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Rosmarinic acid improves oxidative stress parameters and mitochondrial respiratory chain activity following 4-aminopyridine and picrotoxin-induced seizure in mice.

Luft JG, Steffens L, Morás AM, da Rosa MS, Leipnitz G, Regner GG, Pflüger PF, Gonçalves D, Moura DJ, Pereira P.

Naunyn Schmiedebergs Arch Pharmacol. 2019 Nov;392(11):1347-1358. doi: 10.1007/s00210-019-01675-6. Epub 2019 Jun 14.


Role of Linker Length and Antigen Density in Nanoparticle Peptide Vaccine.

Kapadia CH, Tian S, Perry JL, Luft JC, DeSimone JM.

ACS Omega. 2019 Mar 31;4(3):5547-5555. doi: 10.1021/acsomega.8b03391. Epub 2019 Mar 19.


Zapped assembly of polymeric (ZAP) nanoparticles for anti-cancer drug delivery.

Dunn SS, Luft JC, Parrott MC.

Nanoscale. 2019 Jan 23;11(4):1847-1855. doi: 10.1039/c8nr09944h.


Synthesis and Characterization of Cetuximab-Docetaxel and Panitumumab-Docetaxel Antibody-Drug Conjugates for EGFR-Overexpressing Cancer Therapy.

Glatt DM, Beckford Vera DR, Prabhu SS, Mumper RJ, Luft JC, Benhabbour SR, Parrott MC.

Mol Pharm. 2018 Nov 5;15(11):5089-5102. doi: 10.1021/acs.molpharmaceut.8b00672. Epub 2018 Oct 1.


Formulation of High-Performance Dry Powder Aerosols for Pulmonary Protein Delivery.

Wilson EM, Luft JC, DeSimone JM.

Pharm Res. 2018 Aug 23;35(10):195. doi: 10.1007/s11095-018-2452-z.


Spatially controlled coating of continuous liquid interface production microneedles for transdermal protein delivery.

Caudill CL, Perry JL, Tian S, Luft JC, DeSimone JM.

J Control Release. 2018 Aug 28;284:122-132. doi: 10.1016/j.jconrel.2018.05.042. Epub 2018 Jun 9.


Optimization of Surface Display of DENV2 E Protein on a Nanoparticle to Induce Virus Specific Neutralizing Antibody Responses.

Coffman JE, Metz SW, Brackbill A, Paul M, Miley MJ, DeSimone J, Luft JC, de Silva A, Tian S.

Bioconjug Chem. 2018 May 16;29(5):1544-1552. doi: 10.1021/acs.bioconjchem.8b00090. Epub 2018 May 4.


Impact of formulation on the iontophoretic delivery of the FOLFIRINOX regimen for the treatment of pancreatic cancer.

Byrne JD, Jajja MRN, O'Neill AT, Schorzman AN, Keeler AW, Luft JC, Zamboni WC, DeSimone JM, Yeh JJ.

Cancer Chemother Pharmacol. 2018 Jun;81(6):991-998. doi: 10.1007/s00280-018-3570-3. Epub 2018 Mar 30.


Controlling release from 3D printed medical devices using CLIP and drug-loaded liquid resins.

Bloomquist CJ, Mecham MB, Paradzinsky MD, Janusziewicz R, Warner SB, Luft JC, Mecham SJ, Wang AZ, DeSimone JM.

J Control Release. 2018 May 28;278:9-23. doi: 10.1016/j.jconrel.2018.03.026. Epub 2018 Mar 27.


Mediating Passive Tumor Accumulation through Particle Size, Tumor Type, and Location.

Perry JL, Reuter KG, Luft JC, Pecot CV, Zamboni W, DeSimone JM.

Nano Lett. 2017 May 10;17(5):2879-2886. doi: 10.1021/acs.nanolett.7b00021. Epub 2017 Apr 11.


Docetaxel-Loaded PLGA Nanoparticles Improve Efficacy in Taxane-Resistant Triple-Negative Breast Cancer.

