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Items: 37


Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice.

Grenz A, Bauerle JD, Dalton JH, Ridyard D, Badulak A, Tak E, McNamee EN, Clambey E, Moldovan R, Reyes G, Klawitter J, Ambler K, Magee K, Christians U, Brodsky KS, Ravid K, Choi DS, Wen J, Lukashev D, Blackburn MR, Osswald H, Coe IR, Nürnberg B, Haase VH, Xia Y, Sitkovsky M, Eltzschig HK.

J Clin Invest. 2017 Jun 1;127(6):2438. doi: 10.1172/JCI94890. Epub 2017 Jun 1. No abstract available.


Immunological mechanisms of the antitumor effects of supplemental oxygenation.

Hatfield SM, Kjaergaard J, Lukashev D, Schreiber TH, Belikoff B, Abbott R, Sethumadhavan S, Philbrook P, Ko K, Cannici R, Thayer M, Rodig S, Kutok JL, Jackson EK, Karger B, Podack ER, Ohta A, Sitkovsky MV.

Sci Transl Med. 2015 Mar 4;7(277):277ra30. doi: 10.1126/scitranslmed.aaa1260.


Postoperative hyperoxia (60%) worsens hepatic injury in mice.

Zangl Q, Martignoni A, Jackson SH, Ohta A, Klaunberg B, Kaufmann I, Lukashev D, Ward JM, Sitkovsky M, Thiel M, Choukèr A.

Anesthesiology. 2014 Dec;121(6):1217-25. doi: 10.1097/ALN.0000000000000447.


Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection.

Hatfield SM, Kjaergaard J, Lukashev D, Belikoff B, Schreiber TH, Sethumadhavan S, Abbott R, Philbrook P, Thayer M, Shujia D, Rodig S, Kutok JL, Ren J, Ohta A, Podack ER, Karger B, Jackson EK, Sitkovsky M.

J Mol Med (Berl). 2014 Dec;92(12):1283-92. doi: 10.1007/s00109-014-1189-3. Epub 2014 Aug 15.


Hostile, hypoxia-A2-adenosinergic tumor biology as the next barrier to overcome for tumor immunologists.

Sitkovsky MV, Hatfield S, Abbott R, Belikoff B, Lukashev D, Ohta A.

Cancer Immunol Res. 2014 Jul;2(7):598-605. doi: 10.1158/2326-6066.CIR-14-0075. Review.


Novel RNA interference-based therapies for sepsis.

Kosovrasti VY, Lukashev D, Nechev LV, Amiji MM.

Expert Opin Biol Ther. 2014 Apr;14(4):419-35. doi: 10.1517/14712598.2014.875524. Epub 2014 Jan 8. Review.


Genetic deletion of the HIF-1α isoform I.1 in T cells enhances antibacterial immunity and improves survival in a murine peritonitis model.

Georgiev P, Belikoff BG, Hatfield S, Ohta A, Sitkovsky MV, Lukashev D.

Eur J Immunol. 2013 Mar;43(3):655-66. doi: 10.1002/eji.201242765. Epub 2013 Jan 31.


In vivo hypoxic preconditioning protects from warm liver ischemia-reperfusion injury through the adenosine A2B receptor.

Choukèr A, Ohta A, Martignoni A, Lukashev D, Zacharia LC, Jackson EK, Schnermann J, Ward JM, Kaufmann I, Klaunberg B, Sitkovsky MV, Thiel M.

Transplantation. 2012 Nov 15;94(9):894-902. doi: 10.1097/TP.0b013e31826a9a46.


Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice.

Grenz A, Bauerle JD, Dalton JH, Ridyard D, Badulak A, Tak E, McNamee EN, Clambey E, Moldovan R, Reyes G, Klawitter J, Ambler K, Magee K, Christians U, Brodsky KS, Ravid K, Choi DS, Wen J, Lukashev D, Blackburn MR, Osswald H, Coe IR, Nürnberg B, Haase VH, Xia Y, Sitkovsky M, Eltzschig HK.

