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Items: 1 to 50 of 53

1.

Neuroepigenetics of Aging and Age-Related Neurodegenerative Disorders.

Lardenoije R, Pishva E, Lunnon K, van den Hove DL.

Prog Mol Biol Transl Sci. 2018;158:49-82. doi: 10.1016/bs.pmbts.2018.04.008. Epub 2018 Jun 5.

PMID:
30072060
2.

Which Risk Factors Causally Influence Dementia? A Systematic Review of Mendelian Randomization Studies.

Kuźma E, Hannon E, Zhou A, Lourida I, Bethel A, Levine DA, Lunnon K, Thompson-Coon J, Hyppönen E, Llewellyn DJ.

J Alzheimers Dis. 2018;64(1):181-193. doi: 10.3233/JAD-180013.

3.

Peripheral DNA methylation, cognitive decline and brain aging: pilot findings from the Whitehall II imaging study.

Chouliaras L, Pishva E, Haapakoski R, Zsoldos E, Mahmood A, Filippini N, Burrage J, Mill J, Kivimäki M, Lunnon K, Ebmeier KP.

Epigenomics. 2018 May;10(5):585-595. doi: 10.2217/epi-2017-0132. Epub 2018 Apr 25.

4.

Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology.

Smith RG, Hannon E, De Jager PL, Chibnik L, Lott SJ, Condliffe D, Smith AR, Haroutunian V, Troakes C, Al-Sarraj S, Bennett DA, Powell J, Lovestone S, Schalkwyk L, Mill J, Lunnon K.

Alzheimers Dement. 2018 Mar 14. pii: S1552-5260(18)30049-9. doi: 10.1016/j.jalz.2018.01.017. [Epub ahead of print]

5.

Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3.

Sassi C, Nalls MA, Ridge PG, Gibbs JR, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Lord J, Turton J, Bras J; ARUK Consortium, Blumenau S, Thielke M, Josties C, Freyer D, Dietrich A, Hammer M, Baier M, Dirnagl U, Morgan K, Powell JF, Kauwe JS, Cruchaga C, Goate AM, Singleton AB, Guerreiro R, Hodges A, Hardy J.

Neurobiol Aging. 2018 Jun;66:179.e17-179.e29. doi: 10.1016/j.neurobiolaging.2018.01.015. Epub 2018 Feb 2.

6.

Correction: ANK1 is up-regulated in laser captured microglia in Alzheimer's brain; the importance of addressing cellular heterogeneity.

Mastroeni D, Sekar S, Nolz J, Delvaux E, Lunnon K, Mill J, Liang WS, Coleman PD.

PLoS One. 2018 Jan 11;13(1):e0191382. doi: 10.1371/journal.pone.0191382. eCollection 2018.

7.

Using induced pluripotent stem cells to explore genetic and epigenetic variation associated with Alzheimer's disease.

Imm J, Kerrigan TL, Jeffries A, Lunnon K.

Epigenomics. 2017 Nov;9(11):1455-1468. doi: 10.2217/epi-2017-0076. Epub 2017 Oct 3. Review.

PMID:
28969469
8.

Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases.

Roubroeks JAY, Smith RG, van den Hove DLA, Lunnon K.

J Neurochem. 2017 Oct;143(2):158-170. doi: 10.1111/jnc.14148. Epub 2017 Sep 21. Review.

9.

ANK1 is up-regulated in laser captured microglia in Alzheimer's brain; the importance of addressing cellular heterogeneity.

Mastroeni D, Sekar S, Nolz J, Delvaux E, Lunnon K, Mill J, Liang WS, Coleman PD.

PLoS One. 2017 Jul 12;12(7):e0177814. doi: 10.1371/journal.pone.0177814. eCollection 2017. Erratum in: PLoS One. 2018 Jan 11;13(1):e0191382.

10.

Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder.

Rutten BPF, Vermetten E, Vinkers CH, Ursini G, Daskalakis NP, Pishva E, de Nijs L, Houtepen LC, Eijssen L, Jaffe AE, Kenis G, Viechtbauer W, van den Hove D, Schraut KG, Lesch KP, Kleinman JE, Hyde TM, Weinberger DR, Schalkwyk L, Lunnon K, Mill J, Cohen H, Yehuda R, Baker DG, Maihofer AX, Nievergelt CM, Geuze E, Boks MPM.

Mol Psychiatry. 2018 May;23(5):1145-1156. doi: 10.1038/mp.2017.120. Epub 2017 Jun 20.

