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The long noncoding RNA Blnc1 orchestrates homeostatic adipose tissue remodeling to preserve metabolic health.

Zhao XY, Li S, DelProposto JL, Liu T, Mi L, Porsche C, Peng X, Lumeng CN, Lin JD.

Mol Metab. 2018 Jun 8. pii: S2212-8778(18)30490-3. doi: 10.1016/j.molmet.2018.06.005. [Epub ahead of print]


TLR4, TRIF, and MyD88 are essential for myelopoiesis and CD11c+ adipose tissue macrophage production in obese mice.

Griffin C, Eter L, Lanzetta N, Abrishami S, Varghese M, McKernan K, Muir L, Lane J, Lumeng CN, Singer K.

J Biol Chem. 2018 Jun 8;293(23):8775-8786. doi: 10.1074/jbc.RA117.001526. Epub 2018 Apr 10.


Frontline Science: Rapid adipose tissue expansion triggers unique proliferation and lipid accumulation profiles in adipose tissue macrophages.

Muir LA, Kiridena S, Griffin C, DelProposto JB, Geletka L, Martinez-Santibañez G, Zamarron BF, Lucas H, Singer K, O' Rourke RW, Lumeng CN.

J Leukoc Biol. 2018 Apr;103(4):615-628. doi: 10.1002/JLB.3HI1017-422R. Epub 2018 Mar 1.


The IKK-related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists.

Bodur C, Kazyken D, Huang K, Ekim Ustunel B, Siroky KA, Tooley AS, Gonzalez IE, Foley DH, Acosta-Jaquez HA, Barnes TM, Steinl GK, Cho KW, Lumeng CN, Riddle SM, Myers MG Jr, Fingar DC.

EMBO J. 2018 Jan 4;37(1):19-38. doi: 10.15252/embj.201696164. Epub 2017 Nov 17.


Adipocyte hypertrophy-hyperplasia balance contributes to weight loss after bariatric surgery.

Muir LA, Baker NA, Washabaugh AR, Neeley CK, Flesher CG, DelProposto JB, Geletka LM, Ghaferi AA, Finks JF, Singer K, Varban OA, Lumeng CN, O'Rourke RW.

Adipocyte. 2017 Apr 3;6(2):134-140. doi: 10.1080/21623945.2017.1287639. Epub 2017 Jan 27.


Weight loss independent changes in adipose tissue macrophage and T cell populations after sleeve gastrectomy in mice.

Frikke-Schmidt H, Zamarron BF, O'Rourke RW, Sandoval DA, Lumeng CN, Seeley RJ.

Mol Metab. 2017 Feb 16;6(4):317-326. doi: 10.1016/j.molmet.2017.02.004. eCollection 2017 Apr.


Diabetes-Specific Regulation of Adipocyte Metabolism by the Adipose Tissue Extracellular Matrix.

Baker NA, Muir LA, Washabaugh AR, Neeley CK, Chen SY, Flesher CG, Vorwald J, Finks JF, Ghaferi AA, Mulholland MW, Varban OA, Lumeng CN, O'Rourke RW.

J Clin Endocrinol Metab. 2017 Mar 1;102(3):1032-1043. doi: 10.1210/jc.2016-2915.


Differentiation and Metabolic Interrogation of Human Adipocytes.

Baker NA, Muir LA, Lumeng CN, O'Rourke RW.

Methods Mol Biol. 2017;1566:61-76. doi: 10.1007/978-1-4939-6820-6_7.


Macrophage Proliferation Sustains Adipose Tissue Inflammation in Formerly Obese Mice.

Zamarron BF, Mergian TA, Cho KW, Martinez-Santibanez G, Luan D, Singer K, DelProposto JL, Geletka LM, Muir LA, Lumeng CN.

Diabetes. 2017 Feb;66(2):392-406. doi: 10.2337/db16-0500. Epub 2016 Nov 8.


The initiation of metabolic inflammation in childhood obesity.

Singer K, Lumeng CN.

J Clin Invest. 2017 Jan 3;127(1):65-73. doi: 10.1172/JCI88882. Epub 2017 Jan 3. Review.


Genomic binding of PAX8-PPARG fusion protein regulates cancer-related pathways and alters the immune landscape of thyroid cancer.

Zhang Y, Yu J, Grachtchouk V, Qin T, Lumeng CN, Sartor MA, Koenig RJ.

Oncotarget. 2017 Jan 24;8(4):5761-5773. doi: 10.18632/oncotarget.14050.


Adipose Tissue Dendritic Cells Are Independent Contributors to Obesity-Induced Inflammation and Insulin Resistance.

Cho KW, Zamarron BF, Muir LA, Singer K, Porsche CE, DelProposto JB, Geletka L, Meyer KA, O'Rourke RW, Lumeng CN.

