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Items: 1 to 50 of 73

1.

Use of machine learning to identify novel, behaviorally active antagonists of the insect odorant receptor co-receptor (Orco) subunit.

Kepchia D, Xu P, Terryn R, Castro A, Schürer SC, Leal WS, Luetje CW.

Sci Rep. 2019 Mar 11;9(1):4055. doi: 10.1038/s41598-019-40640-4.

2.

Mutant cycle analysis identifies a ligand interaction site in an odorant receptor of the malaria vector Anopheles gambiae.

Rahman S, Luetje CW.

J Biol Chem. 2017 Nov 17;292(46):18916-18923. doi: 10.1074/jbc.M117.810374. Epub 2017 Sep 29.

3.

Mammalian odorant receptor tuning breadth persists across distinct odorant panels.

Kepchia D, Sherman B, Haddad R, Luetje CW.

PLoS One. 2017 Sep 25;12(9):e0185329. doi: 10.1371/journal.pone.0185329. eCollection 2017.

4.

Correction: Inhibition of insect olfactory behavior by an airborne antagonist of the insect odorant receptor co-receptor subunit.

Kepchia D, Moliver S, Chohan K, Phillips C, Luetje CW.

PLoS One. 2017 Aug 3;12(8):e0183009. doi: 10.1371/journal.pone.0183009. eCollection 2017.

5.

Inhibition of insect olfactory behavior by an airborne antagonist of the insect odorant receptor co-receptor subunit.

Kepchia D, Moliver S, Chohan K, Phillips C, Luetje CW.

PLoS One. 2017 May 31;12(5):e0177454. doi: 10.1371/journal.pone.0177454. eCollection 2017. Erratum in: PLoS One. 2017 Aug 3;12 (8):e0183009.

6.

Functional and Nonfunctional Forms of CquiOR91, an Odorant Selectivity Subunit of Culex quinquefasciatus.

Hughes DT, Pelletier J, Rahman S, Chen S, Leal WS, Luetje CW.

Chem Senses. 2017 May 1;42(4):333-341. doi: 10.1093/chemse/bjx011.

7.

Synthesis, Nicotinic Acetylcholine Receptor Binding, and in Vitro and in Vivo Pharmacological Properties of 2'-Fluoro-(substituted thiophenyl)deschloroepibatidine Analogues.

Ondachi PW, Castro AH, Sherman B, Luetje CW, Damaj MI, Mascarella SW, Navarro HA, Carroll FI.

ACS Chem Neurosci. 2017 Jan 18;8(1):115-127. doi: 10.1021/acschemneuro.6b00252. Epub 2016 Oct 20.

PMID:
27726337
8.

Synthesis, Nicotinic Acetylcholine Binding, and in Vitro and in Vivo Pharmacological Properties of 2'-Fluoro-(carbamoylpyridinyl)deschloroepibatidine Analogues.

Ondachi PW, Castro AH, Luetje CW, Wageman CR, Marks MJ, Damaj MI, Mascarella SW, Navarro HA, Carroll FI.

ACS Chem Neurosci. 2016 Jul 20;7(7):1004-12. doi: 10.1021/acschemneuro.6b00107. Epub 2016 May 19.

PMID:
27166021
9.

Synthesis, nicotinic acetylcholine receptor binding, in vitro and in vivo pharmacology properties of 3'-(substituted pyridinyl)-deschloroepibatidine analogs.

Ondachi PW, Ye Z, Castro AH, Luetje CW, Damaj MI, Mascarella SW, Navarro HA, Carroll FI.

Bioorg Med Chem. 2015 Sep 1;23(17):5693-701. doi: 10.1016/j.bmc.2015.07.021. Epub 2015 Jul 17.

10.

Proton-dependent glutamine uptake by aphid bacteriocyte amino acid transporter ApGLNT1.

Price DR, Wilson AC, Luetje CW.

Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):2085-91. doi: 10.1016/j.bbamem.2015.05.019. Epub 2015 May 29.

11.

In vitro and in vivo neuronal nicotinic receptor properties of (+)- and (-)-pyrido[3,4]homotropane [(+)- and (-)-PHT]: (+)-PHT is a potent and selective full agonist at α6β2 containing neuronal nicotinic acetylcholine receptors.

