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Items: 1 to 50 of 74

1.

Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock.

Orvedahl A, McAllaster MR, Sansone A, Dunlap BF, Desai C, Wang YT, Balce DR, Luke CJ, Lee S, Orchard RC, Artyomov MN, Handley SA, Doench JG, Silverman GA, Virgin HW.

Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16497-16506. doi: 10.1073/pnas.1822157116. Epub 2019 Jul 25.

PMID:
31346084
2.

CemOrange2 fusions facilitate multifluorophore subcellular imaging in C. elegans.

Thomas BJ, Wight IE, Chou WYY, Moreno M, Dawson Z, Homayouni A, Huang H, Kim H, Jia H, Buland JR, Wambach JA, Cole FS, Pak SC, Silverman GA, Luke CJ.

PLoS One. 2019 Mar 26;14(3):e0214257. doi: 10.1371/journal.pone.0214257. eCollection 2019.

3.

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation.

Lanik WE, Xu L, Luke CJ, Hu EZ, Agrawal P, Liu VS, Kumar R, Bolock AM, Ma C, Good M.

J Vis Exp. 2018 Feb 15;(132). doi: 10.3791/56921.

4.

Intranasal Live Influenza Vaccine Priming Elicits Localized B Cell Responses in Mediastinal Lymph Nodes.

Jegaskanda S, Mason RD, Andrews SF, Wheatley AK, Zhang R, Reynoso GV, Ambrozak DR, Santos CP, Luke CJ, Matsuoka Y, Brenchley JM, Hickman HD, Talaat KR, Permar SR, Liao HX, Yewdell JW, Koup RA, Roederer M, McDermott AB, Subbarao K.

J Virol. 2018 Apr 13;92(9). pii: e01970-17. doi: 10.1128/JVI.01970-17. Print 2018 May 1.

5.

Serum squamous cell carcinoma antigen as an early indicator of response during therapy of cervical cancer.

Markovina S, Wang S, Henke LE, Luke CJ, Pak SC, DeWees T, Pfeifer JD, Schwarz JK, Liu W, Chen S, Mutch D, Wang X, Powell MA, Siegel BA, Dehdashti F, Silverman GA, Grigsby PW.

Br J Cancer. 2018 Jan;118(1):72-78. doi: 10.1038/bjc.2017.390. Epub 2017 Nov 7.

6.

In a randomized trial, the live attenuated tetravalent dengue vaccine TV003 is well-tolerated and highly immunogenic in subjects with flavivirus exposure prior to vaccination.

Whitehead SS, Durbin AP, Pierce KK, Elwood D, McElvany BD, Fraser EA, Carmolli MP, Tibery CM, Hynes NA, Jo M, Lovchik JM, Larsson CJ, Doty EA, Dickson DM, Luke CJ, Subbarao K, Diehl SA, Kirkpatrick BD.

PLoS Negl Trop Dis. 2017 May 8;11(5):e0005584. doi: 10.1371/journal.pntd.0005584. eCollection 2017 May.

7.

Enteroviruses infect human enteroids and induce antiviral signaling in a cell lineage-specific manner.

Drummond CG, Bolock AM, Ma C, Luke CJ, Good M, Coyne CB.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1672-1677. doi: 10.1073/pnas.1617363114. Epub 2017 Jan 30.

8.

A Live Attenuated Chimeric West Nile Virus Vaccine, rWN/DEN4Δ30, Is Well Tolerated and Immunogenic in Flavivirus-Naive Older Adult Volunteers.

Pierce KK, Whitehead SS, Kirkpatrick BD, Grier PL, Jarvis A, Kenney H, Carmolli MP, Reynolds C, Tibery CM, Lovchik J, Janiak A, Luke CJ, Durbin AP, Pletnev AG.

J Infect Dis. 2017 Jan 1;215(1):52-55. doi: 10.1093/infdis/jiw501. Epub 2016 Oct 25.

9.

Lateral presentation of faces alters overall viewing strategy.

Luke CJ, Pollux PM.

PeerJ. 2016 Jul 19;4:e2241. doi: 10.7717/peerj.2241. eCollection 2016.

10.

Correlates of Immunity to Influenza as Determined by Challenge of Children with Live, Attenuated Influenza Vaccine.

