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Items: 30


Applying switchable Cas9 variants to in vivo gene editing for therapeutic applications.

Mills EM, Barlow VL, Luk LYP, Tsai YH.

Cell Biol Toxicol. 2019 Aug 15. doi: 10.1007/s10565-019-09488-2. [Epub ahead of print] Review.


Crystal Structure and Biophysical Analysis of Furfural-Detoxifying Aldehyde Reductase from Clostridium beijerinckii.

Scott AF, Cresser-Brown J, Williams TL, Rizkallah PJ, Jin Y, Luk LY, Allemann RK.

Appl Environ Microbiol. 2019 Jul 18;85(15). pii: e00978-19. doi: 10.1128/AEM.00978-19. Print 2019 Aug 1.


Using genetically incorporated unnatural amino acids to control protein functions in mammalian cells.

Nödling AR, Spear LA, Williams TL, Luk LYP, Tsai YH.

Essays Biochem. 2019 Jul 3;63(2):237-266. doi: 10.1042/EBC20180042. Print 2019 Jul 3. Review.


Heavy Enzymes and the Rational Redesign of Protein Catalysts.

Scott AF, Luk LY, Tuñón I, Moliner V, Allemann RK.

Chembiochem. 2019 Apr 24. doi: 10.1002/cbic.201900134. [Epub ahead of print]


Cell-penetrating peptide sequence and modification dependent uptake and subcellular distribution of green florescent protein in different cell lines.

Patel SG, Sayers EJ, He L, Narayan R, Williams TL, Mills EM, Allemann RK, Luk LYP, Jones AT, Tsai YH.

Sci Rep. 2019 Apr 18;9(1):6298. doi: 10.1038/s41598-019-42456-8.


Carbapenems as water soluble organocatalysts.

Williams TL, Nödling AR, Tsai YH, Luk LYP.

Wellcome Open Res. 2018 Aug 31;3:107. doi: 10.12688/wellcomeopenres.14721.1. eCollection 2018.


Reactivity and Selectivity of Iminium Organocatalysis Improved by a Protein Host.

Nödling AR, Świderek K, Castillo R, Hall JW, Angelastro A, Morrill LC, Jin Y, Tsai YH, Moliner V, Luk LYP.

Angew Chem Int Ed Engl. 2018 Sep 17;57(38):12478-12482. doi: 10.1002/anie.201806850. Epub 2018 Aug 23.


Switchable genome editing via genetic code expansion.

Suzuki T, Asami M, Patel SG, Luk LYP, Tsai YH, Perry ACF.

Sci Rep. 2018 Jul 3;8(1):10051. doi: 10.1038/s41598-018-28178-3.


Reaction Mechanism of Organocatalytic Michael Addition of Nitromethane to Cinnamaldehyde: A Case Study on Catalyst Regeneration and Solvent Effects.

Świderek K, Nödling AR, Tsai YH, Luk LYP, Moliner V.

J Phys Chem A. 2018 Jan 11;122(1):451-459. doi: 10.1021/acs.jpca.7b11803. Epub 2018 Jan 2.


Acetylome of Acinetobacter baumannii SK17 Reveals a Highly-Conserved Modification of Histone-Like Protein HU.

Liao JH, Tsai CH, Patel SG, Yang JT, Tu IF, Lo Cicero M, Lipka-Lloyd M, Wu WL, Shen WJ, Ho MR, Chou CC, Sharma GR, Okanishi H, Luk LYP, Tsai YH, Wu SH.

Front Mol Biosci. 2017 Nov 27;4:77. doi: 10.3389/fmolb.2017.00077. eCollection 2017.


Chemical Ligation and Isotope Labeling to Locate Dynamic Effects.

Scott AF, Luk LYP, Allemann RK.

Methods Enzymol. 2017;596:23-41. doi: 10.1016/bs.mie.2017.06.040. Epub 2017 Aug 7.


Chemoenzymatic Assembly of Isotopically Labeled Folates.

Angelastro A, Dawson WM, Luk LYP, Loveridge EJ, Allemann RK.

J Am Chem Soc. 2017 Sep 20;139(37):13047-13054. doi: 10.1021/jacs.7b06358. Epub 2017 Sep 6.


Reactions of biologically inspired hydride sources with B(C6F5)3.

Wilkins LC, Santi N, Luk LYP, Melen RL.

Philos Trans A Math Phys Eng Sci. 2017 Aug 28;375(2101). pii: 20170009. doi: 10.1098/rsta.2017.0009.


Site-specific His/Asp phosphoproteomic analysis of prokaryotes reveals putative targets for drug resistance.

Lai SJ, Tu IF, Wu WL, Yang JT, Luk LYP, Lai MC, Tsai YH, Wu SH.

BMC Microbiol. 2017 May 25;17(1):123. doi: 10.1186/s12866-017-1034-2.


Reduction of Folate by Dihydrofolate Reductase from Thermotoga maritima.

Loveridge EJ, Hroch L, Hughes RL, Williams T, Davies RL, Angelastro A, Luk LY, Maglia G, Allemann RK.

