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Items: 1 to 50 of 455

1.

Pharmacological Chaperones: A Therapeutic Approach for Diseases Caused by Destabilizing Missense Mutations.

Liguori L, Monticelli M, Allocca M, Hay Mele B, Lukas J, Cubellis MV, Andreotti G.

Int J Mol Sci. 2020 Jan 13;21(2). pii: E489. doi: 10.3390/ijms21020489. Review.

2.

Proteostasis regulators modulate proteasomal activity and gene expression to attenuate multiple phenotypes in Fabry disease.

Seemann S, Ernst M, Cimmaruta C, Struckmann S, Cozma C, Koczan D, Knospe AM, Haake LR, Citro V, Bräuer AU, Andreotti G, Cubellis MV, Fuellen G, Hermann A, Giese AK, Rolfs A, Lukas J.

Biochem J. 2020 Jan 3. pii: BCJ20190513. doi: 10.1042/BCJ20190513. [Epub ahead of print]

PMID:
31899485
3.

Ectopic thyroid with benign and malignant findings: A case series.

Lukáš J, Drábek J, Lukáš D, Zemanová I, Rulseh A.

Int J Surg Case Rep. 2019 Nov 18;66:33-38. doi: 10.1016/j.ijscr.2019.11.011. [Epub ahead of print]

4.

Generation of the Niemann-Pick type C2 patient-derived iPSC line AKOSi001-A.

Völkner C, Peter F, Liedtke M, Krohn S, Lindner I, Murua Escobar H, Cimmaruta C, Lukas J, Hermann A, Frech MJ.

Stem Cell Res. 2019 Dec;41:101606. doi: 10.1016/j.scr.2019.101606. Epub 2019 Oct 15.

5.

Stabilization of chromatin topology safeguards genome integrity.

Ochs F, Karemore G, Miron E, Brown J, Sedlackova H, Rask MB, Lampe M, Buckle V, Schermelleh L, Lukas J, Lukas C.

Nature. 2019 Oct;574(7779):571-574. doi: 10.1038/s41586-019-1659-4. Epub 2019 Oct 23.

PMID:
31645724
6.

Determination of the Pathological Features of NPC1 Variants in a Cellular Complementation Test.

Feng X, Cozma C, Pantoom S, Hund C, Iwanov K, Petters J, Völkner C, Bauer C, Vogel F, Bauer P, Weiss FU, Lerch MM, Knospe AM, Hermann A, Frech MJ, Luo J, Rolfs A, Lukas J.

Int J Mol Sci. 2019 Oct 19;20(20). pii: E5185. doi: 10.3390/ijms20205185.

7.

Transformed mucosa-associated lymphoid tissue lymphomas: A single institution retrospective study including polymerase chain reaction-based clonality analysis.

Kiesewetter B, Lamm W, Dolak W, Lukas J, Mayerhoefer ME, Weber M, Schiefer AI, Kornauth C, Bayer G, Simonitsch-Klupp I, Raderer M.

Br J Haematol. 2019 Aug;186(3):448-459. doi: 10.1111/bjh.15953. Epub 2019 May 24.

8.

Silent but significant - A synonymous SNV alters prognosis in Pompe disease.

Lukas J, Hermann A, Giese AK.

EBioMedicine. 2019 May;43:20-21. doi: 10.1016/j.ebiom.2019.04.015. Epub 2019 Apr 12. No abstract available.

9.

Role of endoplasmic reticulum stress and protein misfolding in disorders of the liver and pancreas.

Lukas J, Pospech J, Oppermann C, Hund C, Iwanov K, Pantoom S, Petters J, Frech M, Seemann S, Thiel FG, Modenbach JM, Bolsmann R, de Freitas Chama L, Kraatz F, El-Hage F, Gronbach M, Klein A, Müller R, Salloch S, Weiss FU, Simon P, Wagh P, Klemenz A, Krüger E, Mayerle J, Delcea M, Kragl U, Beller M, Rolfs A, Lerch MM, Sendler M.

Adv Med Sci. 2019 Sep;64(2):315-323. doi: 10.1016/j.advms.2019.03.004. Epub 2019 Apr 9. Review.

PMID:
30978662
10.

