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From Hong Kong Diabetes Register to JADE Program to RAMP-DM for Data-Driven Actions.

Chan JCN, Lim LL, Luk AOY, Ozaki R, Kong APS, Ma RCW, So WY, Lo SV.

Diabetes Care. 2019 Sep 17. pii: dci190003. doi: 10.2337/dci19-0003. [Epub ahead of print]


Cardiovascular outcomes trials in type 2 diabetes: Time to include young adults.

Ke C, Shah BR, Luk AO, Di Ruggiero E, Chan JCN.

Diabetes Obes Metab. 2019 Sep 4. doi: 10.1111/dom.13874. [Epub ahead of print] No abstract available.


Association of Surrogate Decision-making Interventions for Critically Ill Adults With Patient, Family, and Resource Use Outcomes: A Systematic Review and Meta-analysis.

Bibas L, Peretz-Larochelle M, Adhikari NK, Goldfarb MJ, Luk A, Englesakis M, Detsky ME, Lawler PR.

JAMA Netw Open. 2019 Jul 3;2(7):e197229. doi: 10.1001/jamanetworkopen.2019.7229.


The predictive and prognostic significance of liquid biopsy in advanced epidermal growth factor receptor-mutated non-small cell lung cancer: A prospective study.

Ding PN, Becker TM, Bray VJ, Chua W, Ma YF, Lynch D, Po J, Luk AWS, Caixeiro N, de Souza P, Roberts TL.

Lung Cancer. 2019 Aug;134:187-193. doi: 10.1016/j.lungcan.2019.06.021. Epub 2019 Jun 24.


Insulin glargine compared to neutral protamine Hagedorn (NPH) insulin in patients with type-2 diabetes uncontrolled with oral anti-diabetic agents alone in Hong Kong: a cost-effectiveness analysis.

Lau E, Salem A, Chan JCN, So WY, Kong A, Lamotte M, Luk A.

Cost Eff Resour Alloc. 2019 Jul 2;17:13. doi: 10.1186/s12962-019-0180-9. eCollection 2019.


Use of sodium-glucose co-transporter-2 inhibitors in patients with type 2 diabetes mellitus and multiple cardiovascular risk factors: An Asian perspective and expert recommendations.

Deerochanawong C, Chan SP, Matawaran BJ, Sheu WH, Chan J, Man NH, Suastika K, Khoo CM, Yoon KH, Luk A, Mithal A, Linong J.

Diabetes Obes Metab. 2019 Nov;21(11):2354-2367. doi: 10.1111/dom.13819. Epub 2019 Jul 17. Review.


Excess Burden of Mental Illness and Hospitalization in Young-Onset Type 2 Diabetes.

Ke C, Shah BR, Stukel TA, Chan JCN, Luk A.

Ann Intern Med. 2019 Jul 2;171(1):78-79. doi: 10.7326/L19-0243. No abstract available.


Sperm swimming behaviors are correlated with sperm haploid genetic variability in the Mexican tetra, Astyanax mexicanus.

Borowsky R, Luk A, Kim RS.

PLoS One. 2019 Jun 26;14(6):e0218538. doi: 10.1371/journal.pone.0218538. eCollection 2019.


Sex differences in the association between socioeconomic status and diabetes prevalence and incidence in China: cross-sectional and prospective studies of 0.5 million adults.

Wu H, Bragg F, Yang L, Du H, Guo Y, Jackson CA, Zhu S, Yu C, Luk AOY, Chan JCN, Gasevic D, Li L, Chen Z, Wild SH.

Diabetologia. 2019 Aug;62(8):1420-1429. doi: 10.1007/s00125-019-4896-z. Epub 2019 May 31.


Temporal changes in obesity and sleep habits in Hong Kong Chinese school children: a prospective study.

Lim LL, Tse G, Choi KC, Zhang J, Luk AOY, Chow E, Ma RCW, Chan MHM, Wing YK, Kong APS, Chan JCN.

Sci Rep. 2019 Apr 10;9(1):5881. doi: 10.1038/s41598-019-42346-z.


Diabetes-Related Complications and Mortality in Patients With Young-Onset Latent Autoimmune Diabetes: A 14-Year Analysis of the Prospective Hong Kong Diabetes Register.

Luk AOY, Lau ESH, Lim C, Kong APS, Chow E, Ma RCW, Chan JCN.

Diabetes Care. 2019 Jun;42(6):1042-1050. doi: 10.2337/dc18-1796. Epub 2019 Apr 9.


Diabetes management and treatment approaches outside of North America and West Europe in 2006 and 2015.

