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Items: 1 to 50 of 56

1.

Afferent neural feedback overrides the modulating effects of arousal, hypercapnia and hypoxaemia on neonatal cardiorespiratory control.

Lumb KJ, Schneider JM, Ibrahim T, Rigaux A, Hasan SU.

J Physiol. 2018 Apr 20. doi: 10.1113/JP275682. [Epub ahead of print]

PMID:
29676798
2.

Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40.

Lu J, Byrne N, Wang J, Bricogne G, Brown FK, Chobanian HR, Colletti SL, Di Salvo J, Thomas-Fowlkes B, Guo Y, Hall DL, Hadix J, Hastings NB, Hermes JD, Ho T, Howard AD, Josien H, Kornienko M, Lumb KJ, Miller MW, Patel SB, Pio B, Plummer CW, Sherborne BS, Sheth P, Souza S, Tummala S, Vonrhein C, Webb M, Allen SJ, Johnston JM, Weinglass AB, Sharma S, Soisson SM.

Nat Struct Mol Biol. 2017 Jul;24(7):570-577. doi: 10.1038/nsmb.3417. Epub 2017 Jun 5.

PMID:
28581512
3.

Insights into activity and inhibition from the crystal structure of human O-GlcNAcase.

Elsen NL, Patel SB, Ford RE, Hall DL, Hess F, Kandula H, Kornienko M, Reid J, Selnick H, Shipman JM, Sharma S, Lumb KJ, Soisson SM, Klein DJ.

Nat Chem Biol. 2017 Jun;13(6):613-615. doi: 10.1038/nchembio.2357. Epub 2017 Mar 27.

PMID:
28346407
4.

Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction.

Blevitt JM, Hack MD, Herman KL, Jackson PF, Krawczuk PJ, Lebsack AD, Liu AX, Mirzadegan T, Nelen MI, Patrick AN, Steinbacher S, Milla ME, Lumb KJ.

J Med Chem. 2017 Apr 27;60(8):3511-3517. doi: 10.1021/acs.jmedchem.6b01836. Epub 2017 Mar 16.

PMID:
28300404
5.

Structural characterization of nonactive site, TrkA-selective kinase inhibitors.

Su HP, Rickert K, Burlein C, Narayan K, Bukhtiyarova M, Hurzy DM, Stump CA, Zhang X, Reid J, Krasowska-Zoladek A, Tummala S, Shipman JM, Kornienko M, Lemaire PA, Krosky D, Heller A, Achab A, Chamberlin C, Saradjian P, Sauvagnat B, Yang X, Ziebell MR, Nickbarg E, Sanders JM, Bilodeau MT, Carroll SS, Lumb KJ, Soisson SM, Henze DA, Cooke AJ.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):E297-E306. doi: 10.1073/pnas.1611577114. Epub 2016 Dec 30.

6.

Integration of Affinity Selection-Mass Spectrometry and Functional Cell-Based Assays to Rapidly Triage Druggable Target Space within the NF-κB Pathway.

Kutilek VD, Andrews CL, Richards MP, Xu Z, Sun T, Chen Y, Hashke A, Smotrov N, Fernandez R, Nickbarg EB, Chamberlin C, Sauvagnat B, Curran PJ, Boinay R, Saradjian P, Allen SJ, Byrne N, Elsen NL, Ford RE, Hall DL, Kornienko M, Rickert KW, Sharma S, Shipman JM, Lumb KJ, Coleman K, Dandliker PJ, Kariv I, Beutel B.

J Biomol Screen. 2016 Jul;21(6):608-19. doi: 10.1177/1087057116637353. Epub 2016 Mar 11.

PMID:
26969322
7.

Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4.

Allen SJ, Parthasarathy G, Darke PL, Diehl RE, Ford RE, Hall DL, Johnson SA, Reid JC, Rickert KW, Shipman JM, Soisson SM, Zuck P, Munshi SK, Lumb KJ.

J Biol Chem. 2015 Aug 14;290(33):20360-73. doi: 10.1074/jbc.M115.648907. Epub 2015 Jul 1.

8.

Structures of kibdelomycin bound to Staphylococcus aureus GyrB and ParE showed a novel U-shaped binding mode.

Lu J, Patel S, Sharma N, Soisson SM, Kishii R, Takei M, Fukuda Y, Lumb KJ, Singh SB.