Pre-Therapeutic Total Lesion Glycolysis on [18F]FDG-PET Enables Prognostication of 2-Year Progression-Free Survival in MALT Lymphoma Patients Treated with CD20-Antibody-Based Immunotherapy.

Mayerhoefer ME, Staudenherz A, Kiesewetter B, Weber M, Simonitsch-Klupp I, Gibbs P, Dolak W, Lukas J, Raderer M.

Mol Imaging Biol. 2019 Dec;21(6):1192-1199. doi: 10.1007/s11307-019-01329-2.

PMID:
30847823
11.

Initial safety analysis of a randomized phase II trial of nelipepimut-S + GM-CSF and trastuzumab compared to trastuzumab alone to prevent recurrence in breast cancer patients with HER2 low-expressing tumors.

Clifton GT, Peace KM, Holmes JP, Vreeland TJ, Hale DF, Herbert GS, Litton JK, Murthy RK, Lukas J, Peoples GE, Mittendorf Elizabeth A.

Clin Immunol. 2019 Apr;201:48-54. doi: 10.1016/j.clim.2019.02.011. Epub 2019 Feb 25.

PMID:
30817999
12.

53BP1 nuclear bodies enforce replication timing at under-replicated DNA to limit heritable DNA damage.

Spies J, Lukas C, Somyajit K, Rask MB, Lukas J, Neelsen KJ.

Nat Cell Biol. 2019 Apr;21(4):487-497. doi: 10.1038/s41556-019-0293-6. Epub 2019 Feb 25.

PMID:
30804506
13.

Model-informed pediatric development applied to bilastine: Analysis of the clinical PK data and confirmation of the dose selected for the target population.

Vozmediano V, Lukas JC, Encinas E, Schmidt S, Sologuren A, Valiente R, Labeaga L, Campo C, Rodriguez M.

Eur J Pharm Sci. 2019 Feb 1;128:180-192. doi: 10.1016/j.ejps.2018.11.016. Epub 2018 Nov 22.

PMID:
30468868
14.

Dose-Dependent Effect of Enzyme Replacement Therapy on Neutralizing Antidrug Antibody Titers and Clinical Outcome in Patients with Fabry Disease.

Lenders M, Neußer LP, Rudnicki M, Nordbeck P, Canaan-Kühl S, Nowak A, Cybulla M, Schmitz B, Lukas J, Wanner C, Brand SM, Brand E.

J Am Soc Nephrol. 2018 Dec;29(12):2879-2889. doi: 10.1681/ASN.2018070740. Epub 2018 Nov 1.

15.

Positive Antithyroid Antibodies and Nonsuppressed TSH Are Associated with Thyroid Cancer: A Retrospective Cross-Sectional Study.

Krátký J, Ježková J, Kosák M, Vítková H, Bartáková J, Mráz M, Lukáš J, Límanová Z, Jiskra J.

Int J Endocrinol. 2018 Sep 6;2018:9793850. doi: 10.1155/2018/9793850. eCollection 2018.

16.

Using a robotic fish to investigate individual differences in social responsiveness in the guppy.

Bierbach D, Landgraf T, Romanczuk P, Lukas J, Nguyen H, Wolf M, Krause J.

R Soc Open Sci. 2018 Aug 8;5(8):181026. doi: 10.1098/rsos.181026. eCollection 2018 Aug.

17.

Total thyroidectomy (Tx) versus thionamides (antithyroid drugs) in patients with moderate-to-severe Graves' ophthalmopathy - a 1-year follow-up: study protocol for a randomized controlled trial.

Brammen L, Riss P, Lukas J, Gessl A, Dunkler D, Li S, Leisser A, Rezar-Dreindl S, Eibenberger K, Selberherr A, Scheuba C, Papp A.

Trials. 2018 Sep 15;19(1):495. doi: 10.1186/s13063-018-2876-0.

18.

DNA damage-induced dynamic changes in abundance and cytosol-nuclear translocation of proteins involved in translational processes, metabolism, and autophagy.

Bennetzen MV, Kosar M, Bunkenborg J, Payne MR, Bartkova J, Lindström MS, Lukas J, Andersen JS, Bartek J, Larsen DH.

