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Items: 1 to 50 of 155

1.

Genomic epidemiology of syphilis reveals independent emergence of macrolide resistance across multiple circulating lineages.

Beale MA, Marks M, Sahi SK, Tantalo LC, Nori AV, French P, Lukehart SA, Marra CM, Thomson NR.

Nat Commun. 2019 Jul 22;10(1):3255. doi: 10.1038/s41467-019-11216-7.

2.

Primary Syphilis in the Male Urethra: A Case Report.

Chambers LC, Srinivasan S, Lukehart SA, Ocbamichael N, Morgan JL, Lowens MS, Fredricks DN, Golden MR, Manhart LE.

Clin Infect Dis. 2019 Mar 19;68(7):1231-1234. doi: 10.1093/cid/ciy771.

PMID:
30202933
3.

New Tools for Syphilis Research.

Lukehart SA.

MBio. 2018 Jul 31;9(4). pii: e01417-18. doi: 10.1128/mBio.01417-18.

4.

Biomedical Research Priorities for Modern Syphilis Clinical Management, Diagnosis, and Vaccines: Overview and Commentary for Unit 1.

Kersh EN, Lukehart SA.

Sex Transm Dis. 2018 Sep;45(9S Suppl 1):S7-S9. doi: 10.1097/OLQ.0000000000000830.

PMID:
29528993
5.

Re-emergence of yaws after single mass azithromycin treatment followed by targeted treatment: a longitudinal study.

Mitjà O, Godornes C, Houinei W, Kapa A, Paru R, Abel H, González-Beiras C, Bieb SV, Wangi J, Barry AE, Sanz S, Bassat Q, Lukehart SA.

Lancet. 2018 Apr 21;391(10130):1599-1607. doi: 10.1016/S0140-6736(18)30204-6. Epub 2018 Feb 7.

6.

Development of a Multilocus Sequence Typing (MLST) scheme for Treponema pallidum subsp. pertenue: Application to yaws in Lihir Island, Papua New Guinea.

Godornes C, Giacani L, Barry AE, Mitja O, Lukehart SA.

PLoS Negl Trop Dis. 2017 Dec 27;11(12):e0006113. doi: 10.1371/journal.pntd.0006113. eCollection 2017 Dec.

7.

Effectiveness of single-dose azithromycin to treat latent yaws: a longitudinal comparative cohort study.

Mitjà O, González-Beiras C, Godornes C, Kolmau R, Houinei W, Abel H, Kapa A, Paru R, Bieb SV, Wangi J, Sanz S, Asiedu K, Lukehart SA, Bassat Q.

Lancet Glob Health. 2017 Dec;5(12):e1268-e1274. doi: 10.1016/S2214-109X(17)30388-1. Epub 2017 Oct 26.

8.

Diagnostics for Yaws Eradication: Insights From Direct Next-Generation Sequencing of Cutaneous Strains of Treponema pallidum.

Marks M, Fookes M, Wagner J, Butcher R, Ghinai R, Sokana O, Sarkodie YA, Lukehart SA, Solomon AW, Mabey DCW, Thomson N.

Clin Infect Dis. 2018 Mar 5;66(6):818-824. doi: 10.1093/cid/cix892.

9.

Neurosyphilis Increases Human Immunodeficiency Virus (HIV)-associated Central Nervous System Inflammation but Does Not Explain Cognitive Impairment in HIV-infected Individuals With Syphilis.

Ho EL, Maxwell CL, Dunaway SB, Sahi SK, Tantalo LC, Lukehart SA, Marra CM.

Clin Infect Dis. 2017 Sep 15;65(6):943-948. doi: 10.1093/cid/cix473.

10.

Haemophilus ducreyi DNA is detectable on the skin of asymptomatic children, flies and fomites in villages of Papua New Guinea.

Houinei W, Godornes C, Kapa A, Knauf S, Mooring EQ, González-Beiras C, Watup R, Paru R, Advent P, Bieb S, Sanz S, Bassat Q, Spinola SM, Lukehart SA, Mitjà O.

PLoS Negl Trop Dis. 2017 May 10;11(5):e0004958. doi: 10.1371/journal.pntd.0004958. eCollection 2017 May.

11.

Survey of Treponemal Infections in Free-Ranging and Captive Macaques, 1999-2012.

Klegarth AR, Ezeonwu CA, Rompis A, Lee BPY, Aggimarangsee N, Chalise M, Cortes J, Feeroz M, Molini BJ, Godornes BC, Marks M, Schillaci M, Engel G, Knauf S, Lukehart SA, Jones-Engel L.

Emerg Infect Dis. 2017 May;23(5):816-819. doi: 10.3201/eid2305.161838.

