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Functional contribution of sphingosine-1-phosphate to airway pathology in cigarette smoke-exposed mice.

De Cunto G, Brancaleone V, Riemma MA, Cerqua I, Vellecco V, Spaziano G, Cavarra E, Bartalesi B, D'Agostino B, Lungarella G, Cirino G, Lucattelli M, Roviezzo F.

Br J Pharmacol. 2020 Jan;177(2):267-281. doi: 10.1111/bph.14861. Epub 2019 Nov 6.


Ongoing Lung Inflammation and Disease Progression in Mice after Smoking Cessation: Beneficial Effects of Formyl-Peptide Receptor Blockade.

De Cunto G, Bartalesi B, Cavarra E, Balzano E, Lungarella G, Lucattelli M.

Am J Pathol. 2018 Oct;188(10):2195-2206. doi: 10.1016/j.ajpath.2018.06.010. Epub 2018 Jul 20.


Middermal Elastolysis: Dermal Fibroblasts Cooperate with Inflammatory Cells to the Elastolytic Disorder.

De Cunto G, Lamberti A, de Santi MM, Miracco C, Fimiani M, Lungarella G, Cavarra E.

Mediators Inflamm. 2017;2017:9524594. doi: 10.1155/2017/9524594. Epub 2017 Sep 17.


P2Y6 Receptor Activation Promotes Inflammation and Tissue Remodeling in Pulmonary Fibrosis.

Müller T, Fay S, Vieira RP, Karmouty-Quintana H, Cicko S, Ayata CK, Zissel G, Goldmann T, Lungarella G, Ferrari D, Di Virgilio F, Robaye B, Boeynaems JM, Lazarowski ER, Blackburn MR, Idzko M.

Front Immunol. 2017 Aug 22;8:1028. doi: 10.3389/fimmu.2017.01028. eCollection 2017.


Vulnerability and Genetic Susceptibility to Cigarette Smoke-Induced Emphysema in Mice.

Rahman I, De Cunto G, Sundar IK, Lungarella G.

Am J Respir Cell Mol Biol. 2017 Sep;57(3):270-271. doi: 10.1165/rcmb.2017-0175ED. No abstract available.


The purinergic receptor subtype P2Y2 mediates chemotaxis of neutrophils and fibroblasts in fibrotic lung disease.

Müller T, Fay S, Vieira RP, Karmouty-Quintana H, Cicko S, Ayata K, Zissel G, Goldmann T, Lungarella G, Ferrari D, Di Virgilio F, Robaye B, Boeynaems JM, Blackburn MR, Idzko M.

Oncotarget. 2017 May 30;8(22):35962-35972. doi: 10.18632/oncotarget.16414.


Proteinase activated receptor-2 counterbalances the vascular effects of endothelin-1 in fibrotic tight-skin mice.

Roviezzo F, Brancaleone V, Mattera Iacono V, Bertolino A, De Cunto G, Vellecco V, Lungarella G, Lucattelli M, Cirino G.

Br J Pharmacol. 2017 Nov;174(22):4032-4042. doi: 10.1111/bph.13618. Epub 2016 Oct 5.


Chairs' Comments.

Wanner A, Lungarella G.

Ann Am Thorac Soc. 2016 Aug;13 Suppl 4:S279. doi: 10.1513/AnnalsATS.201602-092KV. No abstract available.


Severe Reduction in Number and Function of Peripheral T Cells Does Not Afford Protection toward Emphysema and Bronchial Remodeling Induced in Mice by Cigarette Smoke.

De Cunto G, Lunghi B, Bartalesi B, Cavarra E, Fineschi S, Ulivieri C, Lungarella G, Lucattelli M.

Am J Pathol. 2016 Jul;186(7):1814-1824. doi: 10.1016/j.ajpath.2016.03.002. Epub 2016 May 6.


Ajulemic acid exerts potent anti-fibrotic effect during the fibrogenic phase of bleomycin lung.