Cell Cycle. 2018;17(17):2146-2163. doi: 10.1080/15384101.2018.1515552. Epub 2018 Sep 22.

19.

Time Scaling for In Vitro-In Vivo Correlation: the Inverse Release Function (IRF) Approach.

Cardot JM, Lukas JC, Muniz P.

AAPS J. 2018 Aug 29;20(6):95. doi: 10.1208/s12248-018-0250-5.

PMID:
30159772
20.

Treatment of mucosa associated lymphoid tissue lymphoma with a long-term once-weekly regimen of oral azithromycin: Results from the phase II MALT-A trial.

Lagler H, Kiesewetter B, Dolak W, Obermueller M, Simonitsch-Klupp I, Lukas J, Neuper O, Lamm WW, Mayerhoefer ME, Raderer M.

Hematol Oncol. 2019 Feb;37(1):22-26. doi: 10.1002/hon.2555. Epub 2018 Sep 19.

21.

Extending Endovascular Embolization to Type A Spinal Perimedullary Arteriovenous Fistula Using Liquid Embolic Agent: Technical Nuances, Challenges and Initial Outcome.

Malik V, Kannath SK, Rajan JE, Lukas J.

World Neurosurg. 2018 Nov;119:267-273. doi: 10.1016/j.wneu.2018.08.021. Epub 2018 Aug 15.

PMID:
30118864
22.

Job satisfaction among disabled people in the sheltered workshop: Differential analysis.

Lukas JF, Lizasoain L, Galarreta J, Etxeberria J.

J Appl Res Intellect Disabil. 2018 Nov;31(6):1174-1185. doi: 10.1111/jar.12492. Epub 2018 Jun 27.

PMID:
29947455
23.

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

Gupta R, Somyajit K, Narita T, Maskey E, Stanlie A, Kremer M, Typas D, Lammers M, Mailand N, Nussenzweig A, Lukas J, Choudhary C.

Cell. 2018 May 3;173(4):972-988.e23. doi: 10.1016/j.cell.2018.03.050. Epub 2018 Apr 12.

24.

Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.

Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis NN, Glytsou C, Pateras IS, Swain U, Souliotis VL, Georgakilas AG, Geacintov N, Scorrano L, Lukas C, Lukas J, Livneh Z, Lygerou Z, Chowdhury D, Sørensen CS, Bartek J, Gorgoulis VG.

Genome Biol. 2018 Mar 16;19(1):37. doi: 10.1186/s13059-018-1401-9.

25.

In Vitro Enzyme Measurement to Test Pharmacological Chaperone Responsiveness in Fabry and Pompe Disease.

Lukas J, Knospe AM, Seemann S, Citro V, Cubellis MV, Rolfs A.

J Vis Exp. 2017 Dec 20;(130). doi: 10.3791/56550.

26.

Redox-sensitive alteration of replisome architecture safeguards genome integrity.

Somyajit K, Gupta R, Sedlackova H, Neelsen KJ, Ochs F, Rask MB, Choudhary C, Lukas J.

Science. 2017 Nov 10;358(6364):797-802. doi: 10.1126/science.aao3172.

PMID:
29123070
27.

Glucosylsphingosine Causes Hematological and Visceral Changes in Mice-Evidence for a Pathophysiological Role in Gaucher Disease.

Lukas J, Cozma C, Yang F, Kramp G, Meyer A, Neßlauer AM, Eichler S, Böttcher T, Witt M, Bräuer AU, Kropp P, Rolfs A.

Int J Mol Sci. 2017 Oct 20;18(10). pii: E2192. doi: 10.3390/ijms18102192.

28.

Model Informed Pediatric Development Applied to Bilastine: Ontogenic PK Model Development, Dose Selection for First Time in Children and PK Study Design.

Vozmediano V, Sologuren A, Lukas JC, Leal N, Rodriguez M.

Pharm Res. 2017 Dec;34(12):2720-2734. doi: 10.1007/s11095-017-2248-6. Epub 2017 Oct 2.

PMID:
28971281
29.

Repeat: a framework to assess empirical reproducibility in biomedical research.

McIntosh LD, Juehne A, Vitale CRH, Liu X, Alcoser R, Lukas JC, Evanoff B.

