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Application of ultrasound-guided cholecystocentesis to the evaluation of the metabolite profiling in bile of dogs and cynomolgus monkeys.

Dierks EA, Luk CE, Cai H, MacGuire J, Fox M, Smalley J, Fancher RM, Janovitz E, Foster K, Sun Q.

Pharmacol Res Perspect. 2019 May 27;7(3):e00488. doi: 10.1002/prp2.488. eCollection 2019 Jun.


Urinary miRNA profile for the diagnosis of IgA nephropathy.

Szeto CC, Wang G, Ng JK, Kwan BC, Mac-Moune Lai F, Chow KM, Luk CC, Lai KB, Li PK.

BMC Nephrol. 2019 Mar 4;20(1):77. doi: 10.1186/s12882-019-1267-4.


Urinary mitochondrial DNA level as a biomarker of tissue injury in non-diabetic chronic kidney diseases.

Wei Z, Kwan BC, Chow KM, Cheng PM, Luk CC, Lai KB, Li PK, Szeto CC.

BMC Nephrol. 2018 Dec 19;19(1):367. doi: 10.1186/s12882-018-1178-9.


Alzheimer's disease: 3-Dimensional MRI texture for prediction of conversion from mild cognitive impairment.

Luk CC, Ishaque A, Khan M, Ta D, Chenji S, Yang YH, Eurich D, Kalra S; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement (Amst). 2018 Nov 2;10:755-763. doi: 10.1016/j.dadm.2018.09.002. eCollection 2018.


Evaluating the cerebral correlates of survival in amyotrophic lateral sclerosis.

Ishaque A, Mah D, Seres P, Luk C, Eurich D, Johnston W, Yang YH, Kalra S.

Ann Clin Transl Neurol. 2018 Sep 23;5(11):1350-1361. doi: 10.1002/acn3.655. eCollection 2018 Nov.


Neurocognitive function, performance status, and quality of life in pediatric intracranial germ cell tumor survivors.

Tso WWY, Liu APY, Lee TMC, Cheuk KL, Shing MK, Luk CW, Ling SC, Ku DTL, Li K, Yung AWY, Fung CW, Chan SHS, Ho ACC, Ho FKW, Ip P, Chan GCF.

J Neurooncol. 2019 Jan;141(2):393-401. doi: 10.1007/s11060-018-03045-3. Epub 2018 Nov 20.


Corticospinal tract degeneration in ALS unmasked in T1-weighted images using texture analysis.

Ishaque A, Mah D, Seres P, Luk C, Johnston W, Chenji S, Beaulieu C, Yang YH, Kalra S.

Hum Brain Mapp. 2019 Mar;40(4):1174-1183. doi: 10.1002/hbm.24437. Epub 2018 Oct 27.


Treatment outcome and pattern of failure in hepatoblastoma treated with a consensus protocol in Hong Kong.

Liu APY, Ip JJK, Leung AWK, Luk CW, Li CH, Ho KKH, Lo R, Chan EKW, Chan ACY, Chung PHY, Chiang AKS.

Pediatr Blood Cancer. 2019 Jan;66(1):e27482. doi: 10.1002/pbc.27482. Epub 2018 Sep 30.


Excellent outcome of acute lymphoblastic leukaemia with TCF3-PBX1 rearrangement in Hong Kong.

Lin A, Cheng FWT, Chiang AKS, Luk CW, Li RCH, Ling ASC, Cheuk DKL, Chang KO, Ku D, Lee V, Ha SY, Li CK.

Pediatr Blood Cancer. 2018 Dec;65(12):e27346. doi: 10.1002/pbc.27346. Epub 2018 Jul 26.


An introduction to the Journal of Thoracic Disease focused issue "Hong Kong Queen Mary Hospital Second Thoracic Surgery Symposium".

Luk CC.

J Thorac Dis. 2018 Jun;10(Suppl 16):S1841-S1842. doi: 10.21037/jtd.2018.04.105. No abstract available.


SLC6A14, an amino acid transporter, modifies the primary CF defect in fluid secretion.

Ahmadi S, Xia S, Wu YS, Di Paola M, Kissoon R, Luk C, Lin F, Du K, Rommens J, Bear CE.

Elife. 2018 Jul 13;7. pii: e37963. doi: 10.7554/eLife.37963.


Urinary mitochondrial DNA level in non-diabetic chronic kidney diseases.

Wei PZ, Kwan BC, Chow KM, Cheng PM, Luk CC, Lai KB, Li PK, Szeto CC.

Clin Chim Acta. 2018 Sep;484:36-39. doi: 10.1016/j.cca.2018.05.036. Epub 2018 May 17.


Outcomes and morbidities of patients who survive haemoglobin Bart's hydrops fetalis syndrome: 20-year retrospective review.

