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The Impact of Individual Mentored Career Development (K) Awards on the Research Trajectories of Early-Career Scientists.

Nikaj S, Lund PK.

Acad Med. 2019 May;94(5):708-714. doi: 10.1097/ACM.0000000000002543.


Examining trends in the diversity of the U.S. National Institutes of Health participating and funded workforce.

Nikaj S, Roychowdhury D, Lund PK, Matthews M, Pearson K.

FASEB J. 2018 Jun 19:fj201800639. doi: 10.1096/fj.201800639. [Epub ahead of print]


Ex Vivo and In Vivo Noninvasive Imaging of Epidermal Growth Factor Receptor Inhibition on Colon Tumorigenesis Using Activatable Near-Infrared Fluorescent Probes.

Ding S, Blue RE, Moorefield E, Yuan H, Lund PK.

Mol Imaging. 2017 Jan-Dec;16:1536012117729044. doi: 10.1177/1536012117729044.


Clinician-Investigator Training and the Need to Pilot New Approaches to Recruiting and Retaining This Workforce.

Hall AK, Mills SL, Lund PK.

Acad Med. 2017 Oct;92(10):1382-1389. doi: 10.1097/ACM.0000000000001859.


A Summary of the 2016 James W. Freston Conference of the American Gastroenterological Association: Intestinal Metaplasia in the Esophagus and Stomach: Origins, Differences, Similarities and Significance.

Spechler SJ, Merchant JL, Wang TC, Chandrasoma P, Fox JG, Genta RM, Goldenring JR, Hayakawa Y, Kuipers EJ, Lund PK, McKeon F, Mills JC, Odze RD, Peek RM Jr, Pham T, Que J, Rustgi AK, Shaheen NJ, Shivdasani RA, Souza RF, Storz P, Todisco A, Wang DH, Wright NA.

Gastroenterology. 2017 Jul;153(1):e6-e13. doi: 10.1053/j.gastro.2017.05.050. Epub 2017 Jun 3. No abstract available.


Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation.

Kechele DO, Blue RE, Zwarycz B, Espenschied ST, Mah AT, Siegel MB, Perou CM, Ding S, Magness ST, Lund PK, Caron KM.

J Clin Invest. 2017 Feb 1;127(2):593-607. doi: 10.1172/JCI87588. Epub 2017 Jan 17.


Functional Transcriptomics in Diverse Intestinal Epithelial Cell Types Reveals Robust MicroRNA Sensitivity in Intestinal Stem Cells to Microbial Status.

Peck BC, Mah AT, Pitman WA, Ding S, Lund PK, Sethupathy P.

J Biol Chem. 2017 Feb 17;292(7):2586-2600. doi: 10.1074/jbc.M116.770099. Epub 2017 Jan 4.


From the NIH: A Systems Approach to Increasing the Diversity of the Biomedical Research Workforce.

Valantine HA, Lund PK, Gammie AE.

CBE Life Sci Educ. Fall 2016;15(3). pii: fe4. doi: 10.1187/cbe.16-03-0138.


Women's Careers in Biomedical Sciences: Implications for the Economy, Scientific Discovery, and Women's Health.

Plank-Bazinet JL, Heggeness ML, Lund PK, Clayton JA.

J Womens Health (Larchmt). 2017 May;26(5):525-529. doi: 10.1089/jwh.2016.6012. Epub 2016 Aug 10.


Intestinal bacteria are necessary for doxorubicin-induced intestinal damage but not for doxorubicin-induced apoptosis.

Rigby RJ, Carr J, Orgel K, King SL, Lund PK, Dekaney CM.

Gut Microbes. 2016 Sep 2;7(5):414-23. doi: 10.1080/19490976.2016.1215806. Epub 2016 Jul 26.


Singling Out Intestinal Epithelial Stem Cells.

Lund PK, Verzi MP.

Gastroenterology. 2016 Aug;151(2):228-31. doi: 10.1053/j.gastro.2016.06.031. Epub 2016 Jun 29. No abstract available.


miR-30 Family Controls Proliferation and Differentiation of Intestinal Epithelial Cell Models by Directing a Broad Gene Expression Program That Includes SOX9 and the Ubiquitin Ligase Pathway.

Peck BC, Sincavage J, Feinstein S, Mah AT, Simmons JG, Lund PK, Sethupathy P.

J Biol Chem. 2016 Jul 29;291(31):15975-84. doi: 10.1074/jbc.M116.733733. Epub 2016 Jun 3.


The Innate Immune Receptor NLRX1 Functions as a Tumor Suppressor by Reducing Colon Tumorigenesis and Key Tumor-Promoting Signals.