Bowerman CJ, Byrne JD, Chu KS, Schorzman AN, Keeler AW, Sherwood CA, Perry JL, Luft JC, Darr DB, Deal AM, Napier ME, Zamboni WC, Sharpless NE, Perou CM, DeSimone JM.

Nano Lett. 2017 Jan 11;17(1):242-248. doi: 10.1021/acs.nanolett.6b03971. Epub 2016 Dec 22.


Single-Step Fabrication of Computationally Designed Microneedles by Continuous Liquid Interface Production.

Johnson AR, Caudill CL, Tumbleston JR, Bloomquist CJ, Moga KA, Ermoshkin A, Shirvanyants D, Mecham SJ, Luft JC, DeSimone JM.

PLoS One. 2016 Sep 8;11(9):e0162518. doi: 10.1371/journal.pone.0162518. eCollection 2016.


Reduction Sensitive PEG Hydrogels for Codelivery of Antigen and Adjuvant To Induce Potent CTLs.

Kapadia CH, Tian S, Perry JL, Luft JC, DeSimone JM.

Mol Pharm. 2016 Oct 3;13(10):3381-3394. Epub 2016 Sep 22.


Efficacy and pharmacokinetics of a modified acid-labile docetaxel-PRINT(®) nanoparticle formulation against non-small-cell lung cancer brain metastases.

Sambade M, Deal A, Schorzman A, Luft JC, Bowerman C, Chu K, Karginova O, Swearingen AV, Zamboni W, DeSimone J, Anders CK.

Nanomedicine (Lond). 2016 Aug;11(15):1947-55. doi: 10.2217/nnm-2016-0147. Epub 2016 Jul 26.


The Interplay of Antigen Affinity, Internalization, and Pharmacokinetics on CD44-Positive Tumor Targeting of Monoclonal Antibodies.

Glatt DM, Beckford Vera DR, Parrott MC, Luft JC, Benhabbour SR, Mumper RJ.

Mol Pharm. 2016 Jun 6;13(6):1894-903. doi: 10.1021/acs.molpharmaceut.6b00063. Epub 2016 Apr 28.


Pulmonary Delivery of Butyrylcholinesterase as a Model Protein to the Lung.

Rahhal TB, Fromen CA, Wilson EM, Kai MP, Shen TW, Luft JC, DeSimone JM.

Mol Pharm. 2016 May 2;13(5):1626-35. doi: 10.1021/acs.molpharmaceut.6b00066. Epub 2016 Apr 5.


Spiritual Care and CPE: 2nd Year Experience.

Luft JP.

J Pastoral Care Counsel. 2016 Mar;70(1):40-2. doi: 10.1177/1542305015621705.


Iontophoretic device delivery for the localized treatment of pancreatic ductal adenocarcinoma.

Byrne JD, Jajja MR, Schorzman AN, Keeler AW, Luft JC, Zamboni WC, DeSimone JM, Yeh JJ.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2200-5. doi: 10.1073/pnas.1600421113. Epub 2016 Feb 8.


Particles for Local Delivery of Proteins Using Intra-Articular Route.

Khodabandehlou K, Tian S, Luft JC, Khan SA, DeSimone JM.

Adv Healthc Mater. 2016 Mar;5(6):653-8, 626. doi: 10.1002/adhm.201500797. Epub 2016 Feb 2.


The detection and subsequent volume optimization of biological nanocrystals.

Luft JR, Wolfley JR, Franks EC, Lauricella AM, Gualtieri EJ, Snell EH, Xiao R, Everett JK, Montelione GT.

Struct Dyn. 2015 May 15;2(4):041710. doi: 10.1063/1.4921199. eCollection 2015 Jul.


Subtumoral analysis of PRINT nanoparticle distribution reveals targeting variation based on cellular and particle properties.

Roode LE, Brighton H, Bo T, Perry JL, Parrott MC, Kersey F, Luft JC, Bear JE, DeSimone JM, Davis IJ.

