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Items: 1 to 50 of 116

1.

Colonic Lesions, Cytokine Profiles, and Gut Microbiota in Plasminogen-Deficient Mice.

Vestergaard B, Krych Ł, Lund LR, Jørgensen BP, Hansen L, Jensen HE, Nielsen DS, Hansen AK.

Comp Med. 2015 Oct;65(5):382-97.

2.

Spontaneous lung and lymph node metastasis in transgenic breast cancer is independent of the urokinase receptor uPAR.

Almholt K, Lærum OD, Nielsen BS, Lund IK, Lund LR, Rømer J, Jögi A.

Clin Exp Metastasis. 2015 Aug;32(6):543-54. doi: 10.1007/s10585-015-9726-1. Epub 2015 Jun 4.

PMID:
26040548
3.

Differential HIF-1α and HIF-2α Expression in Mammary Epithelial Cells during Fat Pad Invasion, Lactation, and Involution.

Påhlman S, Lund LR, Jögi A.

PLoS One. 2015 May 8;10(5):e0125771. doi: 10.1371/journal.pone.0125771. eCollection 2015.

4.

Gender affects skin wound healing in plasminogen deficient mice.

Rønø B, Engelholm LH, Lund LR, Hald A.

PLoS One. 2013;8(3):e59942. doi: 10.1371/journal.pone.0059942. Epub 2013 Mar 20.

5.

Spontaneous metastasis in congenic mice with transgenic breast cancer is unaffected by plasminogen gene ablation.

Almholt K, Juncker-Jensen A, Lærum OD, Johnsen M, Rømer J, Lund LR.

Clin Exp Metastasis. 2013 Mar;30(3):277-88. doi: 10.1007/s10585-012-9534-9. Epub 2012 Sep 21.

PMID:
22996753
6.

Plasmin-driven fibrinolysis facilitates skin tumor growth in a gender-dependent manner.

Hald A, Eickhardt H, Maerkedahl RB, Feldborg CW, Egerod KL, Engelholm LH, Laerum OD, Lund LR, Rønø B.

FASEB J. 2012 Nov;26(11):4445-57. doi: 10.1096/fj.12-208025. Epub 2012 Jul 19.

PMID:
22815383
7.

No effect of NGAL/lipocalin-2 on aggressiveness of cancer in the MMTV-PyMT/FVB/N mouse model for breast cancer.

Cramer EP, Glenthøj A, Häger M, Juncker-Jensen A, Engelholm LH, Santoni-Rugiu E, Lund LR, Laerum OD, Cowland JB, Borregaard N.

PLoS One. 2012;7(6):e39646. doi: 10.1371/journal.pone.0039646. Epub 2012 Jun 21.

8.

Gene expression profiles in stages II and III colon cancers: application of a 128-gene signature.

Thorsteinsson M, Kirkeby LT, Hansen R, Lund LR, Sørensen LT, Gerds TA, Jess P, Olsen J.

Int J Colorectal Dis. 2012 Dec;27(12):1579-86. doi: 10.1007/s00384-012-1517-4. Epub 2012 Jun 19.

PMID:
22710688
9.

LPS counter regulates RNA expression of extracellular proteases and their inhibitors in murine macrophages.

Hald A, Rønø B, Lund LR, Egerod KL.

Mediators Inflamm. 2012;2012:157894. doi: 10.1155/2012/157894. Epub 2012 Mar 14.

10.

Concomitant lack of MMP9 and uPA disturbs physiological tissue remodeling.

Lund IK, Nielsen BS, Almholt K, Rønø B, Hald A, Illemann M, Green KA, Christensen IJ, Rømer J, Lund LR.

Dev Biol. 2011 Oct 1;358(1):56-67. doi: 10.1016/j.ydbio.2011.07.021. Epub 2011 Jul 22.

11.

Phenotypic overlap between MMP-13 and the plasminogen activation system during wound healing in mice.

Juncker-Jensen A, Lund LR.

PLoS One. 2011 Feb 4;6(2):e16954. doi: 10.1371/journal.pone.0016954.

12.

MMP9 is protective against lethal inflammatory mass lesions in the mouse colon.

Hald A, Rønø B, Melander MC, Ding M, Holck S, Lund LR.

Dis Model Mech. 2011 Mar;4(2):212-27. doi: 10.1242/dmm.005801. Epub 2010 Dec 1.