Koblansky AA, Truax AD, Liu R, Montgomery SA, Ding S, Wilson JE, Brickey WJ, Mühlbauer M, McFadden RM, Hu P, Li Z, Jobin C, Lund PK, Ting JP.

Cell Rep. 2016 Mar 22;14(11):2562-75. doi: 10.1016/j.celrep.2016.02.064. Epub 2016 Mar 10.


Obesity and intestinal epithelial deletion of the insulin receptor, but not the IGF 1 receptor, affect radiation-induced apoptosis in colon.

Santoro MA, Blue RE, Andres SF, Mah AT, Van Landeghem L, Lund PK.

Am J Physiol Gastrointest Liver Physiol. 2015 Oct 1;309(7):G578-89. doi: 10.1152/ajpgi.00189.2015. Epub 2015 Aug 6.


IGF1 stimulates crypt expansion via differential activation of 2 intestinal stem cell populations.

Van Landeghem L, Santoro MA, Mah AT, Krebs AE, Dehmer JJ, McNaughton KK, Helmrath MA, Magness ST, Lund PK.

FASEB J. 2015 Jul;29(7):2828-42. doi: 10.1096/fj.14-264010. Epub 2015 Apr 2.


High rate of galactose-alpha-1,3-galactose sensitization in both eosinophilic esophagitis and patients undergoing upper endoscopy.

Burk CM, Beitia R, Lund PK, Dellon ES.

Dis Esophagus. 2016 Aug;29(6):558-62. doi: 10.1111/dote.12356. Epub 2015 Mar 23.


Transcriptional corepressor MTG16 regulates small intestinal crypt proliferation and crypt regeneration after radiation-induced injury.

Poindexter SV, Reddy VK, Mittal MK, Williams AM, Washington MK, Harris E, Mah A, Hiebert SW, Singh K, Chaturvedi R, Wilson KT, Lund PK, Williams CS.

Am J Physiol Gastrointest Liver Physiol. 2015 Mar 15;308(6):G562-71. doi: 10.1152/ajpgi.00253.2014. Epub 2015 Jan 8.


Deletion of intestinal epithelial insulin receptor attenuates high-fat diet-induced elevations in cholesterol and stem, enteroendocrine, and Paneth cell mRNAs.

Andres SF, Santoro MA, Mah AT, Keku JA, Bortvedt AE, Blue RE, Lund PK.

Am J Physiol Gastrointest Liver Physiol. 2015 Jan 15;308(2):G100-11. doi: 10.1152/ajpgi.00287.2014. Epub 2014 Nov 13.


Reduced insulin-like growth factor I receptor and altered insulin receptor isoform mRNAs in normal mucosa predict colorectal adenoma risk.

Santoro MA, Andres SF, Galanko JA, Sandler RS, Keku TO, Lund PK.

Cancer Epidemiol Biomarkers Prev. 2014 Oct;23(10):2093-100. doi: 10.1158/1055-9965.EPI-14-0177. Epub 2014 Jul 13.


Impact of diet-induced obesity on intestinal stem cells: hyperproliferation but impaired intrinsic function that requires insulin/IGF1.

Mah AT, Van Landeghem L, Gavin HE, Magness ST, Lund PK.

Endocrinology. 2014 Sep;155(9):3302-14. doi: 10.1210/en.2014-1112. Epub 2014 Jun 10.


MicroRNA-29 fine-tunes the expression of key FOXA2-activated lipid metabolism genes and is dysregulated in animal models of insulin resistance and diabetes.

Kurtz CL, Peck BC, Fannin EE, Beysen C, Miao J, Landstreet SR, Ding S, Turaga V, Lund PK, Turner S, Biddinger SB, Vickers KC, Sethupathy P.

Diabetes. 2014 Sep;63(9):3141-8. doi: 10.2337/db13-1015. Epub 2014 Apr 10.


Comparison of multiple enzyme activatable near-infrared fluorescent molecular probes for detection and quantification of inflammation in murine colitis models.

Ding S, Blue RE, Morgan DR, Lund PK.

Inflamm Bowel Dis. 2014 Feb;20(2):363-77. doi: 10.1097/01.MIB.0000440612.98950.79.


Insulin receptor isoform switching in intestinal stem cells, progenitors, differentiated lineages and tumors: evidence that IR-B limits proliferation.

Andres SF, Simmons JG, Mah AT, Santoro MA, Van Landeghem L, Lund PK.

J Cell Sci. 2013 Dec 15;126(Pt 24):5645-56. doi: 10.1242/jcs.132985. Epub 2013 Oct 14.


Impact of ileocecal resection and concomitant antibiotics on the microbiome of the murine jejunum and colon.

