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Translational genomics of nasopharyngeal cancer.

Tsang CM, Lui VWY, Bruce JP, Pugh TJ, Lo KW.

Semin Cancer Biol. 2019 Sep 12. pii: S1044-579X(19)30284-6. doi: 10.1016/j.semcancer.2019.09.006. [Epub ahead of print] Review.


Germline mutation and aberrant transcripts of WWOX in a syndrome with multiple primary tumors.

Xu A, Wang W, Nie J, Lui VW, Hong B, Lin W.

J Pathol. 2019 Sep;249(1):19-25. doi: 10.1002/path.5288. Epub 2019 Jun 17.


Mesenchymal stem cells participate in oral mucosa carcinogenesis by regulating T cell proliferation.

Chen Y, Wang X, Fang J, Song J, Ma D, Luo L, He B, Xia J, Lui VWY, Cheng B, Wang Z.

Clin Immunol. 2019 Jan;198:46-53. doi: 10.1016/j.clim.2018.12.001. Epub 2018 Dec 4.


Effects of Salivary Mg on Head and Neck Carcinoma via TRPM7.

Qiao W, Lan XM, Ma HX, Chan JYK, Lui VWY, Yeung KWK, Kwong DLW, Hu Z, Tsoi JKH, Matinlinna JP, Su YX.

J Dent Res. 2019 Mar;98(3):304-312. doi: 10.1177/0022034518813359. Epub 2018 Dec 4.


Analysis of oncogenic activities of protein kinase D1 in head and neck squamous cell carcinoma.

Zhang L, Li Z, Liu Y, Xu S, Tandon M, Appelboom B, LaValle CR, Chiosea SI, Wang L, Sen M, Lui VWY, Grandis JR, Wang QJ.

BMC Cancer. 2018 Nov 12;18(1):1107. doi: 10.1186/s12885-018-4965-6.


Stromal interleukin-33 promotes regulatory T cell-mediated immunosuppression in head and neck squamous cell carcinoma and correlates with poor prognosis.

Wen YH, Lin HQ, Li H, Zhao Y, Lui VWY, Chen L, Wu XM, Sun W, Wen WP.

Cancer Immunol Immunother. 2019 Feb;68(2):221-232. doi: 10.1007/s00262-018-2265-2. Epub 2018 Oct 25.


Microneedle-Mediated Delivery of Lipid-Coated Cisplatin Nanoparticles for Efficient and Safe Cancer Therapy.

Lan X, She J, Lin DA, Xu Y, Li X, Yang WF, Lui VWY, Jin L, Xie X, Su YX.

ACS Appl Mater Interfaces. 2018 Oct 3;10(39):33060-33069. doi: 10.1021/acsami.8b12926. Epub 2018 Sep 24.


Sodium chloride (NaCl) potentiates digoxin-induced anti-tumor activity in small cell lung cancer.

Deng K, Shen J, Wang W, Li M, Li H, Chen C, Zhao H, Zhang M, Xue T, Liu Q, Lui VWY, Hong B, Lin W.

Cancer Biol Ther. 2019;20(1):52-64. doi: 10.1080/15384047.2018.1504723. Epub 2018 Sep 5.


Genomic Landscapes of EBV-Associated Nasopharyngeal Carcinoma vs. HPV-Associated Head and Neck Cancer.

Ngan HL, Wang L, Lo KW, Lui VWY.

Cancers (Basel). 2018 Jun 21;10(7). pii: E210. doi: 10.3390/cancers10070210. Review.


Case Report: Exome sequencing reveals recurrent RETSAT mutations and a loss-of-function POLDIP2 mutation in a rare undifferentiated tongue sarcoma.

Chan JYK, Poon PHY, Zhang Y, Ng CWK, Piao WY, Ma M, Yip KY, Chan ABW, Lui VWY.

F1000Res. 2018 Apr 26;7:499. doi: 10.12688/f1000research.14383.1. eCollection 2018.


Thrombomodulin (TM) in tumor cell differentiation and periphery blood immune microenvironment in oral squamous cell carcinoma.