Chan WY, Leung AW, Luk CW, Li RC, Ling AS, Ha SY.

Hong Kong Med J. 2018 Apr;24(2):107-118. doi: 10.12809/hkmj176336. Epub 2018 Apr 6.


Neurofilament light chain and tau concentrations are markedly increased in the serum of patients with sporadic Creutzfeldt-Jakob disease, and tau correlates with rate of disease progression.

Thompson AGB, Luk C, Heslegrave AJ, Zetterberg H, Mead SH, Collinge J, Jackson GS.

J Neurol Neurosurg Psychiatry. 2018 Sep;89(9):955-961. doi: 10.1136/jnnp-2017-317793. Epub 2018 Feb 27.


Urinary mitochondrial DNA level is an indicator of intra-renal mitochondrial depletion and renal scarring in diabetic nephropathy.

Wei PZ, Kwan BC, Chow KM, Cheng PM, Luk CC, Li PK, Szeto CC.

Nephrol Dial Transplant. 2018 May 1;33(5):784-788. doi: 10.1093/ndt/gfx339.


Radium, biophysics, and radiobiology: tracing the history of radiobiology in twentieth-century China.

Luk CYL.

Hist Philos Life Sci. 2017 Nov 2;40(1):2. doi: 10.1007/s40656-017-0169-7.


Oxidizing capacity of the rural atmosphere in Hong Kong, Southern China.

Li Z, Xue L, Yang X, Zha Q, Tham YJ, Yan C, Louie PKK, Luk CWY, Wang T, Wang W.

Sci Total Environ. 2018 Jan 15;612:1114-1122. doi: 10.1016/j.scitotenv.2017.08.310. Epub 2017 Sep 8.


Urinary Mitochondrial DNA Level as a Biomarker of Acute Kidney Injury Severity.

Ho PW, Pang WF, Luk CC, Ng JK, Chow KM, Kwan BC, Li PK, Szeto CC.

Kidney Dis (Basel). 2017 Jul;3(2):78-83. doi: 10.1159/000475883. Epub 2017 May 17.


Macrophage JAK2 deficiency protects against high-fat diet-induced inflammation.

Desai HR, Sivasubramaniyam T, Revelo XS, Schroer SA, Luk CT, Rikkala PR, Metherel AH, Dodington DW, Park YJ, Kim MJ, Rapps JA, Besla R, Robbins CS, Wagner KU, Bazinet RP, Winer DA, Woo M.

Sci Rep. 2017 Aug 9;7(1):7653. doi: 10.1038/s41598-017-07923-0.


Hepatic JAK2 protects against atherosclerosis through circulating IGF-1.

Sivasubramaniyam T, Schroer SA, Li A, Luk CT, Shi SY, Besla R, Dodington DW, Metherel AH, Kitson AP, Brunt JJ, Lopes J, Wagner KU, Bazinet RP, Bendeck MP, Robbins CS, Woo M.

JCI Insight. 2017 Jul 20;2(14). pii: 93735. doi: 10.1172/jci.insight.93735. eCollection 2017 Jul 20.


Biosorption Performance of Encapsulated Candida krusei for the removal of Copper(II).

Luk CHJ, Yip J, Yuen CWM, Pang SK, Lam KH, Kan CW.

Sci Rep. 2017 May 19;7(1):2159. doi: 10.1038/s41598-017-02350-7.


FAK signalling controls insulin sensitivity through regulation of adipocyte survival.

Luk CT, Shi SY, Cai EP, Sivasubramaniyam T, Krishnamurthy M, Brunt JJ, Schroer SA, Winer DA, Woo M.

Nat Commun. 2017 Feb 6;8:14360. doi: 10.1038/ncomms14360.


Lower Rates of Promotion of Generalists in Academic Medicine: A Follow-up to the National Faculty Survey.

Blazey-Martin D, Carr PL, Terrin N, Breeze JL, Luk C, Raj A, Freund KM.

J Gen Intern Med. 2017 Jul;32(7):747-752. doi: 10.1007/s11606-016-3961-2. Epub 2017 Jan 24.


Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice.

Shi SY, Luk CT, Schroer SA, Kim MJ, Dodington DW, Sivasubramaniyam T, Lin L, Cai EP, Lu SY, Wagner KU, Bazinet RP, Woo M.

J Biol Chem. 2017 Mar 3;292(9):3789-3799. doi: 10.1074/jbc.M116.752519. Epub 2017 Jan 18.


Peritoneal dialysis effluent miR-21 and miR-589 levels correlate with longitudinal change in peritoneal transport characteristics.

Szeto CC, Chow KM, Kwan BC, Cheng PM, Luk CC, Ng JK, Law MC, Leung CB, Li PK.

