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Items: 44

1.

Is leptin resistance the cause or the consequence of diet-induced obesity?

de Git KCG, Peterse C, Beerens S, Luijendijk MCM, van der Plasse G, la Fleur SE, Adan RAH.

Int J Obes (Lond). 2018 May 22. doi: 10.1038/s41366-018-0111-4. [Epub ahead of print]

PMID:
29789721
2.

A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states.

Verharen JPH, de Jong JW, Roelofs TJM, Huffels CFM, van Zessen R, Luijendijk MCM, Hamelink R, Willuhn I, den Ouden HEM, van der Plasse G, Adan RAH, Vanderschuren LJMJ.

Nat Commun. 2018 Feb 21;9(1):731. doi: 10.1038/s41467-018-03087-1.

3.

Enhancing excitability of dopamine neurons promotes motivational behaviour through increased action initiation.

Boekhoudt L, Wijbrans EC, Man JHK, Luijendijk MCM, de Jong JW, van der Plasse G, Vanderschuren LJMJ, Adan RAH.

Eur Neuropsychopharmacol. 2018 Jan;28(1):171-184. doi: 10.1016/j.euroneuro.2017.11.005. Epub 2017 Nov 17.

PMID:
29153928
4.

A novel approach to map induced activation of neuronal networks using chemogenetics and functional neuroimaging in rats: A proof-of-concept study on the mesocorticolimbic system.

Roelofs TJM, Verharen JPH, van Tilborg GAF, Boekhoudt L, van der Toorn A, de Jong JW, Luijendijk MCM, Otte WM, Adan RAH, Dijkhuizen RM.

Neuroimage. 2017 Aug 1;156:109-118. doi: 10.1016/j.neuroimage.2017.05.021. Epub 2017 May 11.

PMID:
28502844
5.

Does activation of midbrain dopamine neurons promote or reduce feeding?

Boekhoudt L, Roelofs TJM, de Jong JW, de Leeuw AE, Luijendijk MCM, Wolterink-Donselaar IG, van der Plasse G, Adan RAH.

Int J Obes (Lond). 2017 Jul;41(7):1131-1140. doi: 10.1038/ijo.2017.74. Epub 2017 Mar 21.

PMID:
28321131
6.

Chemogenetic Activation of Midbrain Dopamine Neurons Affects Attention, but not Impulsivity, in the Five-Choice Serial Reaction Time Task in Rats.

Boekhoudt L, Voets ES, Flores-Dourojeanni JP, Luijendijk MC, Vanderschuren LJ, Adan RA.

Neuropsychopharmacology. 2017 May;42(6):1315-1325. doi: 10.1038/npp.2016.235. Epub 2016 Oct 17.

7.

Chemogenetic activation of dopamine neurons in the ventral tegmental area, but not substantia nigra, induces hyperactivity in rats.

Boekhoudt L, Omrani A, Luijendijk MC, Wolterink-Donselaar IG, Wijbrans EC, van der Plasse G, Adan RA.

Eur Neuropsychopharmacol. 2016 Nov;26(11):1784-1793. doi: 10.1016/j.euroneuro.2016.09.003. Epub 2016 Oct 4.

PMID:
27712862
8.

Melanocortin 3 Receptor Signaling in Midbrain Dopamine Neurons Increases the Motivation for Food Reward.

Pandit R, Omrani A, Luijendijk MC, de Vrind VA, Van Rozen AJ, Ophuis RJ, Garner K, Kallo I, Ghanem A, Liposits Z, Conzelmann KK, Vanderschuren LJ, la Fleur SE, Adan RA.

Neuropsychopharmacology. 2016 Aug;41(9):2241-51. doi: 10.1038/npp.2016.19. Epub 2016 Feb 8.

9.

Modulation of cue-induced firing of ventral tegmental area dopamine neurons by leptin and ghrelin.

van der Plasse G, van Zessen R, Luijendijk MC, Erkan H, Stuber GD, Ramakers GM, Adan RA.

Int J Obes (Lond). 2015 Dec;39(12):1742-9. doi: 10.1038/ijo.2015.131. Epub 2015 Jul 17.

10.

Central melanocortins regulate the motivation for sucrose reward.

