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Items: 42


Necroptosis and apoptosis contribute to cisplatin and aminoglycoside ototoxicity.

Ruhl D, Du TT, Wagner EL, Hwan Choi J, Li S, Reed R, Kim K, Freeman M, Hashisaki G, Lukens JR, Shin JB.

J Neurosci. 2019 Feb 7. pii: 1384-18. doi: 10.1523/JNEUROSCI.1384-18.2019. [Epub ahead of print]


CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature.

Louveau A, Herz J, Alme MN, Salvador AF, Dong MQ, Viar KE, Herod SG, Knopp J, Setliff JC, Lupi AL, Da Mesquita S, Frost EL, Gaultier A, Harris TH, Cao R, Hu S, Lukens JR, Smirnov I, Overall CC, Oliver G, Kipnis J.

Nat Neurosci. 2018 Oct;21(10):1380-1391. doi: 10.1038/s41593-018-0227-9. Epub 2018 Sep 17.


Th17 Cells in Parkinson's Disease: The Bane of the Midbrain.

Bolte AC, Lukens JR.

Cell Stem Cell. 2018 Jul 5;23(1):5-6. doi: 10.1016/j.stem.2018.06.016.


Cutting Edge: Critical Roles for Microbiota-Mediated Regulation of the Immune System in a Prenatal Immune Activation Model of Autism.

Lammert CR, Frost EL, Bolte AC, Paysour MJ, Shaw ME, Bellinger CE, Weigel TK, Zunder ER, Lukens JR.

J Immunol. 2018 Aug 1;201(3):845-850. doi: 10.4049/jimmunol.1701755. Epub 2018 Jul 2.


NLR-Dependent Regulation of Inflammation in Multiple Sclerosis.

Gharagozloo M, Gris KV, Mahvelati T, Amrani A, Lukens JR, Gris D.

Front Immunol. 2018 Jan 18;8:2012. doi: 10.3389/fimmu.2017.02012. eCollection 2017. Review. Erratum in: Front Immunol. 2018 Feb 28;9:404.


Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease.

Gurung P, Fan G, Lukens JR, Vogel P, Tonks NK, Kanneganti TD.

Immunity. 2017 Apr 18;46(4):635-648. doi: 10.1016/j.immuni.2017.03.014. Epub 2017 Apr 11.


Oxidized Low-Density Lipoprotein Immune Complex Priming of the Nlrp3 Inflammasome Involves TLR and FcγR Cooperation and Is Dependent on CARD9.

Rhoads JP, Lukens JR, Wilhelm AJ, Moore JL, Mendez-Fernandez Y, Kanneganti TD, Major AS.

J Immunol. 2017 Mar 1;198(5):2105-2114. doi: 10.4049/jimmunol.1601563. Epub 2017 Jan 27.


Emerging Roles for the Immune System in Traumatic Brain Injury.

McKee CA, Lukens JR.

Front Immunol. 2016 Dec 5;7:556. eCollection 2016. Review.


The brain's reward circuitry regulates immunity.

Frost EL, Lukens JR.

Nat Med. 2016 Aug 4;22(8):835-7. doi: 10.1038/nm.4157. No abstract available.


Dealing with Danger in the CNS: The Response of the Immune System to Injury.

Gadani SP, Walsh JT, Lukens JR, Kipnis J.

Neuron. 2015 Jul 1;87(1):47-62. doi: 10.1016/j.neuron.2015.05.019. Review.


MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4.

Walsh JT, Hendrix S, Boato F, Smirnov I, Zheng J, Lukens JR, Gadani S, Hechler D, Gölz G, Rosenberger K, Kammertöns T, Vogt J, Vogelaar C, Siffrin V, Radjavi A, Fernandez-Castaneda A, Gaultier A, Gold R, Kanneganti TD, Nitsch R, Zipp F, Kipnis J.

J Clin Invest. 2015 Jun;125(6):2547. doi: 10.1172/JCI82458. Epub 2015 May 4. No abstract available.


The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells.

Lukens JR, Gurung P, Shaw PJ, Barr MJ, Zaki MH, Brown SA, Vogel P, Chi H, Kanneganti TD.

Immunity. 2015 Apr 21;42(4):654-64. doi: 10.1016/j.immuni.2015.03.006. Epub 2015 Apr 14.


MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4.

