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Conditional deletion of platelet derived growth factor receptor alpha (Pdgfra) in urorectal mesenchyme causes mesenchyme apoptosis and urorectal developmental anomalies in mice.

Qian C, Wu Z, Ng RC, Garcia-Barceló MM, Yuan ZW, Wong KKY, Tam PKH, Lui VCH.

Cell Death Differ. 2018 Oct 15. doi: 10.1038/s41418-018-0216-2. [Epub ahead of print]


The Role of Neonatal Gr-1+ Myeloid Cells in a Murine Model of Rhesus-Rotavirus-Induced Biliary Atresia.

Zhang R, Lin Z, Fu M, Guan X, Yu J, Zhong W, Zeng J, Lui VCH, Tam PKH, Lamb JR, Xia H, Chen Y.

Am J Pathol. 2018 Nov;188(11):2617-2628. doi: 10.1016/j.ajpath.2018.07.024. Epub 2018 Sep 8.


Downregulation of Hes1 expression in experimental biliary atresia and its effects on bile duct structure.

Zhang RZ, Zeng XH, Lin ZF, Ming-Fu, Tong YL, Lui VC, Tam PK, Lamb JR, Xia HM, Chen Y.

World J Gastroenterol. 2018 Aug 7;24(29):3260-3272. doi: 10.3748/wjg.v24.i29.3260.


De novo mutations in Caudal Type Homeo Box transcription Factor 2 (CDX2) in patients with persistent cloaca.

Hsu JSJ, So M, Tang CSM, Karim A, Porsch RM, Wong C, Yu M, Yeung F, Xia H, Zhang R, Cherny SS, Chung PHY, Wong KKY, Sham PC, Ngo ND, Li M, Tam PKH, Lui VCH, Garcia-Barcelo MM.

Hum Mol Genet. 2018 Jan 15;27(2):351-358. doi: 10.1093/hmg/ddx406.


Stage specific requirement of platelet-derived growth factor receptor-α in embryonic development.

Qian C, Wong CWY, Wu Z, He Q, Xia H, Tam PKH, Wong KKY, Lui VCH.

PLoS One. 2017 Sep 21;12(9):e0184473. doi: 10.1371/journal.pone.0184473. eCollection 2017.


Whole exome sequencing coupled with unbiased functional analysis reveals new Hirschsprung disease genes.

Gui H, Schriemer D, Cheng WW, Chauhan RK, Antiňolo G, Berrios C, Bleda M, Brooks AS, Brouwer RW, Burns AJ, Cherny SS, Dopazo J, Eggen BJ, Griseri P, Jalloh B, Le TL, Lui VC, Luzón-Toro B, Matera I, Ngan ES, Pelet A, Ruiz-Ferrer M, Sham PC, Shepherd IT, So MT, Sribudiani Y, Tang CS, van den Hout MC, van der Linde HC, van Ham TJ, van IJcken WF, Verheij JB, Amiel J, Borrego S, Ceccherini I, Chakravarti A, Lyonnet S, Tam PK, Garcia-Barceló MM, Hofstra RM.

Genome Biol. 2017 Mar 8;18(1):48. doi: 10.1186/s13059-017-1174-6.


Silver nanoparticle treatment ameliorates biliary atresia syndrome in rhesus rotavirus inoculated mice.

Zhang R, Lin Z, Lui VCH, Wong KKY, Tam PKH, Lee P, Lok CN, Lamb JR, Chen Y, Xia H.

Nanomedicine. 2017 Apr;13(3):1041-1050. doi: 10.1016/j.nano.2016.11.013. Epub 2016 Nov 25.


Role of CD56-expressing immature biliary epithelial cells in biliary atresia.

Zhang RZ, Yu JK, Peng J, Wang FH, Liu HY, Lui VC, Nicholls JM, Tam PK, Lamb JR, Chen Y, Xia HM.

World J Gastroenterol. 2016 Feb 28;22(8):2545-57. doi: 10.3748/wjg.v22.i8.2545.


Silver nanoparticles promote osteogenesis of mesenchymal stem cells and improve bone fracture healing in osteogenesis mechanism mouse model.

Zhang R, Lee P, Lui VC, Chen Y, Liu X, Lok CN, To M, Yeung KW, Wong KK.

Nanomedicine. 2015 Nov;11(8):1949-59. doi: 10.1016/j.nano.2015.07.016. Epub 2015 Aug 15.


Depletion of the IKBKAP ortholog in zebrafish leads to hirschsprung disease-like phenotype.