Pandit R, van der Zwaal EM, Luijendijk MC, Brans MA, van Rozen AJ, Oude Ophuis RJ, Vanderschuren LJ, Adan RA, la Fleur SE.

PLoS One. 2015 Mar 26;10(3):e0121768. doi: 10.1371/journal.pone.0121768. eCollection 2015.

11.

Reducing Ventral Tegmental Dopamine D2 Receptor Expression Selectively Boosts Incentive Motivation.

de Jong JW, Roelofs TJ, Mol FM, Hillen AE, Meijboom KE, Luijendijk MC, van der Eerden HA, Garner KM, Vanderschuren LJ, Adan RA.

Neuropsychopharmacology. 2015 Aug;40(9):2085-95. doi: 10.1038/npp.2015.60. Epub 2015 Mar 4.

12.

FTO knockdown in rat ventromedial hypothalamus does not affect energy balance.

van Gestel MA, Sanders LE, de Jong JW, Luijendijk MC, Adan RA.

Physiol Rep. 2014 Dec 11;2(12). pii: e12152. doi: 10.14814/phy2.12152. Print 2014 Dec 1.

13.

The obesity-associated gene Negr1 regulates aspects of energy balance in rat hypothalamic areas.

Boender AJ, van Gestel MA, Garner KM, Luijendijk MC, Adan RA.

Physiol Rep. 2014 Jul 30;2(7). pii: e12083. doi: 10.14814/phy2.12083. Print 2014 Jul 1.

14.

Recombinant adeno-associated virus: efficient transduction of the rat VMH and clearance from blood.

van Gestel MA, Boender AJ, de Vrind VA, Garner KM, Luijendijk MC, Adan RA.

PLoS One. 2014 May 23;9(5):e97639. doi: 10.1371/journal.pone.0097639. eCollection 2014.

15.

Combined use of the canine adenovirus-2 and DREADD-technology to activate specific neural pathways in vivo.

Boender AJ, de Jong JW, Boekhoudt L, Luijendijk MC, van der Plasse G, Adan RA.

PLoS One. 2014 Apr 15;9(4):e95392. doi: 10.1371/journal.pone.0095392. eCollection 2014.

16.

AAV-mediated gene transfer of the obesity-associated gene Etv5 in rat midbrain does not affect energy balance or motivated behavior.

Boender AJ, Koning NA, van den Heuvel JK, Luijendijk MC, van Rozen AJ, la Fleur SE, Adan RA.

PLoS One. 2014 Apr 7;9(4):e94159. doi: 10.1371/journal.pone.0094159. eCollection 2014.

17.

Neuropeptide Y and leptin sensitivity is dependent on diet composition.

van den Heuvel JK, Eggels L, van Rozen AJ, Luijendijk MC, Fliers E, Kalsbeek A, Adan RA, la Fleur SE.

J Neuroendocrinol. 2014 Jun;26(6):377-85. doi: 10.1111/jne.12155.

PMID:
24698502
18.

Limbic substrates of the effects of neuropeptide Y on intake of and motivation for palatable food.

Pandit R, Luijendijk MC, Vanderschuren LJ, la Fleur SE, Adan RA.

Obesity (Silver Spring). 2014 May;22(5):1216-9. doi: 10.1002/oby.20718. Epub 2014 Feb 19.

19.

shRNA-induced saturation of the microRNA pathway in the rat brain.

van Gestel MA, van Erp S, Sanders LE, Brans MA, Luijendijk MC, Merkestein M, Pasterkamp RJ, Adan RA.

Gene Ther. 2014 Feb;21(2):205-11. doi: 10.1038/gt.2013.76. Epub 2014 Jan 2.

PMID:
24385145
20.

The snacking rat as model of human obesity: effects of a free-choice high-fat high-sugar diet on meal patterns.

la Fleur SE, Luijendijk MC, van der Zwaal EM, Brans MA, Adan RA.

Int J Obes (Lond). 2014 May;38(5):643-9. doi: 10.1038/ijo.2013.159. Epub 2013 Aug 27.

PMID:
23979221
21.

GHS-R1a signaling in the DMH and VMH contributes to food anticipatory activity.

Merkestein M, van Gestel MA, van der Zwaal EM, Brans MA, Luijendijk MC, van Rozen AJ, Hendriks J, Garner KM, Boender AJ, Pandit R, Adan R.