Song J, Ma D, Liu X, Chen Y, Fang J, Lui VWY, Zhao S, Xia J, Cheng B, Wang Z.

Clin Immunol. 2018 Jun;191:27-33. doi: 10.1016/j.clim.2018.02.011. Epub 2018 Mar 18.


Prediction of radiotherapy response with a 5-microRNA signature-based nomogram in head and neck squamous cell carcinoma.

Chen L, Wen Y, Zhang J, Sun W, Lui VWY, Wei Y, Chen F, Wen W.

Cancer Med. 2018 Mar;7(3):726-735. doi: 10.1002/cam4.1369. Epub 2018 Feb 23.


Hypermethylation of NF-κB-Activating Protein-Like (NKAPL) Promoter in Hepatocellular Carcinoma Suppresses Its Expression and Predicts a Poor Prognosis.

Ng PKS, Lau CPY, Lam EKY, Li SSK, Lui VWY, Yeo W, Ng YK, Lai PBS, Tsui SKW.

Dig Dis Sci. 2018 Mar;63(3):676-686. doi: 10.1007/s10620-018-4929-3. Epub 2018 Jan 20.


Blockade of PD-1 effectively inhibits in vivo malignant transformation of oral mucosa.

Chen Y, Li Q, Li X, Ma D, Fang J, Luo L, Liu X, Wang X, Lui VWY, Xia J, Cheng B, Wang Z.

Oncoimmunology. 2017 Nov 6;7(2):e1388484. doi: 10.1080/2162402X.2017.1388484. eCollection 2018.


Genomic profiles of nasopharyngeal carcinoma: The importance of histological subtyping and Epstein-Barr virus in situ assays.

Lui VWY, To KF, Lo KW.

Cancer. 2018 Jan 15;124(2):434-435. doi: 10.1002/cncr.31131. Epub 2017 Nov 22. No abstract available.


The RARS-MAD1L1 Fusion Gene Induces Cancer Stem Cell-like Properties and Therapeutic Resistance in Nasopharyngeal Carcinoma.

Zhong Q, Liu ZH, Lin ZR, Hu ZD, Yuan L, Liu YM, Zhou AJ, Xu LH, Hu LJ, Wang ZF, Guan XY, Hao JJ, Lui VWY, Guo L, Mai HQ, Chen MY, Han F, Xia YF, Grandis JR, Zhang X, Zeng MS.

Clin Cancer Res. 2018 Feb 1;24(3):659-673. doi: 10.1158/1078-0432.CCR-17-0352. Epub 2017 Nov 13.


An update on genomic-guided therapies for pediatric solid tumors.

Tsui PC, Lee YF, Liu ZWY, Ip LRH, Piao W, Chiang AKS, Lui VWY.

Future Oncol. 2017 Jun;13(15):1345-1358. doi: 10.2217/fon-2017-0003. Epub 2017 Jun 7. Review.


Prognostic significance of tumor infiltrating immune cells in oral squamous cell carcinoma.

Fang J, Li X, Ma D, Liu X, Chen Y, Wang Y, Lui VWY, Xia J, Cheng B, Wang Z.

BMC Cancer. 2017 May 26;17(1):375. doi: 10.1186/s12885-017-3317-2.


Validation of an Instrument to Assess the Mental Capacity to Sign an Enduring Power of Attorney.

Ko RS, Lui VW, Lai KC, Chiu CC, Lam LC.

East Asian Arch Psychiatry. 2017 Mar;27(1):11-7.


Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations.

Li YY, Chung GT, Lui VW, To KF, Ma BB, Chow C, Woo JK, Yip KY, Seo J, Hui EP, Mak MK, Rusan M, Chau NG, Or YY, Law MH, Law PP, Liu ZW, Ngan HL, Hau PM, Verhoeft KR, Poon PH, Yoo SK, Shin JY, Lee SD, Lun SW, Jia L, Chan AW, Chan JY, Lai PB, Fung CY, Hung ST, Wang L, Chang AM, Chiosea SI, Hedberg ML, Tsao SW, van Hasselt AC, Chan AT, Grandis JR, Hammerman PS, Lo KW.

