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Items: 46


High-throughput analysis of vocalizations reveals sex-specific changes in Fmr1 mutant pups.

Nolan SO, Hodges SL, Lugo JN.

Genes Brain Behav. 2019 Oct 6:e12611. doi: 10.1111/gbb.12611. [Epub ahead of print]


NS-Pten adult knockout mice display both quantitative and qualitative changes in urine-induced ultrasonic vocalizations.

Binder MS, Jones DG, Hodges SL, Lugo JN.

Behav Brain Res. 2019 Oct 3:112189. doi: 10.1016/j.bbr.2019.112189. [Epub ahead of print]


A single early-life seizure results in long-term behavioral changes in the adult Fmr1 knockout mouse.

Hodges SL, Reynolds CD, Nolan SO, Huebschman JL, Okoh JT, Binder MS, Lugo JN.

Epilepsy Res. 2019 Aug 29;157:106193. doi: 10.1016/j.eplepsyres.2019.106193. [Epub ahead of print]


High seizure load during sensitive periods of development leads to broad shifts in ultrasonic vocalization behavior in neonatal male and female C57BL/6J mice.

Nolan SO, Hodges SL, Condon SM, Muhammed IDA, Tomac LA, Binder MS, Reynolds CD, Lugo JN.

Epilepsy Behav. 2019 Jun;95:26-33. doi: 10.1016/j.yebeh.2019.03.037. Epub 2019 Apr 22.


Neuronal deletion of phosphatase and tensin homolog results in cerebellar motor learning dysfunction and alterations in intracellular signaling.

Nolan SO, Jefferson TS, Reynolds CD, Smith GD, Holley AJ, Hodges SL, Lugo JN.

Neuroreport. 2019 May 22;30(8):556-561. doi: 10.1097/WNR.0000000000001241.


A single seizure selectively impairs hippocampal-dependent memory and is associated with alterations in PI3K/Akt/mTOR and FMRP signaling.

Holley AJ, Hodges SL, Nolan SO, Binder M, Okoh JT, Ackerman K, Tomac LA, Lugo JN.

Epilepsia Open. 2018 Oct 28;3(4):511-523. doi: 10.1002/epi4.12273. eCollection 2018 Dec.


A comparison of the Avisoft (5.2) and Ultravox (2.0) recording systems: Implications for early-life communication and vocalization research.

Binder MS, Hernandez-Zegada CJ, Potter CT, Nolan SO, Lugo JN.

J Neurosci Methods. 2018 Nov 1;309:6-12. doi: 10.1016/j.jneumeth.2018.08.015. Epub 2018 Aug 14.


Neuronal subset-specific deletion of Pten results in aberrant Wnt signaling and memory impairments.

Hodges SL, Reynolds CD, Smith GD, Jefferson TS, Gao N, Morrison JB, White J, Nolan SO, Lugo JN.

Brain Res. 2018 Nov 15;1699:100-106. doi: 10.1016/j.brainres.2018.08.007. Epub 2018 Aug 4.


Reversal learning paradigm reveals deficits in cognitive flexibility in the Fmr1 knockout male mouse.

Nolan SO, Lugo JN.

F1000Res. 2018 Jun 7;7:711. doi: 10.12688/f1000research.14969.1. eCollection 2018.


Wnt/β-catenin signaling as a potential target for novel epilepsy therapies.

Hodges SL, Lugo JN.

Epilepsy Res. 2018 Oct;146:9-16. doi: 10.1016/j.eplepsyres.2018.07.002. Epub 2018 Jul 24. Review.


Oral aniracetam treatment in C57BL/6J mice without pre-existing cognitive dysfunction reveals no changes in learning, memory, anxiety or stereotypy.

Reynolds CD, Jefferson TS, Volquardsen M, Pandian A, Smith GD, Holley AJ, Lugo JN.

Version 3. F1000Res. 2017 Aug 14 [revised 2018 Jan 1];6:1452. doi: 10.12688/f1000research.11023.3. eCollection 2017.


Molecular interplay between hyperactive mammalian target of rapamycin signaling and Alzheimer's disease neuropathology in the NS-Pten knockout mouse model.

Hodges SL, Reynolds CD, Smith GD, Jefferson TS, Nolan SO, Lugo JN.

Neuroreport. 2018 Sep 5;29(13):1109-1113. doi: 10.1097/WNR.0000000000001081.


Neuroinflammation Alters Integrative Properties of Rat Hippocampal Pyramidal Cells.

Frigerio F, Flynn C, Han Y, Lyman K, Lugo JN, Ravizza T, Ghestem A, Pitsch J, Becker A, Anderson AE, Vezzani A, Chetkovich D, Bernard C.

Mol Neurobiol. 2018 Sep;55(9):7500-7511. doi: 10.1007/s12035-018-0915-1. Epub 2018 Feb 9.