Clin Chim Acta. 2017 Jan;464:106-112. doi: 10.1016/j.cca.2016.11.020. Epub 2016 Nov 17.


Diagnosing Sporadic Creutzfeldt-Jakob Disease by the Detection of Abnormal Prion Protein in Patient Urine.

Luk C, Jones S, Thomas C, Fox NC, Mok TH, Mead S, Collinge J, Jackson GS.

JAMA Neurol. 2016 Dec 1;73(12):1454-1460. doi: 10.1001/jamaneurol.2016.3733.


Spatiotemporal variation of ozone precursors and ozone formation in Hong Kong: Grid field measurement and modelling study.

Lyu XP, Liu M, Guo H, Ling ZH, Wang Y, Louie PKK, Luk CWY.

Sci Total Environ. 2016 Nov 1;569-570:1341-1349. doi: 10.1016/j.scitotenv.2016.06.214. Epub 2016 Jul 5.


School Children's Attributions of Intentions for Parental Behaviors: Development of a Measure.

Zhang L, Wan WW, Luk CL, Tam VC, Wu P.

Psychol Rep. 2016 Jun;118(3):1011-38. doi: 10.1177/0033294116648361. Epub 2016 May 15.


Objective measurement of two clinical signs in childhood atopic eczema in research and therapeutics.

Hon KL, Luk CK, Tsang YC, Pong NH, Leung TF.

J Dermatolog Treat. 2017 Feb;28(1):47-49. doi: 10.1080/09546634.2016.1178376. Epub 2016 May 6.


Methods for Assessing the In Vivo Role of PTEN in Glucose Homeostasis.

Luk CT, Schroer SA, Woo M.

Methods Mol Biol. 2016;1388:75-91. doi: 10.1007/978-1-4939-3299-3_7.


Urinary sediment mRNA level of extracellular matrix molecules in adult nephrotic syndrome.

Wang G, Kwan BC, Lai FM, Chow KM, Ng KJ, Luk CC, Li PK, Szeto CC.

Clin Chim Acta. 2016 May 1;456:157-162. doi: 10.1016/j.cca.2016.03.006. Epub 2016 Mar 16.


Development and Application of a Next Generation Air Sensor Network for the Hong Kong Marathon 2015 Air Quality Monitoring.

Sun L, Wong KC, Wei P, Ye S, Huang H, Yang F, Westerdahl D, Louie PK, Luk CW, Ning Z.

Sensors (Basel). 2016 Feb 5;16(2):211. doi: 10.3390/s16020211.


Acute Leukemia in Down Syndrome Children in Hong Kong: Retrospective Review.

Lam GK, Leung AW, Ha SY, Luk CW, Li CH, Ling SC, Chiang AK, Li CK.

J Pediatr Hematol Oncol. 2016 Mar;38(2):102-6. doi: 10.1097/MPH.0000000000000500.


JAK2 promotes brown adipose tissue function and is required for diet- and cold-induced thermogenesis in mice.

Shi SY, Zhang W, Luk CT, Sivasubramaniyam T, Brunt JJ, Schroer SA, Desai HR, Majerski A, Woo M.

Diabetologia. 2016 Jan;59(1):187-196. doi: 10.1007/s00125-015-3786-2. Epub 2015 Oct 29.


Rosuvastatin Liver Partitioning in Cynomolgus Monkeys: Measurement In Vivo and Prediction Using In Vitro Monkey Hepatocyte Uptake.

Morse BL, Cai H, MacGuire JG, Fox M, Zhang L, Zhang Y, Gu X, Shen H, Dierks EA, Su H, Luk CE, Marathe P, Shu YZ, Humphreys WG, Lai Y.

Drug Metab Dispos. 2015 Nov;43(11):1788-94. doi: 10.1124/dmd.115.065946. Epub 2015 Sep 4.


Podocyte mRNA in the urinary sediment of minimal change nephropathy and focal segmental glomerulosclerosis.

Szeto CC, Wang G, Chow KM, Lai FM, Ma TK, Kwan BC, Luk CC, Li PK.

Clin Nephrol. 2015 Oct;84(4):198-205. doi: 10.5414/CN108607.


DJ-1 links muscle ROS production with metabolic reprogramming and systemic energy homeostasis in mice.

Shi SY, Lu SY, Sivasubramaniyam T, Revelo XS, Cai EP, Luk CT, Schroer SA, Patel P, Kim RH, Bombardier E, Quadrilatero J, Tupling AR, Mak TW, Winer DA, Woo M.

Nat Commun. 2015 Jun 16;6:7415. doi: 10.1038/ncomms8415.


Functional and histological improvement after everolimus rescue of chronic allograft dysfunction in renal transplant recipients.

Chow KM, Szeto CC, Lai FM, Luk CC, Kwan BC, Leung CB, Li PK.