Cheng WW, Tang CS, Gui HS, So MT, Lui VC, Tam PK, Garcia-Barcelo MM.

World J Gastroenterol. 2015 Feb 21;21(7):2040-6. doi: 10.3748/wjg.v21.i7.2040.


Roles of Hoxb5 in the development of vagal and trunk neural crest cells.

Kam MK, Lui VC.

Dev Growth Differ. 2015 Feb;57(2):158-68. doi: 10.1111/dgd.12199. Epub 2015 Feb 19. Review.


Modulatory effects of adiponectin on the polarization of tumor-associated macrophages.

Peng J, Tsang JY, Ho DH, Zhang R, Xiao H, Li D, Zhu J, Wang F, Bian Z, Lui VC, Xu A, Tam PK, Lamb JR, Xia H, Chen Y.

Int J Cancer. 2015 Aug 15;137(4):848-58. doi: 10.1002/ijc.29485. Epub 2015 Mar 4.


Homeobox b5 (Hoxb5) regulates the expression of Forkhead box D3 gene (Foxd3) in neural crest.

Kam MK, Cheung M, Zhu JJ, Cheng WW, Sat EW, Tam PK, Lui VC.

Int J Biochem Cell Biol. 2014 Oct;55:144-52. doi: 10.1016/j.biocel.2014.09.002. Epub 2014 Sep 8.


G1 checkpoint establishment in vivo during embryonic liver development.

Wang XQ, Chan KK, Ming X, Lui VC, Poon RY, Lo CM, Norbury C, Poon RT.

BMC Dev Biol. 2014 May 19;14:23. doi: 10.1186/1471-213X-14-23.


HOXB5 binds to multi-species conserved sequence (MCS+9.7) of RET gene and regulates RET expression.

Zhu JJ, Kam MK, Garcia-Barceló MM, Tam PK, Lui VC.

Int J Biochem Cell Biol. 2014 Jun;51:142-9. doi: 10.1016/j.biocel.2014.04.013. Epub 2014 Apr 29.


Dysregulation of Wnt inhibitory factor 1 (Wif1) expression resulted in aberrant Wnt-β-catenin signaling and cell death of the cloaca endoderm, and anorectal malformations.

Ng RC, Matsumaru D, Ho AS, Garcia-Barceló MM, Yuan ZW, Smith D, Kodjabachian L, Tam PK, Yamada G, Lui VC.

Cell Death Differ. 2014 Jun;21(6):978-89. doi: 10.1038/cdd.2014.20. Epub 2014 Mar 14.


Disruption of the temporally regulated cloaca endodermal β-catenin signaling causes anorectal malformations.

Miyagawa S, Harada M, Matsumaru D, Tanaka K, Inoue C, Nakahara C, Haraguchi R, Matsushita S, Suzuki K, Nakagata N, Ng RC, Akita K, Lui VC, Yamada G.

Cell Death Differ. 2014 Jun;21(6):990-7. doi: 10.1038/cdd.2014.21. Epub 2014 Mar 14.


Perturbation of Hoxb5 signaling in vagal and trunk neural crest cells causes apoptosis and neurocristopathies in mice.

Kam MK, Cheung MC, Zhu JJ, Cheng WW, Sat EW, Tam PK, Lui VC.

Cell Death Differ. 2014 Feb;21(2):278-89. doi: 10.1038/cdd.2013.142. Epub 2013 Oct 18.


Gene network analysis of candidate loci for human anorectal malformations.

Wong EH, Ng CL, Lui VC, So MT, Cherny SS, Sham PC, Tam PK, Garcia-Barceló MM.

PLoS One. 2013 Aug 1;8(8):e69142. doi: 10.1371/journal.pone.0069142. Print 2013.


Common genetic variants regulating ADD3 gene expression alter biliary atresia risk.

Cheng G, Tang CS, Wong EH, Cheng WW, So MT, Miao X, Zhang R, Cui L, Liu X, Ngan ES, Lui VC, Chung PH, Chan IH, Liu J, Zhong W, Xia H, Yu J, Qiu X, Wu XZ, Wang B, Dong X, Tou J, Huang L, Yi B, Ren H, Chan EK, Ye K, O'Reilly PF, Wong KK, Sham PC, Cherny SS, Tam PK, Garcia-Barceló MM.

J Hepatol. 2013 Dec;59(6):1285-91. doi: 10.1016/j.jhep.2013.07.021. Epub 2013 Jul 19.