NS-Pten knockout mice show sex- and age-specific differences in ultrasonic vocalizations.

Binder MS, Lugo JN.

Brain Behav. 2017 Oct 18;7(11):e00857. doi: 10.1002/brb3.857. eCollection 2017 Nov.


Deletion of Fmr1 results in sex-specific changes in behavior.

Nolan SO, Reynolds CD, Smith GD, Holley AJ, Escobar B, Chandler MA, Volquardsen M, Jefferson T, Pandian A, Smith T, Huebschman J, Lugo JN.

Brain Behav. 2017 Aug 25;7(10):e00800. doi: 10.1002/brb3.800. eCollection 2017 Oct.


Adult Fmr1 knockout mice present with deficiencies in hippocampal interleukin-6 and tumor necrosis factor-α expression.

Hodges SL, Nolan SO, Taube JH, Lugo JN.

Neuroreport. 2017 Dec 13;28(18):1246-1249. doi: 10.1097/WNR.0000000000000905.


A critical review of the postulated role of the non-essential amino acid, β-N-methylamino-L-alanine, in neurodegenerative disease in humans.

Chernoff N, Hill DJ, Diggs DL, Faison BD, Francis BM, Lang JR, Larue MM, Le TT, Loftin KA, Lugo JN, Schmid JE, Winnik WM.

J Toxicol Environ Health B Crit Rev. 2017;20(4):1-47. doi: 10.1080/10937404.2017.1297592. Epub 2017 Jun 9. Review.


Early-life status epilepticus acutely impacts select quantitative and qualitative features of neonatal vocalization behavior: Spectrographic and temporal characterizations in C57BL/6 mice.

Reynolds CD, Nolan SO, Huebschman JL, Hodges SL, Lugo JN.

Epilepsy Behav. 2017 Jul;72:58-62. doi: 10.1016/j.yebeh.2017.04.025. Epub 2017 May 30.


Spectral and temporal properties of calls reveal deficits in ultrasonic vocalizations of adult Fmr1 knockout mice.

Hodges SL, Nolan SO, Reynolds CD, Lugo JN.

Behav Brain Res. 2017 Aug 14;332:50-58. doi: 10.1016/j.bbr.2017.05.052. Epub 2017 May 26.


Neuron subset-specific Pten deletion induces abnormal skeletal activity in mice.

Lugo JN, Thompson MH, Huber P, Smith G, Kwon RY.

Exp Neurol. 2017 May;291:98-105. doi: 10.1016/j.expneurol.2017.02.002. Epub 2017 Feb 2.


Sex-specific and genotype-specific differences in vocalization development in FMR1 knockout mice.

Reynolds CD, Nolan SO, Jefferson T, Lugo JN.

Neuroreport. 2016 Dec 14;27(18):1331-1335.


The effect of early life status epilepticus on ultrasonic vocalizations in mice.

Reynolds CD, Smith G, Jefferson T, Lugo JN.

Epilepsia. 2016 Sep;57(9):1377-85. doi: 10.1111/epi.13450. Epub 2016 Jul 5.


Kv4.2 knockout mice display learning and memory deficits in the Lashley maze.

Smith GD, Gao N, Lugo JN.

Version 2. F1000Res. 2016 Oct 5 [revised 2017 Jan 1];5:2456. doi: 10.12688/f1000research.9664.2. eCollection 2016.


Effects of an acute seizure on associative learning and memory.

Holley AJ, Lugo JN.

Epilepsy Behav. 2016 Jan;54:51-7. doi: 10.1016/j.yebeh.2015.11.001. Epub 2015 Dec 3.


Comparison of Equivalence between Two Commercially Available S499-Phosphorylated FMRP Antibodies in Mice.

Reynolds CD, Smith GD, Jefferson TS, Lugo JN.

PLoS One. 2015 Nov 18;10(11):e0143134. doi: 10.1371/journal.pone.0143134. eCollection 2015.


Testing for odor discrimination and habituation in mice.

Arbuckle EP, Smith GD, Gomez MC, Lugo JN.

J Vis Exp. 2015 May 5;(99):e52615. doi: 10.3791/52615.


Aniracetam does not alter cognitive and affective behavior in adult C57BL/6J mice.

Elston TW, Pandian A, Smith GD, Holley AJ, Gao N, Lugo JN.

PLoS One. 2014 Aug 6;9(8):e104443. doi: 10.1371/journal.pone.0104443. eCollection 2014.


Deletion of PTEN produces autism-like behavioral deficits and alterations in synaptic proteins.

Lugo JN, Smith GD, Arbuckle EP, White J, Holley AJ, Floruta CM, Ahmed N, Gomez MC, Okonkwo O.

Front Mol Neurosci. 2014 Apr 16;7:27. doi: 10.3389/fnmol.2014.00027. eCollection 2014.


Trace fear conditioning in mice.