Nanomedicine. 2016 May;12(4):1053-1062. doi: 10.1016/j.nano.2015.12.382. Epub 2016 Jan 7.


Nanoparticle surface charge impacts distribution, uptake and lymph node trafficking by pulmonary antigen-presenting cells.

Fromen CA, Rahhal TB, Robbins GR, Kai MP, Shen TW, Luft JC, DeSimone JM.

Nanomedicine. 2016 Apr;12(3):677-687. doi: 10.1016/j.nano.2015.11.002. Epub 2015 Dec 1.


Tumor Presence Induces Global Immune Changes and Enhances Nanoparticle Clearance.

Kai MP, Brighton HE, Fromen CA, Shen TW, Luft JC, Luft YE, Keeler AW, Robbins GR, Ting JP, Zamboni WC, Bear JE, DeSimone JM.

ACS Nano. 2016 Jan 26;10(1):861-70. doi: 10.1021/acsnano.5b05999. Epub 2015 Dec 2.


Nanoparticulate immunotherapy for cancer.

Kapadia CH, Perry JL, Tian S, Luft JC, DeSimone JM.

J Control Release. 2015 Dec 10;219:167-180. doi: 10.1016/j.jconrel.2015.09.062. Epub 2015 Oct 10. Review.


Targeted PRINT Hydrogels: The Role of Nanoparticle Size and Ligand Density on Cell Association, Biodistribution, and Tumor Accumulation.

Reuter KG, Perry JL, Kim D, Luft JC, Liu R, DeSimone JM.

Nano Lett. 2015 Oct 14;15(10):6371-8. doi: 10.1021/acs.nanolett.5b01362. Epub 2015 Sep 30.


Towards programming immune tolerance through geometric manipulation of phosphatidylserine.

Roberts RA, Eitas TK, Byrne JD, Johnson BM, Short PJ, McKinnon KP, Reisdorf S, Luft JC, DeSimone JM, Ting JP.

Biomaterials. 2015 Dec;72:1-10. doi: 10.1016/j.biomaterials.2015.08.040. Epub 2015 Aug 20.


Reductively Responsive Hydrogel Nanoparticles with Uniform Size, Shape, and Tunable Composition for Systemic siRNA Delivery in Vivo.

Ma D, Tian S, Baryza J, Luft JC, DeSimone JM.

Mol Pharm. 2015 Oct 5;12(10):3518-3526. doi: 10.1021/acs.molpharmaceut.5b00054. Epub 2015 Sep 4.


Distribution and Cellular Uptake of PEGylated Polymeric Particles in the Lung Towards Cell-Specific Targeted Delivery.

Shen TW, Fromen CA, Kai MP, Luft JC, Rahhal TB, Robbins GR, DeSimone JM.

Pharm Res. 2015 Oct;32(10):3248-60. doi: 10.1007/s11095-015-1701-7. Epub 2015 May 23.


Biodistribution and trafficking of hydrogel nanoparticles in adult mosquitoes.

Paquette CC, Phanse Y, Perry JL, Sanchez-Vargas I, Airs PM, Dunphy BM, Xu J, Carlson JO, Luft JC, DeSimone JM, Bartholomay LC, Beaty BJ.

PLoS Negl Trop Dis. 2015 May 21;9(5):e0003745. doi: 10.1371/journal.pntd.0003745. eCollection 2015 May.


Biodistribution and Toxicity Studies of PRINT Hydrogel Nanoparticles in Mosquito Larvae and Cells.

Phanse Y, Dunphy BM, Perry JL, Airs PM, Paquette CC, Carlson JO, Xu J, Luft JC, DeSimone JM, Beaty BJ, Bartholomay LC.

PLoS Negl Trop Dis. 2015 May 21;9(5):e0003735. doi: 10.1371/journal.pntd.0003735. eCollection 2015 May.


Preparation and biological evaluation of synthetic and polymer-encapsulated congeners of the antitumor agent pactamycin: insight into functional group effects and biological activity.

Sharpe RJ, Malinowski JT, Sorana F, Luft JC, Bowerman CJ, DeSimone JM, Johnson JS.

