jirsa M, Egorova D, Kulikov A, Kubinová Š, Dejneka A, Lunov O.

Cell Mol Life Sci. 2019 Oct 3. doi: 10.1007/s00018-019-03321-z. [Epub ahead of print]


Preliminary Study of Ge-DLC Nanocomposite Biomaterials Prepared by Laser Codeposition.

Jelinek M, Kocourek T, Jurek K, Jelinek M, Smolková B, Uzhytchak M, Lunov O.

Nanomaterials (Basel). 2019 Mar 18;9(3). pii: E451. doi: 10.3390/nano9030451.


Non-Thermal Plasma, as a New Physicochemical Source, to Induce Redox Imbalance and Subsequent Cell Death in Liver Cancer Cell Lines.

Smolková B, Lunova M, Lynnyk A, Uzhytchak M, Churpita O, Jirsa M, Kubinová Š, Lunov O, Dejneka A.

Cell Physiol Biochem. 2019;52(1):119-140. doi: 10.33594/000000009. Epub 2019 Feb 18.


Targeting the mTOR Signaling Pathway Utilizing Nanoparticles: A Critical Overview.

Lunova M, Smolková B, Lynnyk A, Uzhytchak M, Jirsa M, Kubinová Š, Dejneka A, Lunov O.

Cancers (Basel). 2019 Jan 11;11(1). pii: E82. doi: 10.3390/cancers11010082. Review.


A Critical Review on Selected External Physical Cues and Modulation of Cell Behavior: Magnetic Nanoparticles, Non-thermal Plasma and Lasers.

Smolková B, Uzhytchak M, Lynnyk A, Kubinová Š, Dejneka A, Lunov O.

J Funct Biomater. 2018 Dec 24;10(1). pii: E2. doi: 10.3390/jfb10010002. Review.


Manipulating the mitochondria activity in human hepatic cell line Huh7 by low-power laser irradiation.

Lynnyk A, Lunova M, Jirsa M, Egorova D, Kulikov A, Kubinová Š, Lunov O, Dejneka A.

Biomed Opt Express. 2018 Feb 21;9(3):1283-1300. doi: 10.1364/BOE.9.001283. eCollection 2018 Mar 1.


Nanoparticle core stability and surface functionalization drive the mTOR signaling pathway in hepatocellular cell lines.

Lunova M, Prokhorov A, Jirsa M, Hof M, Olżyńska A, Jurkiewicz P, Kubinová Š, Lunov O, Dejneka A.

Sci Rep. 2017 Nov 22;7(1):16049. doi: 10.1038/s41598-017-16447-6.


Extracellular Matrix Hydrogel Derived from Human Umbilical Cord as a Scaffold for Neural Tissue Repair and Its Comparison with Extracellular Matrix from Porcine Tissues.

Kočí Z, Výborný K, Dubišová J, Vacková I, Jäger A, Lunov O, Jiráková K, Kubinová Š.

Tissue Eng Part C Methods. 2017 Jun;23(6):333-345. doi: 10.1089/ten.TEC.2017.0089. Epub 2017 May 25.


Chemically different non-thermal plasmas target distinct cell death pathways.

Lunov O, Zablotskii V, Churpita O, Lunova M, Jirsa M, Dejneka A, Kubinová Š.

Sci Rep. 2017 Apr 4;7(1):600. doi: 10.1038/s41598-017-00689-5.


Non-thermal air plasma promotes the healing of acute skin wounds in rats.

Kubinova S, Zaviskova K, Uherkova L, Zablotskii V, Churpita O, Lunov O, Dejneka A.

Sci Rep. 2017 Mar 24;7:45183. doi: 10.1038/srep45183.


How a High-Gradient Magnetic Field Could Affect Cell Life.

Zablotskii V, Polyakova T, Lunov O, Dejneka A.

Sci Rep. 2016 Nov 18;6:37407. doi: 10.1038/srep37407.


Modulation of collective cell behaviour by geometrical constraints.

Lunova M, Zablotskii V, Dempsey NM, Devillers T, Jirsa M, Syková E, Kubinová Š, Lunov O, Dejneka A.

Integr Biol (Camb). 2016 Nov 7;8(11):1099-1110.


Plasma will….

Lunov O.

Br J Dermatol. 2016 Mar;174(3):486-7. doi: 10.1111/bjd.14428. No abstract available.


The interplay between biological and physical scenarios of bacterial death induced by non-thermal plasma.

Lunov O, Zablotskii V, Churpita O, Jäger A, Polívka L, Syková E, Dejneka A, Kubinová Š.

Biomaterials. 2016 Mar;82:71-83. doi: 10.1016/j.biomaterials.2015.12.027. Epub 2015 Dec 21.


An effective strategy of magnetic stem cell delivery for spinal cord injury therapy.

Tukmachev D, Lunov O, Zablotskii V, Dejneka A, Babic M, Syková E, Kubinová Š.

Nanoscale. 2015 Mar 7;7(9):3954-8. doi: 10.1039/c4nr05791k.


Cell death induced by ozone and various non-thermal plasmas: therapeutic perspectives and limitations.