J Immunol. 2016 Nov 1;197(9):3650-3661. Epub 2016 Sep 28.


Adipocytes promote pancreatic cancer cell proliferation via glutamine transfer.

Meyer KA, Neeley CK, Baker NA, Washabaugh AR, Flesher CG, Nelson BS, Frankel TL, Lumeng CN, Lyssiotis CA, Wynn ML, Rhim AD, O'Rourke RW.

Biochem Biophys Rep. 2016 Sep;7:144-149. Epub 2016 Jun 7.


Does bariatric surgery improve adipose tissue function?

Frikke-Schmidt H, O'Rourke RW, Lumeng CN, Sandoval DA, Seeley RJ.

Obes Rev. 2016 Sep;17(9):795-809. doi: 10.1111/obr.12429. Epub 2016 Jun 8. Review.


Lung Macrophage Diversity and Asthma.

Lumeng CN.

Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S31-4. doi: 10.1513/AnnalsATS.201506-384MG. Review.


Adipose tissue fibrosis, hypertrophy, and hyperplasia: Correlations with diabetes in human obesity.

Muir LA, Neeley CK, Meyer KA, Baker NA, Brosius AM, Washabaugh AR, Varban OA, Finks JF, Zamarron BF, Flesher CG, Chang JS, DelProposto JB, Geletka L, Martinez-Santibanez G, Kaciroti N, Lumeng CN, O'Rourke RW.

Obesity (Silver Spring). 2016 Mar;24(3):597-605. doi: 10.1002/oby.21377.


CD40 promotes MHC class II expression on adipose tissue macrophages and regulates adipose tissue CD4+ T cells with obesity.

Morris DL, Oatmen KE, Mergian TA, Cho KW, DelProposto JL, Singer K, Evans-Molina C, O'Rourke RW, Lumeng CN.

J Leukoc Biol. 2016 Jun;99(6):1107-19. doi: 10.1189/jlb.3A0115-009R. Epub 2015 Dec 11.


Obesity-induced remodeling of the adipose tissue elastin network is independent of the metalloelastase MMP-12.

Martinez-Santibanez G, Singer K, Cho KW, DelProposto JL, Mergian T, Lumeng CN.

Adipocyte. 2015 Apr 20;4(4):264-72. doi: 10.1080/21623945.2015.1027848. eCollection 2015 Oct-Dec.


Depletion of macrophages in CD11b diphtheria toxin receptor mice induces brain inflammation and enhances inflammatory signaling during traumatic brain injury.

Frieler RA, Nadimpalli S, Boland LK, Xie A, Kooistra LJ, Song J, Chung Y, Cho KW, Lumeng CN, Wang MM, Mortensen RM.

Brain Res. 2015 Oct 22;1624:103-112. doi: 10.1016/j.brainres.2015.07.011. Epub 2015 Jul 21.


Differences in Hematopoietic Stem Cells Contribute to Sexually Dimorphic Inflammatory Responses to High Fat Diet-induced Obesity.

Singer K, Maley N, Mergian T, DelProposto J, Cho KW, Zamarron BF, Martinez-Santibanez G, Geletka L, Muir L, Wachowiak P, Demirjian C, Lumeng CN.

J Biol Chem. 2015 May 22;290(21):13250-62. doi: 10.1074/jbc.M114.634568. Epub 2015 Apr 13.


A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis.

Reilly SM, Ahmadian M, Zamarron BF, Chang L, Uhm M, Poirier B, Peng X, Krause DM, Korytnaya E, Neidert A, Liddle C, Yu RT, Lumeng CN, Oral EA, Downes M, Evans RM, Saltiel AR.

Nat Commun. 2015 Jan 12;6:6047. doi: 10.1038/ncomms7047.


Fractalkine signaling in regulation of insulin secretion.

Gregg B, Lumeng CN, Bernal-Mizrachi E.

Islets. 2014;6(1):e27861. doi: 10.4161/isl.27861.


Child body shape measurement using depth cameras and a statistical body shape model.

Park BK, Lumeng JC, Lumeng CN, Ebert SM, Reed MP.

Ergonomics. 2015;58(2):301-9. doi: 10.1080/00140139.2014.965754. Epub 2014 Oct 17.


An MHC II-dependent activation loop between adipose tissue macrophages and CD4+ T cells controls obesity-induced inflammation.

Cho KW, Morris DL, DelProposto JL, Geletka L, Zamarron B, Martinez-Santibanez G, Meyer KA, Singer K, O'Rourke RW, Lumeng CN.

Cell Rep. 2014 Oct 23;9(2):605-17. doi: 10.1016/j.celrep.2014.09.004. Epub 2014 Oct 9.