ACS Chem Biol. 2014 Sep 19;9(9):2023-31. doi: 10.1021/cb5001197. Epub 2014 Jul 3.

PMID:
24992706
9.

Structure of the bacterial deacetylase LpxC bound to the nucleotide reaction product reveals mechanisms of oxyanion stabilization and proton transfer.

Clayton GM, Klein DJ, Rickert KW, Patel SB, Kornienko M, Zugay-Murphy J, Reid JC, Tummala S, Sharma S, Singh SB, Miesel L, Lumb KJ, Soisson SM.

J Biol Chem. 2013 Nov 22;288(47):34073-80. doi: 10.1074/jbc.M113.513028. Epub 2013 Oct 9.

10.

Mechanism of action of the cell-division inhibitor PC190723: modulation of FtsZ assembly cooperativity.

Elsen NL, Lu J, Parthasarathy G, Reid JC, Sharma S, Soisson SM, Lumb KJ.

J Am Chem Soc. 2012 Aug 1;134(30):12342-5. doi: 10.1021/ja303564a. Epub 2012 Jul 20.

PMID:
22793495
11.

Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics.

Tan CM, Therien AG, Lu J, Lee SH, Caron A, Gill CJ, Lebeau-Jacob C, Benton-Perdomo L, Monteiro JM, Pereira PM, Elsen NL, Wu J, Deschamps K, Petcu M, Wong S, Daigneault E, Kramer S, Liang L, Maxwell E, Claveau D, Vaillancourt J, Skorey K, Tam J, Wang H, Meredith TC, Sillaots S, Wang-Jarantow L, Ramtohul Y, Langlois E, Landry F, Reid JC, Parthasarathy G, Sharma S, Baryshnikova A, Lumb KJ, Pinho MG, Soisson SM, Roemer T.

Sci Transl Med. 2012 Mar 21;4(126):126ra35. doi: 10.1126/scitranslmed.3003592.

12.

Prenatal cigarette smoke exposure and postnatal respiratory responses to hypoxia and hypercapnia.

Pendlebury JD, Yusuf K, Bano S, Lumb KJ, Schneider JM, Hasan SU.

Pediatr Pulmonol. 2012 May;47(5):487-97. doi: 10.1002/ppul.21578. Epub 2011 Oct 25.

PMID:
22028310
13.

Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer.

Katz JD, Jewell JP, Guerin DJ, Lim J, Dinsmore CJ, Deshmukh SV, Pan BS, Marshall CG, Lu W, Altman MD, Dahlberg WK, Davis L, Falcone D, Gabarda AE, Hang G, Hatch H, Holmes R, Kunii K, Lumb KJ, Lutterbach B, Mathvink R, Nazef N, Patel SB, Qu X, Reilly JF, Rickert KW, Rosenstein C, Soisson SM, Spencer KB, Szewczak AA, Walker D, Wang W, Young J, Zeng Q.

J Med Chem. 2011 Jun 23;54(12):4092-108. doi: 10.1021/jm200112k. Epub 2011 May 24.

PMID:
21608528
14.

Structural basis for selective small molecule kinase inhibition of activated c-Met.

Rickert KW, Patel SB, Allison TJ, Byrne NJ, Darke PL, Ford RE, Guerin DJ, Hall DL, Kornienko M, Lu J, Munshi SK, Reid JC, Shipman JM, Stanton EF, Wilson KJ, Young JR, Soisson SM, Lumb KJ.

J Biol Chem. 2011 Apr 1;286(13):11218-25. doi: 10.1074/jbc.M110.204404. Epub 2011 Jan 18.

15.

Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase.

Soisson SM, Patel SB, Abeywickrema PD, Byrne NJ, Diehl RE, Hall DL, Ford RE, Reid JC, Rickert KW, Shipman JM, Sharma S, Lumb KJ.

BMC Struct Biol. 2010 Jun 11;10:16. doi: 10.1186/1472-6807-10-16.

16.

Expression, purification and crystallization of human prolylcarboxypeptidase.

Abeywickrema PD, Patel SB, Byrne NJ, Diehl RE, Hall DL, Ford RE, Rickert KW, Reid JC, Shipman JM, Geissler WM, Pryor KD, SinhaRoy R, Soisson SM, Lumb KJ, Sharma S.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jun 1;66(Pt 6):702-5. doi: 10.1107/S1744309110014041. Epub 2010 May 27.

17.

Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation.

Sunami T, Byrne N, Diehl RE, Funabashi K, Hall DL, Ikuta M, Patel SB, Shipman JM, Smith RF, Takahashi I, Zugay-Murphy J, Iwasawa Y, Lumb KJ, Munshi SK, Sharma S.

J Biol Chem. 2010 Feb 12;285(7):4587-94. doi: 10.1074/jbc.M109.040667. Epub 2009 Oct 28.

18.

Respiratory control in neonatal rats exposed to prenatal cigarette smoke.

Pendlebury JD, Wilson RJ, Bano S, Lumb KJ, Schneider JM, Hasan SU.

Am J Respir Crit Care Med. 2008 Jun 1;177(11):1255-61. doi: 10.1164/rccm.200711-1739OC. Epub 2008 Feb 28.

PMID:
18310476
19.

A novel long-acting selective neuropeptide Y2 receptor polyethylene glycol-conjugated peptide agonist reduces food intake and body weight and improves glucose metabolism in rodents.

Ortiz AA, Milardo LF, DeCarr LB, Buckholz TM, Mays MR, Claus TH, Livingston JN, Mahle CD, Lumb KJ.

J Pharmacol Exp Ther. 2007 Nov;323(2):692-700. Epub 2007 Aug 1.

20.

Generation and characterization of a monoclonal IgG antibody to polyethylene glycol.

Wunderlich DA, Macdougall M, Mierz DV, Toth JG, Buckholz TM, Lumb KJ, Vasavada H.

Hybridoma (Larchmt). 2007 Jun;26(3):168-72.

PMID:
17600499
21.

High-throughput screening by mass spectrometry: comparison with the scintillation proximity assay with a focused-file screen of AKT1/PKB alpha.

Quercia AK, LaMarr WA, Myung J, Ozbal CC, Landro JA, Lumb KJ.

J Biomol Screen. 2007 Jun;12(4):473-80. Epub 2007 May 3.

PMID:
17478485
22.

High-throughput mass spectrometry screening for inhibitors of phosphatidylserine decarboxylase.

Forbes CD, Toth JG, Ozbal CC, Lamarr WA, Pendleton JA, Rocks S, Gedrich RW, Osterman DG, Landro JA, Lumb KJ.

J Biomol Screen. 2007 Aug;12(5):628-34. Epub 2007 May 3.

PMID:
17478478
23.

Novel selective neuropeptide Y2 receptor PEGylated peptide agonists reduce food intake and body weight in mice.

Lumb KJ, DeCarr LB, Milardo LF, Mays MR, Buckholz TM, Fisk SE, Pellegrino CM, Ortiz AA, Mahle CD.

J Med Chem. 2007 May 3;50(9):2264-8. Epub 2007 Apr 11.

PMID:
17425299
24.

A long-acting selective neuropeptide Y2 receptor PEGylated peptide agonist reduces food intake in mice.

DeCarr LB, Buckholz TM, Milardo LF, Mays MR, Ortiz A, Lumb KJ.

Bioorg Med Chem Lett. 2007 Apr 1;17(7):1916-9. Epub 2007 Jan 24.

PMID:
17292607
25.

Engineering of a VPAC2 receptor peptide agonist to impart dipeptidyl peptidase IV stability and enhance in vivo glucose disposal.

Clairmont KB, Buckholz TM, Pellegrino CM, Buxton JM, Barucci N, Bell A, Ha S, Li F, Claus TH, Salhanick AI, Lumb KJ.

J Med Chem. 2006 Dec 14;49(25):7545-8.

PMID:
17149884
26.

Identification of selective neuropeptide Y2 peptide agonists.

DeCarr LB, Buckholz TM, Coish PD, Fathi Z, Fisk SE, Mays MR, O'Connor SJ, Lumb KJ.

Bioorg Med Chem Lett. 2007 Jan 15;17(2):538-41. Epub 2006 Oct 7.

PMID:
17055726
27.

Contribution of site-specific PEGylation to the dipeptidyl peptidase IV stability of glucose-dependent insulinotropic polypeptide.

Salhanick AI, Clairmont KB, Buckholz TM, Pellegrino CM, Ha S, Lumb KJ.

Bioorg Med Chem Lett. 2005 Sep 15;15(18):4114-7.

PMID:
15993590
28.

Slow folding of a three-helix protein via a compact intermediate.