Carroll FI, Navarro HA, Mascarella SW, Castro AH, Luetje CW, Wageman CR, Marks MJ, Jackson A, Damaj MI.

ACS Chem Neurosci. 2015 Jun 17;6(6):920-6. doi: 10.1021/acschemneuro.5b00077. Epub 2015 Apr 30.

12.

Receptive range analysis of a mouse odorant receptor subfamily.

Li J, Haddad R, Santos V, Bavan S, Luetje CW.

J Neurochem. 2015 Jul;134(1):47-55. doi: 10.1111/jnc.13095. Epub 2015 Mar 25.

13.

A determinant of odorant specificity is located at the extracellular loop 2-transmembrane domain 4 interface of an Anopheles gambiae odorant receptor subunit.

Hughes DT, Wang G, Zwiebel LJ, Luetje CW.

Chem Senses. 2014 Nov;39(9):761-9. doi: 10.1093/chemse/bju048. Epub 2014 Sep 30.

14.

Trace amines inhibit insect odorant receptor function through antagonism of the co-receptor subunit.

Chen S, Luetje CW.

F1000Res. 2014 Apr 3;3:84. doi: 10.12688/f1000research.3825.1. eCollection 2014.

15.

Discovery of novel ligands for mouse olfactory receptor MOR42-3 using an in silico screening approach and in vitro validation.

Bavan S, Sherman B, Luetje CW, Abaffy T.

PLoS One. 2014 Mar 17;9(3):e92064. doi: 10.1371/journal.pone.0092064. eCollection 2014.

16.

Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2'-fluoro-3'-(substituted pyridinyl)-7-deschloroepibatidine analogues.

Ondachi PW, Castro AH, Bartkowiak JM, Luetje CW, Damaj MI, Mascarella SW, Navarro HA, Carroll FI.

J Med Chem. 2014 Feb 13;57(3):836-48. doi: 10.1021/jm401602p. Epub 2014 Jan 28.

17.

Aphid amino acid transporter regulates glutamine supply to intracellular bacterial symbionts.

Price DR, Feng H, Baker JD, Bavan S, Luetje CW, Wilson AC.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):320-5. doi: 10.1073/pnas.1306068111. Epub 2013 Dec 23.

18.

Phenylthiophenecarboxamide antagonists of the olfactory receptor co-receptor subunit from a mosquito.

Chen S, Luetje CW.

PLoS One. 2013 Dec 17;8(12):e84575. doi: 10.1371/journal.pone.0084575. eCollection 2013.

19.

Silent, generic and plant kairomone sensitive odorant receptors from the Southern house mosquito.

Xu P, Choo YM, Pelletier J, Sujimoto FR, Hughes DT, Zhu F, Atungulu E, Cornel AJ, Luetje CW, Leal WS.

J Insect Physiol. 2013 Sep;59(9):961-6. doi: 10.1016/j.jinsphys.2013.07.004. Epub 2013 Jul 19.

20.

Functional assay of mammalian and insect olfactory receptors using Xenopus oocytes.

Luetje CW, Nichols AS, Castro A, Sherman BL.

Methods Mol Biol. 2013;1003:187-202. doi: 10.1007/978-1-62703-377-0_14.

PMID:
23585043
21.

Receptors: Chemical courtship in mice.

Luetje CW.

Nat Chem Biol. 2013 Mar;9(3):140-1. doi: 10.1038/nchembio.1180. No abstract available.

PMID:
23416397
22.

Synthesis and nicotinic acetylcholine receptor in vitro and in vivo pharmacological properties of 2'-fluoro-3'-(substituted phenyl)deschloroepibatidine analogues of 2'-fluoro-3'-(4-nitrophenyl)deschloroepibatidine.

Ondachi P, Castro A, Luetje CW, Damaj MI, Mascarella SW, Navarro HA, Carroll FI.

J Med Chem. 2012 Jul 26;55(14):6512-22. doi: 10.1021/jm300575y. Epub 2012 Jul 11.

23.

Identification of new agonists and antagonists of the insect odorant receptor co-receptor subunit.