Bioorg Med Chem. 2015 Apr 15;23(8):1849-57. doi: 10.1016/j.bmc.2015.02.022. Epub 2015 Feb 21.


Evaluation of drug loading, pharmacokinetic behavior, and toxicity of a cisplatin-containing hydrogel nanoparticle.

Kai MP, Keeler AW, Perry JL, Reuter KG, Luft JC, O'Neal SK, Zamboni WC, DeSimone JM.

J Control Release. 2015 Apr 28;204:70-7. doi: 10.1016/j.jconrel.2015.03.001. Epub 2015 Mar 3.


Silylated precision particles for controlled release of proteins.

Khodabandehlou K, Kumbhar AS, Habibi S, Pandya AA, Luft JC, Khan SA, DeSimone JM.

ACS Appl Mater Interfaces. 2015 Mar 18;7(10):5756-67. doi: 10.1021/am508520z. Epub 2015 Mar 5.


Local iontophoretic administration of cytotoxic therapies to solid tumors.

Byrne JD, Jajja MR, O'Neill AT, Bickford LR, Keeler AW, Hyder N, Wagner K, Deal A, Little RE, Moffitt RA, Stack C, Nelson M, Brooks CR, Lee W, Luft JC, Napier ME, Darr D, Anders CK, Stack R, Tepper JE, Wang AZ, Zamboni WC, Yeh JJ, DeSimone JM.

Sci Transl Med. 2015 Feb 4;7(273):273ra14. doi: 10.1126/scitranslmed.3009951.


The accurate assessment of small-angle X-ray scattering data.

Grant TD, Luft JR, Carter LG, Matsui T, Weiss TM, Martel A, Snell EH.

Acta Crystallogr D Biol Crystallogr. 2015 Jan 1;71(Pt 1):45-56. doi: 10.1107/S1399004714010876. Epub 2015 Jan 1.


Total- and methyl-mercury concentrations and methylation rates across the freshwater to hypersaline continuum of the Great Salt Lake, Utah, USA.

Johnson WP, Swanson N, Black B, Rudd A, Carling G, Fernandez DP, Luft J, Van Leeuwen J, Marvin-DiPasquale M.

Sci Total Environ. 2015 Apr 1;511:489-500. doi: 10.1016/j.scitotenv.2014.12.092. Epub 2015 Jan 7.


A hybrid NMR/SAXS-based approach for discriminating oligomeric protein interfaces using Rosetta.

Rossi P, Shi L, Liu G, Barbieri CM, Lee HW, Grant TD, Luft JR, Xiao R, Acton TB, Snell EH, Montelione GT, Baker D, Lange OF, Sgourakis NG.

Proteins. 2015 Feb;83(2):309-17. doi: 10.1002/prot.24719. Epub 2014 Dec 19.


Identifying, studying and making good use of macromolecular crystals.

Calero G, Cohen AE, Luft JR, Newman J, Snell EH.

Acta Crystallogr F Struct Biol Commun. 2014 Aug;70(Pt 8):993-1008. doi: 10.1107/S2053230X14016574. Epub 2014 Jul 25.


Crystallization screening: the influence of history on current practice.

Luft JR, Newman J, Snell EH.

Acta Crystallogr F Struct Biol Commun. 2014 Jul;70(Pt 7):835-53. doi: 10.1107/S2053230X1401262X. Epub 2014 Jun 27. Review.


Statistical analysis of crystallization database links protein physico-chemical features with crystallization mechanisms.

Fusco D, Barnum TJ, Bruno AE, Luft JR, Snell EH, Mukherjee S, Charbonneau P.

PLoS One. 2014 Jul 2;9(7):e101123. doi: 10.1371/journal.pone.0101123. eCollection 2014.


Comparing chemistry to outcome: the development of a chemical distance metric, coupled with clustering and hierarchal visualization applied to macromolecular crystallography.

Bruno AE, Ruby AM, Luft JR, Grant TD, Seetharaman J, Montelione GT, Hunt JF, Snell EH.