11.

DNA Modifications and Alzheimer's Disease.

Smith RG, Lunnon K.

Adv Exp Med Biol. 2017;978:303-319. doi: 10.1007/978-3-319-53889-1_16. Review.

PMID:
28523553
12.

Genetic architecture of epigenetic and neuronal ageing rates in human brain regions.

Lu AT, Hannon E, Levine ME, Crimmins EM, Lunnon K, Mill J, Geschwind DH, Horvath S.

Nat Commun. 2017 May 18;8:15353. doi: 10.1038/ncomms15353.

13.

Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue.

Devall M, Smith RG, Jeffries A, Hannon E, Davies MN, Schalkwyk L, Mill J, Weedon M, Lunnon K.

Clin Epigenetics. 2017 May 3;9:47. doi: 10.1186/s13148-017-0337-3. eCollection 2017.

14.

Mitochondrial genes are altered in blood early in Alzheimer's disease.

Lunnon K, Keohane A, Pidsley R, Newhouse S, Riddoch-Contreras J, Thubron EB, Devall M, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Schalkwyk L, Dobson R, Malik AN, Powell J, Lovestone S, Hodges A; AddNeuroMed Consortium.

Neurobiol Aging. 2017 May;53:36-47. doi: 10.1016/j.neurobiolaging.2016.12.029. Epub 2017 Jan 7.

15.

Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain.

Smith AR, Smith RG, Condliffe D, Hannon E, Schalkwyk L, Mill J, Lunnon K.

Neurobiol Aging. 2016 Nov;47:35-40. doi: 10.1016/j.neurobiolaging.2016.07.008. Epub 2016 Jul 16.

16.

Epigenetic dysregulation of brainstem nuclei in the pathogenesis of Alzheimer's disease: looking in the correct place at the right time?

Iatrou A, Kenis G, Rutten BP, Lunnon K, van den Hove DL.

Cell Mol Life Sci. 2017 Feb;74(3):509-523. doi: 10.1007/s00018-016-2361-4. Epub 2016 Sep 14. Review.

17.

Erratum to: Variation in 5-hydroxymethylcytosine across human cortex and cerebellum.

Lunnon K, Hannon E, G Smith R, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, Mill J.

Genome Biol. 2016 Jun 17;17(1):131. No abstract available.

18.

ABCA7 p.G215S as potential protective factor for Alzheimer's disease.

Sassi C, Nalls MA, Ridge PG, Gibbs JR, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Clement N, Lord J, Turton J, Bras J, Almeida MR; ARUK Consortium, Holstege H, Louwersheimer E, van der Flier WM, Scheltens P, Van Swieten JC, Santana I, Oliveira C, Morgan K, Powell JF, Kauwe JS, Cruchaga C, Goate AM, Singleton AB, Guerreiro R, Hardy J.

Neurobiol Aging. 2016 Oct;46:235.e1-9. doi: 10.1016/j.neurobiolaging.2016.04.004. Epub 2016 Apr 20.

19.

Influence of Coding Variability in APP-Aβ Metabolism Genes in Sporadic Alzheimer's Disease.

Sassi C, Ridge PG, Nalls MA, Gibbs R, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Lord J, Turton J; ARUK Consortium, Morgan K, Powell JF, Kauwe JS, Cruchaga C, Bras J, Goate AM, Singleton AB, Guerreiro R, Hardy J.

PLoS One. 2016 Jun 1;11(6):e0150079. doi: 10.1371/journal.pone.0150079. eCollection 2016.

20.

Variation in 5-hydroxymethylcytosine across human cortex and cerebellum.

Lunnon K, Hannon E, Smith RG, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, Mill J.

Genome Biol. 2016 Feb 16;17:27. doi: 10.1186/s13059-016-0871-x. Erratum in: Genome Biol. 2016;17(1):131.

21.

Epigenetic regulation of mitochondrial function in neurodegenerative disease: New insights from advances in genomic technologies.

Devall M, Roubroeks J, Mill J, Weedon M, Lunnon K.

Neurosci Lett. 2016 Jun 20;625:47-55. doi: 10.1016/j.neulet.2016.02.013. Epub 2016 Feb 10. Review.

22.

Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum.

Lu AT, Hannon E, Levine ME, Hao K, Crimmins EM, Lunnon K, Kozlenkov A, Mill J, Dracheva S, Horvath S.