Inhibition of TGF-β signaling in combination with TLR7 ligation re-programs a tumoricidal phenotype in tumor-associated macrophages.

Peng J, Tsang JY, Li D, Niu N, Ho DH, Lau KF, Lui VC, Lamb JR, Chen Y, Tam PK.

Cancer Lett. 2013 May 1;331(2):239-49. doi: 10.1016/j.canlet.2013.01.001. Epub 2013 Jan 11.


Adiponectin mediated MHC class II mismatched cardiac graft rejection in mice is IL-4 dependent.

Li D, Tsang JY, Peng J, Ho DH, Chan YK, Zhu J, Lui VC, Xu A, Lamb JR, Tam PK, Chen Y.

PLoS One. 2012;7(11):e48893. doi: 10.1371/journal.pone.0048893. Epub 2012 Nov 14.


Genome-wide copy number variation study in anorectal malformations.

Wong EH, Cui L, Ng CL, Tang CS, Liu XL, So MT, Yip BH, Cheng G, Zhang R, Tang WK, Yang W, Lau YL, Baum L, Kwan P, Sun LD, Zuo XB, Ren YQ, Yin XY, Miao XP, Liu J, Lui VC, Ngan ES, Yuan ZW, Zhang SW, Xia J, Wang H, Sun XB, Wang R, Chang T, Chan IH, Chung PH, Zhang XJ, Wong KK, Cherny SS, Sham PC, Tam PK, Garcia-Barcelo MM.

Hum Mol Genet. 2013 Feb 1;22(3):621-31. doi: 10.1093/hmg/dds451. Epub 2012 Oct 29.


Genome-wide copy number analysis uncovers a new HSCR gene: NRG3.

Tang CS, Cheng G, So MT, Yip BH, Miao XP, Wong EH, Ngan ES, Lui VC, Song YQ, Chan D, Cheung K, Yuan ZW, Lei L, Chung PH, Liu XL, Wong KK, Marshall CR, Scherer SW, Cherny SS, Sham PC, Tam PK, Garcia-Barceló MM.

PLoS Genet. 2012;8(5):e1002687. doi: 10.1371/journal.pgen.1002687. Epub 2012 May 10. Erratum in: PLoS Genet. 2012 May;8(5): doi/10.1371/annotation/0ffda9e0-ba27-40c1-b766-df58de9083d5. Scherer, Steve [corrected to Scherer, Stephen W]..


Generation of NSE-MerCreMer transgenic mice with tamoxifen inducible Cre activity in neurons.

Kam MK, Lee KY, Tam PK, Lui VC.

PLoS One. 2012;7(5):e35799. doi: 10.1371/journal.pone.0035799. Epub 2012 May 7.


Granulin-epithelin precursor is an oncofetal protein defining hepatic cancer stem cells.

Cheung PF, Cheng CK, Wong NC, Ho JC, Yip CW, Lui VC, Cheung AN, Fan ST, Cheung ST.

PLoS One. 2011;6(12):e28246. doi: 10.1371/journal.pone.0028246. Epub 2011 Dec 16.


RET mutational spectrum in Hirschsprung disease: evaluation of 601 Chinese patients.

So MT, Leon TY, Cheng G, Tang CS, Miao XP, Cornes BK, Diem NN, Cui L, Ngan ES, Lui VC, Wu XZ, Wang B, Wang H, Yuan ZW, Huang LM, Li L, Xia H, Zhu D, Liu J, Nguyen TL, Chan IH, Chung PH, Liu XL, Zhang R, Wong KK, Sham PC, Cherny SS, Tam PK, Garcia-Barcelo MM.

PLoS One. 2011;6(12):e28986. doi: 10.1371/journal.pone.0028986. Epub 2011 Dec 9.


Functional analyses of RET mutations in Chinese Hirschsprung disease patients.

Leon TY, So MT, Lui VC, Hofstra RM, Tam PK, Ngan ES, Garcia-Barceló MM.

Birth Defects Res A Clin Mol Teratol. 2012 Jan;94(1):47-51. doi: 10.1002/bdra.22863. Epub 2011 Dec 1.


Therapeutic potential of in utero mesenchymal stem cell (MSCs) transplantation in rat foetuses with spina bifida aperta.

Li H, Gao F, Ma L, Jiang J, Miao J, Jiang M, Fan Y, Wang L, Wu D, Liu B, Wang W, Lui VC, Yuan Z.

J Cell Mol Med. 2012 Jul;16(7):1606-17. doi: 10.1111/j.1582-4934.2011.01470.x.


Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans.

Ngan ES, Garcia-Barceló MM, Yip BH, Poon HC, Lau ST, Kwok CK, Sat E, Sham MH, Wong KK, Wainwright BJ, Cherny SS, Hui CC, Sham PC, Lui VC, Tam PK.

J Clin Invest. 2011 Sep;121(9):3467-78. doi: 10.1172/JCI43737. Epub 2011 Aug 15.


HOXB5 cooperates with NKX2-1 in the transcription of human RET.

Zhu J, Garcia-Barcelo MM, Tam PK, Lui VC.

PLoS One. 2011;6(6):e20815. doi: 10.1371/journal.pone.0020815. Epub 2011 Jun 3.


PPAR-γ signaling and IL-5 inhibition together prevent chronic rejection of MHC Class II-mismatched cardiac grafts.

Chen Y, Li D, Tsang JY, Niu N, Peng J, Zhu J, Hui K, Xu A, Lui VC, Lamb JR, Tam PK.

J Heart Lung Transplant. 2011 Jun;30(6):698-706. doi: 10.1016/j.healun.2011.01.704. Epub 2011 Mar 23.


Fine mapping of the NRG1 Hirschsprung's disease locus.

Tang CS, Tang WK, So MT, Miao XP, Leung BM, Yip BH, Leon TY, Ngan ES, Lui VC, Chen Y, Chan IH, Chung PH, Liu XL, Wu XZ, Wong KK, Sham PC, Cherny SS, Tam PK, Garcia-Barceló MM.

PLoS One. 2011 Jan 20;6(1):e16181. doi: 10.1371/journal.pone.0016181.


Invasion of human glioma cells is regulated by multiple chloride channels including ClC-3.

Lui VC, Lung SS, Pu JK, Hung KN, Leung GK.

Anticancer Res. 2010 Nov;30(11):4515-24.


Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2.

Garcia-Barceló MM, Yeung MY, Miao XP, Tang CS, Cheng G, So MT, Ngan ES, Lui VC, Chen Y, Liu XL, Hui KJ, Li L, Guo WH, Sun XB, Tou JF, Chan KW, Wu XZ, Song YQ, Chan D, Cheung K, Chung PH, Wong KK, Sham PC, Cherny SS, Tam PK.

Hum Mol Genet. 2010 Jul 15;19(14):2917-25. doi: 10.1093/hmg/ddq196. Epub 2010 May 11. Erratum in: Hum Mol Genet. 2011 Mar 1;20(5):1048. Chen, Guo [corrected to Cheng, Guo].


Lack of association between nNOS -84G>A polymorphism and risk of infantile hypertrophic pyloric stenosis in a Chinese population.

Miao X, Garcia-Barceló MM, So MT, Tang WK, Dong X, Wang B, Mao J, Ngan ES, Chen Y, Lui VC, Wong KK, Liu L, Tam PK.

J Pediatr Surg. 2010 Apr;45(4):709-13. doi: 10.1016/j.jpedsurg.2009.07.067.


Silver nanoparticles mediate differential responses in keratinocytes and fibroblasts during skin wound healing.

Liu X, Lee PY, Ho CM, Lui VC, Chen Y, Che CM, Tam PK, Wong KK.

ChemMedChem. 2010 Mar 1;5(3):468-75. doi: 10.1002/cmdc.200900502.


Reduced RET expression in gut tissue of individuals carrying risk alleles of Hirschsprung's disease.

Miao X, Leon TY, Ngan ES, So MT, Yuan ZW, Lui VC, Chen Y, Wong KK, Tam PK, Garcia-Barceló M.

Hum Mol Genet. 2010 Apr 15;19(8):1461-7. doi: 10.1093/hmg/ddq020. Epub 2010 Jan 20.


Transcriptional regulation of RET by Nkx2-1, Phox2b, Sox10, and Pax3.

Leon TY, Ngan ES, Poon HC, So MT, Lui VC, Tam PK, Garcia-Barcelo MM.

J Pediatr Surg. 2009 Oct;44(10):1904-12. doi: 10.1016/j.jpedsurg.2008.11.055.


MNX1 (HLXB9) mutations in Currarino patients.

Garcia-Barceló MM, Lui VC, So MT, Miao X, Leon TY, Yuan ZW, Ngan ES, Ehsan T, Chung PH, Khong PL, Wong KK, Tam PK.

J Pediatr Surg. 2009 Oct;44(10):1892-8. doi: 10.1016/j.jpedsurg.2009.03.039.