BMC Med Res Methodol. 2017 Sep 18;17(1):143. doi: 10.1186/s12874-017-0377-6.

30.

Immunohistochemical expression of cereblon and MUM1 as potential predictive markers of response to lenalidomide in extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma).

Kiesewetter B, Simonitsch-Klupp I, Kornauth C, Dolak W, Lukas J, Mayerhoefer ME, Raderer M.

Hematol Oncol. 2018 Feb;36(1):62-67. doi: 10.1002/hon.2472. Epub 2017 Aug 22.

PMID:
28833354
31.

ADAM23 promotes neuronal differentiation of human neural progenitor cells.

Markus-Koch A, Schmitt O, Seemann S, Lukas J, Koczan D, Ernst M, Fuellen G, Wree A, Rolfs A, Luo J.

Cell Mol Biol Lett. 2017 Aug 18;22:16. doi: 10.1186/s11658-017-0045-1. eCollection 2017.

32.

Fluorescent probes for selective protein labeling in lysosomes: a case of α-galactosidase A.

Bohl C, Pomorski A, Seemann S, Knospe AM, Zheng C, Krężel A, Rolfs A, Lukas J.

FASEB J. 2017 Dec;31(12):5258-5267. doi: 10.1096/fj.201700058RRRR. Epub 2017 Aug 15.

PMID:
28821638
33.

Enhanced Degradation of TCE on a Superfund Site Using Endophyte-Assisted Poplar Tree Phytoremediation.

Doty SL, Freeman JL, Cohu CM, Burken JG, Firrincieli A, Simon A, Khan Z, Isebrands JG, Lukas J, Blaylock MJ.

Environ Sci Technol. 2017 Sep 5;51(17):10050-10058. doi: 10.1021/acs.est.7b01504. Epub 2017 Aug 11.

PMID:
28737929
34.

C26-Ceramide as highly sensitive biomarker for the diagnosis of Farber Disease.

Cozma C, Iurașcu MI, Eichler S, Hovakimyan M, Brandau O, Zielke S, Böttcher T, Giese AK, Lukas J, Rolfs A.

Sci Rep. 2017 Jul 21;7(1):6149. doi: 10.1038/s41598-017-06604-2.

35.

A pilot phase II study of ofatumumab monotherapy for extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) lymphoma.

Kiesewetter B, Neuper O, Mayerhoefer ME, Dolak W, Lukas J, Simonitsch-Klupp I, Raderer M.

Hematol Oncol. 2018 Feb;36(1):49-55. doi: 10.1002/hon.2454. Epub 2017 Jul 10.

PMID:
28695630
36.

On the occurrence of three non-native cichlid species including the first record of a feral population of Pelmatolapia (Tilapia) mariae (Boulenger, 1899) in Europe.

Lukas JAY, Jourdan J, Kalinkat G, Emde S, Miesen FW, Jüngling H, Cocchiararo B, Bierbach D.

R Soc Open Sci. 2017 Jun 21;4(6):170160. doi: 10.1098/rsos.170160. eCollection 2017 Jun.

37.

Replication Catastrophe: When a Checkpoint Fails because of Exhaustion.

Toledo L, Neelsen KJ, Lukas J.

Mol Cell. 2017 Jun 15;66(6):735-749. doi: 10.1016/j.molcel.2017.05.001. Review.

38.

Bilateral Infiltrative Dacryoadenitis and Granulomatous Pneumonia in an 11-Year-Old Boy: A Case Report.

Diesner SC, Lukas J, Stifter E, Raimann A, Nachbaur E, Eiwegger T, Renner S, Emminger W, Geleff S, Szepfalusi Z.

Klin Padiatr. 2017 Mar;229(2):96-99. doi: 10.1055/s-0043-100381. Epub 2017 Apr 25. No abstract available.

PMID:
28444655
39.

Treating Prey With Glyphosate Does Not Alter the Demographic Parameters and Predation of the Harmonia axyridis (Coleoptera: Coccinellidae).

Saska P, Skuhrovec J, Lukáš J, Vlach M, Chi H, Tuan SJ, Honek A.

J Econ Entomol. 2017 Apr 1;110(2):392-399. doi: 10.1093/jee/tow325.