12.

Macrolide Resistance in Treponema pallidum Correlates With 23S rDNA Mutations in Recently Isolated Clinical Strains.

Molini BJ, Tantalo LC, Sahi SK, Rodriguez VI, Brandt SL, Fernandez MC, Godornes CB, Marra CM, Lukehart SA.

Sex Transm Dis. 2016 Sep;43(9):579-83. doi: 10.1097/OLQ.0000000000000486.

13.

Isolation of Treponema DNA from Necrophagous Flies in a Natural Ecosystem.

Knauf S, Raphael J, Mitjà O, Lejora IAV, Chuma IS, Batamuzi EK, Keyyu JD, Fyumagwa R, Lüert S, Godornes C, Liu H, Schwarz C, Šmajs D, Grange P, Zinner D, Roos C, Lukehart SA.

EBioMedicine. 2016 Sep;11:85-90. doi: 10.1016/j.ebiom.2016.07.033. Epub 2016 Jul 28.

14.

Molecular Typing of Treponema pallidum in Ocular Syphilis.

Oliver S, Sahi SK, Tantalo LC, Godornes C, Neblett Fanfair R, Markowitz LE, Lukehart SA, Marra CM.

Sex Transm Dis. 2016 Aug;43(8):524-7. doi: 10.1097/OLQ.0000000000000478.

15.

Reduced Treponema pallidum-Specific Opsonic Antibody Activity in HIV-Infected Patients With Syphilis.

Marra CM, Tantalo LC, Sahi SK, Dunaway SB, Lukehart SA.

J Infect Dis. 2016 Apr 15;213(8):1348-54. doi: 10.1093/infdis/jiv591. Epub 2015 Dec 9.

16.

Syphilis? An Unusual Cause of Surgical Emergency in a Human Immunodeficiency Virus-Infected Man.

Bender Ignacio RA, Koch LL, Dhanireddy S, Charmie Godornes B, Lukehart SA, Marrazzo JM.

Open Forum Infect Dis. 2015 Jun 20;2(3):ofv094. doi: 10.1093/ofid/ofv094. eCollection 2015 Sep.

17.

Transcription of TP0126, Treponema pallidum putative OmpW homolog, is regulated by the length of a homopolymeric guanosine repeat.

Giacani L, Brandt SL, Ke W, Reid TB, Molini BJ, Iverson-Cabral S, Ciccarese G, Drago F, Lukehart SA, Centurion-Lara A.

Infect Immun. 2015 Jun;83(6):2275-89. doi: 10.1128/IAI.00360-15. Epub 2015 Mar 23.

18.

Treponema pallidum subsp. pallidum TP0136 protein is heterogeneous among isolates and binds cellular and plasma fibronectin via its NH2-terminal end.

Ke W, Molini BJ, Lukehart SA, Giacani L.

PLoS Negl Trop Dis. 2015 Mar 20;9(3):e0003662. doi: 10.1371/journal.pntd.0003662. eCollection 2015 Mar.

19.

Antigenic variation of TprK facilitates development of secondary syphilis.

Reid TB, Molini BJ, Fernandez MC, Lukehart SA.

Infect Immun. 2014 Dec;82(12):4959-67. doi: 10.1128/IAI.02236-14. Epub 2014 Sep 15.

20.

When is syphilis not syphilis? Or is it?

Lukehart SA, Giacani L.

Sex Transm Dis. 2014 Sep;41(9):554-5. doi: 10.1097/OLQ.0000000000000179. No abstract available.

21.

Rapid molecular diagnosis of chronic skin ulcers--authors' reply.

Mitjà O, Lukehart SA.

Lancet Glob Health. 2014 Jul;2(7):e386. doi: 10.1016/S2214-109X(14)70243-8. Epub 2014 Jun 25. No abstract available.

22.

Haemophilus ducreyi as a cause of skin ulcers in children from a yaws-endemic area of Papua New Guinea: a prospective cohort study.

Mitjà O, Lukehart SA, Pokowas G, Moses P, Kapa A, Godornes C, Robson J, Cherian S, Houinei W, Kazadi W, Siba P, de Lazzari E, Bassat Q.

Lancet Glob Health. 2014 Apr;2(4):e235-41. doi: 10.1016/S2214-109X(14)70019-1. Epub 2014 Mar 27.

23.

Complete Genome Sequence of the Treponema pallidum subsp. pallidum Sea81-4 Strain.

Giacani L, Iverson-Cabral SL, King JC, Molini BJ, Lukehart SA, Centurion-Lara A.

Genome Announc. 2014 Apr 17;2(2). pii: e00333-14. doi: 10.1128/genomeA.00333-14.