Lucattelli M, Fineschi S, Selvi E, Garcia Gonzalez E, Bartalesi B, De Cunto G, Lorenzini S, Galeazzi M, Lungarella G.

Respir Res. 2016 May 6;17(1):49. doi: 10.1186/s12931-016-0373-0.


Histopathological data of iron and calcium in the mouse lung after asbestos exposure.

Trevisan E, Zabucchi G, Pascolo L, Pascotto E, Casarsa C, Lucattelli M, Lungarella G, Cavarra E, Bartalesi B, Zweyer M, Borelli V.

Data Brief. 2016 Jan 21;6:769-75. doi: 10.1016/j.dib.2016.01.026. eCollection 2016 Mar.


Synchrotron X-ray microscopy reveals early calcium and iron interaction with crocidolite fibers in the lung of exposed mice.

Pascolo L, Zabucchi G, Gianoncelli A, Kourousias G, Trevisan E, Pascotto E, Casarsa C, Ryan C, Lucattelli M, Lungarella G, Cavarra E, Bartalesi B, Zweyer M, Cammisuli F, Melato M, Borelli V.

Toxicol Lett. 2016 Jan 22;241:111-20. doi: 10.1016/j.toxlet.2015.11.016. Epub 2015 Nov 18.


NTPDase1/CD39 and aberrant purinergic signalling in the pathogenesis of COPD.

Lazar Z, Müllner N, Lucattelli M, Ayata CK, Cicko S, Yegutkin GG, De Cunto G, Müller T, Meyer A, Hossfeld M, Sorichter S, Horvath I, Virchow CJ, Robson SC, Lungarella G, Idzko M.

Eur Respir J. 2016 Jan;47(1):254-63. doi: 10.1183/13993003.02144-2014. Epub 2015 Nov 5.


Genetic Deletion and Pharmacological Inhibition of PI3K γ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease.

Galluzzo M, Ciraolo E, Lucattelli M, Hoxha E, Ulrich M, Campa CC, Lungarella G, Doring G, Zhou-Suckow Z, Mall M, Hirsch E, De Rose V.

Mediators Inflamm. 2015;2015:545417. doi: 10.1155/2015/545417. Epub 2015 Jun 21.


Smoking p66Shc knocked out mice develop respiratory bronchiolitis with fibrosis but not emphysema.

Lunghi B, De Cunto G, Cavarra E, Fineschi S, Bartalesi B, Lungarella G, Lucattelli M.

PLoS One. 2015 Mar 19;10(3):e0119797. doi: 10.1371/journal.pone.0119797. eCollection 2015.


Receptor for advanced glycation end products contributes to postnatal pulmonary development and adult lung maintenance program in mice.

Fineschi S, De Cunto G, Facchinetti F, Civelli M, Imbimbo BP, Carnini C, Villetti G, Lunghi B, Stochino S, Gibbons DL, Hayday A, Lungarella G, Cavarra E.

Am J Respir Cell Mol Biol. 2013 Feb;48(2):164-71. doi: 10.1165/rcmb.2012-0111OC. Epub 2012 Nov 9.


Skeletal muscle oxidative metabolism in an animal model of pulmonary emphysema: formoterol and skeletal muscle dysfunction.

Sullo N, Roviezzo F, Matteis M, Spaziano G, Del Gaudio S, Lombardi A, Lucattelli M, Polverino F, Lungarella G, Cirino G, Rossi F, D'Agostino B.

Am J Respir Cell Mol Biol. 2013 Feb;48(2):198-203. doi: 10.1165/rcmb.2012-0167OC. Epub 2012 Nov 9.


Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR(2) ) is involved in vascular function.

Bucci M, Vellecco V, Harrington L, Brancaleone V, Roviezzo F, Mattace Raso G, Ianaro A, Lungarella G, De Palma R, Meli R, Cirino G.