Nat Commun. 2016 Feb 2;7:10561. doi: 10.1038/ncomms10561.

23.

Tissue-specific patterns of allelically-skewed DNA methylation.

Marzi SJ, Meaburn EL, Dempster EL, Lunnon K, Paya-Cano JL, Smith RG, Volta M, Troakes C, Schalkwyk LC, Mill J.

Epigenetics. 2016;11(1):24-35. doi: 10.1080/15592294.2015.1127479. Epub 2016 Jan 19.

24.

Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases.

Guerreiro R, Escott-Price V, Darwent L, Parkkinen L, Ansorge O, Hernandez DG, Nalls MA, Clark L, Honig L, Marder K, van der Flier W, Holstege H, Louwersheimer E, Lemstra A, Scheltens P, Rogaeva E, St George-Hyslop P, Londos E, Zetterberg H, Ortega-Cubero S, Pastor P, Ferman TJ, Graff-Radford NR, Ross OA, Barber I, Braae A, Brown K, Morgan K, Maetzler W, Berg D, Troakes C, Al-Sarraj S, Lashley T, Compta Y, Revesz T, Lees A, Cairns NJ, Halliday GM, Mann D, Pickering-Brown S, Powell J, Lunnon K, Lupton MK; International Parkinson's Disease Genomics Consortium (IPDGC), Dickson D, Hardy J, Singleton A, Bras J.

Neurobiol Aging. 2016 Feb;38:214.e7-214.e10. doi: 10.1016/j.neurobiolaging.2015.10.028. Epub 2015 Nov 2.

25.

A Pathway Based Classification Method for Analyzing Gene Expression for Alzheimer's Disease Diagnosis.

Voyle N, Keohane A, Newhouse S, Lunnon K, Johnston C, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Hodges A, Kiddle S, Dobson RJ.

J Alzheimers Dis. 2016;49(3):659-69. doi: 10.3233/JAD-150440.

26.

A comparison of mitochondrial DNA isolation methods in frozen post-mortem human brain tissue--applications for studies of mitochondrial genetics in brain disorders.

Devall M, Burrage J, Caswell R, Johnson M, Troakes C, Al-Sarraj S, Jeffries AR, Mill J, Lunnon K.

Biotechniques. 2015 Oct 1;59(4):241-2, 244-6. doi: 10.2144/000114343. eCollection 2015 Oct.

27.
28.

No Evidence to Suggest that the Use of Acetylcholinesterase Inhibitors Confounds the Results of Two Blood-Based Biomarker Studies in Alzheimer's Disease.

Chiam JT, Lunnon K, Voyle N, Proitsi P, Coppola G, Geschwind D, Nelson S, Johnston C, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Hodges A, Lovestone S, Newhouse S, Dobson RJ, Kiddle SJ, Sattlecker M.

J Alzheimers Dis. 2015;47(3):741-50. doi: 10.3233/JAD-150289.

PMID:
26401708
29.

A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status.

Sood S, Gallagher IJ, Lunnon K, Rullman E, Keohane A, Crossland H, Phillips BE, Cederholm T, Jensen T, van Loon LJ, Lannfelt L, Kraus WE, Atherton PJ, Howard R, Gustafsson T, Hodges A, Timmons JA.

Genome Biol. 2015 Sep 7;16:185. doi: 10.1186/s13059-015-0750-x.

30.

Blood methylomic signatures of presymptomatic dementia in elderly subjects with type 2 diabetes mellitus.

Lunnon K, Smith RG, Cooper I, Greenbaum L, Mill J, Beeri MS.

Neurobiol Aging. 2015 Mar;36(3):1600.e1-4. doi: 10.1016/j.neurobiolaging.2014.12.023. Epub 2014 Dec 24.

31.

The mitochondrial epigenome: a role in Alzheimer's disease?

Devall M, Mill J, Lunnon K.

Epigenomics. 2014;6(6):665-75. doi: 10.2217/epi.14.50. Review.

32.

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease.

Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, Condliffe D, Harries LW, Katsel P, Haroutunian V, Kaminsky Z, Joachim C, Powell J, Lovestone S, Bennett DA, Schalkwyk LC, Mill J.

Nat Neurosci. 2014 Sep;17(9):1164-70. doi: 10.1038/nn.3782. Epub 2014 Aug 17.

33.

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.