Walsh JT, Hendrix S, Boato F, Smirnov I, Zheng J, Lukens JR, Gadani S, Hechler D, Gölz G, Rosenberger K, Kammertöns T, Vogt J, Vogelaar C, Siffrin V, Radjavi A, Fernandez-Castaneda A, Gaultier A, Gold R, Kanneganti TD, Nitsch R, Zipp F, Kipnis J.

J Clin Invest. 2015 Feb;125(2):699-714. doi: 10.1172/JCI76210. Epub 2015 Jan 20. Erratum in: J Clin Invest. 2015 Jun;125(6):2547.


Drak2 is not required for tumor surveillance and suppression.

Edwards BA, Harris TL, Floersh H, Lukens JR, Zaki MH, Vogel P, Kanneganti TD, Bui JD, McGargill MA.

Int Immunol. 2015 Mar;27(3):161-6. doi: 10.1093/intimm/dxu146. Epub 2015 Jan 7.


Mitochondria: diversity in the regulation of the NLRP3 inflammasome.

Gurung P, Lukens JR, Kanneganti TD.

Trends Mol Med. 2015 Mar;21(3):193-201. doi: 10.1016/j.molmed.2014.11.008. Epub 2014 Nov 27. Review.


Dietary modulation of the microbiome affects autoinflammatory disease.

Lukens JR, Gurung P, Vogel P, Johnson GR, Carter RA, McGoldrick DJ, Bandi SR, Calabrese CR, Vande Walle L, Lamkanfi M, Kanneganti TD.

Nature. 2014 Dec 11;516(7530):246-9. doi: 10.1038/nature13788. Epub 2014 Sep 28.


SHP-1 and IL-1α conspire to provoke neutrophilic dermatoses.

Lukens JR, Kanneganti TD.

Rare Dis. 2014 Jan 31;2:e27742. doi: 10.4161/rdis.27742. eCollection 2014.


Beyond canonical inflammasomes: emerging pathways in IL-1-mediated autoinflammatory disease.

Lukens JR, Kanneganti TD.

Semin Immunopathol. 2014 Sep;36(5):595-609. doi: 10.1007/s00281-014-0434-8. Epub 2014 May 17. Review.


Critical role for inflammasome-independent IL-1β production in osteomyelitis.

Lukens JR, Gross JM, Calabrese C, Iwakura Y, Lamkanfi M, Vogel P, Kanneganti TD.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1066-71. doi: 10.1073/pnas.1318688111. Epub 2014 Jan 6.


Apolipoprotein A-I protection against atherosclerosis is dependent on genetic background.

Sontag TJ, Krishack PA, Lukens JR, Bhanvadia CV, Getz GS, Reardon CA.

Arterioscler Thromb Vasc Biol. 2014 Feb;34(2):262-9. doi: 10.1161/ATVBAHA.113.302831. Epub 2013 Dec 12.


Protective roles for caspase-8 and cFLIP in adult homeostasis.

Weinlich R, Oberst A, Dillon CP, Janke LJ, Milasta S, Lukens JR, Rodriguez DA, Gurung P, Savage C, Kanneganti TD, Green DR.

Cell Rep. 2013 Oct 31;5(2):340-8. doi: 10.1016/j.celrep.2013.08.045. Epub 2013 Oct 3.


RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.

Lukens JR, Vogel P, Johnson GR, Kelliher MA, Iwakura Y, Lamkanfi M, Kanneganti TD.

Nature. 2013 Jun 13;498(7453):224-7. doi: 10.1038/nature12174. Epub 2013 May 26.


IL-1 family cytokines trigger sterile inflammatory disease.

Lukens JR, Gross JM, Kanneganti TD.

Front Immunol. 2012 Oct 9;3:315. doi: 10.3389/fimmu.2012.00315. eCollection 2012.


Fat chance: not much against NKT cells.

Lukens JR, Kanneganti TD.

Immunity. 2012 Sep 21;37(3):447-9. doi: 10.1016/j.immuni.2012.09.006.


NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens.

Anand PK, Malireddi RK, Lukens JR, Vogel P, Bertin J, Lamkanfi M, Kanneganti TD.

Nature. 2012 Aug 16;488(7411):389-93. doi: 10.1038/nature11250.


Inflammasome-derived IL-1β regulates the production of GM-CSF by CD4(+) T cells and γδ T cells.

Lukens JR, Barr MJ, Chaplin DD, Chi H, Kanneganti TD.

J Immunol. 2012 Apr 1;188(7):3107-15. doi: 10.4049/jimmunol.1103308. Epub 2012 Feb 17.


