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Items: 1 to 50 of 85


Short-term cellular memory tunes the signaling responses of the chemokine receptor CXCR4.

Spinosa PC, Humphries BA, Lewin Mejia D, Buschhaus JM, Linderman JJ, Luker GD, Luker KE.

Sci Signal. 2019 Jul 9;12(589). pii: eaaw4204. doi: 10.1126/scisignal.aaw4204.


The effect of mechanosensitive channel MscL expression in cancer cells on 3D confined migration.

Heureaux-Torres J, Luker KE, Haley H, Pirone M, Lee LM, Herrera Y, Luker GD, Liu AP.

APL Bioeng. 2018 Jun 8;2(3):032001. doi: 10.1063/1.5019770. eCollection 2018 Sep.


Characterization, Dynamics, and Mechanism of CXCR4 Antagonists on a Constitutively Active Mutant.

Rosenberg EM Jr, Harrison RES, Tsou LK, Drucker N, Humphries B, Rajasekaran D, Luker KE, Wu CH, Song JS, Wang CJ, Murphy JW, Cheng YC, Shia KS, Luker GD, Morikis D, Lolis EJ.

Cell Chem Biol. 2019 May 16;26(5):662-673.e7. doi: 10.1016/j.chembiol.2019.01.012. Epub 2019 Feb 28.


A Caspase-3 Reporter for Fluorescence Lifetime Imaging of Single-Cell Apoptosis.

Buschhaus JM, Humphries B, Luker KE, Luker GD.

Cells. 2018 Jun 13;7(6). pii: E57. doi: 10.3390/cells7060057.


Plasminogen Activator Inhibitor 1 (PAI1) Promotes Actin Cytoskeleton Reorganization and Glycolytic Metabolism in Triple-Negative Breast Cancer.

Humphries BA, Buschhaus JM, Chen YC, Haley HR, Qyli T, Chiang B, Shen N, Rajendran S, Cutter A, Cheng YH, Chen YT, Cong J, Spinosa PC, Yoon E, Luker KE, Luker GD.

Mol Cancer Res. 2019 May;17(5):1142-1154. doi: 10.1158/1541-7786.MCR-18-0836. Epub 2019 Feb 4.


Morphology-based prediction of cancer cell migration using an artificial neural network and a random decision forest.

Zhang Z, Chen L, Humphries B, Brien R, Wicha MS, Luker KE, Luker GD, Chen YC, Yoon E.

Integr Biol (Camb). 2018 Dec 19;10(12):758-767. doi: 10.1039/c8ib00106e.


Mammary fibroblasts remodel fibrillar collagen microstructure in a biomimetic nanocomposite hydrogel.

Liu C, Chiang B, Lewin Mejia D, Luker KE, Luker GD, Lee A.

Acta Biomater. 2019 Jan 1;83:221-232. doi: 10.1016/j.actbio.2018.11.010. Epub 2018 Nov 7.


Enhanced Bone Metastases in Skeletally Immature Mice.

Haley HR, Shen N, Qyli T, Buschhaus JM, Pirone M, Luker KE, Luker GD.

Tomography. 2018 Jun;4(2):84-93. doi: 10.18383/j.tom.2018.00010.


Hybrid collagen alginate hydrogel as a platform for 3D tumor spheroid invasion.

Liu C, Lewin Mejia D, Chiang B, Luker KE, Luker GD.

Acta Biomater. 2018 Jul 15;75:213-225. doi: 10.1016/j.actbio.2018.06.003. Epub 2018 Jun 5.


Dual Reporter Bioluminescence Imaging with NanoLuc and Firefly Luciferase.

Gibbons AE, Luker KE, Luker GD.

Methods Mol Biol. 2018;1790:41-50. doi: 10.1007/978-1-4939-7860-1_4.


Three-dimensional tumor model mimics stromal - breast cancer cells signaling.

Ham SL, Thakuri PS, Plaster M, Li J, Luker KE, Luker GD, Tavana H.

Oncotarget. 2017 Dec 5;9(1):249-267. doi: 10.18632/oncotarget.22922. eCollection 2018 Jan 2.


Functional Isolation of Tumor-Initiating Cells using Microfluidic-Based Migration Identifies Phosphatidylserine Decarboxylase as a Key Regulator.

Chen YC, Humphries B, Brien R, Gibbons AE, Chen YT, Qyli T, Haley HR, Pirone ME, Chiang B, Xiao A, Cheng YH, Luan Y, Zhang Z, Cong J, Luker KE, Luker GD, Yoon E.

