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Items: 37


Espeland og medarbeidere svarer.

Espeland T, Lunde IG, Amundsen BH, Gullestad L, Aakhus S.

Tidsskr Nor Laegeforen. 2018 Nov 26;138(19). doi: 10.4045/tidsskr.18.0865. Print 2018 Nov 27. Norwegian. No abstract available.

Free Article

Myocardial fibrosis.

Espeland T, Lunde IG, H Amundsen B, Gullestad L, Aakhus S.

Tidsskr Nor Laegeforen. 2018 Oct 12;138(16). doi: 10.4045/tidsskr.17.1027. Print 2018 Oct 16. English, Norwegian.


Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology.

Maack C, Lehrke M, Backs J, Heinzel FR, Hulot JS, Marx N, Paulus WJ, Rossignol P, Taegtmeyer H, Bauersachs J, Bayes-Genis A, Brutsaert D, Bugger H, Clarke K, Cosentino F, De Keulenaer G, Dei Cas A, González A, Huelsmann M, Iaccarino G, Lunde IG, Lyon AR, Pollesello P, Rena G, Riksen NP, Rosano G, Staels B, van Laake LW, Wanner C, Farmakis D, Filippatos G, Ruschitzka F, Seferovic P, de Boer RA, Heymans S.

Eur Heart J. 2018 Oct 8. doi: 10.1093/eurheartj/ehy596. [Epub ahead of print] No abstract available.


The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling.

Andenæs K, Lunde IG, Mohammadzadeh N, Dahl CP, Aronsen JM, Strand ME, Palmero S, Sjaastad I, Christensen G, Engebretsen KVT, Tønnessen T.

PLoS One. 2018 Jul 27;13(7):e0201422. doi: 10.1371/journal.pone.0201422. eCollection 2018.


A novel method for high precision aortic constriction that allows for generation of specific cardiac phenotypes in mice.

Melleby AO, Romaine A, Aronsen JM, Veras I, Zhang L, Sjaastad I, Lunde IG, Christensen G.

Cardiovasc Res. 2018 Oct 1;114(12):1680-1690. doi: 10.1093/cvr/cvy141.


Sweet, yet underappreciated: Proteoglycans and extracellular matrix remodeling in heart disease.

Christensen G, Herum KM, Lunde IG.

Matrix Biol. 2018 Jan 12. pii: S0945-053X(17)30271-8. doi: 10.1016/j.matbio.2018.01.001. [Epub ahead of print] Review.


The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology.

van Bilsen M, Patel HC, Bauersachs J, Böhm M, Borggrefe M, Brutsaert D, Coats AJS, de Boer RA, de Keulenaer GW, Filippatos GS, Floras J, Grassi G, Jankowska EA, Kornet L, Lunde IG, Maack C, Mahfoud F, Pollesello P, Ponikowski P, Ruschitzka F, Sabbah HN, Schultz HD, Seferovic P, Slart RHJA, Taggart P, Tocchetti CG, Van Laake LW, Zannad F, Heymans S, Lyon AR.

Eur J Heart Fail. 2017 Nov;19(11):1361-1378. doi: 10.1002/ejhf.921. Epub 2017 Sep 26. Review.


Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy.

Abraityte A, Lunde IG, Askevold ET, Michelsen AE, Christensen G, Aukrust P, Yndestad A, Fiane A, Andreassen A, Aakhus S, Dahl CP, Gullestad L, Broch K, Ueland T.

Sci Rep. 2017 Jun 14;7(1):3490. doi: 10.1038/s41598-017-03625-9.


The Soft- and Hard-Heartedness of Cardiac Fibroblasts: Mechanotransduction Signaling Pathways in Fibrosis of the Heart.

Herum KM, Lunde IG, McCulloch AD, Christensen G.

J Clin Med. 2017 May 19;6(5). pii: E53. doi: 10.3390/jcm6050053. Review.


Bigger is not better: cortisol-induced cardiac growth and dysfunction in salmonids.

Johansen IB, Sandblom E, Skov PV, Gräns A, Ekström A, Lunde IG, Vindas MA, Zhang L, Höglund E, Frisk M, Sjaastad I, Nilsson GE, Øverli Ø.

J Exp Biol. 2017 Jul 15;220(Pt 14):2545-2553. doi: 10.1242/jeb.135046. Epub 2017 May 5.


The Notch Ligands DLL1 and Periostin Are Associated with Symptom Severity and Diastolic Function in Dilated Cardiomyopathy.

Norum HM, Broch K, Michelsen AE, Lunde IG, Lekva T, Abraityte A, Dahl CP, Fiane AE, Andreassen AK, Christensen G, Aakhus S, Aukrust P, Gullestad L, Ueland T.

J Cardiovasc Transl Res. 2017 Aug;10(4):401-410. doi: 10.1007/s12265-017-9748-y. Epub 2017 May 4.


Wnt5a is elevated in heart failure and affects cardiac fibroblast function.

Abraityte A, Vinge LE, Askevold ET, Lekva T, Michelsen AE, Ranheim T, Alfsnes K, Fiane A, Aakhus S, Lunde IG, Dahl CP, Aukrust P, Christensen G, Gullestad L, Yndestad A, Ueland T.