Tabesh M, Magliano DJ, Tanamas SK, Surmont F, Bahendeka S, Chiang CE, Elgart JF, Gagliardino JJ, Kalra S, Krishnamoorthy S, Luk A, Maegawa H, Motala AA, Pirie F, Ramachandran A, Tayeb K, Vikulova O, Wong J, Shaw JE.

Acta Diabetol. 2019 Aug;56(8):889-897. doi: 10.1007/s00592-018-01284-4. Epub 2019 Apr 8.


Ingestion of resistant starch by mice markedly increases microbiome-derived metabolites.

Koay YC, Wali JA, Luk AWS, Macia L, Cogger VC, Pulpitel TJ, Wahl D, Solon-Biet SM, Holmes A, Simpson SJ, O'Sullivan JF.

FASEB J. 2019 Jul;33(7):8033-8042. doi: 10.1096/fj.201900177R. Epub 2019 Mar 29.


Revealing cellular and molecular transitions in neonatal germ cell differentiation using single cell RNA sequencing.

Liao J, Ng SH, Luk AC, Suen HC, Qian Y, Lee AWT, Tu J, Fung JCL, Tang NLS, Feng B, Chan WY, Fouchet P, Hobbs RM, Lee TL.

Development. 2019 Mar 27;146(6). pii: dev174953. doi: 10.1242/dev.174953.


Role of Two-Component System Response Regulator bceR in the Antimicrobial Resistance, Virulence, Biofilm Formation, and Stress Response of Group B Streptococcus.

Yang Y, Luo M, Zhou H, Li C, Luk A, Zhao G, Fung K, Ip M.

Front Microbiol. 2019 Jan 23;10:10. doi: 10.3389/fmicb.2019.00010. eCollection 2019.


Gender differences in the associations between insomnia and glycemic control in patients with type 2 diabetes: a cross-sectional study.

Ding C, Zhang J, Lau ESH, Luk AOY, So WY, Ma RCW, Choi KC, Chan JCN, Wing YK, Kong APS.

Sleep. 2019 Apr 1;42(4). pii: zsz014. doi: 10.1093/sleep/zsz014.


Automatic Breast and Fibroglandular Tissue Segmentation in Breast MRI Using Deep Learning by a Fully-Convolutional Residual Neural Network U-Net.

Zhang Y, Chen JH, Chang KT, Park VY, Kim MJ, Chan S, Chang P, Chow D, Luk A, Kwong T, Su MY.

Acad Radiol. 2019 Jan 31. pii: S1076-6332(19)30036-4. doi: 10.1016/j.acra.2019.01.012. [Epub ahead of print]


Excess Burden of Mental Illness and Hospitalization in Young-Onset Type 2 Diabetes: A Population-Based Cohort Study.

Ke C, Lau E, Shah BR, Stukel TA, Ma RC, So WY, Kong AP, Chow E, Clarke P, Goggins W, Chan JCN, Luk A.

Ann Intern Med. 2019 Feb 5;170(3):145-154. doi: 10.7326/M18-1900. Epub 2019 Jan 15.


Association between educational level and cardiovascular disease and all-cause mortality in patients with type 2 diabetes: a prospective study in the Joint Asia Diabetes Evaluation Program.

Wu H, Lau ES, Kong AP, Ma RC, Ozaki R, Cheung KK, Chow E, Tsang CC, Lau KP, Hui EM, So WY, Gasevic D, Wild SH, Chan JC, Luk A.

Clin Epidemiol. 2018 Oct 25;10:1561-1571. doi: 10.2147/CLEP.S177437. eCollection 2018.


Progression of diabetic kidney disease and trajectory of kidney function decline in Chinese patients with Type 2 diabetes.

Jiang G, Luk AOY, Tam CHT, Xie F, Carstensen B, Lau ESH, Lim CKP, Lee HM, Ng ACW, Ng MCY, Ozaki R, Kong APS, Chow CC, Yang X, Lan HY, Tsui SKW, Fan X, Szeto CC, So WY, Chan JCN, Ma RCW; Hong Kong Diabetes Register TRS Study Group.

Kidney Int. 2019 Jan;95(1):178-187. doi: 10.1016/j.kint.2018.08.026. Epub 2018 Nov 8.


Cardiovascular disease management in people with diabetes outside North America and Western Europe in 2006 and 2015.

Tabesh M, Magliano DJ, Tanamas SK, Surmont F, Bahendeka S, Chiang CE, Elgart JF, Gagliardino JJ, Kalra S, Krishnamoorthy S, Luk A, Maegawa H, Motala AA, Pirie F, Ramachandran A, Tayeb K, Vikulova O, Wong J, Shaw JE.