13.

Neutralisation of uPA with a monoclonal antibody reduces plasmin formation and delays skin wound healing in tPA-deficient mice.

Jögi A, Rønø B, Lund IK, Nielsen BS, Ploug M, Høyer-Hansen G, Rømer J, Lund LR.

PLoS One. 2010 Sep 15;5(9):e12746. doi: 10.1371/journal.pone.0012746.

14.

Does plasminogen activator inhibitor-1 drive lymphangiogenesis?

Bruyère F, Melen-Lamalle L, Blacher S, Detry B, Masset A, Lecomte J, Lambert V, Maillard C, Høyer-Hansen G, Lund LR, Foidart JM, Noël A.

PLoS One. 2010 Mar 11;5(3):e9653. doi: 10.1371/journal.pone.0009653.

15.

Skin wound healing in MMP2-deficient and MMP2 / plasminogen double-deficient mice.

Frøssing S, Rønø B, Hald A, Rømer J, Lund LR.

Exp Dermatol. 2010 Aug;19(8):e234-40. doi: 10.1111/j.1600-0625.2009.01062.x.

16.

Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration.

Ohki M, Ohki Y, Ishihara M, Nishida C, Tashiro Y, Akiyama H, Komiyama H, Lund LR, Nitta A, Yamada K, Zhu Z, Ogawa H, Yagita H, Okumura K, Nakauchi H, Werb Z, Heissig B, Hattori K.

Blood. 2010 May 27;115(21):4302-12. doi: 10.1182/blood-2009-08-236851. Epub 2010 Jan 28.

17.

Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17.

Muñoz M, Heimesaat MM, Danker K, Struck D, Lohmann U, Plickert R, Bereswill S, Fischer A, Dunay IR, Wolk K, Loddenkemper C, Krell HW, Libert C, Lund LR, Frey O, Hölscher C, Iwakura Y, Ghilardi N, Ouyang W, Kamradt T, Sabat R, Liesenfeld O.

J Exp Med. 2009 Dec 21;206(13):3047-59. doi: 10.1084/jem.20090900. Epub 2009 Dec 7.

18.

Neutrophil gelatinase-associated lipocalin (NGAL/Lcn2) is upregulated in gastric mucosa infected with Helicobacter pylori.

Alpízar-Alpízar W, Laerum OD, Illemann M, Ramírez JA, Arias A, Malespín-Bendaña W, Ramírez V, Lund LR, Borregaard N, Nielsen BS.

Virchows Arch. 2009 Sep;455(3):225-33. doi: 10.1007/s00428-009-0825-8.

PMID:
19727808
19.

RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells.

Doehn U, Hauge C, Frank SR, Jensen CJ, Duda K, Nielsen JV, Cohen MS, Johansen JV, Winther BR, Lund LR, Winther O, Taunton J, Hansen SH, Frödin M.

Mol Cell. 2009 Aug 28;35(4):511-22. doi: 10.1016/j.molcel.2009.08.002.

20.

Urokinase plasminogen activator receptor is expressed in invasive cells in gastric carcinomas from high- and low-risk countries.

Alpízar-Alpízar W, Nielsen BS, Sierra R, Illemann M, Ramírez JA, Arias A, Durán S, Skarstein A, Ovrebo K, Lund LR, Laerum OD.

Int J Cancer. 2010 Jan 15;126(2):405-15. doi: 10.1002/ijc.24755.

21.

Two distinct expression patterns of urokinase, urokinase receptor and plasminogen activator inhibitor-1 in colon cancer liver metastases.

Illemann M, Bird N, Majeed A, Laerum OD, Lund LR, Danø K, Nielsen BS.

Int J Cancer. 2009 Apr 15;124(8):1860-70. doi: 10.1002/ijc.24166.

22.

Spontaneous metastasis in matrix metalloproteinase 3-deficient mice.

Juncker-Jensen A, Rømer J, Pennington CJ, Lund LR, Almholt K.

Mol Carcinog. 2009 Jul;48(7):618-25. doi: 10.1002/mc.20503.

PMID:
19058297
23.

Antibody-mediated targeting of the urokinase-type plasminogen activator proteolytic function neutralizes fibrinolysis in vivo.

