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Items: 40


BRK phosphorylates SMAD4 for proteasomal degradation and inhibits tumor suppressor FRK to control SNAIL, SLUG, and metastatic potential.

Miah S, Banks CAS, Ogunbolude Y, Bagu ET, Berg JM, Saraf A, Tettey TT, Hattem G, Dayebgadoh G, Kempf CG, Sardiu M, Napper S, Florens L, Lukong KE, Washburn MP.

Sci Adv. 2019 Oct 23;5(10):eaaw3113. doi: 10.1126/sciadv.aaw3113. eCollection 2019 Oct.


Possible involvement of transcriptional activation of nuclear factor erythroid 2-related factor 2 (Nrf2) in the protective effect of caffeic acid on paraquat-induced oxidative damage in Drosophila melanogaster.

Dos Santos Nunes RG, Pereira PS, Elekofehinti OO, Fidelis KR, da Silva CS, Ibrahim M, Barros LM, da Cunha FAB, Lukong KE, de Menezes IRA, Tsopmo A, Duarte AE, Kamdem JP.

Pestic Biochem Physiol. 2019 Jun;157:161-168. doi: 10.1016/j.pestbp.2019.03.017. Epub 2019 Mar 28.


Development of a low-cost and portable smart fluorometer for detecting breast cancer cells.

Alam MW, Wahid KA, Goel RK, Lukong KE.

Biomed Opt Express. 2019 Jan 4;10(2):399-410. doi: 10.1364/BOE.10.000399. eCollection 2019 Feb 1.


Estrogen receptor signaling regulates the expression of the breast tumor kinase in breast cancer cells.

Miah S, Bagu E, Goel R, Ogunbolude Y, Dai C, Ward A, Vizeacoumar FS, Davies G, Vizeacoumar FJ, Anderson D, Lukong KE.

BMC Cancer. 2019 Jan 16;19(1):78. doi: 10.1186/s12885-018-5186-8.


Global phosphoproteomic analysis identifies SRMS-regulated secondary signaling intermediates.

Goel RK, Meyer M, Paczkowska M, Reimand J, Vizeacoumar F, Vizeacoumar F, Lam TT, Lukong KE.

Proteome Sci. 2018 Aug 18;16:16. doi: 10.1186/s12953-018-0143-7. eCollection 2018.


Simulated Microgravity Reduces Focal Adhesions and Alters Cytoskeleton and Nuclear Positioning Leading to Enhanced Apoptosis via Suppressing FAK/RhoA-Mediated mTORC1/NF-κB and ERK1/2 Pathways.

Zhao T, Li R, Tan X, Zhang J, Fan C, Zhao Q, Deng Y, Xu A, Lukong KE, Genth H, Xiang J.

Int J Mol Sci. 2018 Jul 8;19(7). pii: E1994. doi: 10.3390/ijms19071994.


Phosphoproteomics Analysis Identifies Novel Candidate Substrates of the Nonreceptor Tyrosine Kinase, Src-related Kinase Lacking C-terminal Regulatory Tyrosine and N-terminal Myristoylation Sites (SRMS).

Goel RK, Paczkowska M, Reimand J, Napper S, Lukong KE.

Mol Cell Proteomics. 2018 May;17(5):925-947. doi: 10.1074/mcp.RA118.000643. Epub 2018 Mar 1.


FRK inhibits breast cancer cell migration and invasion by suppressing epithelial-mesenchymal transition.

Ogunbolude Y, Dai C, Bagu ET, Goel RK, Miah S, MacAusland-Berg J, Ng CY, Chibbar R, Napper S, Raptis L, Vizeacoumar F, Vizeacoumar F, Bonham K, Lukong KE.

Oncotarget. 2017 Dec 6;8(68):113034-113065. doi: 10.18632/oncotarget.22958. eCollection 2017 Dec 22.


Caffeine-supplemented diet modulates oxidative stress markers and improves locomotor behavior in the lobster cockroach Nauphoeta cinerea.

da Silva CS, de Cássia Gonçalves de Lima R, Elekofehinti OO, Ogunbolude Y, Duarte AE, Rocha JBT, Alencar de Menezes IR, Barros LM, Tsopmo A, Lukong KE, Kamdem JP.

Chem Biol Interact. 2018 Feb 25;282:77-84. doi: 10.1016/j.cbi.2018.01.011. Epub 2018 Jan 13.


Biochemical characterization of INTS3 and C9ORF80, two subunits of hNABP1/2 heterotrimeric complex in nucleic acid binding.