J Clin Invest. 2012 Feb;122(2):693-710. doi: 10.1172/JCI60214. Epub 2012 Jan 24. Retraction in: J Clin Invest. 2017 Jun 1;127(6):2438.


A2B adenosine receptor blockade enhances macrophage-mediated bacterial phagocytosis and improves polymicrobial sepsis survival in mice.

Belikoff BG, Hatfield S, Georgiev P, Ohta A, Lukashev D, Buras JA, Remick DG, Sitkovsky M.

J Immunol. 2011 Feb 15;186(4):2444-53. doi: 10.4049/jimmunol.1001567. Epub 2011 Jan 17.


Toll-like receptor 3 regulates angiogenesis and apoptosis in prostate cancer cell lines through hypoxia-inducible factor 1 alpha.

Paone A, Galli R, Gabellini C, Lukashev D, Starace D, Gorlach A, De Cesaris P, Ziparo E, Del Bufalo D, Sitkovsky MV, Filippini A, Riccioli A.

Neoplasia. 2010 Jul;12(7):539-49.


Importance of mRNA secondary structural elements for the expression of influenza virus genes.

Ilyinskii PO, Schmidt T, Lukashev D, Meriin AB, Thoidis G, Frishman D, Shneider AM.

OMICS. 2009 Oct;13(5):421-30. doi: 10.1089/omi.2009.0036.


The antihypoxia-adenosinergic pathogenesis as a result of collateral damage by overactive immune cells.

Hatfield S, Belikoff B, Lukashev D, Sitkovsky M, Ohta A.

J Leukoc Biol. 2009 Sep;86(3):545-8. doi: 10.1189/jlb.0908577. Epub 2009 Jun 29. Review.


Differential regulation of HIF-1alpha isoforms in murine macrophages by TLR4 and adenosine A(2A) receptor agonists.

Ramanathan M, Luo W, Csóka B, Haskó G, Lukashev D, Sitkovsky MV, Leibovich SJ.

J Leukoc Biol. 2009 Sep;86(3):681-9. doi: 10.1189/jlb.0109021. Epub 2009 May 28.


Hypoxia-adenosinergic immunosuppression: tumor protection by T regulatory cells and cancerous tissue hypoxia.

Sitkovsky MV, Kjaergaard J, Lukashev D, Ohta A.

Clin Cancer Res. 2008 Oct 1;14(19):5947-52. doi: 10.1158/1078-0432.CCR-08-0229. Review.


Preferential expression of the novel alternative isoform I.3 of hypoxia-inducible factor 1alpha in activated human T lymphocytes.

Lukashev D, Sitkovsky M.

Hum Immunol. 2008 Jul;69(7):421-5. doi: 10.1016/j.humimm.2008.05.004. Epub 2008 Jun 11.


From "Hellstrom Paradox" to anti-adenosinergic cancer immunotherapy.

Lukashev D, Sitkovsky M, Ohta A.

Purinergic Signal. 2007 Mar;3(1-2):129-34. doi: 10.1007/s11302-006-9044-9. Epub 2007 Jan 24.


Adenosine A2A receptor antagonists: blockade of adenosinergic effects and T regulatory cells.

Sitkovsky M, Lukashev D, Deaglio S, Dwyer K, Robson SC, Ohta A.

Br J Pharmacol. 2008 Mar;153 Suppl 1:S457-64. doi: 10.1038/bjp.2008.23. Review.


Critical role of hypoxia and A2A adenosine receptors in liver tissue-protecting physiological anti-inflammatory pathway.

Choukèr A, Thiel M, Lukashev D, Ward JM, Kaufmann I, Apasov S, Sitkovsky MV, Ohta A.

Mol Med. 2008 Mar-Apr;14(3-4):116-23.


Sphingosine-1-phosphate reduces CD4+ T-cell activation in type 1 diabetes through regulation of hypoxia-inducible factor short isoform I.1 and CD69.

Srinivasan S, Bolick DT, Lukashev D, Lappas C, Sitkovsky M, Lynch KR, Hedrick CC.

