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Treatment of hematological malignancies with T cell redirected bispecific antibodies: current status and future needs.

Foster LH, Lum LG.

Expert Opin Biol Ther. 2019 Jul;19(7):707-720. doi: 10.1080/14712598.2019.1604672. Epub 2019 May 13.


Parental concern of feeding difficulty predicts poor growth status in their child.

Lee WS, Tee CW, Tan AG, Wong SY, Chew KS, Cheang HK, Lim T, Lum LC, Aw MM.

Pediatr Neonatol. 2019 Apr 13. pii: S1875-9572(18)30549-7. doi: 10.1016/j.pedneo.2019.04.004. [Epub ahead of print]


Stereoselective fatty acylation is essential for the release of lipidated WNT proteins from the acyltransferase Porcupine (PORCN).

Tuladhar R, Yarravarapu N, Ma Y, Zhang C, Herbert J, Kim J, Chen C, Lum L.

J Biol Chem. 2019 Apr 19;294(16):6273-6282. doi: 10.1074/jbc.RA118.007268. Epub 2019 Feb 8.


Using clinical practice guidelines to manage dengue: a qualitative study in a Malaysian hospital.

Wharton-Smith A, Green J, Loh EC, Gorrie A, Omar SFS, Bacchus L, Lum LCS.

BMC Infect Dis. 2019 Jan 11;19(1):45. doi: 10.1186/s12879-019-3680-5.


Winds of change in medical education in Singapore: what does the future hold?

Lum LHW, Poh KK, Tambyah PA.

Singapore Med J. 2018 Dec;59(12):614-615. doi: 10.11622/smedj.2018142. No abstract available.


Immune T cells can transfer and boost anti-breast cancer immunity.

Thakur A, Rathore R, Kondadasula SV, Uberti JP, Ratanatharathorn V, Lum LG.

Oncoimmunology. 2018 Aug 27;7(12):e1500672. doi: 10.1080/2162402X.2018.1500672. eCollection 2018.


Installation of a cancer promoting WNT/SIX1 signaling axis by the oncofusion protein MLL-AF9.

Zhang LS, Kang X, Lu J, Zhang Y, Wu X, Wu G, Zheng J, Tuladhar R, Shi H, Wang Q, Morlock L, Yao H, Huang LJ, Maire P, Kim J, Williams N, Xu J, Chen C, Zhang CC, Lum L.

EBioMedicine. 2019 Jan;39:145-158. doi: 10.1016/j.ebiom.2018.11.039. Epub 2018 Dec 6.


Regulation of tankyrase activity by a catalytic domain dimer interface.

Fan C, Yarravarapu N, Chen H, Kulak O, Dasari P, Herbert J, Yamaguchi K, Lum L, Zhang X.

Biochem Biophys Res Commun. 2018 Sep 10;503(3):1780-1785. doi: 10.1016/j.bbrc.2018.07.113. Epub 2018 Jul 26.


Differences Between Pulmonary and Extrapulmonary Pediatric Acute Respiratory Distress Syndrome: A Multicenter Analysis.

Gan CS, Wong JJ, Samransamruajkit R, Chuah SL, Chor YK, Qian S, Anantasit N, Feng X, Ong JSM, Phuc PH, Phumeetham S, Sultana R, Loh TF, Lum LCS, Lee JH; Pediatric Acute and Critical Care Medicine Asian Network (PACCMAN).

Pediatr Crit Care Med. 2018 Oct;19(10):e504-e513. doi: 10.1097/PCC.0000000000001667.


Culture-confirmed cryptococcal meningitis not detected by Cryptococcus PCR on the Biofire meningitis/encephalitis panel®.

Chew KL, Lee CK, Cross GB, Lum LHW, Yan B, Jureen R.

Clin Microbiol Infect. 2018 Jul;24(7):791-792. doi: 10.1016/j.cmi.2018.02.024. Epub 2018 Mar 1. No abstract available.


EGF Receptor and mTORC1 Are Novel Therapeutic Targets in Nonseminomatous Germ Cell Tumors.

Chen KS, Fustino NJ, Shukla AA, Stroup EK, Budhipramono A, Ateek C, Stuart SH, Yamaguchi K, Kapur P, Frazier AL, Lum L, Looijenga LHJ, Laetsch TW, Rakheja D, Amatruda JF.

Mol Cancer Ther. 2018 May;17(5):1079-1089. doi: 10.1158/1535-7163.MCT-17-0137. Epub 2018 Feb 26.


Bispecific antibody based therapeutics: Strengths and challenges.

