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Items: 20

1.

Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint.

Roversi P, Marti L, Caputo AT, Alonzi DS, Hill JC, Dent KC, Kumar A, Levasseur MD, Lia A, Waksman T, Basu S, Soto Albrecht Y, Qian K, McIvor JP, Lipp CB, Siliqi D, Vasiljević S, Mohammed S, Lukacik P, Walsh MA, Santino A, Zitzmann N.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8544-8549. doi: 10.1073/pnas.1703682114. Epub 2017 Jul 24.

2.

High-resolution structures of Lactobacillus salivarius transketolase in the presence and absence of thiamine pyrophosphate.

Lukacik P, Lobley CM, Bumann M, Arena de Souza V, Owens RJ, O'Toole PW, Walsh MA.

Acta Crystallogr F Struct Biol Commun. 2015 Oct;71(Pt 10):1327-34. doi: 10.1107/S2053230X1501657X. Epub 2015 Sep 23.

3.

Streptococcus pneumoniae NanC: STRUCTURAL INSIGHTS INTO THE SPECIFICITY AND MECHANISM OF A SIALIDASE THAT PRODUCES A SIALIDASE INHIBITOR.

Owen CD, Lukacik P, Potter JA, Sleator O, Taylor GL, Walsh MA.

J Biol Chem. 2015 Nov 13;290(46):27736-48. doi: 10.1074/jbc.M115.673632. Epub 2015 Sep 14.

4.

Application of in situ diffraction in high-throughput structure determination platforms.

Aller P, Sanchez-Weatherby J, Foadi J, Winter G, Lobley CM, Axford D, Ashton AW, Bellini D, Brandao-Neto J, Culurgioni S, Douangamath A, Duman R, Evans G, Fisher S, Flaig R, Hall DR, Lukacik P, Mazzorana M, McAuley KE, Mykhaylyk V, Owen RL, Paterson NG, Romano P, Sandy J, Sorensen T, von Delft F, Wagner A, Warren A, Williams M, Stuart DI, Walsh MA.

Methods Mol Biol. 2015;1261:233-53. doi: 10.1007/978-1-4939-2230-7_13. Review.

PMID:
25502203
5.

Structural insight into the biogenesis of β-barrel membrane proteins.

Noinaj N, Kuszak AJ, Gumbart JC, Lukacik P, Chang H, Easley NC, Lithgow T, Buchanan SK.

Nature. 2013 Sep 19;501(7467):385-90. doi: 10.1038/nature12521. Epub 2013 Sep 1.

6.

Using high-throughput in situ plate screening to evaluate the effect of dehydration on protein crystals.

Douangamath A, Aller P, Lukacik P, Sanchez-Weatherby J, Moraes I, Brandao-Neto J.

Acta Crystallogr D Biol Crystallogr. 2013 May;69(Pt 5):920-3. doi: 10.1107/S0907444913002412. Epub 2013 Apr 19.

PMID:
23633603
7.

Specific targeting and killing of Gram-negative pathogens with an engineered phage lytic enzyme.

Lukacik P, Barnard TJ, Hinnebusch BJ, Buchanan SK.

Virulence. 2013 Jan 1;4(1):90-1. doi: 10.4161/viru.22683. No abstract available.

8.

Using a bacteriocin structure to engineer a phage lysin that targets Yersinia pestis.

Lukacik P, Barnard TJ, Buchanan SK.

Biochem Soc Trans. 2012 Dec 1;40(6):1503-6. doi: 10.1042/BST20120209.

9.

Structural engineering of a phage lysin that targets gram-negative pathogens.

Lukacik P, Barnard TJ, Keller PW, Chaturvedi KS, Seddiki N, Fairman JW, Noinaj N, Kirby TL, Henderson JP, Steven AC, Hinnebusch BJ, Buchanan SK.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9857-62. doi: 10.1073/pnas.1203472109. Epub 2012 Jun 7.

10.

Structural insights into Ail-mediated adhesion in Yersinia pestis.

Yamashita S, Lukacik P, Barnard TJ, Noinaj N, Felek S, Tsang TM, Krukonis ES, Hinnebusch BJ, Buchanan SK.

Structure. 2011 Nov 9;19(11):1672-82. doi: 10.1016/j.str.2011.08.010.

11.

Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4.

Lee WH, Lukacik P, Guo K, Ugochukwu E, Kavanagh KL, Marsden B, Oppermann U.

Mol Cell Endocrinol. 2009 Mar 25;301(1-2):199-204. doi: 10.1016/j.mce.2008.09.042. Epub 2008 Oct 22.

PMID:
19013211
12.

Autotransporter structure reveals intra-barrel cleavage followed by conformational changes.

Barnard TJ, Dautin N, Lukacik P, Bernstein HD, Buchanan SK.

Nat Struct Mol Biol. 2007 Dec;14(12):1214-20. Epub 2007 Nov 11.

13.

Structure of colicin I receptor bound to the R-domain of colicin Ia: implications for protein import.

Buchanan SK, Lukacik P, Grizot S, Ghirlando R, Ali MM, Barnard TJ, Jakes KS, Kienker PK, Esser L.

EMBO J. 2007 May 16;26(10):2594-604. Epub 2007 Apr 26.

14.

SDR-type human hydroxysteroid dehydrogenases involved in steroid hormone activation.

Wu X, Lukacik P, Kavanagh KL, Oppermann U.

Mol Cell Endocrinol. 2007 Feb;265-266:71-6. Epub 2007 Jan 17. Review.

PMID:
17234335
15.

Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity.

Lukacik P, Keller B, Bunkoczi G, Kavanagh KL, Lee WH, Adamski J, Oppermann U.

Biochem J. 2007 Mar 15;402(3):419-27. Erratum in: Biochem J. 2007 May 1;403(3):615. Kavanagh, Kathryn [Kavanagh, Kathryn L]; Hwa, Lee Wen [corrected to Lee, Wen Hwa].

16.

Structure and function of human 17beta-hydroxysteroid dehydrogenases.

Lukacik P, Kavanagh KL, Oppermann U.

Mol Cell Endocrinol. 2006 Mar 27;248(1-2):61-71. Epub 2006 Jan 18. Review.

PMID:
16414178
17.

Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase.

Guo K, Lukacik P, Papagrigoriou E, Meier M, Lee WH, Adamski J, Oppermann U.

J Biol Chem. 2006 Apr 14;281(15):10291-7. Epub 2005 Dec 27.

18.

Biological activity, membrane-targeting modification, and crystallization of soluble human decay accelerating factor expressed in E. coli.

White J, Lukacik P, Esser D, Steward M, Giddings N, Bright JR, Fritchley SJ, Morgan BP, Lea SM, Smith GP, Smith RA.

Protein Sci. 2004 Sep;13(9):2406-15.

19.

Crystallization and preliminary X-ray diffraction analysis of three EGF domains of EMR2, a 7TM immune-system molecule.

Abbott RJ, Knott V, Roversi P, Neudeck S, Lukacik P, Handford PA, Lea SM.

Acta Crystallogr D Biol Crystallogr. 2004 May;60(Pt 5):936-8. Epub 2004 Apr 21.

PMID:
15103144
20.

Complement regulation at the molecular level: the structure of decay-accelerating factor.

Lukacik P, Roversi P, White J, Esser D, Smith GP, Billington J, Williams PA, Rudd PM, Wormald MR, Harvey DJ, Crispin MD, Radcliffe CM, Dwek RA, Evans DJ, Morgan BP, Smith RA, Lea SM.

Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1279-84. Epub 2004 Jan 20.

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