Diabet Med. 2019 Jul;36(7):878-887. doi: 10.1111/dme.13858. Epub 2018 Nov 21.


Long-term succession in a coal seam microbiome during in situ biostimulation of coalbed-methane generation.

Beckmann S, Luk AWS, Gutierrez-Zamora ML, Chong NHH, Thomas T, Lee M, Manefield M.

ISME J. 2019 Mar;13(3):632-650. doi: 10.1038/s41396-018-0296-5. Epub 2018 Oct 15.


Interactive effects of testosterone and the androgen receptor CAG repeat length polymorphism on cardiovascular-renal events and mortality in men with diabetes.

Wong PW, Lee HM, Lau ESH, Lim C, Ma RCW, Kong APS, Chan JCN, Luk AOY.

Diabetes Metab Res Rev. 2019 Jan;35(1):e3081. doi: 10.1002/dmrr.3081. Epub 2018 Oct 23.


A proof-of-concept study to evaluate the efficacy and safety of BTI320 on post-prandial hyperglycaemia in Chinese subjects with pre-diabetes.

Luk AOY, Zee BCY, Chong M, Ozaki R, Rausch CW, Chan MHM, Ma RCW, Kong APS, Chow FCC, Chan JCN.

BMC Endocr Disord. 2018 Aug 31;18(1):59. doi: 10.1186/s12902-018-0288-5.


Type I and III Interferon Productions Are Impaired in X-Linked Agammaglobulinemia Patients Toward Poliovirus but Not Influenza Virus.

Luk ADW, Ni K, Wu Y, Lam KT, Chan KW, Lee PP, Tu W, Mao H, Lau YL.

Front Immunol. 2018 Aug 10;9:1826. doi: 10.3389/fimmu.2018.01826. eCollection 2018.


Laparoscopic renal surgery is here to stay.

Luk ACO, Pandian RMK, Heer R.

Arab J Urol. 2018 Mar 6;16(3):314-320. doi: 10.1016/j.aju.2018.01.003. eCollection 2018 Sep. Review.


Dependency of DNA extraction efficiency on cell concentration confounds molecular quantification of microorganisms in groundwater.

Luk AW, Beckmann S, Manefield M.

FEMS Microbiol Ecol. 2018 Oct 1;94(10). doi: 10.1093/femsec/fiy146.


Effectiveness of reminder strategies on cancer screening adherence: a randomised controlled trial.

Wong MC, Ching JY, Huang J, Wong JC, Lam TY, Chan VC, Ng SK, Hui Z, Luk AK, Wu JC, Chan FK.

Br J Gen Pract. 2018 Sep;68(674):e604-e611. doi: 10.3399/bjgp18X698369. Epub 2018 Aug 13.


Short-term association between ambient temperature and acute myocardial infarction hospitalizations for diabetes mellitus patients: A time series study.

Lam HCY, Chan JCN, Luk AOY, Chan EYY, Goggins WB.

PLoS Med. 2018 Jul 17;15(7):e1002612. doi: 10.1371/journal.pmed.1002612. eCollection 2018 Jul.


Unique sperm haplotypes are associated with phenotypically different sperm subpopulations in Astyanax fish.

Borowsky R, Luk A, He X, Kim RS.

BMC Biol. 2018 Jul 5;16(1):72. doi: 10.1186/s12915-018-0538-z.


Urinary schistosomiasis presented as bladder malignancy with pulmonary metastases: a case report.

Hosny K, Luk A.

Ann R Coll Surg Engl. 2018 Jul;100(6):e145-e146. doi: 10.1308/rcsann.2018.0072.


Sudomotor dysfunction independently predicts incident cardiovascular-renal events and all-cause death in type 2 diabetes: the Joint Asia Diabetes Evaluation register.

Lim LL, Fu AWC, Lau ESH, Ozaki R, Cheung KKT, Ma RCW, Luk AOY, Chan JCN, Kong APS.

Nephrol Dial Transplant. 2018 Jun 22. doi: 10.1093/ndt/gfy154. [Epub ahead of print]


First spot urine sodium after initial diuretic identifies patients at high risk for adverse outcome after heart failure hospitalization.

Luk A, Groarke JD, Desai AS, Mahmood SS, Gopal DM, Joyce E, Shah SP, Lindenfeld J, Stevenson L, Lakdawala NK.

Am Heart J. 2018 Sep;203:95-100. doi: 10.1016/j.ahj.2018.01.013. Epub 2018 May 19.


Depressive Symptoms, Co-Morbidities, and Glycemic Control in Hong Kong Chinese Elderly Patients With Type 2 Diabetes Mellitus.