PLoS One. 2014 Jun 27;9(6):e100782. doi: 10.1371/journal.pone.0100782. eCollection 2014. Erratum in: PLoS One. 2014;9(8):e105260.


Design of asymmetric particles containing a charged interior and a neutral surface charge: comparative study on in vivo circulation of polyelectrolyte microgels.

Chen K, Xu J, Luft JC, Tian S, Raval JS, DeSimone JM.

J Am Chem Soc. 2014 Jul 16;136(28):9947-52. doi: 10.1021/ja503939n. Epub 2014 Jun 30.


A new view on crystal harvesting.

Luft JR, Grant TD, Wolfley JR, Snell EH.

J Appl Crystallogr. 2014 May 29;47(Pt 3):1158-1161. eCollection 2014 Jun 1.


Metronomic docetaxel in PRINT nanoparticles and EZH2 silencing have synergistic antitumor effect in ovarian cancer.

Gharpure KM, Chu KS, Bowerman CJ, Miyake T, Pradeep S, Mangala SL, Han HD, Rupaimoole R, Armaiz-Pena GN, Rahhal TB, Wu SY, Luft JC, Napier ME, Lopez-Berestein G, DeSimone JM, Sood AK.

Mol Cancer Ther. 2014 Jul;13(7):1750-7. doi: 10.1158/1535-7163.MCT-13-0930. Epub 2014 Apr 22.


Particle replication in nonwetting templates nanoparticles with tumor selective alkyl silyl ether docetaxel prodrug reduces toxicity.

Chu KS, Finniss MC, Schorzman AN, Kuijer JL, Luft JC, Bowerman CJ, Napier ME, Haroon ZA, Zamboni WC, DeSimone JM.

Nano Lett. 2014 Mar 12;14(3):1472-6. doi: 10.1021/nl4046558. Epub 2014 Feb 24.


RNA replicon delivery via lipid-complexed PRINT protein particles.

Xu J, Luft JC, Yi X, Tian S, Owens G, Wang J, Johnson A, Berglund P, Smith J, Napier ME, DeSimone JM.

Mol Pharm. 2013 Sep 3;10(9):3366-74. doi: 10.1021/mp400190z. Epub 2013 Aug 21.


Nanoparticle drug loading as a design parameter to improve docetaxel pharmacokinetics and efficacy.

Chu KS, Schorzman AN, Finniss MC, Bowerman CJ, Peng L, Luft JC, Madden AJ, Wang AZ, Zamboni WC, DeSimone JM.

Biomaterials. 2013 Nov;34(33):8424-9. doi: 10.1016/j.biomaterials.2013.07.038. Epub 2013 Jul 27.


The structure of yeast glutaminyl-tRNA synthetase and modeling of its interaction with tRNA.

Grant TD, Luft JR, Wolfley JR, Snell ME, Tsuruta H, Corretore S, Quartley E, Phizicky EM, Grayhack EJ, Snell EH.

J Mol Biol. 2013 Jul 24;425(14):2480-93. doi: 10.1016/j.jmb.2013.03.043. Epub 2013 Apr 10.


Purification and SAXS analysis of the integrin linked kinase, PINCH, parvin (IPP) heterotrimeric complex.

Stiegler AL, Grant TD, Luft JR, Calderwood DA, Snell EH, Boggon TJ.

PLoS One. 2013;8(1):e55591. doi: 10.1371/journal.pone.0055591. Epub 2013 Jan 31.


Plasma, tumor and tissue pharmacokinetics of Docetaxel delivered via nanoparticles of different sizes and shapes in mice bearing SKOV-3 human ovarian carcinoma xenograft.

Chu KS, Hasan W, Rawal S, Walsh MD, Enlow EM, Luft JC, Bridges AS, Kuijer JL, Napier ME, Zamboni WC, DeSimone JM.

Nanomedicine. 2013 Jul;9(5):686-93. doi: 10.1016/j.nano.2012.11.008. Epub 2012 Dec 6.

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