J Mol Med (Berl). 2017 Jul;95(7):767-777. doi: 10.1007/s00109-017-1529-1. Epub 2017 Mar 30.


The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling.

Melleby AO, Strand ME, Romaine A, Herum KM, Skrbic B, Dahl CP, Sjaastad I, Fiane AE, Filmus J, Christensen G, Lunde IG.

PLoS One. 2016 Oct 21;11(10):e0165079. doi: 10.1371/journal.pone.0165079. eCollection 2016.


Exercise training increases protein O-GlcNAcylation in rat skeletal muscle.

Hortemo KH, Lunde PK, Anonsen JH, Kvaløy H, Munkvik M, Rehn TA, Sjaastad I, Lunde IG, Aronsen JM, Sejersted OM.

Physiol Rep. 2016 Sep;4(18). pii: e12896.


Increased hypertrophic response with increased mechanical load in skeletal muscles receiving identical activity patterns.

Eftestøl E, Egner IM, Lunde IG, Ellefsen S, Andersen T, Sjåland C, Gundersen K, Bruusgaard JC.

Am J Physiol Cell Physiol. 2016 Oct 1;311(4):C616-C629. doi: 10.1152/ajpcell.00016.2016. Epub 2016 Aug 3.


Syndecans in heart fibrosis.

Lunde IG, Herum KM, Carlson CC, Christensen G.

Cell Tissue Res. 2016 Sep;365(3):539-52. doi: 10.1007/s00441-016-2454-2. Epub 2016 Jul 14. Review.


Shedding of syndecan-4 promotes immune cell recruitment and mitigates cardiac dysfunction after lipopolysaccharide challenge in mice.

Strand ME, Aronsen JM, Braathen B, Sjaastad I, Kvaløy H, Tønnessen T, Christensen G, Lunde IG.

J Mol Cell Cardiol. 2015 Nov;88:133-44. doi: 10.1016/j.yjmcc.2015.10.003. Epub 2015 Oct 9.


Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice.

Cero FT, Hillestad V, Sjaastad I, Yndestad A, Aukrust P, Ranheim T, Lunde IG, Olsen MB, Lien E, Zhang L, Haugstad SB, Løberg EM, Christensen G, Larsen KO, Skjønsberg OH.

Am J Physiol Lung Cell Mol Physiol. 2015 Aug 15;309(4):L378-87. doi: 10.1152/ajplung.00342.2014. Epub 2015 Jun 12.


Exhausting treadmill running causes dephosphorylation of sMLC2 and reduced level of myofilament MLCK2 in slow twitch rat soleus muscle.

Hortemo KH, Aronsen JM, Lunde IG, Sjaastad I, Lunde PK, Sejersted OM.

Physiol Rep. 2015 Feb 22;3(2). pii: e12285. doi: 10.14814/phy2.12285. Print 2015 Feb 1.


Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice.

Skrbic B, Engebretsen KV, Strand ME, Lunde IG, Herum KM, Marstein HS, Sjaastad I, Lunde PK, Carlson CR, Christensen G, Bjørnstad JL, Tønnessen T.

Cardiovasc Res. 2015 Apr 1;106(1):32-42. doi: 10.1093/cvr/cvv041. Epub 2015 Feb 17.


Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart.

Herum KM, Lunde IG, Skrbic B, Louch WE, Hasic A, Boye S, Unger A, Brorson SH, Sjaastad I, Tønnessen T, Linke WA, Gomez MF, Christensen G.

Cardiovasc Res. 2015 May 1;106(2):217-26. doi: 10.1093/cvr/cvv002. Epub 2015 Jan 12.


Molecular basis of calpain cleavage and inactivation of the sodium-calcium exchanger 1 in heart failure.

Wanichawan P, Hafver TL, Hodne K, Aronsen JM, Lunde IG, Dalhus B, Lunde M, Kvaløy H, Louch WE, Tønnessen T, Sjaastad I, Sejersted OM, Carlson CR.

J Biol Chem. 2014 Dec 5;289(49):33984-98. doi: 10.1074/jbc.M114.602581. Epub 2014 Oct 21.


Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding.

Vistnes M, Aronsen JM, Lunde IG, Sjaastad I, Carlson CR, Christensen G.

PLoS One. 2014 Mar 3;9(3):e89621. doi: 10.1371/journal.pone.0089621. eCollection 2014.


Reduced visfatin levels in aortic stenosis increase after aortic valve replacement and may contribute to reverse left ventricular remodelling.

Majak P, Lunde IG, Hasic AK, Husebye T, Christensen G, Tønnessen T, Bjørnstad JL.

J Cardiovasc Surg (Torino). 2015 Jun;56(3):483-92. Epub 2014 Jan 16.


The cardiokine secreted Frizzled-related protein 3, a modulator of Wnt signalling, in clinical and experimental heart failure.