Wright PF, Hoen AG, Ilyushina NA, Brown EP, Ackerman ME, Wieland-Alter W, Connor RI, Jegaskanda S, Rosenberg-Hasson Y, Haynes BC, Luke CJ, Subbarao K, Treanor JJ.

Open Forum Infect Dis. 2016 May 23;3(2):ofw108. doi: 10.1093/ofid/ofw108. eCollection 2016 Apr.

11.

Activation of the Caenorhabditis elegans Degenerin Channel by Shear Stress Requires the MEC-10 Subunit.

Shi S, Luke CJ, Miedel MT, Silverman GA, Kleyman TR.

J Biol Chem. 2016 Jul 1;291(27):14012-22. doi: 10.1074/jbc.M116.718031. Epub 2016 May 4.

12.

The live attenuated dengue vaccine TV003 elicits complete protection against dengue in a human challenge model.

Kirkpatrick BD, Whitehead SS, Pierce KK, Tibery CM, Grier PL, Hynes NA, Larsson CJ, Sabundayo BP, Talaat KR, Janiak A, Carmolli MP, Luke CJ, Diehl SA, Durbin AP.

Sci Transl Med. 2016 Mar 16;8(330):330ra36. doi: 10.1126/scitranslmed.aaf1517. Epub 2016 Mar 16.

PMID:
27089205
13.

A 12-Month-Interval Dosing Study in Adults Indicates That a Single Dose of the National Institute of Allergy and Infectious Diseases Tetravalent Dengue Vaccine Induces a Robust Neutralizing Antibody Response.

Durbin AP, Kirkpatrick BD, Pierce KK, Carmolli MP, Tibery CM, Grier PL, Hynes N, Opert K, Jarvis AP, Sabundayo BP, McElvany BD, Sendra EA, Larsson CJ, Jo M, Lovchik JM, Luke CJ, Walsh MC, Fraser EA, Subbarao K, Whitehead SS.

J Infect Dis. 2016 Sep 15;214(6):832-5. doi: 10.1093/infdis/jiw067. Epub 2016 Feb 16.

14.

Deficient and Null Variants of SERPINA1 Are Proteotoxic in a Caenorhabditis elegans Model of α1-Antitrypsin Deficiency.

Cummings EE, O'Reilly LP, King DE, Silverman RM, Miedel MT, Luke CJ, Perlmutter DH, Silverman GA, Pak SC.

PLoS One. 2015 Oct 29;10(10):e0141542. doi: 10.1371/journal.pone.0141542. eCollection 2015.

15.

SERPINB12 Is a Slow-Binding Inhibitor of Granzyme A and Hepsin.

Niehaus JZ, Miedel MT, Good M, Wyatt AN, Pak SC, Silverman GA, Luke CJ.

Biochemistry. 2015 Nov 17;54(45):6756-9. doi: 10.1021/acs.biochem.5b01042. Epub 2015 Nov 5.

16.

Microscopic Investigation of Protein Function in C. elegans Using Fluorescent Imaging.

Luke CJ, O'Reilly LP.

Curr Protoc Cytom. 2015 Oct 1;74:12.41.1-17. doi: 10.1002/0471142956.cy1241s74.

PMID:
26423692
17.

Human SERPINB12 Is an Abundant Intracellular Serpin Expressed in Most Surface and Glandular Epithelia.

Niehaus JZ, Good M, Jackson LE, Ozolek JA, Silverman GA, Luke CJ.

J Histochem Cytochem. 2015 Nov;63(11):854-65. doi: 10.1369/0022155415600498. Epub 2015 Jul 28.

18.

Boosted Influenza-Specific T Cell Responses after H5N1 Pandemic Live Attenuated Influenza Virus Vaccination.

Peng Y, Wang B, Talaat K, Karron R, Powell TJ, Zeng H, Dong D, Luke CJ, McMichael A, Subbarao K, Dong T.

Front Immunol. 2015 Jun 2;6:287. doi: 10.3389/fimmu.2015.00287. eCollection 2015.

19.

Robust and Balanced Immune Responses to All 4 Dengue Virus Serotypes Following Administration of a Single Dose of a Live Attenuated Tetravalent Dengue Vaccine to Healthy, Flavivirus-Naive Adults.