De Jager PL, Srivastava G, Lunnon K, Burgess J, Schalkwyk LC, Yu L, Eaton ML, Keenan BT, Ernst J, McCabe C, Tang A, Raj T, Replogle J, Brodeur W, Gabriel S, Chai HS, Younkin C, Younkin SG, Zou F, Szyf M, Epstein CB, Schneider JA, Bernstein BE, Meissner A, Ertekin-Taner N, Chibnik LB, Kellis M, Mill J, Bennett DA.

Nat Neurosci. 2014 Sep;17(9):1156-63. doi: 10.1038/nn.3786. Epub 2014 Aug 17.

34.

Plasma proteins predict conversion to dementia from prodromal disease.

Hye A, Riddoch-Contreras J, Baird AL, Ashton NJ, Bazenet C, Leung R, Westman E, Simmons A, Dobson R, Sattlecker M, Lupton M, Lunnon K, Keohane A, Ward M, Pike I, Zucht HD, Pepin D, Zheng W, Tunnicliffe A, Richardson J, Gauthier S, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S.

Alzheimers Dement. 2014 Nov;10(6):799-807.e2. doi: 10.1016/j.jalz.2014.05.1749. Epub 2014 Jul 8.

35.

Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease.

Fitzsimons CP, van Bodegraven E, Schouten M, Lardenoije R, Kompotis K, Kenis G, van den Hurk M, Boks MP, Biojone C, Joca S, Steinbusch HW, Lunnon K, Mastroeni DF, Mill J, Lucassen PJ, Coleman PD, van den Hove DL, Rutten BP.

Mol Neurodegener. 2014 Jun 25;9:25. doi: 10.1186/1750-1326-9-25. Review.

36.

Exome sequencing identifies 2 novel presenilin 1 mutations (p.L166V and p.S230R) in British early-onset Alzheimer's disease.

Sassi C, Guerreiro R, Gibbs R, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Lord J, Turton J, Mann D, Snowden J, Neary D, Harris J, Bras J; ARUK Consortium, Morgan K, Powell JF, Singleton A, Hardy J.

Neurobiol Aging. 2014 Oct;35(10):2422.e13-6. doi: 10.1016/j.neurobiolaging.2014.04.026. Epub 2014 May 2.

37.

Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain.

Condliffe D, Wong A, Troakes C, Proitsi P, Patel Y, Chouliaras L, Fernandes C, Cooper J, Lovestone S, Schalkwyk L, Mill J, Lunnon K.

Neurobiol Aging. 2014 Aug;35(8):1850-4. doi: 10.1016/j.neurobiolaging.2014.02.002. Epub 2014 Feb 6.

38.

Alzheimer's disease susceptibility variants in the MS4A6A gene are associated with altered levels of MS4A6A expression in blood.

Proitsi P, Lee SH, Lunnon K, Keohane A, Powell J, Troakes C, Al-Sarraj S, Furney S, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Hodges A; AddNeuroMed Consortium.

Neurobiol Aging. 2014 Feb;35(2):279-90. doi: 10.1016/j.neurobiolaging.2013.08.002. Epub 2013 Sep 21.

PMID:
24064185
39.

Epigenetic studies in Alzheimer's disease: current findings, caveats, and considerations for future studies.

Lunnon K, Mill J.

Am J Med Genet B Neuropsychiatr Genet. 2013 Dec;162B(8):789-99. doi: 10.1002/ajmg.b.32201. Epub 2013 Sep 13. Review.

40.

Inflammatory proteins in plasma are associated with severity of Alzheimer's disease.

Leung R, Proitsi P, Simmons A, Lunnon K, Güntert A, Kronenberg D, Pritchard M, Tsolaki M, Mecocci P, Kloszewska I, Vellas B, Soininen H, Wahlund LO, Lovestone S.

PLoS One. 2013 Jun 10;8(6):e64971. doi: 10.1371/journal.pone.0064971. Print 2013.

41.

A data-driven approach to preprocessing Illumina 450K methylation array data.

Pidsley R, Y Wong CC, Volta M, Lunnon K, Mill J, Schalkwyk LC.

BMC Genomics. 2013 May 1;14:293. doi: 10.1186/1471-2164-14-293.

42.

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway.

Killick R, Ribe EM, Al-Shawi R, Malik B, Hooper C, Fernandes C, Dobson R, Nolan PM, Lourdusamy A, Furney S, Lin K, Breen G, Wroe R, To AW, Leroy K, Causevic M, Usardi A, Robinson M, Noble W, Williamson R, Lunnon K, Kellie S, Reynolds CH, Bazenet C, Hodges A, Brion JP, Stephenson J, Simons JP, Lovestone S.