Fung ACH, Tse G, Cheng HL, Lau ESH, Luk A, Ozaki R, So TTY, Wong RYM, Tsoh J, Chow E, Wing YK, Chan JCN, Kong APS.

Front Endocrinol (Lausanne). 2018 May 29;9:261. doi: 10.3389/fendo.2018.00261. eCollection 2018.


A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.

van Zuydam NR, Ahlqvist E, Sandholm N, Deshmukh H, Rayner NW, Abdalla M, Ladenvall C, Ziemek D, Fauman E, Robertson NR, McKeigue PM, Valo E, Forsblom C, Harjutsalo V; Finnish Diabetic Nephropathy Study (FinnDiane), Perna A, Rurali E, Marcovecchio ML, Igo RP Jr, Salem RM, Perico N, Lajer M, Käräjämäki A, Imamura M, Kubo M, Takahashi A, Sim X, Liu J, van Dam RM, Jiang G, Tam CHT, Luk AOY, Lee HM, Lim CKP, Szeto CC, So WY, Chan JCN; Hong Kong Diabetes Registry Theme-based Research Scheme Project Group, Ang SF, Dorajoo R, Wang L, Clara TSH, McKnight AJ, Duffy S; Warren 3 and Genetics of Kidneys in Diabetes (GoKinD) Study Group, Pezzolesi MG; GENIE (GEnetics of Nephropathy an International Effort) Consortium, Marre M, Gyorgy B, Hadjadj S, Hiraki LT; Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group, Ahluwalia TS, Almgren P, Schulz CA, Orho-Melander M, Linneberg A, Christensen C, Witte DR, Grarup N, Brandslund I, Melander O, Paterson AD, Tregouet D, Maxwell AP, Lim SC, Ma RCW, Tai ES, Maeda S, Lyssenko V, Tuomi T, Krolewski AS, Rich SS, Hirschhorn JN, Florez JC, Dunger D, Pedersen O, Hansen T, Rossing P, Remuzzi G; SUrrogate markers for Micro- and Macrovascular hard endpoints for Innovative diabetes Tools (SUMMIT) Consortium, Brosnan MJ, Palmer CNA, Groop PH, Colhoun HM, Groop LC, McCarthy MI.

Diabetes. 2018 Jul;67(7):1414-1427. doi: 10.2337/db17-0914. Epub 2018 Apr 27.


Cross-sectional survey of biosimilar insulin utilization in Asia: The Joint Asia Diabetes Evaluation Program.

Gani L, Lau E, Luk A, Sobrepena L, Tran QK, Kesavadev J, Jia W, Yu W, Tsang CC, Mukhopadhyay M, Jha S, Sheu W, Ho YK, Nguyen TK, Ozaki R, So WY, Kwan C, Fu AWC, Mirasol R, Phatak SR, Kumar KMP, Aravind S, Janakiraman H, Chan JCN; JADE Collaborative Study Group.

J Diabetes Investig. 2018 Nov;9(6):1312-1322. doi: 10.1111/jdi.12843. Epub 2018 Apr 24.


Determinants of hospitalization in Chinese patients with type 2 diabetes receiving a peer support intervention and JADE integrated care: the PEARL randomised controlled trial.

Yeung RO, Cai JH, Zhang Y, Luk AO, Pan JH, Yin J, Ozaki R, Kong APS, Ma R, So WY, Tsang CC, Lau KP, Fisher E, Goggins W, Oldenburg B, Chan J.

Clin Diabetes Endocrinol. 2018 Mar 7;4:5. doi: 10.1186/s40842-018-0055-6. eCollection 2018.


The Relationship of Quantitative Retinal Capillary Network to Kidney Function in Type 2 Diabetes.

Cheung CY, Tang F, Ng DS, Wong R, Lok J, Sun Z, Tso T, Lam A, Brelén M, Chong KK, Luk AO, Chan JC, Wong TY, Tham CC.

Am J Kidney Dis. 2018 Jun;71(6):916-918. doi: 10.1053/j.ajkd.2017.12.010. Epub 2018 Feb 28. No abstract available.


Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer.

Brungs D, Lynch D, Luk AW, Minaei E, Ranson M, Aghmesheh M, Vine KL, Carolan M, Jaber M, de Souza P, Becker TM.

World J Gastroenterol. 2018 Feb 21;24(7):810-818. doi: 10.3748/wjg.v24.i7.810.


Consequences of Preservative Uptake and Release by Contact Lenses.

Morris CA, Maltseva IA, Rogers VA, Ni J, Khong KT, Derringer CB, George MD, Luk AS.