Lund IK, Jögi A, Rønø B, Rasch MG, Lund LR, Almholt K, Gårdsvoll H, Behrendt N, Rømer J, Høyer-Hansen G.

J Biol Chem. 2008 Nov 21;283(47):32506-15. doi: 10.1074/jbc.M801924200. Epub 2008 Sep 17.

24.

Metastasis is strongly reduced by the matrix metalloproteinase inhibitor Galardin in the MMTV-PymT transgenic breast cancer model.

Almholt K, Juncker-Jensen A, Laerum OD, Danø K, Johnsen M, Lund LR, Rømer J.

Mol Cancer Ther. 2008 Sep;7(9):2758-67. doi: 10.1158/1535-7163.MCT-08-0251.

25.

Matrix metalloproteinase 13 is induced in fibroblasts in polyomavirus middle T antigen-driven mammary carcinoma without influencing tumor progression.

Nielsen BS, Egeblad M, Rank F, Askautrud HA, Pennington CJ, Pedersen TX, Christensen IJ, Edwards DR, Werb Z, Lund LR.

PLoS One. 2008 Aug 13;3(8):e2959. doi: 10.1371/journal.pone.0002959.

26.

Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells.

Ingvarsen S, Madsen DH, Hillig T, Lund LR, Holmbeck K, Behrendt N, Engelholm LH.

Biol Chem. 2008 Jul;389(7):943-53. doi: 10.1515/BC.2008.097.

PMID:
18627313
27.

Cellular cross talk in the small intestinal mucosa: postnatal lymphocytic immigration elicits a specific epithelial transcriptional response.

Schjoldager KT, Maltesen HR, Balmer S, Lund LR, Claesson MH, Sjöström H, Troelsen JT, Olsen J.

Am J Physiol Gastrointest Liver Physiol. 2008 Jun;294(6):G1335-43. doi: 10.1152/ajpgi.00265.2007. Epub 2008 Apr 3.

28.

The plasminogen fibrinolytic pathway is required for hematopoietic regeneration.

Heissig B, Lund LR, Akiyama H, Ohki M, Morita Y, Rømer J, Nakauchi H, Okumura K, Ogawa H, Werb Z, Danø K, Hattori K.

Cell Stem Cell. 2007 Dec 13;1(6):658-70. doi: 10.1016/j.stem.2007.10.012. Erratum in: Cell Stem Cell. 2008 Jul 3;3(1):120.

29.

Profibrinolytic effects of metalloproteinases during skin wound healing in the absence of plasminogen.

Green KA, Almholt K, Ploug M, Rønø B, Castellino FJ, Johnsen M, Bugge TH, Rømer J, Lund LR.

J Invest Dermatol. 2008 Aug;128(8):2092-101. doi: 10.1038/jid.2008.54. Epub 2008 Mar 13.

30.

Quantification of in vivo tumor invasion and vascularization by computerized image analysis.

Blacher S, Jost M, Melen-Lamalle L, Lund LR, Romer J, Foidart JM, Noël A.

Microvasc Res. 2008 Mar;75(2):169-78. Epub 2007 Oct 31.

PMID:
17976661
31.
32.

Murine monoclonal antibodies against murine uPA receptor produced in gene-deficient mice: inhibitory effects on receptor-mediated uPA activity in vitro and in vivo.

Pass J, Jögi A, Lund IK, Rønø B, Rasch MG, Gårdsvoll H, Lund LR, Ploug M, Rømer J, Danø K, Høyer-Hansen G.

Thromb Haemost. 2007 Jun;97(6):1013-22.

PMID:
17549305
33.
34.

Extracellular proteolysis in transgenic mouse models of breast cancer.

Almholt K, Green KA, Juncker-Jensen A, Nielsen BS, Lund LR, Rømer J.

J Mammary Gland Biol Neoplasia. 2007 Mar;12(1):83-97. Review.

35.

Functional corpora lutea are formed in matrix metalloproteinase inhibitor-treated plasminogen-deficient mice.

Wahlberg P, Bodén I, Paulsson J, Lund LR, Liu K, Ny T.

Endocrinology. 2007 Mar;148(3):1226-34. Epub 2006 Nov 22.

PMID:
17122079
36.

Lack of plasminogen leads to milk stasis and premature mammary gland involution during lactation.

