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Items: 4


Probing the mutational landscape of regulators of G protein signaling proteins in cancer.

DiGiacomo V, Maziarz M, Luebbers A, Norris JM, Laksono P, Garcia-Marcos M.

Sci Signal. 2020 Feb 4;13(617). pii: eaax8620. doi: 10.1126/scisignal.aax8620.


Atypical activation of the G protein Gαq by the oncogenic mutation Q209P.

Maziarz M, Leyme A, Marivin A, Luebbers A, Patel PP, Chen Z, Sprang SR, Garcia-Marcos M.

J Biol Chem. 2018 Dec 21;293(51):19586-19599. doi: 10.1074/jbc.RA118.005291. Epub 2018 Oct 23.


A biochemical and genetic discovery pipeline identifies PLCδ4b as a nonreceptor activator of heterotrimeric G-proteins.

Maziarz M, Broselid S, DiGiacomo V, Park JC, Luebbers A, Garcia-Navarrete L, Blanco-Canosa JB, Baillie GS, Garcia-Marcos M.

J Biol Chem. 2018 Nov 2;293(44):16964-16983. doi: 10.1074/jbc.RA118.003580. Epub 2018 Sep 7.


A novel broad specificity fucosidase capable of core α1-6 fucose release from N-glycans labeled with urea-linked fluorescent dyes.

Vainauskas S, Kirk CH, Petralia L, Guthrie EP, McLeod E, Bielik A, Luebbers A, Foster JM, Hokke CH, Rudd PM, Shi X, Taron CH.

Sci Rep. 2018 Jun 22;8(1):9504. doi: 10.1038/s41598-018-27797-0.

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