Thakur A, Huang M, Lum LG.

Blood Rev. 2018 Jul;32(4):339-347. doi: 10.1016/j.blre.2018.02.004. Epub 2018 Feb 20. Review.


Chemical Modulation of WNT Signaling in Cancer.

Zhang LS, Lum L.

Prog Mol Biol Transl Sci. 2018 Jan;153:245-269. doi: 10.1016/bs.pmbts.2017.11.008. Epub 2018 Jan 8. Review.


A synthetic combinatorial approach to disabling deviant Hedgehog signaling.

Fan CW, Yarravarapu N, Shi H, Kulak O, Kim J, Chen C, Lum L.

Sci Rep. 2018 Jan 18;8(1):1133. doi: 10.1038/s41598-018-19408-9.


Bispecific Antibody Armed T Cells to Target Cancer Cells.

Thakur A, Lum LG, Mittal S.

Methods Mol Biol. 2018;1722:117-126. doi: 10.1007/978-1-4939-7553-2_8.


Effectiveness of a fluid chart in outpatient management of suspected dengue fever: A pilot study.

Nasir NH, Mohamad M, Lum LCS, Ng CJ.

PLoS One. 2017 Oct 4;12(10):e0183544. doi: 10.1371/journal.pone.0183544. eCollection 2017.


Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor.

Wu X, Zhang LS, Toombs J, Kuo YC, Piazza JT, Tuladhar R, Barrett Q, Fan CW, Zhang X, Walensky LD, Kool M, Cheng SY, Brekken R, Opferman JT, Green DR, Moldoveanu T, Lum L.

Nat Cell Biol. 2017 Oct;19(10):1226-1236. doi: 10.1038/ncb3616. Epub 2017 Sep 25.


Immune Modulation Therapy and Imaging: Workshop Report.

Shields AF, Jacobs PM, Sznol M, Graham MM, Germain RN, Lum LG, Jaffee EM, de Vries EGE, Nimmagadda S, Van den Abbeele AD, Leung DK, Wu AM, Sharon E, Shankar LK.

J Nucl Med. 2018 Mar;59(3):410-417. doi: 10.2967/jnumed.117.195610. Epub 2017 Aug 17.


Fever and Pancytopenia in a Liver Transplant Recipient: Going Against the Rules of Occam's Razor.

Lum LHW, Chen FW, Jackett L, Strasser SI, Davis RJ.

Transplant Direct. 2017 Jun 6;3(7):e169. doi: 10.1097/TXD.0000000000000691. eCollection 2017 Jul.


Low incidence of severe cGvHD and late NRM in a phase II trial of thymoglobulin, tacrolimus and sirolimus for GvHD prevention.

Al-Kadhimi Z, Gul Z, Abidi M, Lum LG, Deol A, Chen W, Jang H, Ozust C, Langston A, Waller E, Uberti J.

Bone Marrow Transplant. 2017 Sep;52(9):1304-1310. doi: 10.1038/bmt.2017.95. Epub 2017 Jun 5.


Fluoroquinolone prophylaxis in autologous hematopoietic stem cell transplant recipients.

Modi D, Jang H, Kim S, Surapaneni M, Sankar K, Deol A, Ayash L, Bhutani D, Lum LG, Ratanatharathorn V, Manasa R, Mellert K, Chandrasekar P, Uberti JP.

Support Care Cancer. 2017 Aug;25(8):2593-2601. doi: 10.1007/s00520-017-3670-3. Epub 2017 Apr 2.


Prophylactic platelet transfusion plus supportive care versus supportive care alone in adults with dengue and thrombocytopenia: a multicentre, open-label, randomised, superiority trial.

Lye DC, Archuleta S, Syed-Omar SF, Low JG, Oh HM, Wei Y, Fisher D, Ponnampalavanar SSL, Wijaya L, Lee LK, Ooi EE, Kamarulzaman A, Lum LC, Tambyah PA, Leo YS.

Lancet. 2017 Apr 22;389(10079):1611-1618. doi: 10.1016/S0140-6736(17)30269-6. Epub 2017 Mar 8.


The Assessment, Evaluation, and Management of the Critically Ill Child When Resources are Limited-Southeast Asian Perspective.

Tang SF, Lum L.

J Pediatr Intensive Care. 2017 Mar;6(1):6-11. doi: 10.1055/s-0036-1584672. Epub 2016 Jun 20. Review.


Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist.