PMID:
28131988
40.

Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks.

Sotiriou SK, Kamileri I, Lugli N, Evangelou K, Da-Ré C, Huber F, Padayachy L, Tardy S, Nicati NL, Barriot S, Ochs F, Lukas C, Lukas J, Gorgoulis VG, Scapozza L, Halazonetis TD.

Mol Cell. 2016 Dec 15;64(6):1127-1134. doi: 10.1016/j.molcel.2016.10.038.

41.

Profiling DNA damage response following mitotic perturbations.

S Pedersen R, Karemore G, Gudjonsson T, Rask MB, Neumann B, Hériché JK, Pepperkok R, Ellenberg J, Gerlich DW, Lukas J, Lukas C.

Nat Commun. 2016 Dec 15;7:13887. doi: 10.1038/ncomms13887.

42.

The Large Phenotypic Spectrum of Fabry Disease Requires Graduated Diagnosis and Personalized Therapy: A Meta-Analysis Can Help to Differentiate Missense Mutations.

Citro V, Cammisa M, Liguori L, Cimmaruta C, Lukas J, Cubellis MV, Andreotti G.

Int J Mol Sci. 2016 Dec 1;17(12). pii: E2010. Review.

44.

Identification of an Allosteric Binding Site on Human Lysosomal Alpha-Galactosidase Opens the Way to New Pharmacological Chaperones for Fabry Disease.

Citro V, Peña-García J, den-Haan H, Pérez-Sánchez H, Del Prete R, Liguori L, Cimmaruta C, Lukas J, Cubellis MV, Andreotti G.

PLoS One. 2016 Oct 27;11(10):e0165463. doi: 10.1371/journal.pone.0165463. eCollection 2016.

45.

Can Interim 18F-FDG PET or Diffusion-Weighted MRI Predict End-of-Treatment Outcome in FDG-Avid MALT Lymphoma After Rituximab-Based Therapy?: A Preliminary Study in 15 Patients.

Mayerhoefer ME, Karanikas G, Kletter K, Kiesewetter B, Weber M, Rausch I, Pones M, Simonitsch-Klupp I, Müllauer L, Dolak W, Lukas J, Raderer M.

Clin Nucl Med. 2016 Nov;41(11):837-843.

PMID:
27648705
46.

Gender Aspects in Extranodal Marginal Zone B-Cell Lymphoma of the Mucosa-Associated Lymphoid Tissue: Does Sex Matter?

Kiesewetter B, Lukas J, Dolak W, Simonitsch-Klupp I, Mayerhoefer ME, Raderer M.

Oncology. 2016;91(5):243-250. Epub 2016 Aug 23.

PMID:
27548082
47.

HGSNAT has a TATA-less promoter with multiple starts of transcription.

Richtrova E, Mrazova LS, Musalkova D, Luksan O, Stolnaya L, Minks J, Lukas J, Dvorakova L, Jirsa M, Hrebicek M.

Gene. 2016 Oct 30;592(1):36-42. doi: 10.1016/j.gene.2016.07.051. Epub 2016 Jul 22.

PMID:
27452122
48.

53BP1 fosters fidelity of homology-directed DNA repair.

Ochs F, Somyajit K, Altmeyer M, Rask MB, Lukas J, Lukas C.

Nat Struct Mol Biol. 2016 Aug;23(8):714-21. doi: 10.1038/nsmb.3251. Epub 2016 Jun 27.

PMID:
27348077
49.

Treatment by glyphosate-based herbicide alters life history parameters of the rose-grain aphid Metopolophium dirhodum.

Saska P, Skuhrovec J, Lukáš J, Chi H, Tuan SJ, Honěk A.

Sci Rep. 2016 Jun 15;6:27801. doi: 10.1038/srep27801.

50.

Neck Muscles and Content of Carotid Artery as Reference Tissue for Strain Ratio - a Novel Approach to Improve the Diagnostic Performance of Thyroid Elastography?

Kratky J, Vitkova H, Bartakova J, Lukas J, Jiskra J.

Exp Clin Endocrinol Diabetes. 2016 Mar;124(3):192-7. doi: 10.1055/s-0035-1569359. Epub 2016 Mar 23.

PMID:
27008636

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