Lugo JN, Smith GD, Holley AJ.

J Vis Exp. 2014 Mar 20;(85). doi: 10.3791/51180.


Early-life seizures result in deficits in social behavior and learning.

Lugo JN, Swann JW, Anderson AE.

Exp Neurol. 2014 Jun;256:74-80. doi: 10.1016/j.expneurol.2014.03.014. Epub 2014 Mar 29.


Deletion of PTEN produces deficits in conditioned fear and increases fragile X mental retardation protein.

Lugo JN, Smith GD, Morrison JB, White J.

Learn Mem. 2013 Nov 15;20(12):670-3. doi: 10.1101/lm.032839.113.


Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage.

Brewster AL, Lugo JN, Patil VV, Lee WL, Qian Y, Vanegas F, Anderson AE.

PLoS One. 2013;8(3):e57808. doi: 10.1371/journal.pone.0057808. Epub 2013 Mar 11.


Differential dorso-ventral distributions of Kv4.2 and HCN proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites.

Marcelin B, Lugo JN, Brewster AL, Liu Z, Lewis AS, McClelland S, Chetkovich DM, Baram TZ, Anderson AE, Becker A, Esclapez M, Bernard C.

J Biol Chem. 2012 May 18;287(21):17656-61. doi: 10.1074/jbc.C112.367110. Epub 2012 Apr 16.


Kv4.2 knockout mice have hippocampal-dependent learning and memory deficits.

Lugo JN, Brewster AL, Spencer CM, Anderson AE.

Learn Mem. 2012 Apr 13;19(5):182-9. doi: 10.1101/lm.023614.111.


Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice.

Sunnen CN, Brewster AL, Lugo JN, Vanegas F, Turcios E, Mukhi S, Parghi D, D'Arcangelo G, Anderson AE.

Epilepsia. 2011 Nov;52(11):2065-75. doi: 10.1111/j.1528-1167.2011.03280.x. Epub 2011 Oct 5.


Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia.

Ljungberg MC, Sunnen CN, Lugo JN, Anderson AE, D'Arcangelo G.

Dis Model Mech. 2009 Jul-Aug;2(7-8):389-98. doi: 10.1242/dmm.002386. Epub 2009 May 26.


Kv4.2 knockout mice demonstrate increased susceptibility to convulsant stimulation.

Barnwell LF, Lugo JN, Lee WL, Willis SE, Gertz SJ, Hrachovy RA, Anderson AE.

Epilepsia. 2009 Jul;50(7):1741-51. doi: 10.1111/j.1528-1167.2009.02086.x. Epub 2009 May 11.


Altered phosphorylation and localization of the A-type channel, Kv4.2 in status epilepticus.

Lugo JN, Barnwell LF, Ren Y, Lee WL, Johnston LD, Kim R, Hrachovy RA, Sweatt JD, Anderson AE.

J Neurochem. 2008 Aug;106(4):1929-40. doi: 10.1111/j.1471-4159.2008.05508.x. Epub 2008 May 31.


Progressive dendritic HCN channelopathy during epileptogenesis in the rat pilocarpine model of epilepsy.

Jung S, Jones TD, Lugo JN Jr, Sheerin AH, Miller JW, D'Ambrosio R, Anderson AE, Poolos NP.

J Neurosci. 2007 Nov 21;27(47):13012-21.


Alcohol exposure during development: analysis of effects on female sexual behavior.

Gass JT, Jenkins WJ, Marino MD, Lugo JN Jr, Kelly SJ.

Alcohol Clin Exp Res. 2007 Dec;31(12):2065-72. Epub 2007 Oct 19.


Perinatal ethanol exposure alters met-enkephalin levels of male and female rats.

Lugo JN Jr, Wilson MA, Kelly SJ.

Neurotoxicol Teratol. 2006 Mar-Apr;28(2):238-44. Epub 2006 Feb 2.


Ethanol exposure during development reduces resident aggression and testosterone in rats.

Lugo JN Jr, Marino MD, Gass JT, Wilson MA, Kelly SJ.

Physiol Behav. 2006 Feb 28;87(2):330-7. Epub 2005 Dec 5.


Effect of amygdalar opioids on the anxiolytic properties of ethanol.

Wilson MA, Burghardt PR, Lugo JN Jr, Primeaux SD, Wilson SP.

Ann N Y Acad Sci. 2003 Apr;985:472-5. No abstract available.


Effects of alcohol exposure during development on social behavior in rats.

Lugo JN Jr, Marino MD, Cronise K, Kelly SJ.

Physiol Behav. 2003 Feb;78(2):185-94.


Ultrasonic vocalizations and maternal-infant interactions in a rat model of fetal alcohol syndrome.

Marino MD, Cronise K, Lugo JN Jr, Kelly SJ.

Dev Psychobiol. 2002 Dec;41(4):341-51.


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