24.

The endemic treponematoses.

Giacani L, Lukehart SA.

Clin Microbiol Rev. 2014 Jan;27(1):89-115. doi: 10.1128/CMR.00070-13. Review.

25.

Current status of syphilis vaccine development: need, challenges, prospects.

Cameron CE, Lukehart SA.

Vaccine. 2014 Mar 20;32(14):1602-9. doi: 10.1016/j.vaccine.2013.09.053. Epub 2013 Oct 14.

26.

Fine analysis of genetic diversity of the tpr gene family among treponemal species, subspecies and strains.

Centurion-Lara A, Giacani L, Godornes C, Molini BJ, Brinck Reid T, Lukehart SA.

PLoS Negl Trop Dis. 2013 May 16;7(5):e2222. doi: 10.1371/journal.pntd.0002222. Print 2013.

27.

Two mutations associated with macrolide resistance in Treponema pallidum: increasing prevalence and correlation with molecular strain type in Seattle, Washington.

Grimes M, Sahi SK, Godornes BC, Tantalo LC, Roberts N, Bostick D, Marra CM, Lukehart SA.

Sex Transm Dis. 2012 Dec;39(12):954-8. doi: 10.1097/OLQ.0b013e31826ae7a8.

28.

Footprint of positive selection in Treponema pallidum subsp. pallidum genome sequences suggests adaptive microevolution of the syphilis pathogen.

Giacani L, Chattopadhyay S, Centurion-Lara A, Jeffrey BM, Le HT, Molini BJ, Lukehart SA, Sokurenko EV, Rockey DD.

PLoS Negl Trop Dis. 2012;6(6):e1698. doi: 10.1371/journal.pntd.0001698. Epub 2012 Jun 12.

29.

Comparative investigation of the genomic regions involved in antigenic variation of the TprK antigen among treponemal species, subspecies, and strains.

Giacani L, Brandt SL, Puray-Chavez M, Reid TB, Godornes C, Molini BJ, Benzler M, Hartig JS, Lukehart SA, Centurion-Lara A.

J Bacteriol. 2012 Aug;194(16):4208-25. doi: 10.1128/JB.00863-12. Epub 2012 Jun 1.

30.

Antimicrobial resistance in Neisseria gonorrhoeae and Treponema pallidum: evolution, therapeutic challenges and the need to strengthen global surveillance.

Lewis DA, Lukehart SA.

Sex Transm Infect. 2011 Dec;87 Suppl 2:ii39-43. doi: 10.1136/sti.2010.047712. Review. No abstract available.

31.

Syphilis: using modern approaches to understand an old disease.

Ho EL, Lukehart SA.

J Clin Invest. 2011 Dec;121(12):4584-92. doi: 10.1172/JCI57173. Epub 2011 Dec 1. Review.

32.

The evolution of infectious agents in relation to sex in animals and humans: brief discussions of some individual organisms.

Reed DL, Currier RW, Walton SF, Conrad M, Sullivan SA, Carlton JM, Read TD, Severini A, Tyler S, Eberle R, Johnson WE, Silvestri G, Clarke IN, Lagergård T, Lukehart SA, Unemo M, Shafer WM, Beasley RP, Bergström T, Norberg P, Davison AJ, Sharp PM, Hahn BH, Blomberg J.

Ann N Y Acad Sci. 2011 Aug;1230:74-107. doi: 10.1111/j.1749-6632.2011.06133.x. Review.

33.

Enhanced molecular typing of treponema pallidum: geographical distribution of strain types and association with neurosyphilis.

Marra C, Sahi S, Tantalo L, Godornes C, Reid T, Behets F, Rompalo A, Klausner JD, Yin Y, Mulcahy F, Golden MR, Centurion-Lara A, Lukehart SA.

J Infect Dis. 2010 Nov 1;202(9):1380-8. doi: 10.1086/656533.

34.

CXCL13 as a cerebrospinal fluid marker for neurosyphilis in HIV-infected patients with syphilis.

Marra CM, Tantalo LC, Sahi SK, Maxwell CL, Lukehart SA.

Sex Transm Dis. 2010 May;37(5):283-7. doi: 10.1097/OLQ.0b013e3181d877a1.

35.

Complete genome sequence and annotation of the Treponema pallidum subsp. pallidum Chicago strain.

Giacani L, Jeffrey BM, Molini BJ, Le HT, Lukehart SA, Centurion-Lara A, Rockey DD.

J Bacteriol. 2010 May;192(10):2645-6. doi: 10.1128/JB.00159-10. Epub 2010 Mar 26.

36.

Antigenic variation in Treponema pallidum: TprK sequence diversity accumulates in response to immune pressure during experimental syphilis.