Inflammasome activation in obesity-related inflammatory diseases and autoimmunity.

Lukens JR, Dixit VD, Kanneganti TD.

Discov Med. 2011 Jul;12(62):65-74. Review.


Signaling via the RIP2 adaptor protein in central nervous system-infiltrating dendritic cells promotes inflammation and autoimmunity.

Shaw PJ, Barr MJ, Lukens JR, McGargill MA, Chi H, Mak TW, Kanneganti TD.

Immunity. 2011 Jan 28;34(1):75-84. doi: 10.1016/j.immuni.2010.12.015. Epub 2011 Jan 13.


Cutting edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis.

Shaw PJ, Lukens JR, Burns S, Chi H, McGargill MA, Kanneganti TD.

J Immunol. 2010 May 1;184(9):4610-4. doi: 10.4049/jimmunol.1000217. Epub 2010 Apr 5.


Intrahepatic IL-10 maintains NKG2A+Ly49- liver NK cells in a functionally hyporesponsive state.

Lassen MG, Lukens JR, Dolina JS, Brown MG, Hahn YS.

J Immunol. 2010 Mar 1;184(5):2693-701. doi: 10.4049/jimmunol.0901362. Epub 2010 Feb 1.


Liver is able to activate naïve CD8+ T cells with dysfunctional anti-viral activity in the murine system.

Lukens JR, Dolina JS, Kim TS, Tacke RS, Hahn YS.

PLoS One. 2009 Oct 30;4(10):e7619. doi: 10.1371/journal.pone.0007619.


Lipid-lowering effects of ethyl 2-phenacyl-3-aryl-1H-pyrrole- 4-carboxylates in rodents.

Holub JM, O'Toole-Colin K, Getzel A, Argenti A, Evans MA, Smith DC, Dalglish GA, Rifat S, Wilson DL, Taylor BM, Miott U, Glersaye J, Lam KS, McCranor BJ, Berkowitz JD, Miller RB, Lukens JR, Krumpe K, Gupton JT, Burnham BS.

Molecules. 2004 Feb 28;9(3):134-57.


Fas ligand is responsible for CXCR3 chemokine induction in CD4+ T cell-dependent liver damage.

Cruise MW, Lukens JR, Nguyen AP, Lassen MG, Waggoner SN, Hahn YS.

J Immunol. 2006 May 15;176(10):6235-44.


In vivo studies of HDL assembly and metabolism using adenovirus-mediated transfer of ApoA-I mutants in ApoA-I-deficient mice.

Reardon CA, Kan HY, Cabana V, Blachowicz L, Lukens JR, Wu Q, Liadaki K, Getz GS, Zannis VI.

Biochemistry. 2001 Nov 13;40(45):13670-80.


SAA-only HDL formed during the acute phase response in apoA-I+/+ and apoA-I-/- mice.

Cabana VG, Reardon CA, Wei B, Lukens JR, Getz GS.

J Lipid Res. 1999 Jun;40(6):1090-103.


Nascent astrocyte particles differ from lipoproteins in CSF.

LaDu MJ, Gilligan SM, Lukens JR, Cabana VG, Reardon CA, Van Eldik LJ, Holtzman DM.

J Neurochem. 1998 May;70(5):2070-81.


Association of human, rat, and rabbit apolipoprotein E with beta-amyloid.

LaDu MJ, Lukens JR, Reardon CA, Getz GS.

J Neurosci Res. 1997 Jul 1;49(1):9-18.


HDL content and composition in acute phase response in three species: triglyceride enrichment of HDL a factor in its decrease.

Cabana VG, Lukens JR, Rice KS, Hawkins TJ, Getz GS.

J Lipid Res. 1996 Dec;37(12):2662-74.


Heparin-induced lipolysis in hypertriglyceridemic subjects results in the formation of atypical HDL particles.

O'Meara NM, Cabana VG, Lukens JR, Loharikar B, Forte TM, Polonsky KS, Getz GS.

J Lipid Res. 1994 Dec;35(12):2178-90.


Postprandial triglyceride response in type 1 (insulin-dependent) diabetes mellitus is not altered by short-term deterioration in glycaemic control or level of postprandial insulin replacement.

Lewis GF, O'Meara NM, Cabana VG, Blackman JD, Pugh WL, Druetzler AF, Lukens JR, Getz GS, Polonsky KS.

Diabetologia. 1991 Apr;34(4):253-9.


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