Moon J, Zhou H, Zhang LS, Tan W, Liu Y, Zhang S, Morlock LK, Bao X, Palecek SP, Feng JQ, Williams NS, Amatruda JF, Olson EN, Bassel-Duby R, Lum L.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1649-1654. doi: 10.1073/pnas.1621346114. Epub 2017 Jan 31.


Erratum to: Delivery of the Porcupine Inhibitor WNT974 in Mice.

Zhang LS, Lum L.

Methods Mol Biol. 2016;1481:E1. No abstract available.


Development of a triazole class of highly potent Porcn inhibitors.

You L, Zhang C, Yarravarapu N, Morlock L, Wang X, Zhang L, Williams NS, Lum L, Chen C.

Bioorg Med Chem Lett. 2016 Dec 15;26(24):5891-5895. doi: 10.1016/j.bmcl.2016.11.012. Epub 2016 Nov 11.


Cancer Immunology and Immunotherapy.

Sukari A, Nagasaka M, Al-Hadidi A, Lum LG.

Anticancer Res. 2016 Nov;36(11):5593-5606. Review.


Thirteen years of invasive and noninvasive home ventilation for children in a developing country: A retrospective study.

Nathan AM, Loo HY, de Bruyne JA, Eg KP, Kee SY, Thavagnanam S, Bouniu M, Wong JE, Gan CS, Lum LC.

Pediatr Pulmonol. 2017 Apr;52(4):500-507. doi: 10.1002/ppul.23569. Epub 2016 Oct 6.


Pandemic Preparedness: Nationally-Led Simulation to Test Hospital Systems.

Lum LH, Badaruddin H, Salmon S, Cutter J, Lim AY, Fisher D.

Ann Acad Med Singapore. 2016 Aug;45(8):332-7. No abstract available.


Delivery of the Porcupine Inhibitor WNT974 in Mice.

Zhang LS, Lum L.

Methods Mol Biol. 2016;1481:111-7. doi: 10.1007/978-1-4939-6393-5_12. Erratum in: Methods Mol Biol. 2016;1481:E1.


Monitoring Wnt Protein Acylation Using an In Vitro Cyclo-Addition Reaction.

Tuladhar R, Yarravarapu N, Lum L.

Methods Mol Biol. 2016;1481:11-6. doi: 10.1007/978-1-4939-6393-5_2.


Aminoglycoside-associated acute kidney injury in elderly patients with and without shock.

Ong LZ, Tambyah PA, Lum LH, Low ZJ, Cheng I, Murali TM, Wan MQ, Chua HR.

J Antimicrob Chemother. 2016 Nov;71(11):3250-3257. Epub 2016 Aug 5.


Internationally educated nurses' reflections on nursing communication in Canada.

Lum L, Dowedoff P, Englander K.

Int Nurs Rev. 2016 Sep;63(3):344-51. doi: 10.1111/inr.12300. Epub 2016 Jun 29.


Incidence, etiology, and outcome of pleural effusions in allogeneic hematopoietic stem cell transplantation.

Modi D, Jang H, Kim S, Deol A, Ayash L, Bhutani D, Lum LG, Ratanatharathorn V, Manasa R, Mellert K, Uberti JP.

Am J Hematol. 2016 Sep;91(9):E341-7. doi: 10.1002/ajh.24435. Epub 2016 Jul 14.


Neutralizing Anti-Interferon-Gamma Autoantibody Levels May Not Correlate With Clinical Course of Disease.

Tham EH, Huang CH, Soh JY, Thayalasingam M, Lee AJ, Lum LH, Poon LM, Lye DC, Chai LY, Tambyah PA, Lee BW, Shek LP.

Clin Infect Dis. 2016 Aug 15;63(4):572-3. doi: 10.1093/cid/ciw351. Epub 2016 May 25. No abstract available.


In Situ immunization by bispecific antibody targeted T cell therapy in breast cancer.

Thakur A, Lum LG.

Oncoimmunology. 2015 Jul 15;5(3):e1055061. eCollection 2016 Mar.


Comparison of Pediatric Severe Sepsis Managed in U.S. and European ICUs.

Giuliano JS Jr, Markovitz BP, Brierley J, Levin R, Williams G, Lum LC, Dorofaeff T, Cruces P, Bush JL, Keele L, Nadkarni VM, Thomas NJ, Fitzgerald JC, Weiss SL; Sepsis PRevalence, OUtcomes, and Therapies Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators Network.

Pediatr Crit Care Med. 2016 Jun;17(6):522-30. doi: 10.1097/PCC.0000000000000760.


Targeted delivery of siRNA to activated T cells via transferrin-polyethylenimine (Tf-PEI) as a potential therapy of asthma.