Giacani L, Molini BJ, Kim EY, Godornes BC, Leader BT, Tantalo LC, Centurion-Lara A, Lukehart SA.

J Immunol. 2010 Apr 1;184(7):3822-9. doi: 10.4049/jimmunol.0902788. Epub 2010 Feb 26.

37.

'Nothing is permanent but change'- antigenic variation in persistent bacterial pathogens.

Palmer GH, Bankhead T, Lukehart SA.

Cell Microbiol. 2009 Dec;11(12):1697-705. doi: 10.1111/j.1462-5822.2009.01366.x. Epub 2009 Aug 25. Review.

38.

Common strategies for antigenic variation by bacterial, fungal and protozoan pathogens.

Deitsch KW, Lukehart SA, Stringer JR.

Nat Rev Microbiol. 2009 Jul;7(7):493-503. doi: 10.1038/nrmicro2145. Epub 2009 Jun 8. Review.

39.

TP0262 is a modulator of promoter activity of tpr Subfamily II genes of Treponema pallidum ssp. pallidum.

Giacani L, Godornes C, Puray-Chavez M, Guerra-Giraldez C, Tompa M, Lukehart SA, Centurion-Lara A.

Mol Microbiol. 2009 Jun;72(5):1087-99. doi: 10.1111/j.1365-2958.2009.06712.x. Epub 2009 Apr 30.

40.

Treponema denticola does not induce production of common innate immune mediators from primary gingival epithelial cells.

Brissette CA, Pham TT, Coats SR, Darveau RP, Lukehart SA.

Oral Microbiol Immunol. 2008 Dec;23(6):474-81. doi: 10.1111/j.1399-302X.2008.00452.x.

41.

Isolation and laboratory maintenance of Treponema pallidum.

Lukehart SA, Marra CM.

Curr Protoc Microbiol. 2007 Nov;Chapter 12:Unit 12A.1. doi: 10.1002/9780471729259.mc12a01s7.

PMID:
18770607
42.

Normalization of serum rapid plasma reagin titer predicts normalization of cerebrospinal fluid and clinical abnormalities after treatment of neurosyphilis.

Marra CM, Maxwell CL, Tantalo LC, Sahi SK, Lukehart SA.

Clin Infect Dis. 2008 Oct 1;47(7):893-9. doi: 10.1086/591534.

43.

Molecular studies in Treponema pallidum evolution: toward clarity?

Mulligan CJ, Norris SJ, Lukehart SA.

PLoS Negl Trop Dis. 2008 Jan 23;2(1):e184. doi: 10.1371/journal.pntd.0000184. No abstract available.

44.

Scientific monogamy: thirty years dancing with the same bug: 2007 Thomas Parran Award Lecture.

Lukehart SA.

Sex Transm Dis. 2008 Jan;35(1):2-7. No abstract available.

PMID:
18157060
45.

Quantitation of rabbit cytokine mRNA by real-time RT-PCR.

Godornes C, Leader BT, Molini BJ, Centurion-Lara A, Lukehart SA.

Cytokine. 2007 Apr;38(1):1-7. Epub 2007 May 22.

46.

CD4+ lymphocytes and gamma interferon predominate in local immune responses in early experimental syphilis.

Leader BT, Godornes C, VanVoorhis WC, Lukehart SA.

Infect Immun. 2007 Jun;75(6):3021-6. Epub 2007 Apr 2.

47.

Mechanisms of decreased susceptibility to beta-defensins by Treponema denticola.

Brissette CA, Lukehart SA.

Infect Immun. 2007 May;75(5):2307-15. Epub 2007 Feb 26.

48.

Excellence in sexually transmitted infection (STI) diagnostics: recognition of past successes and strategies for the future.

Ronald A, Kuypers J, Lukehart SA, Peeling RW, Pope V.

Sex Transm Infect. 2006 Dec;82 Suppl 5:v47-52. Epub 2006 Nov 29.

49.

Antibiotic selection may contribute to increases in macrolide-resistant Treponema pallidum.

Marra CM, Colina AP, Godornes C, Tantalo LC, Puray M, Centurion-Lara A, Lukehart SA.

J Infect Dis. 2006 Dec 15;194(12):1771-3. Epub 2006 Nov 3.

PMID:
17109351
50.

Quantitative analysis of tpr gene expression in Treponema pallidum isolates: Differences among isolates and correlation with T-cell responsiveness in experimental syphilis.

Giacani L, Molini B, Godornes C, Barrett L, Van Voorhis W, Centurion-Lara A, Lukehart SA.

Infect Immun. 2007 Jan;75(1):104-12. Epub 2006 Oct 9.

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