Horng JC, Tracz SM, Lumb KJ, Raleigh DP.

Biochemistry. 2005 Jan 18;44(2):627-34.

PMID:
15641788
29.
30.

KIX-mediated assembly of the CBP-CREB-HTLV-1 tax coactivator-activator complex.

Vendel AC, McBryant SJ, Lumb KJ.

Biochemistry. 2003 Nov 4;42(43):12481-7.

PMID:
14580193
31.

Contribution to stability and folding of a buried polar residue at the CARM1 methylation site of the KIX domain of CBP.

Wei Y, Horng JC, Vendel AC, Raleigh DP, Lumb KJ.

Biochemistry. 2003 Jun 17;42(23):7044-9.

PMID:
12795599
32.
33.

Structurally distinct modes of recognition of the KIX domain of CBP by Jun and CREB.

Campbell KM, Lumb KJ.

Biochemistry. 2002 Nov 26;41(47):13956-64.

PMID:
12437352
34.
35.

Contribution of buried lysine residues to the oligomerization specificity and stability of the fos coiled coil.

Campbell KM, Sholders AJ, Lumb KJ.

Biochemistry. 2002 Apr 16;41(15):4866-71.

PMID:
11939781
36.
37.

Effects of macromolecular crowding on the intrinsically disordered proteins c-Fos and p27(Kip1).

Flaugh SL, Lumb KJ.

Biomacromolecules. 2001 Summer;2(2):538-40.

PMID:
11749217
38.
39.

Transcriptional activity of the TFIIA four-helix bundle in vivo.

Stargell LA, Ogg RC, Adkins JN, Robinson MM, Lumb KJ.

Proteins. 2001 May 1;43(2):227-32.

PMID:
11276091
40.

Stoichiometry of cyclin A-cyclin-dependent kinase 2 inhibition by p21Cip1/Waf1.

Adkins JN, Lumb KJ.

Biochemistry. 2000 Nov 14;39(45):13925-30.

PMID:
11076534
41.

Random-coil chemical shifts of phosphorylated amino acids.

Bienkiewicz EA, Lumb KJ.

J Biomol NMR. 1999 Nov;15(3):203-6.

PMID:
10677823
42.

Intrinsic structural disorder of the C-terminal activation domain from the bZIP transcription factor Fos.

Campbell KM, Terrell AR, Laybourn PJ, Lumb KJ.

Biochemistry. 2000 Mar 14;39(10):2708-13.

PMID:
10704222
43.

Reevaluation of transcriptional regulation by TATA-binding protein oligomerization: predominance of monomers.

Campbell KM, Ranallo RT, Stargell LA, Lumb KJ.

Biochemistry. 2000 Mar 14;39(10):2633-8.

PMID:
10704213
44.

Electrostatic contribution of phosphorylation to the stability of the CREB-CBP activator-coactivator complex.

Mestas SP, Lumb KJ.

Nat Struct Biol. 1999 Jul;6(7):613-4. No abstract available.

PMID:
10404213
45.

A buried polar interaction imparts structural uniqueness in a designed heterodimeric coiled coil

Lumb KJ, Kim PS.

Biochemistry. 1998 Sep 15;37(37):13042. No abstract available.

PMID:
9737894
46.

Response: how much solar radiation do clouds absorb?

Lumb KJ, Kim PS.

Science. 1996 Feb 23;271(5252):1137-8. No abstract available.

PMID:
17792302
47.

Cooperatively folded proteins in random sequence libraries.

Davidson AR, Lumb KJ, Sauer RT.

Nat Struct Biol. 1995 Oct;2(10):856-64.

PMID:
7552709
48.

A buried polar interaction imparts structural uniqueness in a designed heterodimeric coiled coil.

Lumb KJ, Kim PS.

Biochemistry. 1995 Jul 11;34(27):8642-8. Erratum in: Biochemistry 1998 Sep 15;37(37):13042.

PMID:
7612604
49.

Measurement of interhelical electrostatic interactions in the GCN4 leucine zipper.

Lumb KJ, Kim PS.

Science. 1995 Apr 21;268(5209):436-9.

PMID:
7716550
50.

Subdomain folding of the coiled coil leucine zipper from the bZIP transcriptional activator GCN4.

Lumb KJ, Carr CM, Kim PS.

Biochemistry. 1994 Jun 14;33(23):7361-7.

PMID:
8003501

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