Askevold ET, Aukrust P, Nymo SH, Lunde IG, Kaasbøll OJ, Aakhus S, Florholmen G, Ohm IK, Strand ME, Attramadal H, Fiane A, Dahl CP, Finsen AV, Vinge LE, Christensen G, Yndestad A, Gullestad L, Latini R, Masson S, Tavazzi L; GISSI-HF Investigators, Ueland T.

J Intern Med. 2014 Jun;275(6):621-30. doi: 10.1111/joim.12175. Epub 2014 Jan 9.


Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli.

Engebretsen KV, Lunde IG, Strand ME, Waehre A, Sjaastad I, Marstein HS, Skrbic B, Dahl CP, Askevold ET, Christensen G, Bjørnstad JL, Tønnessen T.

FEBS J. 2013 May;280(10):2382-98. doi: 10.1111/febs.12235. Epub 2013 Apr 2.


Innate immune signaling induces expression and shedding of the heparan sulfate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart.

Strand ME, Herum KM, Rana ZA, Skrbic B, Askevold ET, Dahl CP, Vistnes M, Hasic A, Kvaløy H, Sjaastad I, Carlson CR, Tønnessen T, Gullestad L, Christensen G, Lunde IG.

FEBS J. 2013 May;280(10):2228-47. doi: 10.1111/febs.12161. Epub 2013 Feb 24.


Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress.

Herum KM, Lunde IG, Skrbic B, Florholmen G, Behmen D, Sjaastad I, Carlson CR, Gomez MF, Christensen G.

J Mol Cell Cardiol. 2013 Jan;54:73-81. doi: 10.1016/j.yjmcc.2012.11.006. Epub 2012 Nov 22.


Endothelin-1 in the human myocardium and circulating plasma: evaluation before, during and after correction of aortic stenosis with aortic valve replacement.

Majak P, Bjørnstad JL, Braathen B, Lunde IG, Husebye T, Christensen G, Tønnessen T.

Cardiology. 2012;123(1):1-10. doi: 10.1159/000339756. Epub 2012 Aug 17.


Chemokines regulate small leucine-rich proteoglycans in the extracellular matrix of the pressure-overloaded right ventricle.

Waehre A, Vistnes M, Sjaastad I, Nygård S, Husberg C, Lunde IG, Aukrust P, Yndestad A, Vinge LE, Behmen D, Neukamm C, Brun H, Thaulow E, Christensen G.

J Appl Physiol (1985). 2012 Apr;112(8):1372-82. doi: 10.1152/japplphysiol.01350.2011. Epub 2012 Feb 16.


Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway.

Finsen AV, Lunde IG, Sjaastad I, Østli EK, Lyngra M, Jarstadmarken HO, Hasic A, Nygård S, Wilcox-Adelman SA, Goetinck PF, Lyberg T, Skrbic B, Florholmen G, Tønnessen T, Louch WE, Djurovic S, Carlson CR, Christensen G.

PLoS One. 2011;6(12):e28302. doi: 10.1371/journal.pone.0028302. Epub 2011 Dec 2.


Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure.

Lunde IG, Aronsen JM, Kvaløy H, Qvigstad E, Sjaastad I, Tønnessen T, Christensen G, Grønning-Wang LM, Carlson CR.

Physiol Genomics. 2012 Feb 1;44(2):162-72. doi: 10.1152/physiolgenomics.00016.2011. Epub 2011 Nov 29.


Angiotensin II and norepinephrine activate specific calcineurin-dependent NFAT transcription factor isoforms in cardiomyocytes.

Lunde IG, Kvaløy H, Austbø B, Christensen G, Carlson CR.

J Appl Physiol (1985). 2011 Nov;111(5):1278-89. doi: 10.1152/japplphysiol.01383.2010. Epub 2011 Apr 7.


Cortisol response to stress is associated with myocardial remodeling in salmonid fishes.

Johansen IB, Lunde IG, Røsjø H, Christensen G, Nilsson GE, Bakken M, Overli O.

J Exp Biol. 2011 Apr 15;214(Pt 8):1313-21. doi: 10.1242/jeb.053058.


Hypoxia inducible factor 1 links fast-patterned muscle activity and fast muscle phenotype in rats.

Lunde IG, Anton SL, Bruusgaard JC, Rana ZA, Ellefsen S, Gundersen K.

J Physiol. 2011 Mar 15;589(Pt 6):1443-54. doi: 10.1113/jphysiol.2010.202762. Epub 2011 Jan 24.


Trophic structure and community stability in an overfished ecosystem.

Utne-Palm AC, Salvanes AG, Currie B, Kaartvedt S, Nilsson GE, Braithwaite VA, Stecyk JA, Hundt M, van der Bank M, Flynn B, Sandvik GK, Klevjer TA, Sweetman AK, Brüchert V, Pittman K, Peard KR, Lunde IG, Strandabø RA, Gibbons MJ.

Science. 2010 Jul 16;329(5989):333-6. doi: 10.1126/science.1190708.


PPARdelta expression is influenced by muscle activity and induces slow muscle properties in adult rat muscles after somatic gene transfer.

Lunde IG, Ekmark M, Rana ZA, Buonanno A, Gundersen K.

J Physiol. 2007 Aug 1;582(Pt 3):1277-87. Epub 2007 Apr 26.

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