Biochemistry. 2017 Apr 4;56(13):1879-1886. doi: 10.1021/acs.biochem.6b01268. Epub 2017 Mar 24.


β1-subunit-induced structural rearrangements of the Ca2+- and voltage-activated K+ (BK) channel.

Castillo JP, Sánchez-Rodríguez JE, Hyde HC, Zaelzer CA, Aguayo D, Sepúlveda RV, Luk LY, Kent SB, Gonzalez-Nilo FD, Bezanilla F, Latorre R.

Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):E3231-9. doi: 10.1073/pnas.1606381113. Epub 2016 May 23.


Minimization of dynamic effects in the evolution of dihydrofolate reductase.

Ruiz-Pernía JJ, Behiry E, Luk LYP, Loveridge EJ, Tuñón I, Moliner V, Allemann RK.

Chem Sci. 2016 May 1;7(5):3248-3255. doi: 10.1039/c5sc04209g. Epub 2016 Feb 3.


Chemical Ligation and Isotope Labeling to Locate Dynamic Effects during Catalysis by Dihydrofolate Reductase.

Luk LY, Ruiz-Pernía JJ, Adesina AS, Loveridge EJ, Tuñón I, Moliner V, Allemann RK.

Angew Chem Int Ed Engl. 2015 Jul 27;54(31):9016-20. doi: 10.1002/anie.201503968. Epub 2015 Jun 16.


Protein motions and dynamic effects in enzyme catalysis.

Luk LY, Loveridge EJ, Allemann RK.

Phys Chem Chem Phys. 2015 Dec 14;17(46):30817-27. doi: 10.1039/c5cp00794a.


Protein isotope effects in dihydrofolate reductase from Geobacillus stearothermophilus show entropic-enthalpic compensatory effects on the rate constant.

Luk LY, Ruiz-Pernía JJ, Dawson WM, Loveridge EJ, Tuñón I, Moliner V, Allemann RK.

J Am Chem Soc. 2014 Dec 10;136(49):17317-23. doi: 10.1021/ja5102536. Epub 2014 Nov 26.


Role of the occluded conformation in bacterial dihydrofolate reductases.

Behiry EM, Luk LY, Matthews SM, Loveridge EJ, Allemann RK.

Biochemistry. 2014 Jul 29;53(29):4761-8. doi: 10.1021/bi500507v. Epub 2014 Jul 18.


Different dynamical effects in mesophilic and hyperthermophilic dihydrofolate reductases.

Luk LY, Loveridge EJ, Allemann RK.

J Am Chem Soc. 2014 May 14;136(19):6862-5. doi: 10.1021/ja502673h. Epub 2014 May 5.


Thermal adaptation of dihydrofolate reductase from the moderate thermophile Geobacillus stearothermophilus.

Guo J, Luk LY, Loveridge EJ, Allemann RK.

Biochemistry. 2014 May 6;53(17):2855-63. doi: 10.1021/bi500238q. Epub 2014 Apr 22.


Increased dynamic effects in a catalytically compromised variant of Escherichia coli dihydrofolate reductase.

Ruiz-Pernia JJ, Luk LY, García-Meseguer R, Martí S, Loveridge EJ, Tuñón I, Moliner V, Allemann RK.

J Am Chem Soc. 2013 Dec 11;135(49):18689-96. doi: 10.1021/ja410519h. Epub 2013 Nov 26.


Unraveling the role of protein dynamics in dihydrofolate reductase catalysis.

Luk LY, Javier Ruiz-Pernía J, Dawson WM, Roca M, Loveridge EJ, Glowacki DR, Harvey JN, Mulholland AJ, Tuñón I, Moliner V, Allemann RK.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16344-9. doi: 10.1073/pnas.1312437110. Epub 2013 Sep 24.


Effect of dimerization on dihydrofolate reductase catalysis.

Guo J, Loveridge EJ, Luk LY, Allemann RK.

Biochemistry. 2013 Jun 4;52(22):3881-7. doi: 10.1021/bi4005073. Epub 2013 May 22.


A cope rearrangement in the reaction catalyzed by dimethylallyltryptophan synthase?

Luk LY, Qian Q, Tanner ME.

J Am Chem Soc. 2011 Aug 17;133(32):12342-5. doi: 10.1021/ja2034969. Epub 2011 Jul 21.


Clinical significance of CDX2-positive circulating tumour cells in colorectal cancer patients.

Wong SC, Ng SS, Cheung MT, Luk LY, Chan CM, Cheung AH, Lee VH, Lai PB, Ma BB, Hui EP, Lam MY, Au TC, Chan AT.

Br J Cancer. 2011 Mar 15;104(6):1000-6. doi: 10.1038/bjc.2011.32. Epub 2011 Mar 1.


Mechanistic studies on norcoclaurine synthase of benzylisoquinoline alkaloid biosynthesis: an enzymatic Pictet-Spengler reaction.

Luk LY, Bunn S, Liscombe DK, Facchini PJ, Tanner ME.

Biochemistry. 2007 Sep 4;46(35):10153-61. Epub 2007 Aug 15.


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