Diabetes. 2008 Feb;57(2):484-93. Epub 2007 Nov 14.


Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival.

Thiel M, Caldwell CC, Kreth S, Kuboki S, Chen P, Smith P, Ohta A, Lentsch AB, Lukashev D, Sitkovsky MV.

PLoS One. 2007 Sep 5;2(9):e853.


Hypoxia-dependent anti-inflammatory pathways in protection of cancerous tissues.

Lukashev D, Ohta A, Sitkovsky M.

Cancer Metastasis Rev. 2007 Jun;26(2):273-9. Review.


Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes.

Lukashev D, Klebanov B, Kojima H, Grinberg A, Ohta A, Berenfeld L, Wenger RH, Ohta A, Sitkovsky M.

J Immunol. 2006 Oct 15;177(8):4962-5.


A2A adenosine receptor protects tumors from antitumor T cells.

Ohta A, Gorelik E, Prasad SJ, Ronchese F, Lukashev D, Wong MK, Huang X, Caldwell S, Liu K, Smith P, Chen JF, Jackson EK, Apasov S, Abrams S, Sitkovsky M.

Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13132-7. Epub 2006 Aug 17.


TSGA10 prevents nuclear localization of the hypoxia-inducible factor (HIF)-1alpha.

Hägele S, Behnam B, Borter E, Wolfe J, Paasch U, Lukashev D, Sitkovsky M, Wenger RH, Katschinski DM.

FEBS Lett. 2006 Jun 26;580(15):3731-8. Epub 2006 Jun 5.


Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors.

Sitkovsky M, Lukashev D.

Nat Rev Immunol. 2005 Sep;5(9):712-21. Review.


Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury.

Thiel M, Chouker A, Ohta A, Jackson E, Caldwell C, Smith P, Lukashev D, Bittmann I, Sitkovsky MV.

PLoS Biol. 2005 Jun;3(6):e174. Epub 2005 May 3.


Targeting hypoxia--A(2A) adenosine receptor-mediated mechanisms of tissue protection.

Lukashev D, Ohta A, Sitkovsky M.

Drug Discov Today. 2004 May 1;9(9):403-9. Review.


Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors.

Sitkovsky MV, Lukashev D, Apasov S, Kojima H, Koshiba M, Caldwell C, Ohta A, Thiel M.

Annu Rev Immunol. 2004;22:657-82. Review.


Analysis of A2a receptor-deficient mice reveals no significant compensatory increases in the expression of A2b, A1, and A3 adenosine receptors in lymphoid organs.

Lukashev DE, Smith PT, Caldwell CC, Ohta A, Apasov SG, Sitkovsky MV.

Biochem Pharmacol. 2003 Jun 15;65(12):2081-90.


A serine/threonine phosphorylation site in the ectodomain of a T cell receptor beta chain is required for activation by superantigen.

Lukashev DE, Caldwell CC, Chen P, Apasov SG, Margulies DH, Sitkovsky MV.

J Recept Signal Transduct Res. 2003 Feb;23(1):33-52.


Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions.

Caldwell CC, Kojima H, Lukashev D, Armstrong J, Farber M, Apasov SG, Sitkovsky MV.

J Immunol. 2001 Dec 1;167(11):6140-9.


Differential regulation of two alternatively spliced isoforms of hypoxia-inducible factor-1 alpha in activated T lymphocytes.

Lukashev D, Caldwell C, Ohta A, Chen P, Sitkovsky M.

J Biol Chem. 2001 Dec 28;276(52):48754-63. Epub 2001 Oct 15.


Multiple tRNA attachment sites in prothymosin alpha.

Lukashev DE, Chichkova NV, Vartapetian AB.

FEBS Lett. 1999 May 21;451(2):118-24.


Mammalian prothymosin alpha links to tRNA in Escherichia coli cells.

Vartapetian A, Lukashev D, Lyakhov I, Belyaeva A, Chichkova N, Bogdanov A.

RNA. 1997 Oct;3(10):1173-81.

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