Vidhyasagar V, He Y, Guo M, Talwar T, Singh RS, Yadav M, Katselis G, Vizeacoumar FJ, Lukong KE, Wu Y.

Biochem J. 2018 Jan 2;475(1):45-60. doi: 10.1042/BCJ20170351.


Breast cancer in Africa: prevalence, treatment options, herbal medicines, and socioeconomic determinants.

Lukong KE, Ogunbolude Y, Kamdem JP.

Breast Cancer Res Treat. 2017 Nov;166(2):351-365. doi: 10.1007/s10549-017-4408-0. Epub 2017 Aug 4. Review.


The DEAD-box protein DDX43 (HAGE) is a dual RNA-DNA helicase and has a K-homology domain required for full nucleic acid unwinding activity.

Talwar T, Vidhyasagar V, Qing J, Guo M, Kariem A, Lu Y, Singh RS, Lukong KE, Wu Y.

J Biol Chem. 2017 Jun 23;292(25):10429-10443. doi: 10.1074/jbc.M117.774950. Epub 2017 May 3.


Understanding breast cancer - The long and winding road.

Lukong KE.

BBA Clin. 2017 Jan 27;7:64-77. doi: 10.1016/j.bbacli.2017.01.001. eCollection 2017 Jun. Review.


Repression of Fyn-related kinase in breast cancer cells is associated with promoter site-specific CpG methylation.

Bagu ET, Miah S, Dai C, Spriggs T, Ogunbolude Y, Beaton E, Sanders M, Goel RK, Bonham K, Lukong KE.

Oncotarget. 2017 Feb 14;8(7):11442-11459. doi: 10.18632/oncotarget.14546.


A Low-Cost Digital Microscope with Real-Time Fluorescent Imaging Capability.

Hasan MM, Alam MW, Wahid KA, Miah S, Lukong KE.

PLoS One. 2016 Dec 15;11(12):e0167863. doi: 10.1371/journal.pone.0167863. eCollection 2016.


Advancement of mass spectrometry-based proteomics technologies to explore triple negative breast cancer.

Miah S, Banks CA, Adams MK, Florens L, Lukong KE, Washburn MP.

Mol Biosyst. 2016 Dec 20;13(1):42-55. Review.


Understanding the cellular roles of Fyn-related kinase (FRK): implications in cancer biology.

Goel RK, Lukong KE.

Cancer Metastasis Rev. 2016 Jun;35(2):179-99. doi: 10.1007/s10555-016-9623-3. Review.


Tracing the footprints of the breast cancer oncogene BRK - Past till present.

Goel RK, Lukong KE.

Biochim Biophys Acta. 2015 Aug;1856(1):39-54. doi: 10.1016/j.bbcan.2015.05.001. Epub 2015 May 18. Review.


New targeted therapies for breast cancer: A focus on tumor microenvironmental signals and chemoresistant breast cancers.

Nwabo Kamdje AH, Seke Etet PF, Vecchio L, Tagne RS, Amvene JM, Muller JM, Krampera M, Lukong KE.

World J Clin Cases. 2014 Dec 16;2(12):769-86. doi: 10.12998/wjcc.v2.i12.769. Review.


The monoamine oxidase-A inhibitor clorgyline promotes a mesenchymal-to-epithelial transition in the MDA-MB-231 breast cancer cell line.

Satram-Maharaj T, Nyarko JN, Kuski K, Fehr K, Pennington PR, Truitt L, Freywald A, Lukong KE, Anderson DH, Mousseau DD.

Cell Signal. 2014 Dec;26(12):2621-32. doi: 10.1016/j.cellsig.2014.08.005. Epub 2014 Aug 22.


Signaling pathways in breast cancer: therapeutic targeting of the microenvironment.

Nwabo Kamdje AH, Seke Etet PF, Vecchio L, Muller JM, Krampera M, Lukong KE.

Cell Signal. 2014 Dec;26(12):2843-56. doi: 10.1016/j.cellsig.2014.07.034. Epub 2014 Aug 3. Review.


BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration.

Miah S, Goel RK, Dai C, Kalra N, Beaton-Brown E, Bagu ET, Bonham K, Lukong KE.

PLoS One. 2014 Feb 11;9(2):e87684. doi: 10.1371/journal.pone.0087684. eCollection 2014. Erratum in: PLoS One. 2014;9(5):e98814.


The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1.

Goel RK, Miah S, Black K, Kalra N, Dai C, Lukong KE.

FEBS J. 2013 Sep;280(18):4539-59. doi: 10.1111/febs.12420. Epub 2013 Aug 19.