Nat Commun. 2017 Jan 18;8:14121. doi: 10.1038/ncomms14121.


Genomic and Transcriptomic Alterations Associated with STAT3 Activation in Head and Neck Cancer.

Peyser ND, Pendleton K, Gooding WE, Lui VW, Johnson DE, Grandis JR.

PLoS One. 2016 Nov 17;11(11):e0166185. doi: 10.1371/journal.pone.0166185. eCollection 2016.


The cylindromatosis (CYLD) gene and head and neck tumorigenesis.

Verhoeft KR, Ngan HL, Lui VWY.

Cancers Head Neck. 2016 Sep 8;1:10. doi: 10.1186/s41199-016-0012-y. eCollection 2016. Review.


Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma.

Hedberg ML, Goh G, Chiosea SI, Bauman JE, Freilino ML, Zeng Y, Wang L, Diergaarde BB, Gooding WE, Lui VW, Herbst RS, Lifton RP, Grandis JR.

J Clin Invest. 2016 Apr 1;126(4):1606. doi: 10.1172/JCI86862. Epub 2016 Apr 1. No abstract available.


MAPK1E322K mutation increases head and neck squamous cell carcinoma sensitivity to erlotinib through enhanced secretion of amphiregulin.

Wen Y, Li H, Zeng Y, Wen W, Pendleton KP, Lui VW, Egloff AM, Grandis JR.

Oncotarget. 2016 Apr 26;7(17):23300-11. doi: 10.18632/oncotarget.8188.


Andrographis paniculata elicits anti-invasion activities by suppressing TM4SF3 gene expression and by anoikis-sensitization in esophageal cancer cells.

Yue GG, Lee JK, Li L, Chan KM, Wong EC, Chan JY, Fung KP, Lui VW, Chiu PW, Lau CB.

Am J Cancer Res. 2015 Nov 15;5(12):3570-87. eCollection 2015.


Proteomic Characterization of Head and Neck Cancer Patient-Derived Xenografts.

Li H, Wheeler S, Park Y, Ju Z, Thomas SM, Fichera M, Egloff AM, Lui VW, Duvvuri U, Bauman JE, Mills GB, Grandis JR.

Mol Cancer Res. 2016 Mar;14(3):278-86. doi: 10.1158/1541-7786.MCR-15-0354. Epub 2015 Dec 18.


Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma.

Hedberg ML, Goh G, Chiosea SI, Bauman JE, Freilino ML, Zeng Y, Wang L, Diergaarde BB, Gooding WE, Lui VW, Herbst RS, Lifton RP, Grandis JR.

J Clin Invest. 2016 Jan;126(1):169-80. doi: 10.1172/JCI82066. Epub 2015 Nov 30. Erratum in: J Clin Invest. 2016 Apr 1;126(4):1606.


An update of ALK inhibitors in human clinical trials.

Chan EL, Chin CH, Lui VW.

Future Oncol. 2016 Jan;12(1):71-81. doi: 10.2217/fon.15.293. Epub 2015 Nov 30. Review.


Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma.

Van Allen EM, Lui VW, Egloff AM, Goetz EM, Li H, Johnson JT, Duvvuri U, Bauman JE, Stransky N, Zeng Y, Gilbert BR, Pendleton KP, Wang L, Chiosea S, Sougnez C, Wagle N, Zhang F, Du Y, Close D, Johnston PA, McKenna A, Carter SL, Golub TR, Getz G, Mills GB, Garraway LA, Grandis JR.

JAMA Oncol. 2015 May;1(2):238-44. doi: 10.1001/jamaoncol.2015.34.


JAK kinase inhibition abrogates STAT3 activation and head and neck squamous cell carcinoma tumor growth.

Sen M, Pollock NI, Black J, DeGrave KA, Wheeler S, Freilino ML, Joyce S, Lui VW, Zeng Y, Chiosea SI, Grandis JR.