Kirkpatrick BD, Durbin AP, Pierce KK, Carmolli MP, Tibery CM, Grier PL, Hynes N, Diehl SA, Elwood D, Jarvis AP, Sabundayo BP, Lyon CE, Larsson CJ, Jo M, Lovchik JM, Luke CJ, Walsh MC, Fraser EA, Subbarao K, Whitehead SS.

J Infect Dis. 2015 Sep 1;212(5):702-10. doi: 10.1093/infdis/jiv082. Epub 2015 Mar 22.

20.

The aggregation-prone intracellular serpin SRP-2 fails to transit the ER in Caenorhabditis elegans.

Silverman RM, Cummings EE, O'Reilly LP, Miedel MT, Silverman GA, Luke CJ, Perlmutter DH, Pak SC.

Genetics. 2015 May;200(1):207-19. doi: 10.1534/genetics.115.176180. Epub 2015 Mar 18.

21.

Live attenuated and inactivated influenza vaccines in children.

Ilyushina NA, Haynes BC, Hoen AG, Khalenkov AM, Housman ML, Brown EP, Ackerman ME, Treanor JJ, Luke CJ, Subbarao K, Wright PF.

J Infect Dis. 2015 Feb 1;211(3):352-60. doi: 10.1093/infdis/jiu458. Epub 2014 Aug 26.

22.

Development of live attenuated influenza vaccines against pandemic influenza strains.

Coelingh KL, Luke CJ, Jin H, Talaat KR.

Expert Rev Vaccines. 2014 Jul;13(7):855-71. doi: 10.1586/14760584.2014.922417. Epub 2014 May 28. Review.

PMID:
24867587
23.

Improving pandemic H5N1 influenza vaccines by combining different vaccine platforms.

Luke CJ, Subbarao K.

Expert Rev Vaccines. 2014 Jul;13(7):873-83. doi: 10.1586/14760584.2014.922416. Epub 2014 May 23. Review.

PMID:
24855993
24.

A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover.

Long OS, Benson JA, Kwak JH, Luke CJ, Gosai SJ, O'Reilly LP, Wang Y, Li J, Vetica AC, Miedel MT, Stolz DB, Watkins SC, Züchner S, Perlmutter DH, Silverman GA, Pak SC.

Hum Mol Genet. 2014 Oct 1;23(19):5109-22. doi: 10.1093/hmg/ddu235. Epub 2014 May 16.

25.

A genome-wide RNAi screen identifies potential drug targets in a C. elegans model of α1-antitrypsin deficiency.

O'Reilly LP, Long OS, Cobanoglu MC, Benson JA, Luke CJ, Miedel MT, Hale P, Perlmutter DH, Bahar I, Silverman GA, Pak SC.

Hum Mol Genet. 2014 Oct 1;23(19):5123-32. doi: 10.1093/hmg/ddu236. Epub 2014 May 16.

26.

Non-microfluidic methods for imaging live C. elegans.

Luke CJ, Niehaus JZ, O'Reilly LP, Watkins SC.

Methods. 2014 Aug 1;68(3):542-7. doi: 10.1016/j.ymeth.2014.05.002. Epub 2014 May 15.

27.

Isolation of serpin-interacting proteins in C. elegans using protein affinity purification.

Miedel MT, Zeng X, Yates NA, Silverman GA, Luke CJ.

Methods. 2014 Aug 1;68(3):536-41. doi: 10.1016/j.ymeth.2014.04.019. Epub 2014 May 2.

28.

A live attenuated influenza A(H5N1) vaccine induces long-term immunity in the absence of a primary antibody response.

Talaat KR, Luke CJ, Khurana S, Manischewitz J, King LR, McMahon BA, Karron RA, Lewis KD, Qin J, Follmann DA, Golding H, Neuzil KM, Subbarao K.

J Infect Dis. 2014 Jun 15;209(12):1860-9. doi: 10.1093/infdis/jiu123. Epub 2014 Mar 5. Erratum in: J Infect Dis. 2014 Dec 15;210(12):2021.

29.

C. elegans in high-throughput drug discovery.

O'Reilly LP, Luke CJ, Perlmutter DH, Silverman GA, Pak SC.

Adv Drug Deliv Rev. 2014 Apr;69-70:247-53. doi: 10.1016/j.addr.2013.12.001. Epub 2013 Dec 12. Review.

