Format

Send to

Choose Destination
Science. 2002 Jul 26;297(5581):573-8.

Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation.

Author information

1
Department of Odontology/Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.

Abstract

Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid-binding adhesin (SabA) was isolated with the "retagging" method, and the underlying sabA gene (JHP662/HP0725) was identified. The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H. pylori infection.

PMID:
12142529
PMCID:
PMC2570540
DOI:
10.1126/science.1069076
[Indexed for MEDLINE]
Free PMC Article

Publication types, MeSH terms, Substances, Grant support

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center