Int J Obes (Lond). 2014 Apr;38(4):610-8. doi: 10.1038/ijo.2013.131. Epub 2013 Jul 25.

PMID:
23884084
22.

Food cues and ghrelin recruit the same neuronal circuitry.

van der Plasse G, Merkestein M, Luijendijk MC, van der Roest M, Westenberg HG, Mulder AB, Adan RA.

Int J Obes (Lond). 2013 Jul;37(7):1012-9. doi: 10.1038/ijo.2012.174. Epub 2012 Oct 16.

PMID:
23069665
23.

Olanzapine and sibutramine have opposing effects on the motivation for palatable food.

van der Zwaal EM, Janhunen SK, Luijendijk MC, Baclesanu R, Vanderschuren LJ, Adan RA, La Fleur SE.

Behav Pharmacol. 2012 Apr;23(2):198-204. doi: 10.1097/FBP.0b013e3283512ca1.

PMID:
22327018
24.

Ghrelin mediates anticipation to a palatable meal in rats.

Merkestein M, Brans MA, Luijendijk MC, de Jong JW, Egecioglu E, Dickson SL, Adan RA.

Obesity (Silver Spring). 2012 May;20(5):963-71. doi: 10.1038/oby.2011.389. Epub 2012 Jan 26.

25.

Anticipation of meals during restricted feeding increases activity in the hypothalamus in rats.

Verhagen LA, Luijendijk MC, de Groot JW, van Dommelen LP, Klimstra AG, Adan RA, Roeling TA.

Eur J Neurosci. 2011 Nov;34(9):1485-91. doi: 10.1111/j.1460-9568.2011.07880.x.

PMID:
22034979
26.

Recombinant adeno-associated viral vectors.

de Backer MW, Garner KM, Luijendijk MC, Adan RA.

Methods Mol Biol. 2011;789:357-76. doi: 10.1007/978-1-61779-310-3_24.

PMID:
21922421
27.

The acute effects of olanzapine on ghrelin secretion, CCK sensitivity, meal size, locomotor activity and body temperature.

van der Zwaal EM, Merkestein M, Lam YK, Brans MA, Luijendijk MC, Bok LI, Verheij ER, la Fleur SE, Adan RA.

Int J Obes (Lond). 2012 Feb;36(2):254-61. doi: 10.1038/ijo.2011.97. Epub 2011 May 10.

PMID:
21556042
28.

Leptin reduces hyperactivity in an animal model for anorexia nervosa via the ventral tegmental area.

Verhagen LA, Luijendijk MC, Adan RA.

Eur Neuropsychopharmacol. 2011 Mar;21(3):274-81. doi: 10.1016/j.euroneuro.2010.11.006. Epub 2010 Dec 28.

PMID:
21190812
29.

Suppressor of cytokine signaling 3 knockdown in the mediobasal hypothalamus: counterintuitive effects on energy balance.

de Backer MW, Brans MA, van Rozen AJ, van der Zwaal EM, Luijendijk MC, Garner KG, de Krom M, van Beekum O, la Fleur SE, Adan RA.

J Mol Endocrinol. 2010 Nov;45(5):341-53. doi: 10.1677/JME-10-0057. Epub 2010 Sep 6.

PMID:
20819948
30.

Melanocortin receptor-mediated effects on obesity are distributed over specific hypothalamic regions.

de Backer MW, la Fleur SE, Brans MA, van Rozen AJ, Luijendijk MC, Merkestein M, Garner KM, van der Zwaal EM, Adan RA.

Int J Obes (Lond). 2011 May;35(5):629-41. doi: 10.1038/ijo.2010.169. Epub 2010 Aug 24.

PMID:
20733584
31.

A free-choice high-fat high-sugar diet induces glucose intolerance and insulin unresponsiveness to a glucose load not explained by obesity.

la Fleur SE, Luijendijk MC, van Rozen AJ, Kalsbeek A, Adan RA.

Int J Obes (Lond). 2011 Apr;35(4):595-604. doi: 10.1038/ijo.2010.164. Epub 2010 Aug 17.

PMID:
20714332
32.