30.

A small conductance calcium-activated K+ channel in C. elegans, KCNL-2, plays a role in the regulation of the rate of egg-laying.

Chotoo CK, Silverman GA, Devor DC, Luke CJ.

PLoS One. 2013 Sep 10;8(9):e75869. doi: 10.1371/journal.pone.0075869. eCollection 2013.

31.

H5N1 vaccines in humans.

Baz M, Luke CJ, Cheng X, Jin H, Subbarao K.

Virus Res. 2013 Dec 5;178(1):78-98. doi: 10.1016/j.virusres.2013.05.006. Epub 2013 May 28. Review.

32.

B cell response and hemagglutinin stalk-reactive antibody production in different age cohorts following 2009 H1N1 influenza virus vaccination.

Sangster MY, Baer J, Santiago FW, Fitzgerald T, Ilyushina NA, Sundararajan A, Henn AD, Krammer F, Yang H, Luke CJ, Zand MS, Wright PF, Treanor JJ, Topham DJ, Subbarao K.

Clin Vaccine Immunol. 2013 Jun;20(6):867-76. doi: 10.1128/CVI.00735-12. Epub 2013 Apr 10.

33.

A single dose of any of four different live attenuated tetravalent dengue vaccines is safe and immunogenic in flavivirus-naive adults: a randomized, double-blind clinical trial.

Durbin AP, Kirkpatrick BD, Pierce KK, Elwood D, Larsson CJ, Lindow JC, Tibery C, Sabundayo BP, Shaffer D, Talaat KR, Hynes NA, Wanionek K, Carmolli MP, Luke CJ, Murphy BR, Subbarao K, Whitehead SS.

J Infect Dis. 2013 Mar 15;207(6):957-65. doi: 10.1093/infdis/jis936. Epub 2013 Jan 17.

34.

A pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans.

Miedel MT, Graf NJ, Stephen KE, Long OS, Pak SC, Perlmutter DH, Silverman GA, Luke CJ.

PLoS One. 2012;7(7):e40145. doi: 10.1371/journal.pone.0040145. Epub 2012 Jul 2.

35.

An open-label phase I trial of a live attenuated H2N2 influenza virus vaccine in healthy adults.

Talaat KR, Karron RA, Liang PH, McMahon BA, Luke CJ, Thumar B, Chen GL, Min JY, Lamirande EW, Jin H, Coelingh KL, Kemble GW, Subbarao K.

Influenza Other Respir Viruses. 2013 Jan;7(1):66-73. doi: 10.1111/j.1750-2659.2012.00350.x. Epub 2012 Mar 14.

36.

Using C. elegans to identify the protease targets of serpins in vivo.

Bhatia SR, Miedel MT, Chotoo CK, Graf NJ, Hood BL, Conrads TP, Silverman GA, Luke CJ.

Methods Enzymol. 2011;499:283-99. doi: 10.1016/B978-0-12-386471-0.00014-6.

37.

An open label Phase I trial of a live attenuated H6N1 influenza virus vaccine in healthy adults.

Talaat KR, Karron RA, Luke CJ, Thumar B, McMahon BA, Chen GL, Lamirande EW, Jin H, Coelingh KL, Kemble G, Subbarao K.

Vaccine. 2011 Apr 12;29(17):3144-8. doi: 10.1016/j.vaccine.2011.02.043. Epub 2011 Mar 4.

38.

Necrotic cell death: harnessing the Dark side of the Force in mammary gland involution.

Luke CJ, Silverman GA.

Nat Cell Biol. 2011 Mar;13(3):197-9. doi: 10.1038/ncb0311-197.

PMID:
21364568
39.

Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z.

Gosai SJ, Kwak JH, Luke CJ, Long OS, King DE, Kovatch KJ, Johnston PA, Shun TY, Lazo JS, Perlmutter DH, Silverman GA, Pak SC.

PLoS One. 2010 Nov 12;5(11):e15460. doi: 10.1371/journal.pone.0015460.

40.

Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems.

Silverman GA, Whisstock JC, Bottomley SP, Huntington JA, Kaiserman D, Luke CJ, Pak SC, Reichhart JM, Bird PI.