Br J Pharmacol. 2013 Jan;168(2):411-20. doi: 10.1111/j.1476-5381.2012.02205.x.


Genetic ablation of the fpr1 gene confers protection from smoking-induced lung emphysema in mice.

Cardini S, Dalli J, Fineschi S, Perretti M, Lungarella G, Lucattelli M.

Am J Respir Cell Mol Biol. 2012 Sep;47(3):332-9. doi: 10.1165/rcmb.2012-0036OC. Epub 2012 Mar 29.


Pulmonary hypertension in smoking mice over-expressing protease-activated receptor-2.

De Cunto G, Cardini S, Cirino G, Geppetti P, Lungarella G, Lucattelli M.

Eur Respir J. 2011 Apr;37(4):823-34. doi: 10.1183/09031936.00060210. Epub 2010 Aug 6.


Purinergic receptor inhibition prevents the development of smoke-induced lung injury and emphysema.

Cicko S, Lucattelli M, Müller T, Lommatzsch M, De Cunto G, Cardini S, Sundas W, Grimm M, Zeiser R, Dürk T, Zissel G, Boeynaems JM, Sorichter S, Ferrari D, Di Virgilio F, Virchow JC, Lungarella G, Idzko M.

J Immunol. 2010 Jul 1;185(1):688-97. doi: 10.4049/jimmunol.0904042. Epub 2010 Jun 2.


P2X7 receptor signaling in the pathogenesis of smoke-induced lung inflammation and emphysema.

Lucattelli M, Cicko S, Müller T, Lommatzsch M, De Cunto G, Cardini S, Sundas W, Grimm M, Zeiser R, Dürk T, Zissel G, Sorichter S, Ferrari D, Di Virgilio F, Virchow JC, Lungarella G, Idzko M.

Am J Respir Cell Mol Biol. 2011 Mar;44(3):423-9. doi: 10.1165/rcmb.2010-0038OC. Epub 2010 May 27.


The preclinical pharmacology of roflumilast--a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease.

Hatzelmann A, Morcillo EJ, Lungarella G, Adnot S, Sanjar S, Beume R, Schudt C, Tenor H.

Pulm Pharmacol Ther. 2010 Aug;23(4):235-56. doi: 10.1016/j.pupt.2010.03.011. Epub 2010 Apr 7. Review.


Extracellular adenosine triphosphate and chronic obstructive pulmonary disease.

Lommatzsch M, Cicko S, Müller T, Lucattelli M, Bratke K, Stoll P, Grimm M, Dürk T, Zissel G, Ferrari D, Di Virgilio F, Sorichter S, Lungarella G, Virchow JC, Idzko M.

Am J Respir Crit Care Med. 2010 May 1;181(9):928-34. doi: 10.1164/rccm.200910-1506OC. Epub 2010 Jan 21.


Systemic inhibition of NF-kappaB activation protects from silicosis.

Di Giuseppe M, Gambelli F, Hoyle GW, Lungarella G, Studer SM, Richards T, Yousem S, McCurry K, Dauber J, Kaminski N, Leikauf G, Ortiz LA.

PLoS One. 2009 May 25;4(5):e5689. doi: 10.1371/journal.pone.0005689.


Differential thiol status in blood of different mouse strains exposed to cigarette smoke.

Rossi R, Giustarini D, Fineschi S, De Cunto G, Lungarella G, Cavarra E.

Free Radic Res. 2009 Jun;43(6):538-45. doi: 10.1080/10715760902893332.


Absence of proteinase-activated receptor-1 signaling in mice confers protection from fMLP-induced goblet cell metaplasia.

Atzori L, Lucattelli M, Scotton CJ, Laurent GJ, Bartalesi B, De Cunto G, Lunghi B, Chambers RC, Lungarella G.

Am J Respir Cell Mol Biol. 2009 Dec;41(6):680-7. doi: 10.1165/rcmb.2007-0386OC. Epub 2009 Mar 23.