Lunov O, Zablotskii V, Churpita O, Chánová E, Syková E, Dejneka A, Kubinová S.

Sci Rep. 2014 Nov 20;4:7129. doi: 10.1038/srep07129.


Gremlin-1 is an inhibitor of macrophage migration inhibitory factor and attenuates atherosclerotic plaque growth in ApoE-/- Mice.

Müller I, Schönberger T, Schneider M, Borst O, Ziegler M, Seizer P, Leder C, Müller K, Lang M, Appenzeller F, Lunov O, Büchele B, Fahrleitner M, Olbrich M, Langer H, Geisler T, Lang F, Chatterjee M, de Boer JF, Tietge UJ, Bernhagen J, Simmet T, Gawaz M.

J Biol Chem. 2013 Nov 1;288(44):31635-45. doi: 10.1074/jbc.M113.477745. Epub 2013 Sep 3.


Antiviral vaccines license T cell responses by suppressing granzyme B levels in human plasmacytoid dendritic cells.

Fabricius D, Nußbaum B, Busch D, Panitz V, Mandel B, Vollmer A, Westhoff MA, Kaltenmeier C, Lunov O, Tron K, Nienhaus GU, Jahrsdörfer B, Debatin KM.

J Immunol. 2013 Aug 1;191(3):1144-53. doi: 10.4049/jimmunol.1203479. Epub 2013 Jun 19.


WITHDRAWN: Static High-Gradient Magnetic Fields Activate Transient Receptor Potential Vanilloid 4 (TRPV4) Ion Channels Enabling Remote Control of Cell Function.

Lunov O, Zablotskii V, Syrovets T, Buechele B, Schmidt CQ, Dejneka A, Le Roy D, Dumas-Bouchiat F, Dempsey NM, Simmet T.

J Biol Chem. 2013 Jun 24. [Epub ahead of print]


Interleukin 21-induced granzyme B-expressing B cells infiltrate tumors and regulate T cells.

Lindner S, Dahlke K, Sontheimer K, Hagn M, Kaltenmeier C, Barth TF, Beyer T, Reister F, Fabricius D, Lotfi R, Lunov O, Nienhaus GU, Simmet T, Kreienberg R, Möller P, Schrezenmeier H, Jahrsdörfer B.

Cancer Res. 2013 Apr 15;73(8):2468-79. doi: 10.1158/0008-5472.CAN-12-3450. Epub 2013 Feb 5.


Truncated thioredoxin (Trx-80) promotes pro-inflammatory macrophages of the M1 phenotype and enhances atherosclerosis.

Mahmood DF, Abderrazak A, Couchie D, Lunov O, Diderot V, Syrovets T, Slimane MN, Gosselet F, Simmet T, Rouis M, El Hadri K.

J Cell Physiol. 2013 Jul;228(7):1577-83. doi: 10.1002/jcp.24319.


Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses.

Yolamanova M, Meier C, Shaytan AK, Vas V, Bertoncini CW, Arnold F, Zirafi O, Usmani SM, Müller JA, Sauter D, Goffinet C, Palesch D, Walther P, Roan NR, Geiger H, Lunov O, Simmet T, Bohne J, Schrezenmeier H, Schwarz K, Ständker L, Forssmann WG, Salvatella X, Khalatur PG, Khokhlov AR, Knowles TP, Weil T, Kirchhoff F, Münch J.

Nat Nanotechnol. 2013 Feb;8(2):130-6. doi: 10.1038/nnano.2012.248. Epub 2013 Jan 20.


A novel semisynthetic inhibitor of the FRB domain of mammalian target of rapamycin blocks proliferation and triggers apoptosis in chemoresistant prostate cancer cells.

Morad SA, Schmid M, Büchele B, Siehl HU, El Gafaary M, Lunov O, Syrovets T, Simmet T.

Mol Pharmacol. 2013 Feb;83(2):531-41. doi: 10.1124/mol.112.081349. Epub 2012 Dec 3.


Plasmin as a proinflammatory cell activator.

Syrovets T, Lunov O, Simmet T.

J Leukoc Biol. 2012 Sep;92(3):509-19. doi: 10.1189/jlb.0212056. Epub 2012 May 4. Review.


Thioredoxin-1 promotes anti-inflammatory macrophages of the M2 phenotype and antagonizes atherosclerosis.

El Hadri K, Mahmood DF, Couchie D, Jguirim-Souissi I, Genze F, Diderot V, Syrovets T, Lunov O, Simmet T, Rouis M.

Arterioscler Thromb Vasc Biol. 2012 Jun;32(6):1445-52. doi: 10.1161/ATVBAHA.112.249334. Epub 2012 Apr 19.


The bispecific SDF1-GPVI fusion protein preserves myocardial function after transient ischemia in mice.

Ziegler M, Elvers M, Baumer Y, Leder C, Ochmann C, Schönberger T, Jürgens T, Geisler T, Schlosshauer B, Lunov O, Engelhardt S, Simmet T, Gawaz M.