Neoplasia. 2015 Mar;17(3):256-64. doi: 10.1016/j.neo.2015.01.003.


A Pan-Cancer Review of ALK Mutations: Implications for Carcinogenesis and Therapy.

Yau NK, Fong AY, Leung HF, Verhoeft KR, Lim QY, Lam WY, Wong IC, Lui VW.

Curr Cancer Drug Targets. 2015;15(4):327-36. Review.


TP53-induced glycolysis and apoptosis regulator promotes proliferation and invasiveness of nasopharyngeal carcinoma cells.

Wong EY, Wong SC, Chan CM, Lam EK, Ho LY, Lau CP, Au TC, Chan AK, Tsang CM, Tsao SW, Lui VW, Chan AT.

Oncol Lett. 2015 Feb;9(2):569-574. Epub 2014 Dec 12.


miR-466 is putative negative regulator of Coxsackie virus and Adenovirus Receptor.

Lam WY, Cheung AC, Tung CK, Yeung AC, Ngai KL, Lui VW, Chan PK, Tsui SK.

FEBS Lett. 2015 Jan 16;589(2):246-54. doi: 10.1016/j.febslet.2014.12.006. Epub 2014 Dec 10.


Berberine suppresses Id-1 expression and inhibits the growth and development of lung metastases in hepatocellular carcinoma.

Tsang CM, Cheung KC, Cheung YC, Man K, Lui VW, Tsao SW, Feng Y.

Biochim Biophys Acta. 2015 Mar;1852(3):541-51. doi: 10.1016/j.bbadis.2014.12.004. Epub 2014 Dec 8.


Cancers of the lung, head and neck on the rise: perspectives on the genotoxicity of air pollution.

Wong IC, Ng YK, Lui VW.

Chin J Cancer. 2014 Oct;33(10):476-80. doi: 10.5732/cjc.014.10093. Epub 2014 Jul 11. Review.


Inactivation of ATP citrate lyase by Cucurbitacin B: A bioactive compound from cucumber, inhibits prostate cancer growth.

Gao Y, Islam MS, Tian J, Lui VW, Xiao D.

Cancer Lett. 2014 Jul 10;349(1):15-25. doi: 10.1016/j.canlet.2014.03.015. Epub 2014 Mar 29.


The principle of assessing mental capacity for enduring power of attorney.

Lui VW, Chiu CC, Ko RS, Lam LC.

Hong Kong Med J. 2014 Feb;20(1):59-62. doi: 10.12809/hkmj134128.


Assessing mental capacity for everyday decision-making in the Chinese older population.

Lam LC, Lui VW, Chiu HF, Leung KF, Appelbaum PS, Karlawish J.

Hong Kong Med J. 2013 Dec;19 Suppl 9:17-20.


Identification of mutations in the PYRIN-containing NLR genes (NLRP) in Head and Neck Squamous Cell Carcinoma.

Lei Y, Lui VW, Grandis JR, Egloff AM.

PLoS One. 2014 Jan 21;9(1):e85619. doi: 10.1371/journal.pone.0085619. eCollection 2014.


Genomic analysis of head and neck squamous cell carcinoma cell lines and human tumors: a rational approach to preclinical model selection.

Li H, Wawrose JS, Gooding WE, Garraway LA, Lui VW, Peyser ND, Grandis JR.

Mol Cancer Res. 2014 Apr;12(4):571-82. doi: 10.1158/1541-7786.MCR-13-0396. Epub 2014 Jan 14.


Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer.

Lui VW, Peyser ND, Ng PK, Hritz J, Zeng Y, Lu Y, Li H, Wang L, Gilbert BR, General IJ, Bahar I, Ju Z, Wang Z, Pendleton KP, Xiao X, Du Y, Vries JK, Hammerman PS, Garraway LA, Mills GB, Johnson DE, Grandis JR.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1114-9. doi: 10.1073/pnas.1319551111. Epub 2014 Jan 6.