Constitutive activation of breast tumor kinase accelerates cell migration and tumor growth in vivo.

Miah S, Martin A, Lukong KE.

Oncogenesis. 2012 May 7;1:e11. doi: 10.1038/oncsis.2012.11.


BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest.

Lukong KE, Huot ME, Richard S.

Cell Signal. 2009 Sep;21(9):1415-22. doi: 10.1016/j.cellsig.2009.04.008. Epub 2009 May 9.


RNA-binding proteins in human genetic disease.

Lukong KE, Chang KW, Khandjian EW, Richard S.

Trends Genet. 2008 Aug;24(8):416-25. doi: 10.1016/j.tig.2008.05.004. Epub 2008 Jul 1. Review.


Motor coordination defects in mice deficient for the Sam68 RNA-binding protein.

Lukong KE, Richard S.

Behav Brain Res. 2008 Jun 3;189(2):357-63. doi: 10.1016/j.bbr.2008.01.010. Epub 2008 Feb 5.


Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration.

Lukong KE, Richard S.

Cell Signal. 2008 Feb;20(2):432-42. Epub 2007 Nov 13.


Targeting the RNA-binding protein Sam68 as a treatment for cancer?

Lukong KE, Richard S.

Future Oncol. 2007 Oct;3(5):539-44. Review.


Sam68 haploinsufficiency delays onset of mammary tumorigenesis and metastasis.

Richard S, Vogel G, Huot ME, Guo T, Muller WJ, Lukong KE.

Oncogene. 2008 Jan 17;27(4):548-56. Epub 2007 Jul 9.


Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression.

Lukong KE, Larocque D, Tyner AL, Richard S.

J Biol Chem. 2005 Nov 18;280(46):38639-47. Epub 2005 Sep 22.


Arginine methylation signals mRNA export.

Lukong KE, Richard S.

Nat Struct Mol Biol. 2004 Oct;11(10):914-5. No abstract available.


Sam68, the KH domain-containing superSTAR.

Lukong KE, Richard S.

Biochim Biophys Acta. 2003 Dec 5;1653(2):73-86. Review.


Intracellular distribution of lysosomal sialidase is controlled by the internalization signal in its cytoplasmic tail.

Lukong KE, Seyrantepe V, Landry K, Trudel S, Ahmad A, Gahl WA, Lefrancois S, Morales CR, Pshezhetsky AV.

J Biol Chem. 2001 Dec 7;276(49):46172-81. Epub 2001 Sep 24.


Mutations in sialidosis impair sialidase binding to the lysosomal multienzyme complex.

Lukong KE, Landry K, Elsliger MA, Chang Y, Lefrancois S, Morales CR, Pshezhetsky AV.

J Biol Chem. 2001 May 18;276(20):17286-90. Epub 2001 Feb 20.


Clinical presentation of congenital sialidosis in a patient with a neuraminidase gene frameshift mutation.

Buchholz T, Molitor G, Lukong KE, Praun M, Genzel-Boroviczény O, Freund M, Pshezhetsky AV, Schulze A.

Eur J Pediatr. 2001 Jan;160(1):26-30.


Molecular and structural studies of Japanese patients with sialidosis type 1.

Naganawa Y, Itoh K, Shimmoto M, Takiguchi K, Doi H, Nishizawa Y, Kobayashi T, Kamei S, Lukong KE, Pshezhetsky AV, Sakuraba H.

J Hum Genet. 2000;45(4):241-9.


Characterization of the sialidase molecular defects in sialidosis patients suggests the structural organization of the lysosomal multienzyme complex.

Lukong KE, Elsliger MA, Chang Y, Richard C, Thomas G, Carey W, Tylki-Szymanska A, Czartoryska B, Buchholz T, Criado GR, Palmeri S, Pshezhetsky AV.

Hum Mol Genet. 2000 Apr 12;9(7):1075-85.


Identification of UDP-N-acetylglucosamine-phosphotransferase-binding sites on the lysosomal proteases, cathepsins A, B, and D.

Lukong KE, Elsliger MA, Mort JS, Potier M, Pshezhetsky AV.

Biochemistry. 1999 Jan 5;38(1):73-80.


Molecular mechanism of lysosomal sialidase deficiency in galactosialidosis involves its rapid degradation.

Vinogradova MV, Michaud L, Mezentsev AV, Lukong KE, El-Alfy M, Morales CR, Potier M, Pshezhetsky AV.

Biochem J. 1998 Mar 1;330 ( Pt 2):641-50.

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