Obesity-Related Hormones in Low-Income Preschool-Age Children: Implications for School Readiness.

Miller AL, Lumeng CN, Delproposto J, Florek B, Wendorf K, Lumeng JC.

Mind Brain Educ. 2013 Dec;7(4):246-255.


Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells.

Singer K, DelProposto J, Morris DL, Zamarron B, Mergian T, Maley N, Cho KW, Geletka L, Subbaiah P, Muir L, Martinez-Santibanez G, Lumeng CN.

Mol Metab. 2014 Jul 10;3(6):664-75. doi: 10.1016/j.molmet.2014.06.005. eCollection 2014 Sep.


Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction.

Cawthorn WP, Scheller EL, Learman BS, Parlee SD, Simon BR, Mori H, Ning X, Bree AJ, Schell B, Broome DT, Soliman SS, DelProposto JL, Lumeng CN, Mitra A, Pandit SV, Gallagher KA, Miller JD, Krishnan V, Hui SK, Bredella MA, Fazeli PK, Klibanski A, Horowitz MC, Rosen CJ, MacDougald OA.

Cell Metab. 2014 Aug 5;20(2):368-375. doi: 10.1016/j.cmet.2014.06.003. Epub 2014 Jul 3.


Heme oxygenase-1 drives metaflammation and insulin resistance in mouse and man.

Jais A, Einwallner E, Sharif O, Gossens K, Lu TT, Soyal SM, Medgyesi D, Neureiter D, Paier-Pourani J, Dalgaard K, Duvigneau JC, Lindroos-Christensen J, Zapf TC, Amann S, Saluzzo S, Jantscher F, Stiedl P, Todoric J, Martins R, Oberkofler H, Müller S, Hauser-Kronberger C, Kenner L, Casanova E, Sutterlüty-Fall H, Bilban M, Miller K, Kozlov AV, Krempler F, Knapp S, Lumeng CN, Patsch W, Wagner O, Pospisilik JA, Esterbauer H.

Cell. 2014 Jul 3;158(1):25-40. doi: 10.1016/j.cell.2014.04.043.


Systemic NK cell ablation attenuates intra-abdominal adipose tissue macrophage infiltration in murine obesity.

O'Rourke RW, Meyer KA, Neeley CK, Gaston GD, Sekhri P, Szumowski M, Zamarron B, Lumeng CN, Marks DL.

Obesity (Silver Spring). 2014 Oct;22(10):2109-14. doi: 10.1002/oby.20823. Epub 2014 Jun 24.


Flow cytometry analyses of adipose tissue macrophages.

Cho KW, Morris DL, Lumeng CN.

Methods Enzymol. 2014;537:297-314. doi: 10.1016/B978-0-12-411619-1.00016-1.


Imaging white adipose tissue with confocal microscopy.

Martinez-Santibañez G, Cho KW, Lumeng CN.

Methods Enzymol. 2014;537:17-30. doi: 10.1016/B978-0-12-411619-1.00002-1. Review.


The relationship between body fat mass percentiles and inflammation in children.

Singer K, Eng DS, Lumeng CN, Gebremariam A, M Lee J.

Obesity (Silver Spring). 2014 May;22(5):1332-6. doi: 10.1002/oby.20710. Epub 2014 Feb 18.


Otopetrin 1 protects mice from obesity-associated metabolic dysfunction through attenuating adipose tissue inflammation.

Wang GX, Cho KW, Uhm M, Hu CR, Li S, Cozacov Z, Xu AE, Cheng JX, Saltiel AR, Lumeng CN, Lin JD.

Diabetes. 2014 Apr;63(4):1340-52. doi: 10.2337/db13-1139. Epub 2013 Dec 30.


Thrombospondin 1 mediates high-fat diet-induced muscle fibrosis and insulin resistance in male mice.

Inoue M, Jiang Y, Barnes RH 2nd, Tokunaga M, Martinez-Santibañez G, Geletka L, Lumeng CN, Buchner DA, Chun TH.

Endocrinology. 2013 Dec;154(12):4548-59. doi: 10.1210/en.2013-1587. Epub 2013 Oct 18.


Hexosamine biosynthesis is a possible mechanism underlying hypoxia's effects on lipid metabolism in human adipocytes.

O'Rourke RW, Meyer KA, Gaston G, White AE, Lumeng CN, Marks DL.

PLoS One. 2013 Aug 14;8(8):e71165. doi: 10.1371/journal.pone.0071165. eCollection 2013.


Obesity heats up adipose tissue lymphocytes.

O'Rourke RW, Lumeng CN.

Gastroenterology. 2013 Aug;145(2):282-5. doi: 10.1053/j.gastro.2013.06.026. Epub 2013 Jun 24. No abstract available.