Devine AA, Gonzalez A, Speck KE, Knight R, Helmrath M, Lund PK, Azcarate-Peril MA.

PLoS One. 2013 Aug 27;8(8):e73140. doi: 10.1371/journal.pone.0073140. eCollection 2013.


Opportunities and challenges for women PhD investigators in gastrointestinal research.

Hamilton KE, Tétreault MP, Lund PK.

Gastroenterology. 2013 Aug;145(2):266-71. doi: 10.1053/j.gastro.2013.06.024. Epub 2013 Jun 19. No abstract available.


Localized intestinal radiation and liquid diet enhance survival and permit evaluation of long-term intestinal responses to high dose radiation in mice.

Van Landeghem L, Blue RE, Dehmer JJ, Henning SJ, Helmrath MA, Lund PK.

PLoS One. 2012;7(12):e51310. doi: 10.1371/journal.pone.0051310. Epub 2012 Dec 7.


Fixing the breaks in intestinal stem cells after radiation: a matter of DNA damage and death or DNA repair and regeneration.

Lund PK.

Gastroenterology. 2012 Nov;143(5):1144-1147. doi: 10.1053/j.gastro.2012.09.021. Epub 2012 Sep 19. No abstract available.


Elevated C-peptide and insulin predict increased risk of colorectal adenomas in normal mucosa.

Vidal AC, Lund PK, Hoyo C, Galanko J, Burcal L, Holston R, Massa B, Omofoye O, Sandler RS, Keku TO.

BMC Cancer. 2012 Sep 5;12:389. doi: 10.1186/1471-2407-12-389.


Mucosal healing and fibrosis after acute or chronic inflammation in wild type FVB-N mice and C57BL6 procollagen α1(I)-promoter-GFP reporter mice.

Ding S, Walton KL, Blue RE, McNaughton K, Magness ST, Lund PK.

PLoS One. 2012;7(8):e42568. doi: 10.1371/journal.pone.0042568. Epub 2012 Aug 3. Erratum in: PLoS One. 2012;7(10). doi:10.1371/annotation/91f1d7f8-b09d-4067-943c-148e926b403b. Macnaughton, Kirk [corrected to McNaughton, Kirk K].


Activation of two distinct Sox9-EGFP-expressing intestinal stem cell populations during crypt regeneration after irradiation.

Van Landeghem L, Santoro MA, Krebs AE, Mah AT, Dehmer JJ, Gracz AD, Scull BP, McNaughton K, Magness ST, Lund PK.

Am J Physiol Gastrointest Liver Physiol. 2012 May 15;302(10):G1111-32. doi: 10.1152/ajpgi.00519.2011. Epub 2012 Feb 23.


Insulin-like growth factor 1: common mediator of multiple enterotrophic hormones and growth factors.

Bortvedt SF, Lund PK.

Curr Opin Gastroenterol. 2012 Mar;28(2):89-98. doi: 10.1097/MOG.0b013e32835004c6. Review.


Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells.

Hamilton KE, Simmons JG, Ding S, Van Landeghem L, Lund PK.

Mol Cancer Res. 2011 Dec;9(12):1718-31. doi: 10.1158/1541-7786.MCR-10-0210. Epub 2011 Oct 12.


Role of intestinal inflammation as an early event in obesity and insulin resistance.

Ding S, Lund PK.

Curr Opin Clin Nutr Metab Care. 2011 Jul;14(4):328-33. doi: 10.1097/MCO.0b013e3283478727. Review.


Themes in fibrosis and gastrointestinal inflammation.

Fiocchi C, Lund PK.

Am J Physiol Gastrointest Liver Physiol. 2011 May;300(5):G677-83. doi: 10.1152/ajpgi.00104.2011. Epub 2011 Mar 17.


Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts.

Leen JL, Izzo A, Upadhyay C, Rowland KJ, Dubé PE, Gu S, Heximer SP, Rhodes CJ, Storm DR, Lund PK, Brubaker PL.

Endocrinology. 2011 Feb;152(2):436-46. doi: 10.1210/en.2010-0822. Epub 2010 Dec 15.


High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse.

Ding S, Chi MM, Scull BP, Rigby R, Schwerbrock NM, Magness S, Jobin C, Lund PK.

PLoS One. 2010 Aug 16;5(8):e12191. doi: 10.1371/journal.pone.0012191.


Suppressor of cytokine signaling 3 (SOCS3) is not an independent biomarker of colorectal adenoma risk.

Hamilton KE, Lund PK, Galanko JA, Sandler RS, Keku TO.

BMC Res Notes. 2010 May 25;3:144. doi: 10.1186/1756-0500-3-144.