Mol Psychiatry. 2014 Jan;19(1):88-98. doi: 10.1038/mp.2012.163. Epub 2012 Nov 20.

43.

A blood gene expression marker of early Alzheimer's disease.

Lunnon K, Sattlecker M, Furney SJ, Coppola G, Simmons A, Proitsi P, Lupton MK, Lourdusamy A, Johnston C, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Geschwind D, Lovestone S, Dobson R, Hodges A; dNeuroMed Consortium.

J Alzheimers Dis. 2013;33(3):737-53. doi: 10.3233/JAD-2012-121363.

PMID:
23042217
44.

Plasma based markers of [11C] PiB-PET brain amyloid burden.

Kiddle SJ, Thambisetty M, Simmons A, Riddoch-Contreras J, Hye A, Westman E, Pike I, Ward M, Johnston C, Lupton MK, Lunnon K, Soininen H, Kloszewska I, Tsolaki M, Vellas B, Mecocci P, Lovestone S, Newhouse S, Dobson R; Alzheimers Disease Neuroimaging Initiative.

PLoS One. 2012;7(9):e44260. doi: 10.1371/journal.pone.0044260. Epub 2012 Sep 24.

45.

Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood.

Davies MN, Volta M, Pidsley R, Lunnon K, Dixit A, Lovestone S, Coarfa C, Harris RA, Milosavljevic A, Troakes C, Al-Sarraj S, Dobson R, Schalkwyk LC, Mill J.

Genome Biol. 2012 Jun 15;13(6):R43. doi: 10.1186/gb-2012-13-6-r43.

46.

Identification of cis-regulatory variation influencing protein abundance levels in human plasma.

Lourdusamy A, Newhouse S, Lunnon K, Proitsi P, Powell J, Hodges A, Nelson SK, Stewart A, Williams S, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Lovestone S; AddNeuroMed Consortium, Dobson R; Alzheimer's Disease Neuroimaging Initiative.

Hum Mol Genet. 2012 Aug 15;21(16):3719-26. Epub 2012 May 16.

PMID:
22595970
47.

Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's disease blood.

Lunnon K, Ibrahim Z, Proitsi P, Lourdusamy A, Newhouse S, Sattlecker M, Furney S, Saleem M, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Coppola G, Geschwind D, Simmons A, Lovestone S, Dobson R, Hodges A; AddNeuroMed Consortium.

J Alzheimers Dis. 2012;30(3):685-710. doi: 10.3233/JAD-2012-111592.

PMID:
22466004
48.

Systemic inflammation modulates Fc receptor expression on microglia during chronic neurodegeneration.

Lunnon K, Teeling JL, Tutt AL, Cragg MS, Glennie MJ, Perry VH.

J Immunol. 2011 Jun 15;186(12):7215-24. doi: 10.4049/jimmunol.0903833. Epub 2011 May 13.

49.

Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.

Furney SJ, Simmons A, Breen G, Pedroso I, Lunnon K, Proitsi P, Hodges A, Powell J, Wahlund LO, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Spenger C, Lathrop M, Shen L, Kim S, Saykin AJ, Weiner MW, Lovestone S; Alzheimer’s Disease Neuroimaging Initiative; AddNeuroMed Consortium.

Mol Psychiatry. 2011 Nov;16(11):1130-8. doi: 10.1038/mp.2010.123. Epub 2010 Nov 30.

50.

Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease.

Thambisetty M, Simmons A, Velayudhan L, Hye A, Campbell J, Zhang Y, Wahlund LO, Westman E, Kinsey A, Güntert A, Proitsi P, Powell J, Causevic M, Killick R, Lunnon K, Lynham S, Broadstock M, Choudhry F, Howlett DR, Williams RJ, Sharp SI, Mitchelmore C, Tunnard C, Leung R, Foy C, O'Brien D, Breen G, Furney SJ, Ward M, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Hodges A, Murphy DG, Parkins S, Richardson JC, Resnick SM, Ferrucci L, Wong DF, Zhou Y, Muehlboeck S, Evans A, Francis PT, Spenger C, Lovestone S.

Arch Gen Psychiatry. 2010 Jul;67(7):739-48. doi: 10.1001/archgenpsychiatry.2010.78.

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