Chen S, Luetje CW.

PLoS One. 2012;7(5):e36784. doi: 10.1371/journal.pone.0036784. Epub 2012 May 8.

24.

Sequencing and characterizing odorant receptors of the cerambycid beetle Megacyllene caryae.

Mitchell RF, Hughes DT, Luetje CW, Millar JG, Soriano-Agatón F, Hanks LM, Robertson HM.

Insect Biochem Mol Biol. 2012 Jul;42(7):499-505. doi: 10.1016/j.ibmb.2012.03.007. Epub 2012 Apr 5.

25.

A broadly tuned mouse odorant receptor that detects nitrotoluenes.

Li J, Haddad R, Chen S, Santos V, Luetje CW.

J Neurochem. 2012 Jun;121(6):881-90. doi: 10.1111/j.1471-4159.2012.07740.x. Epub 2012 Apr 19.

26.

RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs.

Franco A, Kompella SN, Akondi KB, Melaun C, Daly NL, Luetje CW, Alewood PF, Craik DJ, Adams DJ, Marí F.

Biochem Pharmacol. 2012 Feb 1;83(3):419-26. doi: 10.1016/j.bcp.2011.11.006. Epub 2011 Nov 16.

PMID:
22108175
27.

Biomimetic chemical sensors using nanoelectronic readout of olfactory receptor proteins.

Goldsmith BR, Mitala JJ, Josue J, Castro A, Lerner MB, Bayburt TH, Khamis SM, Jones RA, Brand JG, Sligar SG, Luetje CW, Gelperin A, Rhodes PA, Discher BM, Johnson AT.

ACS Nano. 2011 Jul 26;5(7):5408-16. doi: 10.1021/nn200489j. Epub 2011 Jul 6.

28.

Subunit contributions to insect olfactory receptor function: channel block and odorant recognition.

Nichols AS, Chen S, Luetje CW.

Chem Senses. 2011 Nov;36(9):781-90. doi: 10.1093/chemse/bjr053. Epub 2011 Jun 15.

29.

Odorant receptor from the southern house mosquito narrowly tuned to the oviposition attractant skatole.

Hughes DT, Pelletier J, Luetje CW, Leal WS.

J Chem Ecol. 2010 Aug;36(8):797-800. doi: 10.1007/s10886-010-9828-9. Epub 2010 Jul 11.

30.

An odorant receptor from the southern house mosquito Culex pipiens quinquefasciatus sensitive to oviposition attractants.

Pelletier J, Hughes DT, Luetje CW, Leal WS.

PLoS One. 2010 Apr 8;5(4):e10090. doi: 10.1371/journal.pone.0010090.

31.

Transmembrane segment 3 of Drosophila melanogaster odorant receptor subunit 85b contributes to ligand-receptor interactions.

Nichols AS, Luetje CW.

J Biol Chem. 2010 Apr 16;285(16):11854-62. doi: 10.1074/jbc.M109.058321. Epub 2010 Feb 10.

32.

Sex pheromone receptor specificity in the European corn borer moth, Ostrinia nubilalis.

Wanner KW, Nichols AS, Allen JE, Bunger PL, Garczynski SF, Linn CE, Robertson HM, Luetje CW.

PLoS One. 2010 Jan 13;5(1):e8685. doi: 10.1371/journal.pone.0008685.

33.

Molecular receptive range variation among mouse odorant receptors for aliphatic carboxylic acids.

Repicky SE, Luetje CW.

J Neurochem. 2009 Apr;109(1):193-202. doi: 10.1111/j.1471-4159.2009.05925.x. Epub 2009 Feb 23.

34.

Zinc potentiates neuronal nicotinic receptors by increasing burst duration.

Hsiao B, Mihalak KB, Magleby KL, Luetje CW.

J Neurophysiol. 2008 Feb;99(2):999-1007. Epub 2007 Dec 19.

35.

Genetic elucidation of human hyperosmia to isovaleric acid.

Menashe I, Abaffy T, Hasin Y, Goshen S, Yahalom V, Luetje CW, Lancet D.

PLoS Biol. 2007 Oct 30;5(11):e284.

36.