Xie Y, Kim NH, Nadithe V, Schalk D, Thakur A, Kılıç A, Lum LG, Bassett DJP, Merkel OM.

J Control Release. 2016 May 10;229:120-129. doi: 10.1016/j.jconrel.2016.03.029. Epub 2016 Mar 19.


"NextGen" Biologics: Bispecific Antibodies and Emerging Clinical Results.

Thakur A, Lum LG.

Expert Opin Biol Ther. 2016;16(5):675-88. doi: 10.1517/14712598.2016.1150996. Epub 2016 Mar 16. Review.


Targeting CD138-/CD20+ Clonogenic Myeloma Precursor Cells Decreases These Cells and Induces Transferable Antimyeloma Immunity.

Lum LG, Thakur A, Kondadasula SV, Al-Kadhimi Z, Deol A, Tomaszewski EN, Yano H, Schalk DL, Ayash L, Zonder JA, Uberti JP, Abidi MH, Ratanatharathorn V.

Biol Blood Marrow Transplant. 2016 May;22(5):869-78. doi: 10.1016/j.bbmt.2015.12.030. Epub 2016 Jan 28.


Preferential expression of functional IL-17R in glioma stem cells: potential role in self-renewal.

Parajuli P, Anand R, Mandalaparty C, Suryadevara R, Sriranga PU, Michelhaugh SK, Cazacu S, Finniss S, Thakur A, Lum LG, Schalk D, Brodie C, Mittal S.

Oncotarget. 2016 Feb 2;7(5):6121-35. doi: 10.18632/oncotarget.6847.


Vascular leakage in dengue--clinical spectrum and influence of parenteral fluid therapy.

Rosenberger KD, Lum L, Alexander N, Junghanss T, Wills B, Jaenisch T; DENCO Clinical Study Group.

Trop Med Int Health. 2016 Mar;21(3):445-53. doi: 10.1111/tmi.12666. Epub 2016 Feb 3.


Activated T cells armed with bispecific antibodies kill tumor targets.

Bhutani D, Lum LG.

Curr Opin Hematol. 2015 Nov;22(6):476-83. doi: 10.1097/MOH.0000000000000176. Review.


Impact of infection control training for interns on PICU-acquired bloodstream infections in a middle-income country.

Ng YY, Abdel-Latif Mel-A, Gan CS, Siham A, Zainol H, Lum LC.

Singapore Med J. 2015 Sep;56(9):506-12. doi: 10.11622/smedj.2015135.


Role of the Exocyst Complex Component Sec6/8 in Genomic Stability.

Torres MJ, Pandita RK, Kulak O, Kumar R, Formstecher E, Horikoshi N, Mujoo K, Hunt CR, Zhao Y, Lum L, Zaman A, Yeaman C, White MA, Pandita TK.

Mol Cell Biol. 2015 Nov;35(21):3633-45. doi: 10.1128/MCB.00768-15. Epub 2015 Aug 17.


Strategy in managing anticoagulation therapy following prosthetic heart valve replacement in a patient with dengue fever.

Lum LH, Chan M, Leo YS.

Int J Cardiol. 2015 Nov 15;199:432-4. doi: 10.1016/j.ijcard.2015.07.098. Epub 2015 Aug 2. No abstract available.


BEAM Conditioning Regimen Has Higher Toxicity Compared With High-Dose Melphalan for Salvage Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma.

Veeraputhiran M, Jain T, Deol A, Ayash L, Kim S, Dyson G, Bhutani D, Lum LG, Ratanatharathorn V, Uberti JP, Abidi MH.

Clin Lymphoma Myeloma Leuk. 2015 Sep;15(9):531-5. doi: 10.1016/j.clml.2015.05.008. Epub 2015 Jun 6.


Cohorting Dengue Patients Improves the Quality of Care and Clinical Outcome.

Lum LC, Syed Omar SF, Sri La Sri Ponnampalavanar S, Tan LH, Sekaran SD, Kamarulzaman A.

PLoS Negl Trop Dis. 2015 Jun 5;9(6):e0003836. doi: 10.1371/journal.pntd.0003836. eCollection 2015 Jun.


Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells.

Kulak O, Chen H, Holohan B, Wu X, He H, Borek D, Otwinowski Z, Yamaguchi K, Garofalo LA, Ma Z, Wright W, Chen C, Shay JW, Zhang X, Lum L.

Mol Cell Biol. 2015 Jul;35(14):2425-35. doi: 10.1128/MCB.00392-15. Epub 2015 May 4.

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