DNA damage mediated s and g(2) checkpoints in human embryonal carcinoma cells.

Wang X, Lui VC, Poon RT, Lu P, Poon RY.

Stem Cells. 2009 Mar;27(3):568-76. doi: 10.1634/stemcells.2008-0690.


Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease.

Garcia-Barcelo MM, Tang CS, Ngan ES, Lui VC, Chen Y, So MT, Leon TY, Miao XP, Shum CK, Liu FQ, Yeung MY, Yuan ZW, Guo WH, Liu L, Sun XB, Huang LM, Tou JF, Song YQ, Chan D, Cheung KM, Wong KK, Cherny SS, Sham PC, Tam PK.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2694-9. doi: 10.1073/pnas.0809630105. Epub 2009 Feb 5.


Identification of a HOXD13 mutation in a VACTERL patient.

Garcia-Barceló MM, Wong KK, Lui VC, Yuan ZW, So MT, Ngan ES, Miao XP, Chung PH, Khong PL, Tam PK.

Am J Med Genet A. 2008 Dec 15;146A(24):3181-5. doi: 10.1002/ajmg.a.32426.


Perturbation of hoxb5 signaling in vagal neural crests down-regulates ret leading to intestinal hypoganglionosis in mice.

Lui VC, Cheng WW, Leon TY, Lau DK, Garcia-Barcelo MM, Miao XP, Kam MK, So MT, Chen Y, Wall NA, Sham MH, Tam PK.

Gastroenterology. 2008 Apr;134(4):1104-15. doi: 10.1053/j.gastro.2008.01.028. Epub 2008 Jan 17. Erratum in: Gastroenterology. 2008 Aug;135(2):713. Garcia-Bareclo, Maria-Mercedes [corrected to Garcia-Barcelo, Maria-Mercedes].


Mapping of a Hirschsprung's disease locus in 3p21.

Garcia-Barceló MM, Fong PY, Tang CS, Miao XP, So MT, Yuan ZW, Li L, Guo WH, Liu L, Wang B, Sun XB, Huang LM, Tou JF, Wong KK, Ngan ES, Lui VC, Cherny SS, Sham PC, Tam PK.

Eur J Hum Genet. 2008 Jul;16(7):833-40. doi: 10.1038/ejhg.2008.18. Epub 2008 Feb 20.


Hypoxia modulates lipopolysaccharide induced TNF-alpha expression in murine macrophages.

Liu FQ, Liu Y, Lui VC, Lamb JR, Tam PK, Chen Y.

Exp Cell Res. 2008 Apr 1;314(6):1327-36. doi: 10.1016/j.yexcr.2008.01.007. Epub 2008 Jan 16.


LPS-induced up-regulation of TGF-beta receptor 1 is associated with TNF-alpha expression in human monocyte-derived macrophages.

Chen Y, Kam CS, Liu FQ, Liu Y, Lui VC, Lamb JR, Tam PK.

J Leukoc Biol. 2008 May;83(5):1165-73. doi: 10.1189/jlb.0807521. Epub 2008 Feb 5.


Evaluation of the NK2 homeobox 1 gene (NKX2-1) as a Hirschsprung's disease locus.

Garcia-Barceló MM, Lau DK, Ngan ES, Leon TY, Liu T, So M, Miao X, Lui VC, Wong KK, Ganster RW, Cass DT, Croaker GD, Tam PK.

Ann Hum Genet. 2008 Mar;72(Pt 2):170-7. Epub 2007 Dec 12. Retraction in: Ruiz-Linares A. Ann Hum Genet. 2009 Jan;73(1):131.


Prokineticin-1 (Prok-1) works coordinately with glial cell line-derived neurotrophic factor (GDNF) to mediate proliferation and differentiation of enteric neural crest cells.

Ngan ES, Shum CK, Poon HC, Sham MH, Garcia-Barcelo MM, Lui VC, Tam PK.

Biochim Biophys Acta. 2008 Mar;1783(3):467-78. Epub 2007 Oct 4.


Evaluation of the thyroid transcription factor-1 gene (TITF1) as a Hirschsprung's disease locus.

Garcia-Barceló MM, Lau DK, Ngan ES, Leon TY, Liu TT, So MT, Miao XP, Lui VC, Wong KK, Ganster RW, Cass DT, Croaker GD, Tam PK.

Ann Hum Genet. 2007 Nov;71(Pt 6):746-54. Epub 2007 Jul 19.

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