Berberine suppresses tumorigenicity and growth of nasopharyngeal carcinoma cells by inhibiting STAT3 activation induced by tumor associated fibroblasts.

Tsang CM, Cheung YC, Lui VW, Yip YL, Zhang G, Lin VW, Cheung KC, Feng Y, Tsao SW.

BMC Cancer. 2013 Dec 31;13:619. doi: 10.1186/1471-2407-13-619.


PIK3CA, HRAS and PTEN in human papillomavirus positive oropharyngeal squamous cell carcinoma.

Chiosea SI, Grandis JR, Lui VW, Diergaarde B, Maxwell JH, Ferris RL, Kim SW, Luvison A, Miller M, Nikiforova MN.

BMC Cancer. 2013 Dec 17;13:602. doi: 10.1186/1471-2407-13-602.


Preclinical evaluation of the mTOR-PI3K inhibitor BEZ235 in nasopharyngeal cancer models.

Ma BB, Lui VW, Hui CW, Lau CP, Wong CH, Hui EP, Ng MH, Cheng SH, Tsao SW, Tsang CM, Cheung CS, Ho K, Chan AT.

Cancer Lett. 2014 Feb 1;343(1):24-32. doi: 10.1016/j.canlet.2013.09.007. Epub 2013 Sep 14.


Enhanced IL-6/IL-6R signaling promotes growth and malignant properties in EBV-infected premalignant and cancerous nasopharyngeal epithelial cells.

Zhang G, Tsang CM, Deng W, Yip YL, Lui VW, Wong SC, Cheung AL, Hau PM, Zeng M, Lung ML, Chen H, Lo KW, Takada K, Tsao SW.

PLoS One. 2013 May 1;8(5):e62284. doi: 10.1371/journal.pone.0062284. Print 2013.


Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers.

Lui VW, Hedberg ML, Li H, Vangara BS, Pendleton K, Zeng Y, Lu Y, Zhang Q, Du Y, Gilbert BR, Freilino M, Sauerwein S, Peyser ND, Xiao D, Diergaarde B, Wang L, Chiosea S, Seethala R, Johnson JT, Kim S, Duvvuri U, Ferris RL, Romkes M, Nukui T, Kwok-Shing Ng P, Garraway LA, Hammerman PS, Mills GB, Grandis JR.

Cancer Discov. 2013 Jul;3(7):761-9. doi: 10.1158/2159-8290.CD-13-0103. Epub 2013 Apr 25.


Preclinical evaluation of combined TKI-258 and RAD001 in hepatocellular carcinoma.

Chan SL, Wong CH, Lau CP, Zhou Q, Hui CW, Lui VW, Ma BB, Chan AT, Yeo W.

Cancer Chemother Pharmacol. 2013 Jun;71(6):1417-25. doi: 10.1007/s00280-013-2139-4. Epub 2013 Apr 2.


Enhanced Antitumor Activity with Combining Effect of mTOR Inhibition and Microtubule Stabilization in Hepatocellular Carcinoma.

Zhou Q, Wong CH, Lau CP, Hui CW, Lui VW, Chan SL, Yeo W.

Int J Hepatol. 2013;2013:103830. doi: 10.1155/2013/103830. Epub 2013 Feb 20.


Structured assessment of mental capacity to make financial decisions in Chinese older persons with mild cognitive impairment and mild Alzheimer disease.

Lui VW, Lam LC, Chau RC, Fung AW, Wong BM, Leung GT, Leung KF, Chiu HF, Karlawish JH, Appelbaum PS.

J Geriatr Psychiatry Neurol. 2013 Jun;26(2):69-77. doi: 10.1177/0891988713481268. Epub 2013 Mar 15.


Full-length Mst1 exhibits growth promoting function in human hepatocellular carcinoma cells.

Ng YK, Lau WS, Lui VW, Cheng AS, Ng PK, Tsui SK, Cheung YS, Lai PB.

FEBS Lett. 2013 Mar 1;587(5):496-503. doi: 10.1016/j.febslet.2013.01.018. Epub 2013 Jan 21.

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