J Biol Chem. 2010 Aug 6;285(32):24299-305. doi: 10.1074/jbc.R110.112771. Epub 2010 May 24. Review. Erratum in: J Biol Chem. 2010 Dec 3;285(49):38740.

41.

Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions.

Whisstock JC, Silverman GA, Bird PI, Bottomley SP, Kaiserman D, Luke CJ, Pak SC, Reichhart JM, Huntington JA.

J Biol Chem. 2010 Aug 6;285(32):24307-12. doi: 10.1074/jbc.R110.141408. Epub 2010 May 24. Review.

42.

Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine.

Corti D, Suguitan AL Jr, Pinna D, Silacci C, Fernandez-Rodriguez BM, Vanzetta F, Santos C, Luke CJ, Torres-Velez FJ, Temperton NJ, Weiss RA, Sallusto F, Subbarao K, Lanzavecchia A.

J Clin Invest. 2010 May;120(5):1663-73. doi: 10.1172/JCI41902. Epub 2010 Apr 12.

43.

A live attenuated H7N3 influenza virus vaccine is well tolerated and immunogenic in a Phase I trial in healthy adults.

Talaat KR, Karron RA, Callahan KA, Luke CJ, DiLorenzo SC, Chen GL, Lamirande EW, Jin H, Coelingh KL, Murphy BR, Kemble G, Subbarao K.

Vaccine. 2009 Jun 8;27(28):3744-53. doi: 10.1016/j.vaccine.2009.03.082. Epub 2009 Apr 17.

44.

Modeling molecular and cellular aspects of human disease using the nematode Caenorhabditis elegans.

Silverman GA, Luke CJ, Bhatia SR, Long OS, Vetica AC, Perlmutter DH, Pak SC.

Pediatr Res. 2009 Jan;65(1):10-8. doi: 10.1203/PDR.0b013e31819009b0. Review.

45.

FDA/NIH/WHO public workshop on immune correlates of protection against influenza A viruses in support of pandemic vaccine development, Bethesda, Maryland, US, December 10-11, 2007.

Eichelberger M, Golding H, Hess M, Weir J, Subbarao K, Luke CJ, Friede M, Wood D.

Vaccine. 2008 Aug 12;26(34):4299-303. doi: 10.1016/j.vaccine.2008.06.012. Epub 2008 Jun 26.

PMID:
18582523
46.

Prostasin expression is regulated by airway surface liquid volume and is increased in cystic fibrosis.

Myerburg MM, McKenna EE, Luke CJ, Frizzell RA, Kleyman TR, Pilewski JM.

Am J Physiol Lung Cell Mol Physiol. 2008 May;294(5):L932-41. doi: 10.1152/ajplung.00437.2007. Epub 2008 Feb 29.

47.

An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury.

Luke CJ, Pak SC, Askew YS, Naviglia TL, Askew DJ, Nobar SM, Vetica AC, Long OS, Watkins SC, Stolz DB, Barstead RJ, Moulder GL, Brömme D, Silverman GA.

Cell. 2007 Sep 21;130(6):1108-19.

48.

Vaxfectin-formulated influenza DNA vaccines encoding NP and M2 viral proteins protect mice against lethal viral challenge.

Jimenez GS, Planchon R, Wei Q, Rusalov D, Geall A, Enas J, Lalor P, Leamy V, Vahle R, Luke CJ, Rolland A, Kaslow DC, Smith LR.

Hum Vaccin. 2007 Sep-Oct;3(5):157-64. Epub 2007 Mar 20.

PMID:
17637571
49.

SERPINB11 is a new noninhibitory intracellular serpin. Common single nucleotide polymorphisms in the scaffold impair conformational change.

Askew DJ, Cataltepe S, Kumar V, Edwards C, Pace SM, Howarth RN, Pak SC, Askew YS, Brömme D, Luke CJ, Whisstock JC, Silverman GA.

J Biol Chem. 2007 Aug 24;282(34):24948-60. Epub 2007 Jun 11.

50.

Live, attenuated influenza A H5N1 candidate vaccines provide broad cross-protection in mice and ferrets.

Suguitan AL Jr, McAuliffe J, Mills KL, Jin H, Duke G, Lu B, Luke CJ, Murphy B, Swayne DE, Kemble G, Subbarao K.

PLoS Med. 2006 Sep;3(9):e360.

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