Green KA, Nielsen BS, Castellino FJ, Rømer J, Lund LR.

Dev Biol. 2006 Nov 1;299(1):164-75. Epub 2006 Jul 27.

37.

Metabolome, transcriptome, and bioinformatic cis-element analyses point to HNF-4 as a central regulator of gene expression during enterocyte differentiation.

Stegmann A, Hansen M, Wang Y, Larsen JB, Lund LR, Ritié L, Nicholson JK, Quistorff B, Simon-Assmann P, Troelsen JT, Olsen J.

Physiol Genomics. 2006 Oct 11;27(2):141-55. Epub 2006 Jul 25.

38.

Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice.

Lund LR, Green KA, Stoop AA, Ploug M, Almholt K, Lilla J, Nielsen BS, Christensen IJ, Craik CS, Werb Z, Danø K, Rømer J.

EMBO J. 2006 Jun 21;25(12):2686-97. Epub 2006 Jun 8.

39.

Successful ovulation in plasminogen-deficient mice treated with the broad-spectrum matrix metalloproteinase inhibitor galardin.

Liu K, Wahlberg P, Leonardsson G, Hägglund AC, Ny A, Bodén I, Wibom C, Lund LR, Ny T.

Dev Biol. 2006 Jul 15;295(2):615-22. Epub 2006 Apr 7.

40.

MMP-9 is differentially expressed in primary human colorectal adenocarcinomas and their metastases.

Illemann M, Bird N, Majeed A, Sehested M, Laerum OD, Lund LR, Danø K, Nielsen BS.

Mol Cancer Res. 2006 May;4(5):293-302.

41.

ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma.

Porter S, Span PN, Sweep FC, Tjan-Heijnen VC, Pennington CJ, Pedersen TX, Johnsen M, Lund LR, Rømer J, Edwards DR.

Int J Cancer. 2006 Mar 1;118(5):1241-7.

42.

ECM degrading proteases and tissue remodelling in the mammary gland.

Green KA, Lund LR.

Bioessays. 2005 Sep;27(9):894-903. Review.

PMID:
16108064
43.

Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy.

Curino AC, Engelholm LH, Yamada SS, Holmbeck K, Lund LR, Molinolo AA, Behrendt N, Nielsen BS, Bugge TH.

J Cell Biol. 2005 Jun 20;169(6):977-85.

44.

Plasminogen activation and cancer.

Danø K, Behrendt N, Høyer-Hansen G, Johnsen M, Lund LR, Ploug M, Rømer J.

Thromb Haemost. 2005 Apr;93(4):676-81. Review.

PMID:
15841311
45.

Reduced metastasis of transgenic mammary cancer in urokinase-deficient mice.

Almholt K, Lund LR, Rygaard J, Nielsen BS, Danø K, Rømer J, Johnsen M.

Int J Cancer. 2005 Feb 10;113(4):525-32.

46.

Leading-edge myofibroblasts in human colon cancer express plasminogen activator inhibitor-1.

Illemann M, Hansen U, Nielsen HJ, Andreasen PA, Høyer-Hansen G, Lund LR, Danø K, Nielsen BS.

Am J Clin Pathol. 2004 Aug;122(2):256-65.

PMID:
15323143
47.

Structural analysis and tissue localization of human C4.4A: a protein homologue of the urokinase receptor.

Hansen LV, Gårdsvoll H, Nielsen BS, Lund LR, Danø K, Jensen ON, Ploug M.

Biochem J. 2004 Jun 15;380(Pt 3):845-57.

48.

Latent TGF-beta1 activation by platelets.

Blakytny R, Ludlow A, Martin GE, Ireland G, Lund LR, Ferguson MW, Brunner G.

J Cell Physiol. 2004 Apr;199(1):67-76.

PMID:
14978736
49.

MMP-9 deficiency affects axonal outgrowth, migration, and apoptosis in the developing cerebellum.

Vaillant C, Meissirel C, Mutin M, Belin MF, Lund LR, Thomasset N.

Mol Cell Neurosci. 2003 Oct;24(2):395-408.

PMID:
14572461
50.

Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis.

Wiseman BS, Sternlicht MD, Lund LR, Alexander CM, Mott J, Bissell MJ, Soloway P, Itohara S, Werb Z.

J Cell Biol. 2003 Sep 15;162(6):1123-33.

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