Early response of gene clusters is associated with mouse lung resistance or sensitivity to cigarette smoke.

Cavarra E, Fardin P, Fineschi S, Ricciardi A, De Cunto G, Sallustio F, Zorzetto M, Luisetti M, Pfeffer U, Lungarella G, Varesio L.

Am J Physiol Lung Cell Mol Physiol. 2009 Mar;296(3):L418-29. doi: 10.1152/ajplung.90382.2008. Epub 2008 Dec 31.


Effect of roflumilast on inflammatory cells in the lungs of cigarette smoke-exposed mice.

Martorana PA, Lunghi B, Lucattelli M, De Cunto G, Beume R, Lungarella G.

BMC Pulm Med. 2008 Aug 28;8:17. doi: 10.1186/1471-2466-8-17.


A new mouse model of Peyronie's disease: an increased expression of hypoxia-inducible factor-1 target genes during the development of penile changes.

Lucattelli M, Lunghi B, Fineschi S, Mirone V, d'Emmanuele di Villa Bianca R, Longo N, Imbimbo C, De Palma R, Sorrentino R, Lungarella G, Cirino G.

Int J Biochem Cell Biol. 2008;40(11):2638-48. doi: 10.1016/j.biocel.2008.05.012. Epub 2008 May 28.


Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramide.

Petrache I, Medler TR, Richter AT, Kamocki K, Chukwueke U, Zhen L, Gu Y, Adamowicz J, Schweitzer KS, Hubbard WC, Berdyshev EV, Lungarella G, Tuder RM.

Am J Physiol Lung Cell Mol Physiol. 2008 Jul;295(1):L44-53. doi: 10.1152/ajplung.00448.2007. Epub 2008 Apr 25.


The dual role of neutrophil elastase in lung destruction and repair.

Lungarella G, Cavarra E, Lucattelli M, Martorana PA.

Int J Biochem Cell Biol. 2008;40(6-7):1287-96. doi: 10.1016/j.biocel.2007.12.008. Epub 2007 Dec 24. Review.


Neutrophils activate macrophages for intracellular killing of Leishmania major through recruitment of TLR4 by neutrophil elastase.

Ribeiro-Gomes FL, Moniz-de-Souza MC, Alexandre-Moreira MS, Dias WB, Lopes MF, Nunes MP, Lungarella G, DosReis GA.

J Immunol. 2007 Sep 15;179(6):3988-94.


Substance P released by TRPV1-expressing neurons produces reactive oxygen species that mediate ethanol-induced gastric injury.

Gazzieri D, Trevisani M, Springer J, Harrison S, Cottrell GS, Andre E, Nicoletti P, Massi D, Zecchi S, Nosi D, Santucci M, Gerard NP, Lucattelli M, Lungarella G, Fischer A, Grady EF, Bunnett NW, Geppetti P.

Free Radic Biol Med. 2007 Aug 15;43(4):581-9. Epub 2007 May 18. Erratum in: Free Radic Biol Med. 2007 Dec 15;43(12):1670.


Neurokinin-1 receptor blockade and murine lung tumorigenesis.

Lucattelli M, Fineschi S, Geppetti P, Gerard NP, Lungarella G.

Am J Respir Crit Care Med. 2006 Sep 15;174(6):674-83. Epub 2006 Jun 23.


Metabolism of oxidants by blood from different mouse strains.

Giustarini D, Dalle-Donne I, Cavarra E, Fineschi S, Lungarella G, Milzani A, Rossi R.

Biochem Pharmacol. 2006 Jun 14;71(12):1753-64. Epub 2006 Mar 24.


Proteinase-activated receptor-2 mediates arterial vasodilation in diabetes.

Roviezzo F, Bucci M, Brancaleone V, Di Lorenzo A, Geppetti P, Farneti S, Parente L, Lungarella G, Fiorucci S, Cirino G.

Arterioscler Thromb Vasc Biol. 2005 Nov;25(11):2349-54. Epub 2005 Sep 1.


