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Items: 13

1.

Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan.

Chen AL, Lum KM, Lara-Gonzalez P, Ogasawara D, Cognetta AB 3rd, To A, Parsons WH, Simon GM, Desai A, Petrascheck M, Bar-Peled L, Cravatt BF.

Nat Chem Biol. 2019 May;15(5):453-462. doi: 10.1038/s41589-019-0243-4. Epub 2019 Mar 25.

2.

Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors.

Tan J, Cognetta Iii AB, Diaz DB, Lum KM, Adachi S, Kundu S, Cravatt BF, Yudin AK.

Nat Commun. 2017 Nov 24;8(1):1760. doi: 10.1038/s41467-017-01319-4.

3.

Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics.

Lum KM, Sato Y, Beyer BA, Plaisted WC, Anglin JL, Lairson LL, Cravatt BF.

ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.

4.

Metabolically Labile Fumarate Esters Impart Kinetic Selectivity to Irreversible Inhibitors.

Zaro BW, Whitby LR, Lum KM, Cravatt BF.

J Am Chem Soc. 2016 Dec 14;138(49):15841-15844. Epub 2016 Dec 5.

5.

An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers.

Villa GR, Hulce JJ, Zanca C, Bi J, Ikegami S, Cahill GL, Gu Y, Lum KM, Masui K, Yang H, Rong X, Hong C, Turner KM, Liu F, Hon GC, Jenkins D, Martini M, Armando AM, Quehenberger O, Cloughesy TF, Furnari FB, Cavenee WK, Tontonoz P, Gahman TC, Shiau AK, Cravatt BF, Mischel PS.

Cancer Cell. 2016 Nov 14;30(5):683-693. doi: 10.1016/j.ccell.2016.09.008. Epub 2016 Oct 13.

6.

Chemical Proteomic Profiling of Human Methyltransferases.

Horning BD, Suciu RM, Ghadiri DA, Ulanovskaya OA, Matthews ML, Lum KM, Backus KM, Brown SJ, Rosen H, Cravatt BF.

J Am Chem Soc. 2016 Oct 12;138(40):13335-13343. Epub 2016 Sep 30.

7.

Proteome-wide covalent ligand discovery in native biological systems.

Backus KM, Correia BE, Lum KM, Forli S, Horning BD, González-Páez GE, Chatterjee S, Lanning BR, Teijaro JR, Olson AJ, Wolan DW, Cravatt BF.

Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.

8.

A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells.

Niphakis MJ, Lum KM, Cognetta AB 3rd, Correia BE, Ichu TA, Olucha J, Brown SJ, Kundu S, Piscitelli F, Rosen H, Cravatt BF.

Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.

9.

Safety impacts of red light cameras at signalized intersections based on cellular automata models.

Chai C, Wong YD, Lum KM.

Traffic Inj Prev. 2015;16(4):374-9. doi: 10.1080/15389588.2014.942418. Epub 2014 Dec 23.

PMID:
25022310
10.

Stabilized Wittig olefination for bioconjugation.

Lum KM, Xavier VJ, Ong MJ, Johannes CW, Chan KP.

Chem Commun (Camb). 2013 Dec 11;49(95):11188-90. doi: 10.1039/c3cc45961f. Epub 2013 Oct 23.

PMID:
24150718
11.

Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates.

Chang JW, Niphakis MJ, Lum KM, Cognetta AB 3rd, Wang C, Matthews ML, Niessen S, Buczynski MW, Parsons LH, Cravatt BF.

Chem Biol. 2012 May 25;19(5):579-88. doi: 10.1016/j.chembiol.2012.03.009. Epub 2012 Apr 26.

12.

A before-and-after study of driver stopping propensity at red light camera intersections.

Lum KM, Wong YD.

Accid Anal Prev. 2003 Jan;35(1):111-20.

PMID:
12479902
13.

A study of stopping propensity at matured red light camera T-intersections.

Lum KM, Wong YD.

J Safety Res. 2002 Fall;33(3):355-69.

PMID:
12404998

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