Circulation. 2012 Feb 7;125(5):685-96. doi: 10.1161/CIRCULATIONAHA.111.070508. Epub 2012 Jan 5.


Amino-functionalized polystyrene nanoparticles activate the NLRP3 inflammasome in human macrophages.

Lunov O, Syrovets T, Loos C, Nienhaus GU, Mailänder V, Landfester K, Rouis M, Simmet T.

ACS Nano. 2011 Dec 27;5(12):9648-57. doi: 10.1021/nn203596e. Epub 2011 Dec 8.


Human B cells differentiate into granzyme B-secreting cytotoxic B lymphocytes upon incomplete T-cell help.

Hagn M, Sontheimer K, Dahlke K, Brueggemann S, Kaltenmeier C, Beyer T, Hofmann S, Lunov O, Barth TF, Fabricius D, Tron K, Nienhaus GU, Simmet T, Schrezenmeier H, Jahrsdörfer B.

Immunol Cell Biol. 2012 Apr;90(4):457-67. doi: 10.1038/icb.2011.64. Epub 2011 Aug 2.


Differential uptake of functionalized polystyrene nanoparticles by human macrophages and a monocytic cell line.

Lunov O, Syrovets T, Loos C, Beil J, Delacher M, Tron K, Nienhaus GU, Musyanovych A, Mailänder V, Landfester K, Simmet T.

ACS Nano. 2011 Mar 22;5(3):1657-69. doi: 10.1021/nn2000756. Epub 2011 Feb 23.


Modeling receptor-mediated endocytosis of polymer-functionalized iron oxide nanoparticles by human macrophages.

Lunov O, Zablotskii V, Syrovets T, Röcker C, Tron K, Nienhaus GU, Simmet T.

Biomaterials. 2011 Jan;32(2):547-55. doi: 10.1016/j.biomaterials.2010.08.111. Epub 2010 Sep 28.


Lysosomal degradation of the carboxydextran shell of coated superparamagnetic iron oxide nanoparticles and the fate of professional phagocytes.

Lunov O, Syrovets T, Röcker C, Tron K, Nienhaus GU, Rasche V, Mailänder V, Landfester K, Simmet T.

Biomaterials. 2010 Dec;31(34):9015-22. doi: 10.1016/j.biomaterials.2010.08.003. Epub 2010 Aug 23.


CD5+ B cells from individuals with systemic lupus erythematosus express granzyme B.

Hagn M, Ebel V, Sontheimer K, Schwesinger E, Lunov O, Beyer T, Fabricius D, Barth TF, Viardot A, Stilgenbauer S, Hepp J, Scharffetter-Kochanek K, Simmet T, Jahrsdörfer B.

Eur J Immunol. 2010 Jul;40(7):2060-9. doi: 10.1002/eji.200940113.


The effect of carboxydextran-coated superparamagnetic iron oxide nanoparticles on c-Jun N-terminal kinase-mediated apoptosis in human macrophages.

Lunov O, Syrovets T, Büchele B, Jiang X, Röcker C, Tron K, Nienhaus GU, Walther P, Mailänder V, Landfester K, Simmet T.

Biomaterials. 2010 Jul;31(19):5063-71. doi: 10.1016/j.biomaterials.2010.03.023. Epub 2010 Apr 9.


Model for hyperthermia with arrays of magnetic nanoparticles: spatial and time temperature distributions in tumor.

Zablotskii V, Lunov O, Gómez-Polo C.

J Nanosci Nanotechnol. 2010 Feb;10(2):690-5.


Surface plasmon resonance analysis of nuclear factor-kappaB protein interactions with the sesquiterpene lactone helenalin.

Büchele B, Zugmaier W, Lunov O, Syrovets T, Merfort I, Simmet T.

Anal Biochem. 2010 Jun 1;401(1):30-7. doi: 10.1016/j.ab.2010.02.020. Epub 2010 Feb 20.


Tirucallic acids are novel pleckstrin homology domain-dependent Akt inhibitors inducing apoptosis in prostate cancer cells.

Estrada AC, Syrovets T, Pitterle K, Lunov O, Büchele B, Schimana-Pfeifer J, Schmidt T, Morad SA, Simmet T.

Mol Pharmacol. 2010 Mar;77(3):378-87. doi: 10.1124/mol.109.060475. Epub 2009 Dec 16.


Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion.

Jahrsdörfer B, Vollmer A, Blackwell SE, Maier J, Sontheimer K, Beyer T, Mandel B, Lunov O, Tron K, Nienhaus GU, Simmet T, Debatin KM, Weiner GJ, Fabricius D.

Blood. 2010 Feb 11;115(6):1156-65. doi: 10.1182/blood-2009-07-235382. Epub 2009 Dec 3.


Targeting NF-kappa B with a natural triterpenoid alleviates skin inflammation in a mouse model of psoriasis.

Wang H, Syrovets T, Kess D, Büchele B, Hainzl H, Lunov O, Weiss JM, Scharffetter-Kochanek K, Simmet T.

J Immunol. 2009 Oct 1;183(7):4755-63. doi: 10.4049/jimmunol.0900521. Epub 2009 Sep 14.

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