Is neutrophil elastase the missing link between emphysema and fibrosis? Evidence from two mouse models.

Lucattelli M, Bartalesi B, Cavarra E, Fineschi S, Lunghi B, Martorana PA, Lungarella G.

Respir Res. 2005 Jul 26;6:83.


Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke.

Martorana PA, Beume R, Lucattelli M, Wollin L, Lungarella G.

Am J Respir Crit Care Med. 2005 Oct 1;172(7):848-53. Epub 2005 Jun 16.


Different lung responses to cigarette smoke in two strains of mice sensitive to oxidants.

Bartalesi B, Cavarra E, Fineschi S, Lucattelli M, Lunghi B, Martorana PA, Lungarella G.

Eur Respir J. 2005 Jan;25(1):15-22.


Proteins as biomarkers of oxidative/nitrosative stress in diseases: the contribution of redox proteomics.

Dalle-Donne I, Scaloni A, Giustarini D, Cavarra E, Tell G, Lungarella G, Colombo R, Rossi R, Milzani A.

Mass Spectrom Rev. 2005 Jan-Feb;24(1):55-99. Review.


Early response to bleomycin is characterized by different cytokine and cytokine receptor profiles in lungs.

Cavarra E, Carraro F, Fineschi S, Naldini A, Bartalesi B, Pucci A, Lungarella G.

Am J Physiol Lung Cell Mol Physiol. 2004 Dec;287(6):L1186-92. Epub 2004 Aug 20.


Collagen phagocytosis by lung alveolar macrophages in animal models of emphysema.

Lucattelli M, Cavarra E, de Santi MM, Tetley TD, Martorana PA, Lungarella G.

Eur Respir J. 2003 Nov;22(5):728-34.


Genetically modified animals as models of pulmonary disease.

Lungarella G, Paciocco G, Caterino U, Mazzarella G.

Monaldi Arch Chest Dis. 2002 Jun-Aug;57(3-4):191-2.


Iron overload enhances the development of experimental liver cirrhosis in mice.

Arezzini B, Lunghi B, Lungarella G, Gardi C.

Int J Biochem Cell Biol. 2003 Apr;35(4):486-95.


Urinary desmosine excretion is inversely correlated with the extent of emphysema in patients with chronic obstructive pulmonary disease.

Cocci F, Miniati M, Monti S, Cavarra E, Gambelli F, Battolla L, Lucattelli M, Lungarella G.

Int J Biochem Cell Biol. 2002 Jun;34(6):594-604.


UVA light stimulates the production of cathepsin G and elastase-like enzymes by dermal fibroblasts: a possible contribution to the remodeling of elastotic areas in sun-damaged skin.

Cavarra E, Fimiani M, Lungarella G, Andreassi L, de Santi M, Mazzatenta C, Ciccoli L.

Biol Chem. 2002 Jan;383(1):199-206.


Effects of cigarette smoke in mice with different levels of alpha(1)-proteinase inhibitor and sensitivity to oxidants.

Cavarra E, Bartalesi B, Lucattelli M, Fineschi S, Lunghi B, Gambelli F, Ortiz LA, Martorana PA, Lungarella G.

Am J Respir Crit Care Med. 2001 Sep 1;164(5):886-90.


Human SLPI inactivation after cigarette smoke exposure in a new in vivo model of pulmonary oxidative stress.

Cavarra E, Lucattelli M, Gambelli F, Bartalesi B, Fineschi S, Szarka A, Giannerini F, Martorana PA, Lungarella G.

Am J Physiol Lung Cell Mol Physiol. 2001 Aug;281(2):L412-7.


Genetic deficiency of alpha1-PI in mice influences lung responses to bleomycin.

Cavarra E, Martorana PA, Bartalesi B, Fineschi S, Gambelli F, Lucattelli M, Ortiz L, Lungarella G.

Eur Respir J. 2001 Mar;17(3):474-80.

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