Sci Rep. 2018 Jan 10;8(1):244. doi: 10.1038/s41598-017-18610-5.


Fluorescence Lifetime Imaging of a Caspase-3 Apoptosis Reporter.

Buschhaus JM, Gibbons AE, Luker KE, Luker GD.

Curr Protoc Cell Biol. 2017 Dec 11;77:21.12.1-21.12.12. doi: 10.1002/cpcb.36.


The CXCL12/CXCR7 signaling axis, isoforms, circadian rhythms, and tumor cellular composition dictate gradients in tissue.

Spinosa PC, Luker KE, Luker GD, Linderman JJ.

PLoS One. 2017 Nov 8;12(11):e0187357. doi: 10.1371/journal.pone.0187357. eCollection 2017.


A Facile, In Vitro 384-Well Plate System to Model Disseminated Tumor Cells in the Bone Marrow Microenvironment.

Buschhaus JM, Luker KE, Luker GD.

Methods Mol Biol. 2018;1686:201-213. doi: 10.1007/978-1-4939-7371-2_15.


Correction: Cell, Isoform, and Environment Factors Shape Gradients and Modulate Chemotaxis.

Chang SL, Cavnar SP, Luker KE, Takayama S, Luker GD, Linderman JJ.

PLoS One. 2017 Mar 14;12(3):e0174189. doi: 10.1371/journal.pone.0174189. eCollection 2017.


In vivo targeting of metastatic breast cancer via tumor vasculature-specific nano-graphene oxide.

Yang D, Feng L, Dougherty CA, Luker KE, Chen D, Cauble MA, Banaszak Holl MM, Luker GD, Ross BD, Liu Z, Hong H.

Biomaterials. 2016 Oct;104:361-71. doi: 10.1016/j.biomaterials.2016.07.029. Epub 2016 Jul 26.


Imaging Sensitivity of Quiescent Cancer Cells to Metabolic Perturbations in Bone Marrow Spheroids.

Cavnar SP, Xiao A, Gibbons AE, Rickelmann AD, Neely T, Luker KE, Takayama S, Luker GD.

Tomography. 2016 Jun;2(2):146-157.


Dual-Color Luciferase Complementation for Chemokine Receptor Signaling.

Luker KE, Luker GD.

Methods Enzymol. 2016;570:119-29. doi: 10.1016/bs.mie.2015.08.024. Epub 2015 Nov 14.


Fluorescence Lifetime Imaging of Apoptosis.

Xiao A, Gibbons AE, Luker KE, Luker GD.

Tomography. 2015 Dec;1(2):115-124.


Imaging Reporters for Proteasome Activity Identify Tumor- and Metastasis-Initiating Cells.

Stacer AC, Wang H, Fenner J, Dosch JS, Salomonnson A, Luker KE, Luker GD, Rehemtulla A, Ross BD.

Mol Imaging. 2015;14:414-28.


Modeling selective elimination of quiescent cancer cells from bone marrow.

Cavnar SP, Rickelmann AD, Meguiar KF, Xiao A, Dosch J, Leung BM, Cai Lesher-Perez S, Chitta S, Luker KE, Takayama S, Luker GD.

Neoplasia. 2015 Aug;17(8):625-33. doi: 10.1016/j.neo.2015.08.001.


CXCR4 Protein Epitope Mimetic Antagonist POL5551 Disrupts Metastasis and Enhances Chemotherapy Effect in Triple-Negative Breast Cancer.

Xiang J, Hurchla MA, Fontana F, Su X, Amend SR, Esser AK, Douglas GJ, Mudalagiriyappa C, Luker KE, Pluard T, Ademuyiwa FO, Romagnoli B, Tuffin G, Chevalier E, Luker GD, Bauer M, Zimmermann J, Aft RL, Dembowsky K, Weilbaecher KN.

Mol Cancer Ther. 2015 Nov;14(11):2473-85. doi: 10.1158/1535-7163.MCT-15-0252. Epub 2015 Aug 12.


CXCR4-Targeted Nanocarriers for Triple Negative Breast Cancers.

Misra AC, Luker KE, Durmaz H, Luker GD, Lahann J.

Biomacromolecules. 2015 Aug 10;16(8):2412-7. doi: 10.1021/acs.biomac.5b00653. Epub 2015 Jul 22.