Ther Clin Risk Manag. 2015 May 19;11:829-35. doi: 10.2147/TCRM.S84030. eCollection 2015.


Intrarenal and Urinary Th9 and Th22 Cytokine Gene Expression in Lupus Nephritis.

Luk CC, Tam LS, Kwan BC, Wong PC, Ma TK, Chow KM, Lai FM, Li PK, Szeto CC.

J Rheumatol. 2015 Jul;42(7):1150-5. doi: 10.3899/jrheum.140954. Epub 2015 May 15.


Urinary mRNA levels of ELR-negative CXC chemokine ligand and extracellular matrix in diabetic nephropathy.

Wang G, Lai FM, Chow KM, Kwan BC, Pang WF, Luk CC, Leung CB, Li PK, Szeto CC.

Diabetes Metab Res Rev. 2015 Oct;31(7):699-706. doi: 10.1002/dmrr.2654. Epub 2015 May 13.


Regulation of obesity-related insulin resistance with gut anti-inflammatory agents.

Luck H, Tsai S, Chung J, Clemente-Casares X, Ghazarian M, Revelo XS, Lei H, Luk CT, Shi SY, Surendra A, Copeland JK, Ahn J, Prescott D, Rasmussen BA, Chng MH, Engleman EG, Girardin SE, Lam TK, Croitoru K, Dunn S, Philpott DJ, Guttman DS, Woo M, Winer S, Winer DA.

Cell Metab. 2015 Apr 7;21(4):527-42. doi: 10.1016/j.cmet.2015.03.001.


Trophic factor-induced activity 'signature' regulates the functional expression of postsynaptic excitatory acetylcholine receptors required for synaptogenesis.

Luk CC, Lee AJ, Wijdenes P, Zaidi W, Leung A, Wong NY, Andrews J, Syed NI.

Sci Rep. 2015 Apr 1;5:9523. doi: 10.1038/srep09523.


Photoresponse of polyaniline-functionalized graphene quantum dots.

Lai SK, Luk CM, Tang L, Teng KS, Lau SP.

Nanoscale. 2015 Mar 12;7(12):5338-43. doi: 10.1039/c4nr07565j.


An exploratory study on school children's intent attributions for parental structuring behaviors.

Zhang L, Tam VC, Wan WW, Wu P, Luk CL.

Psychol Rep. 2015 Feb;116(1):249-73. doi: 10.2466/21.PR0.116k17w3. Epub 2015 Feb 10.


Rb and p107 are required for alpha cell survival, beta cell cycle control and glucagon-like peptide-1 action.

Cai EP, Luk CT, Wu X, Schroer SA, Shi SY, Sivasubramaniyam T, Brunt JJ, Zacksenhaus E, Woo M.

Diabetologia. 2014 Dec;57(12):2555-65. doi: 10.1007/s00125-014-3381-y. Epub 2014 Sep 24.


Discovery of 5-chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)-one (BMS-903452), an antidiabetic clinical candidate targeting GPR119.

Wacker DA, Wang Y, Broekema M, Rossi K, O'Connor S, Hong Z, Wu G, Malmstrom SE, Hung CP, LaMarre L, Chimalakonda A, Zhang L, Xin L, Cai H, Chu C, Boehm S, Zalaznick J, Ponticiello R, Sereda L, Han SP, Zebo R, Zinker B, Luk CE, Wong R, Everlof G, Li YX, Wu CK, Lee M, Griffen S, Miller KJ, Krupinski J, Robl JA.

J Med Chem. 2014 Sep 25;57(18):7499-508. doi: 10.1021/jm501175v. Epub 2014 Sep 10.


Neuronal somata and extrasomal compartments play distinct roles during synapse formation between Lymnaea neurons.

Xu F, Luk CC, Wiersma-Meems R, Baehre K, Herman C, Zaidi W, Wong N, Syed NI.

J Neurosci. 2014 Aug 20;34(34):11304-15. doi: 10.1523/JNEUROSCI.1651-14.2014.


Increasing external effects negate local efforts to control ozone air pollution: a case study of Hong Kong and implications for other Chinese cities.

Xue L, Wang T, Louie PK, Luk CW, Blake DR, Xu Z.

Environ Sci Technol. 2014 Sep 16;48(18):10769-75. doi: 10.1021/es503278g. Epub 2014 Aug 27.


PTEN deletion in pancreatic α-cells protects against high-fat diet-induced hyperglucagonemia and insulin resistance.

Wang L, Luk CT, Cai EP, Schroer SA, Allister EM, Shi SY, Wheeler MB, Gaisano HY, Woo M.

Diabetes. 2015 Jan;64(1):147-57. doi: 10.2337/db13-1715. Epub 2014 Aug 4.

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