Suppressor of cytokine signaling-2 gene disruption promotes Apc(Min/+) tumorigenesis and activator protein-1 activation.

Newton VA, Ramocki NM, Scull BP, Simmons JG, McNaughton K, Lund PK.

Am J Pathol. 2010 May;176(5):2320-32. doi: 10.2353/ajpath.2010.090684. Epub 2010 Mar 26.


Inflammation enhances resection-induced intestinal adaptive growth in IL-10 null mice.

Speck KE, Garrison AP, Rigby RJ, von Allmen DC, Lund PK, Helmrath MA.

J Surg Res. 2011 Jun 1;168(1):62-9. doi: 10.1016/j.jss.2009.09.051. Epub 2009 Oct 22.


A new animal model of postsurgical bowel inflammation and fibrosis: the effect of commensal microflora.

Rigby RJ, Hunt MR, Scull BP, Simmons JG, Speck KE, Helmrath MA, Lund PK.

Gut. 2009 Aug;58(8):1104-12. doi: 10.1136/gut.2008.157636. Epub 2009 Apr 26.


Early but not late administration of glucagon-like peptide-2 following ileo-cecal resection augments putative intestinal stem cell expansion.

Garrison AP, Dekaney CM, von Allmen DC, Lund PK, Henning SJ, Helmrath MA.

Am J Physiol Gastrointest Liver Physiol. 2009 Mar;296(3):G643-50. doi: 10.1152/ajpgi.90588.2008. Epub 2008 Dec 31.


Using global gene expression patterns to characterize Annexin V positive and negative human monocytes in culture.

Lund PK, Øvstebø R, Møller AS, Olstad OK, Landsverk KS, Hellum M, Kierulf P.

Scand J Clin Lab Invest. 2009;69(2):251-64. doi: 10.1080/00365510802499399.


What are the mechanisms of fibrosis in IBD?

Lund PK, Rigby RJ.

Inflamm Bowel Dis. 2008 Oct;14 Suppl 2:S127-8. doi: 10.1002/ibd.20681. No abstract available. Erratum in: Inflamm Bowel Dis. 2009 Sep;15(9):1438-47.


Bacterial-dependent up-regulation of intestinal bile acid binding protein and transport is FXR-mediated following ileo-cecal resection.

Dekaney CM, von Allmen DC, Garrison AP, Rigby RJ, Lund PK, Henning SJ, Helmrath MA.

Surgery. 2008 Aug;144(2):174-81. doi: 10.1016/j.surg.2008.03.035.


Biochromoendoscopy: molecular imaging with capsule endoscopy for detection of adenomas of the GI tract.

Zhang H, Morgan D, Cecil G, Burkholder A, Ramocki N, Scull B, Lund PK.

Gastrointest Endosc. 2008 Sep;68(3):520-7. doi: 10.1016/j.gie.2008.02.023. Epub 2008 May 21.


Local IGFBP-3 mRNA expression, apoptosis and risk of colorectal adenomas.

Keku TO, Sandler RS, Simmons JG, Galanko J, Woosley JT, Proffitt M, Omofoye O, McDoom M, Lund PK.

BMC Cancer. 2008 May 22;8:143. doi: 10.1186/1471-2407-8-143.


A general and islet cell-enriched overexpression of IGF-I results in normal islet cell growth, hypoglycemia, and significant resistance to experimental diabetes.

Robertson K, Lu Y, De Jesus K, Li B, Su Q, Lund PK, Liu JL.

Am J Physiol Endocrinol Metab. 2008 May;294(5):E928-38. doi: 10.1152/ajpendo.00606.2007. Epub 2008 Feb 12.


Insulin receptor substrate-1 deficiency promotes apoptosis in the putative intestinal crypt stem cell region, limits Apcmin/+ tumors, and regulates Sox9.

Ramocki NM, Wilkins HR, Magness ST, Simmons JG, Scull BP, Lee GH, McNaughton KK, Lund PK.

Endocrinology. 2008 Jan;149(1):261-7. Epub 2007 Oct 4.


Expansion of intestinal stem cells associated with long-term adaptation following ileocecal resection in mice.

Dekaney CM, Fong JJ, Rigby RJ, Lund PK, Henning SJ, Helmrath MA.

Am J Physiol Gastrointest Liver Physiol. 2007 Nov;293(5):G1013-22. Epub 2007 Sep 13.


Cell-specific effects of insulin receptor substrate-1 deficiency on normal and IGF-I-mediated colon growth.

Simmons JG, Ling Y, Wilkins H, Fuller CR, D'Ercole AJ, Fagin J, Lund PK.

Am J Physiol Gastrointest Liver Physiol. 2007 Nov;293(5):G995-1003. Epub 2007 Sep 6.

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