Endothelial CXCR7 regulates breast cancer metastasis.

Stacer AC, Fenner J, Cavnar SP, Xiao A, Zhao S, Chang SL, Salomonnson A, Luker KE, Luker GD.

Oncogene. 2016 Mar 31;35(13):1716-24. doi: 10.1038/onc.2015.236. Epub 2015 Jun 29.


Comparative study reveals better far-red fluorescent protein for whole body imaging.

Luker KE, Pata P, Shemiakina II, Pereverzeva A, Stacer AC, Shcherbo DS, Pletnev VZ, Skolnaja M, Lukyanov KA, Luker GD, Pata I, Chudakov DM.

Sci Rep. 2015 Jun 2;5:10332. doi: 10.1038/srep10332.


Microscale 3D collagen cell culture assays in conventional flat-bottom 384-well plates.

Leung BM, Moraes C, Cavnar SP, Luker KE, Luker GD, Takayama S.

J Lab Autom. 2015 Apr;20(2):138-45. doi: 10.1177/2211068214563793. Epub 2014 Dec 15.


Macroscopic stiffness of breast tumors predicts metastasis.

Fenner J, Stacer AC, Winterroth F, Johnson TD, Luker KE, Luker GD.

Sci Rep. 2014 Jul 1;4:5512. doi: 10.1038/srep05512.


CXCL12-γ in primary tumors drives breast cancer metastasis.

Ray P, Stacer AC, Fenner J, Cavnar SP, Meguiar K, Brown M, Luker KE, Luker GD.

Oncogene. 2015 Apr 16;34(16):2043-51. doi: 10.1038/onc.2014.157. Epub 2014 Jun 9.


CXCR7 controls competition for recruitment of β-arrestin 2 in cells expressing both CXCR4 and CXCR7.

Coggins NL, Trakimas D, Chang SL, Ehrlich A, Ray P, Luker KE, Linderman JJ, Luker GD.

PLoS One. 2014 Jun 4;9(6):e98328. doi: 10.1371/journal.pone.0098328. eCollection 2014.


Microfluidic source-sink model reveals effects of biophysically distinct CXCL12 isoforms in breast cancer chemotaxis.

Cavnar SP, Ray P, Moudgil P, Chang SL, Luker KE, Linderman JJ, Takayama S, Luker GD.

Integr Biol (Camb). 2014 May;6(5):564-76. doi: 10.1039/c4ib00015c.


NanoLuc reporter for dual luciferase imaging in living animals.

Stacer AC, Nyati S, Moudgil P, Iyengar R, Luker KE, Rehemtulla A, Luker GD.

Mol Imaging. 2013 Oct;12(7):1-13.


Split Gaussia luciferase for imaging ligand-receptor binding.

Luker KE, Luker GD.

Methods Mol Biol. 2014;1098:59-69. doi: 10.1007/978-1-62703-718-1_5.


Transfer, imaging, and analysis plate for facile handling of 384 hanging drop 3D tissue spheroids.

Cavnar SP, Salomonsson E, Luker KE, Luker GD, Takayama S.

J Lab Autom. 2014 Apr;19(2):208-14. doi: 10.1177/2211068213504296. Epub 2013 Sep 19.


Allosteric peptide regulators of chemokine receptors CXCR4 and CXCR7.

Ehrlich A, Ray P, Luker KE, Lolis EJ, Luker GD.

Biochem Pharmacol. 2013 Nov 1;86(9):1263-71. doi: 10.1016/j.bcp.2013.08.019. Epub 2013 Aug 22.


Host-derived CD8+ dendritic cells are required for induction of optimal graft-versus-tumor responses after experimental allogeneic bone marrow transplantation.

Toubai T, Sun Y, Luker G, Liu J, Luker KE, Tawara I, Evers R, Liu C, Mathewson N, Malter C, Nieves E, Choi S, Murphy KM, Reddy P.

Blood. 2013 May 16;121(20):4231-41. doi: 10.1182/blood-2012-05-432872. Epub 2013 Mar 21.


Imaging CXCL12-CXCR4 signaling in ovarian cancer therapy.

Salomonnson E, Stacer AC, Ehrlich A, Luker KE, Luker GD.

PLoS One. 2013;8(1):e51500. doi: 10.1371/journal.pone.0051500. Epub 2013 Jan 23.


Cell-based and in vivo spectral analysis of fluorescent proteins for multiphoton microscopy.