Neuropeptide delivery to the brain: a von Willebrand factor signal peptide to direct neuropeptide secretion.

de Backer MW, Brans MA, Luijendijk MC, Garner KM, van den Heuvel DM, Pasterkamp RJ, Adan RA.

BMC Neurosci. 2010 Aug 11;11:94. doi: 10.1186/1471-2202-11-94.

33.

An adeno-associated viral vector transduces the rat hypothalamus and amygdala more efficient than a lentiviral vector.

de Backer MW, Fitzsimons CP, Brans MA, Luijendijk MC, Garner KM, Vreugdenhil E, Adan RA.

BMC Neurosci. 2010 Jul 13;11:81. doi: 10.1186/1471-2202-11-81.

34.

Acute and chronic suppression of the central ghrelin signaling system reveals a role in food anticipatory activity.

Verhagen LA, Egecioglu E, Luijendijk MC, Hillebrand JJ, Adan RA, Dickson SL.

Eur Neuropsychopharmacol. 2011 May;21(5):384-92. doi: 10.1016/j.euroneuro.2010.06.005.

PMID:
20620030
35.

Olanzapine affects locomotor activity and meal size in male rats.

van der Zwaal EM, Luijendijk MC, Evers SS, la Fleur SE, Adan RA.

Pharmacol Biochem Behav. 2010 Nov;97(1):130-7. doi: 10.1016/j.pbb.2010.05.009. Epub 2010 May 15.

PMID:
20478328
36.

Optimization of adeno-associated viral vector-mediated gene delivery to the hypothalamus.

de Backer MW, Brans MA, Luijendijk MC, Garner KM, Adan RA.

Hum Gene Ther. 2010 Jun;21(6):673-82. doi: 10.1089/hum.2009.169.

PMID:
20073991
37.

A free-choice high-fat high-sugar diet induces changes in arcuate neuropeptide expression that support hyperphagia.

la Fleur SE, van Rozen AJ, Luijendijk MC, Groeneweg F, Adan RA.

Int J Obes (Lond). 2010 Mar;34(3):537-46. doi: 10.1038/ijo.2009.257. Epub 2009 Dec 22.

PMID:
20029382
38.

Sustained NPY overexpression in the PVN results in obesity via temporarily increasing food intake.

Tiesjema B, la Fleur SE, Luijendijk MC, Adan RA.

Obesity (Silver Spring). 2009 Jul;17(7):1448-50. doi: 10.1038/oby.2008.670. Epub 2009 Feb 19.

39.

Dopamine and serotonin release in the nucleus accumbens during starvation-induced hyperactivity.

Verhagen LA, Luijendijk MC, Korte-Bouws GA, Korte SM, Adan RA.

Eur Neuropsychopharmacol. 2009 May;19(5):309-16. doi: 10.1016/j.euroneuro.2008.12.008. Epub 2009 Jan 31.

PMID:
19181487
40.

Dopamine antagonism inhibits anorectic behavior in an animal model for anorexia nervosa.

Verhagen LA, Luijendijk MC, Hillebrand JJ, Adan RA.

Eur Neuropsychopharmacol. 2009 Mar;19(3):153-60. doi: 10.1016/j.euroneuro.2008.09.005. Epub 2008 Nov 1.

PMID:
18977121
41.

Olanzapine-induced weight gain: chronic infusion using osmotic minipumps does not result in stable plasma levels due to degradation of olanzapine in solution.

van der Zwaal EM, Luijendijk MC, Adan RA, la Fleur SE.

Eur J Pharmacol. 2008 May 6;585(1):130-6. doi: 10.1016/j.ejphar.2007.11.078. Epub 2008 Mar 4. Review.

PMID:
18378227
43.

Viral mediated neuropeptide Y expression in the rat paraventricular nucleus results in obesity.

Tiesjema B, la Fleur SE, Luijendijk MC, Brans MA, Lin EJ, During MJ, Adan RA.

Obesity (Silver Spring). 2007 Oct;15(10):2424-35.

44.

A reciprocal interaction between food-motivated behavior and diet-induced obesity.

la Fleur SE, Vanderschuren LJ, Luijendijk MC, Kloeze BM, Tiesjema B, Adan RA.

Int J Obes (Lond). 2007 Aug;31(8):1286-94. Epub 2007 Feb 27.

PMID:
17325683

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