Eye Contact Lens. 2018 Nov;44 Suppl 2:S247-S255. doi: 10.1097/ICL.0000000000000480.


Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant.

George LA, Sullivan SK, Giermasz A, Rasko JEJ, Samelson-Jones BJ, Ducore J, Cuker A, Sullivan LM, Majumdar S, Teitel J, McGuinn CE, Ragni MV, Luk AY, Hui D, Wright JF, Chen Y, Liu Y, Wachtel K, Winters A, Tiefenbacher S, Arruda VR, van der Loo JCM, Zelenaia O, Takefman D, Carr ME, Couto LB, Anguela XM, High KA.

N Engl J Med. 2017 Dec 7;377(23):2215-2227. doi: 10.1056/NEJMoa1708538.


Ex vivo validation of photo-magnetic imaging.

Luk A, Nouizi F, Erkol H, Unlu MB, Gulsen G.

Opt Lett. 2017 Oct 15;42(20):4171-4174. doi: 10.1364/OL.42.004171.


Advanced liver fibrosis but not steatosis is independently associated with albuminuria in Chinese patients with type 2 diabetes.

Yeung MW, Wong GL, Choi KC, Luk AO, Kwok R, Shu SS, Chan AW, Lau ESH, Ma RCW, Chan HL, Chan JC, Wong VW, Kong AP.

J Hepatol. 2017 Oct 6. pii: S0168-8278(17)32334-6. doi: 10.1016/j.jhep.2017.09.020. [Epub ahead of print]


MicroRNA and Diabetic Complications: A Clinical Perspective.

Fan B, Luk AOY, Chan JCN, Ma RCW.

Antioxid Redox Signal. 2018 Oct 10;29(11):1041-1063. doi: 10.1089/ars.2017.7318. Epub 2017 Dec 1. Review.


High risk of conversion to diabetes in first-degree relatives of individuals with young-onset type 2 diabetes: a 12-year follow-up analysis.

Zhang Y, Luk AOY, Chow E, Ko GTC, Chan MHM, Ng M, Kong APS, Ma RCW, Ozaki R, So WY, Chow CC, Chan JCN.

Diabet Med. 2017 Dec;34(12):1701-1709. doi: 10.1111/dme.13516. Epub 2017 Oct 14.


Accuracy of Faecal Immunochemical Test to Predict Endoscopic and Histological Healing in Ulcerative Colitis: A Prospective Study Based on Validated Histological Scores.

Shi HY, Chan FKL, Chan AWH, Higashimori A, Kyaw M, Ching JYL, Luk AKC, Wong SH, Wu JCY, Sung JJY, Ng SC.

J Crohns Colitis. 2017 Sep 1;11(9):1071-1077. doi: 10.1093/ecco-jcc/jjx088.


Family History of Early Infant Death Correlates with Earlier Age at Diagnosis But Not Shorter Time to Diagnosis for Severe Combined Immunodeficiency.

Luk ADW, Lee PP, Mao H, Chan KW, Chen XY, Chen TX, He JX, Kechout N, Suri D, Tao YB, Xu YB, Jiang LP, Liew WK, Jirapongsananuruk O, Daengsuwan T, Gupta A, Singh S, Rawat A, Abdul Latiff AH, Lee ACW, Shek LP, Nguyen TVA, Chin TJ, Chien YH, Latiff ZA, Le TMH, Le NNQ, Lee BW, Li Q, Raj D, Barbouche MR, Thong MK, Ang MCD, Wang XC, Xu CG, Yu HG, Yu HH, Lee TL, Yau FYS, Wong WH, Tu W, Yang W, Chong PCY, Ho MHK, Lau YL.

Front Immunol. 2017 Jul 12;8:808. doi: 10.3389/fimmu.2017.00808. eCollection 2017.


Glycaemia control and the risk of hospitalisation for infection in patients with type 2 diabetes: Hong Kong Diabetes Registry.

Luk AOY, Lau ESH, Cheung KKT, Kong APS, Ma RCW, Ozaki R, Chow FCC, So WY, Chan JCN.

Diabetes Metab Res Rev. 2017 Nov;33(8). doi: 10.1002/dmrr.2923. Epub 2017 Sep 7.


CTC-mRNA (AR-V7) Analysis from Blood Samples-Impact of Blood Collection Tube and Storage Time.

Luk AWS, Ma Y, Ding PN, Young FP, Chua W, Balakrishnar B, Dransfield DT, Souza P, Becker TM.

Int J Mol Sci. 2017 May 12;18(5). pii: E1047. doi: 10.3390/ijms18051047.

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