A honey bee odorant receptor for the queen substance 9-oxo-2-decenoic acid.

Wanner KW, Nichols AS, Walden KK, Brockmann A, Luetje CW, Robertson HM.

Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14383-8. Epub 2007 Aug 30.

37.

The molecular basis for ligand specificity in a mouse olfactory receptor: a network of functionally important residues.

Abaffy T, Malhotra A, Luetje CW.

J Biol Chem. 2007 Jan 12;282(2):1216-24. Epub 2006 Nov 17.

38.

Determinants of alpha-conotoxin BuIA selectivity on the nicotinic acetylcholine receptor beta subunit.

Shiembob DL, Roberts RL, Luetje CW, McIntosh JM.

Biochemistry. 2006 Sep 19;45(37):11200-7.

39.

Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors.

Mihalak KB, Carroll FI, Luetje CW.

Mol Pharmacol. 2006 Sep;70(3):801-5. Epub 2006 Jun 9.

PMID:
16766716
40.

Functional analysis of a mammalian odorant receptor subfamily.

Abaffy T, Matsunami H, Luetje CW.

J Neurochem. 2006 Jun;97(5):1506-18. Epub 2006 Apr 5.

41.

Determinants of zinc potentiation on the alpha4 subunit of neuronal nicotinic receptors.

Hsiao B, Mihalak KB, Repicky SE, Everhart D, Mederos AH, Malhotra A, Luetje CW.

Mol Pharmacol. 2006 Jan;69(1):27-36. Epub 2005 Sep 27.

PMID:
16189299
42.

Getting past the asterisk: the subunit composition of presynaptic nicotinic receptors that modulate striatal dopamine release.

Luetje CW.

Mol Pharmacol. 2004 Jun;65(6):1333-5. Review. No abstract available.

PMID:
15155826
43.

GABAA receptor subunit mRNA expression in cultured embryonic and adult human dorsal root ganglion neurons.

Maddox FN, Valeyev AY, Poth K, Holohean AM, Wood PM, Davidoff RA, Hackman JC, Luetje CW.

Brain Res Dev Brain Res. 2004 Apr 19;149(2):143-51.

PMID:
15063094
44.

Hormone resistance: it's SMRT to fight repression.

Burnstein KL, Luetje CW.

Endocrinology. 2004 Apr;145(4):1525-6. No abstract available.

PMID:
15026376
45.

Determinants of potency on alpha-conotoxin MII, a peptide antagonist of neuronal nicotinic receptors.

Everhart D, Cartier GE, Malhotra A, Gomes AV, McIntosh JM, Luetje CW.

Biochemistry. 2004 Mar 16;43(10):2732-7.

PMID:
15005608
46.

Tyrosine phosphorylation of rod cyclic nucleotide-gated channels switches off Ca2+/calmodulin inhibition.

Krajewski JL, Luetje CW, Kramer RH.

J Neurosci. 2003 Nov 5;23(31):10100-6.

47.

Subunit contributions to phosphorylation-dependent modulation of bovine rod cyclic nucleotide-gated channels.

Molokanova E, Krajewski JL, Satpaev D, Luetje CW, Kramer RH.

J Physiol. 2003 Oct 15;552(Pt 2):345-56.

48.

Identification of residues that confer alpha-conotoxin-PnIA sensitivity on the alpha 3 subunit of neuronal nicotinic acetylcholine receptors.

Everhart D, Reiller E, Mirzoian A, McIntosh JM, Malhotra A, Luetje CW.

J Pharmacol Exp Ther. 2003 Aug;306(2):664-70. Epub 2003 May 6.

PMID:
12734390
49.

Effects of pyridine ring substitutions on affinity, efficacy, and subtype selectivity of neuronal nicotinic receptor agonist epibatidine.

Avalos M, Parker MJ, Maddox FN, Carroll FI, Luetje CW.

J Pharmacol Exp Ther. 2002 Sep;302(3):1246-52.

PMID:
12183686
50.

Modulation of neuronal nicotinic acetylcholine receptors by mercury.

Mirzoian A, Luetje CW.

J Pharmacol Exp Ther. 2002 Aug;302(2):560-7.

PMID:
12130716

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