Targeted deletion of growth hormone (GH) receptor in macrophage reveals novel osteopontin-mediated effects of GH on glucose homeostasis and insulin sensitivity in diet-induced obesity.

Lu C, Kumar PA, Sun J, Aggarwal A, Fan Y, Sperling MA, Lumeng CN, Menon RK.

J Biol Chem. 2013 May 31;288(22):15725-35. doi: 10.1074/jbc.M113.460212. Epub 2013 Apr 17.


Adipose tissue macrophages function as antigen-presenting cells and regulate adipose tissue CD4+ T cells in mice.

Morris DL, Cho KW, Delproposto JL, Oatmen KE, Geletka LM, Martinez-Santibanez G, Singer K, Lumeng CN.

Diabetes. 2013 Aug;62(8):2762-72. doi: 10.2337/db12-1404. Epub 2013 Mar 14.


Neuropeptide Y is produced by adipose tissue macrophages and regulates obesity-induced inflammation.

Singer K, Morris DL, Oatmen KE, Wang T, DelProposto J, Mergian T, Cho KW, Lumeng CN.

PLoS One. 2013;8(3):e57929. doi: 10.1371/journal.pone.0057929. Epub 2013 Mar 5. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/c2432ace-1dd7-4b02-8980-e4e6c085beba.


Phosphorylation of the adaptor protein SH2B1β regulates its ability to enhance growth hormone-dependent macrophage motility.

Su HW, Lanning NJ, Morris DL, Argetsinger LS, Lumeng CN, Carter-Su C.

J Cell Sci. 2013 Apr 15;126(Pt 8):1733-43. doi: 10.1242/jcs.113050. Epub 2013 Feb 26.


Innate immune activation in obesity.

Lumeng CN.

Mol Aspects Med. 2013 Feb;34(1):12-29. doi: 10.1016/j.mam.2012.10.002. Epub 2012 Oct 13. Review.


Macrophages and the regulation of adipose tissue remodeling.

Martinez-Santibañez G, Lumeng CN.

Annu Rev Nutr. 2014;34:57-76. doi: 10.1146/annurev-nutr-071812-161113. Epub 2014 May 14. Review.


Toll-like receptor 4 deficiency promotes the alternative activation of adipose tissue macrophages.

Orr JS, Puglisi MJ, Ellacott KL, Lumeng CN, Wasserman DH, Hasty AH.

Diabetes. 2012 Nov;61(11):2718-27. doi: 10.2337/db11-1595. Epub 2012 Jun 29.


Smooth muscle protein 22 alpha-Cre is expressed in myeloid cells in mice.

Shen Z, Li C, Frieler RA, Gerasimova AS, Lee SJ, Wu J, Wang MM, Lumeng CN, Brosius FC 3rd, Duan SZ, Mortensen RM.

Biochem Biophys Res Commun. 2012 Jun 15;422(4):639-42. doi: 10.1016/j.bbrc.2012.05.041. Epub 2012 May 16.


Daily and intermittent corticosteroids have similar impact on recurrent wheezing in young children.

Ramirez I, Lumeng CN.

J Pediatr. 2012 May;160(5):881. doi: 10.1016/j.jpeds.2012.01.060. No abstract available.


CX3CR1 deficiency does not influence trafficking of adipose tissue macrophages in mice with diet-induced obesity.

Morris DL, Oatmen KE, Wang T, DelProposto JL, Lumeng CN.

Obesity (Silver Spring). 2012 Jun;20(6):1189-99. doi: 10.1038/oby.2012.7. Epub 2012 Jan 17.


SirT1: a guardian at the gates of adipose tissue inflammation.

Cho KW, Lumeng CN.

Diabetes. 2011 Dec;60(12):3100-2. doi: 10.2337/db11-1308. No abstract available.


Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue.

Lumeng CN, Liu J, Geletka L, Delaney C, Delproposto J, Desai A, Oatmen K, Martinez-Santibanez G, Julius A, Garg S, Yung RL.

J Immunol. 2011 Dec 15;187(12):6208-16. doi: 10.4049/jimmunol.1102188. Epub 2011 Nov 9.


Inflammatory links between obesity and metabolic disease.

Lumeng CN, Saltiel AR.

J Clin Invest. 2011 Jun;121(6):2111-7. doi: 10.1172/JCI57132. Epub 2011 Jun 1. Review.


Adipose tissue macrophages: phenotypic plasticity and diversity in lean and obese states.

Morris DL, Singer K, Lumeng CN.

Curr Opin Clin Nutr Metab Care. 2011 Jul;14(4):341-6. doi: 10.1097/MCO.0b013e328347970b. Review.

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