Salomonnson E, Mihalko LA, Verkhusha VV, Luker KE, Luker GD.

J Biomed Opt. 2012 Sep;17(9):96001. doi: 10.1117/1.JBO.17.9.096001.


Carboxy-terminus of CXCR7 regulates receptor localization and function.

Ray P, Mihalko LA, Coggins NL, Moudgil P, Ehrlich A, Luker KE, Luker GD.

Int J Biochem Cell Biol. 2012 Apr;44(4):669-78. doi: 10.1016/j.biocel.2012.01.007. Epub 2012 Jan 25.


Scavenging of CXCL12 by CXCR7 promotes tumor growth and metastasis of CXCR4-positive breast cancer cells.

Luker KE, Lewin SA, Mihalko LA, Schmidt BT, Winkler JS, Coggins NL, Thomas DG, Luker GD.

Oncogene. 2012 Nov 8;31(45):4750-8. doi: 10.1038/onc.2011.633. Epub 2012 Jan 23.


Noninvasive imaging reveals inhibition of ovarian cancer by targeting CXCL12-CXCR4.

Ray P, Lewin SA, Mihalko LA, Schmidt BT, Luker KE, Luker GD.

Neoplasia. 2011 Dec;13(12):1152-61.


Secreted CXCL12 (SDF-1) forms dimers under physiological conditions.

Ray P, Lewin SA, Mihalko LA, Lesher-Perez SC, Takayama S, Luker KE, Luker GD.

Biochem J. 2012 Mar 1;442(2):433-42. doi: 10.1042/BJ20111341.


In vivo imaging of ligand receptor binding with Gaussia luciferase complementation.

Luker KE, Mihalko LA, Schmidt BT, Lewin SA, Ray P, Shcherbo D, Chudakov DM, Luker GD.

Nat Med. 2011 Dec 4;18(1):172-7. doi: 10.1038/nm.2590.


Targeted non-covalent self-assembled nanoparticles based on human serum albumin.

Bunschoten A, Buckle T, Kuil J, Luker GD, Luker KE, Nieweg OE, van Leeuwen FW.

Biomaterials. 2012 Jan;33(3):867-75. doi: 10.1016/j.biomaterials.2011.10.005. Epub 2011 Oct 22.


Polymeric Aqueous Biphasic System Rehydration Facilitates High Throughput Cell Exclusion Patterning For Cell Migration Studies.

Tavana H, Kaylan K, Bersano-Begey T, Luker KE, Luker GD, Takayama S.

Adv Funct Mater. 2011 Aug 9;21(15):2920-2926. Epub 2011 May 24.


Development of a baited oral vaccine for use in reservoir-targeted strategies against Lyme disease.

Bhattacharya D, Bensaci M, Luker KE, Luker G, Wisdom S, Telford SR, Hu LT.

Vaccine. 2011 Oct 13;29(44):7818-25. doi: 10.1016/j.vaccine.2011.07.100. Epub 2011 Aug 2.


Luciferase protein complementation assays for bioluminescence imaging of cells and mice.

Luker GD, Luker KE.

Methods Mol Biol. 2011;680:29-43. doi: 10.1007/978-1-60761-901-7_2.


Longitudinal molecular imaging with single cell resolution of disseminated ovarian cancer in mice with a LED-based confocal microendoscope.

Elahi SF, Liu Z, Luker KE, Kwon RS, Luker GD, Wang TD.

Mol Imaging Biol. 2011 Dec;13(6):1157-62. doi: 10.1007/s11307-010-0455-1.


Microfluidic platform for chemotaxis in gradients formed by CXCL12 source-sink cells.

Torisawa YS, Mosadegh B, Bersano-Begey T, Steele JM, Luker KE, Luker GD, Takayama S.

Integr Biol (Camb). 2010 Nov;2(11-12):680-6. doi: 10.1039/c0ib00041h. Epub 2010 Sep 27.


Near-infrared fluorescent proteins.

Shcherbo D, Shemiakina II, Ryabova AV, Luker KE, Schmidt BT, Souslova EA, Gorodnicheva TV, Strukova L, Shidlovskiy KM, Britanova OV, Zaraisky AG, Lukyanov KA, Loschenov VB, Luker GD, Chudakov DM.

Nat Methods. 2010 Oct;7(10):827-9. doi: 10.1038/nmeth.1501. Epub 2010 Sep 5.

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