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Telomere Trimming and DNA Damage as Signatures of High Risk Neuroblastoma.

Yu EY, Cheung IY, Feng Y, Rabie MO, Roboz GJ, Guzman ML, Cheung NV, Lue NF.

Neoplasia. 2019 Jul;21(7):689-701. doi: 10.1016/j.neo.2019.04.002. Epub 2019 May 23.


Evolving Linear Chromosomes and Telomeres: A C-Strand-Centric View.

Lue NF.

Trends Biochem Sci. 2018 May;43(5):314-326. doi: 10.1016/j.tibs.2018.02.008. Epub 2018 Mar 14. Review.


The mechanisms of K. lactis Cdc13 in telomere DNA-binding and telomerase regulation.

Hsu M, Lue NF.

DNA Repair (Amst). 2018 Jan;61:37-45. doi: 10.1016/j.dnarep.2017.11.007. Epub 2017 Nov 28.


Contributions of recombination and repair proteins to telomere maintenance in telomerase-positive and negative Ustilago maydis.

Yu EY, Hsu M, Holloman WK, Lue NF.

Mol Microbiol. 2018 Jan;107(1):81-93. doi: 10.1111/mmi.13866. Epub 2017 Nov 9.


STN1-POLA2 interaction provides a basis for primase-pol α stimulation by human STN1.

Ganduri S, Lue NF.

Nucleic Acids Res. 2017 Sep 19;45(16):9455-9466. doi: 10.1093/nar/gkx621.


Analysis of Yeast Telomerase by Primer Extension Assays.

Hsu M, Lue NF.

Methods Mol Biol. 2017;1587:83-93. doi: 10.1007/978-1-4939-6892-3_8.


Telomere recombination pathways: tales of several unhappy marriages.

Lue NF, Yu EY.

Curr Genet. 2017 Jun;63(3):401-409. doi: 10.1007/s00294-016-0653-8. Epub 2016 Sep 25. Review.


Mre11 and Blm-Dependent Formation of ALT-Like Telomeres in Ku-Deficient Ustilago maydis.

Yu EY, Pérez-Martín J, Holloman WK, Lue NF.

PLoS Genet. 2015 Oct 22;11(10):e1005570. doi: 10.1371/journal.pgen.1005570. eCollection 2015 Oct.


Telomere DNA recognition in Saccharomycotina yeast: potential lessons for the co-evolution of ssDNA and dsDNA-binding proteins and their target sites.

Steinberg-Neifach O, Lue NF.

Front Genet. 2015 May 1;6:162. doi: 10.3389/fgene.2015.00162. eCollection 2015. Review.


Combinatorial recognition of a complex telomere repeat sequence by the Candida parapsilosis Cdc13AB heterodimer.

Steinberg-Neifach O, Wellington K, Vazquez L, Lue NF.

Nucleic Acids Res. 2015 Feb 27;43(4):2164-76.


Fungal Ku prevents permanent cell cycle arrest by suppressing DNA damage signaling at telomeres.

de Sena-Tomás C, Yu EY, Calzada A, Holloman WK, Lue NF, Pérez-Martín J.

Nucleic Acids Res. 2015 Feb 27;43(4):2138-51. doi: 10.1093/nar/gkv082. Epub 2015 Feb 4.


The CDC13-STN1-TEN1 complex stimulates Pol α activity by promoting RNA priming and primase-to-polymerase switch.

Lue NF, Chan J, Wright WE, Hurwitz J.

Nat Commun. 2014 Dec 12;5:5762. doi: 10.1038/ncomms6762.


SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres.

Wan B, Yin J, Horvath K, Sarkar J, Chen Y, Wu J, Wan K, Lu J, Gu P, Yu EY, Lue NF, Chang S, Liu Y, Lei M.

Cell Rep. 2013 Sep 12;4(5):861-9. doi: 10.1016/j.celrep.2013.08.017. Epub 2013 Sep 5.


Duplication and functional specialization of the telomere-capping protein Cdc13 in Candida species.

Lue NF, Chan J.

J Biol Chem. 2013 Oct 4;288(40):29115-23. doi: 10.1074/jbc.M113.506519. Epub 2013 Aug 21.


Brh2 and Rad51 promote telomere maintenance in Ustilago maydis, a new model system of DNA repair proteins at telomeres.

Yu EY, Kojic M, Holloman WK, Lue NF.

DNA Repair (Amst). 2013 Jul;12(7):472-9. doi: 10.1016/j.dnarep.2013.04.027. Epub 2013 May 28.


The telomere capping complex CST has an unusual stoichiometry, makes multipartite interaction with G-Tails, and unfolds higher-order G-tail structures.

Lue NF, Zhou R, Chico L, Mao N, Steinberg-Neifach O, Ha T.

PLoS Genet. 2013;9(1):e1003145. doi: 10.1371/journal.pgen.1003145. Epub 2013 Jan 3.


A popular engagement at the ends.

Lue NF, Yu EY, Lei M.

Nat Struct Mol Biol. 2013 Jan;20(1):10-2. doi: 10.1038/nsmb.2483.


Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.

Lovejoy CA, Li W, Reisenweber S, Thongthip S, Bruno J, de Lange T, De S, Petrini JH, Sung PA, Jasin M, Rosenbluh J, Zwang Y, Weir BA, Hatton C, Ivanova E, Macconaill L, Hanna M, Hahn WC, Lue NF, Reddel RR, Jiao Y, Kinzler K, Vogelstein B, Papadopoulos N, Meeker AK; ALT Starr Cancer Consortium.

PLoS Genet. 2012;8(7):e1002772. Epub 2012 Jul 19.


Functional analysis of the single Est1/Ebs1 homologue in Kluyveromyces lactis reveals roles in both telomere maintenance and rapamycin resistance.

Hsu M, Yu EY, Sprušanský O, McEachern MJ, Lue NF.

Eukaryot Cell. 2012 Jul;11(7):932-42. doi: 10.1128/EC.05319-11. Epub 2012 Apr 27.


Telomerase and retrotransposons: reverse transcriptases that shaped genomes.

Belfort M, Curcio MJ, Lue NF.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20304-10. doi: 10.1073/pnas.1100269109. No abstract available.


The Candida albicans Ku70 modulates telomere length and structure by regulating both telomerase and recombination.

Chico L, Ciudad T, Hsu M, Lue NF, Larriba G.

PLoS One. 2011;6(8):e23732. doi: 10.1371/journal.pone.0023732. Epub 2011 Aug 23.


Telomerase regulatory subunit Est3 in two Candida species physically interacts with the TEN domain of TERT and telomeric DNA.

Yen WF, Chico L, Lei M, Lue NF.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20370-5. doi: 10.1073/pnas.1017855108. Epub 2011 Jun 17.


A web of interactions at the ends.

Lue NF, Hsu M.

Mol Cell. 2011 May 6;42(3):269-71. doi: 10.1016/j.molcel.2011.04.014.


Analysis of yeast telomerase by primer extension assays.

Hsu M, Lue NF.

Methods Mol Biol. 2011;735:97-106. doi: 10.1007/978-1-61779-092-8_9.


Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase α.

Sun J, Yang Y, Wan K, Mao N, Yu TY, Lin YC, DeZwaan DC, Freeman BC, Lin JJ, Lue NF, Lei M.

Cell Res. 2011 Feb;21(2):258-74. doi: 10.1038/cr.2010.138. Epub 2010 Sep 28.


Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres.

Sun J, Yu EY, Yang Y, Confer LA, Sun SH, Wan K, Lue NF, Lei M.

Genes Dev. 2009 Dec 15;23(24):2900-14. doi: 10.1101/gad.1851909.


Rap1 in Candida albicans: an unusual structural organization and a critical function in suppressing telomere recombination.

Yu EY, Yen WF, Steinberg-Neifach O, Lue NF.

Mol Cell Biol. 2010 Mar;30(5):1254-68. doi: 10.1128/MCB.00986-09. Epub 2009 Dec 14.


Plasticity of telomere maintenance mechanisms in yeast.

Lue NF.

Trends Biochem Sci. 2010 Jan;35(1):8-17. doi: 10.1016/j.tibs.2009.08.006. Epub 2009 Oct 19. Review.


Closing the feedback loop: how cells "count" telomere-bound proteins.

Lue NF.

Mol Cell. 2009 Feb 27;33(4):413-4. doi: 10.1016/j.molcel.2009.02.001.


A proposed OB-fold with a protein-interaction surface in Candida albicans telomerase protein Est3.

Yu EY, Wang F, Lei M, Lue NF.

Nat Struct Mol Biol. 2008 Sep;15(9):985-9.


Modeling and structure function analysis of the putative anchor site of yeast telomerase.

Lue NF, Li Z.

Nucleic Acids Res. 2007;35(15):5213-22. Epub 2007 Aug 1.


Telomerase core components protect Candida telomeres from aberrant overhang accumulation.

Hsu M, McEachern MJ, Dandjinou AT, Tzfati Y, Orr E, Blackburn EH, Lue NF.

Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11682-7. Epub 2007 Jul 3.


Regulation of telomere structure and functions by subunits of the INO80 chromatin remodeling complex.

Yu EY, Steinberg-Neifach O, Dandjinou AT, Kang F, Morrison AJ, Shen X, Lue NF.

Mol Cell Biol. 2007 Aug;27(16):5639-49. Epub 2007 Jun 11.


Mutual dependence of Candida albicans Est1p and Est3p in telomerase assembly and activation.

Hsu M, Yu EY, Singh SM, Lue NF.

Eukaryot Cell. 2007 Aug;6(8):1330-8. Epub 2007 Jun 1.


The structure and function of telomerase reverse transcriptase.

Autexier C, Lue NF.

Annu Rev Biochem. 2006;75:493-517. Review.


Modulation of telomere terminal structure by telomerase components in Candida albicans.

Steinberg-Neifach O, Lue NF.

Nucleic Acids Res. 2006 May 19;34(9):2710-22. Print 2006.


Teaching resources. Chromatin remodeling.

Lue NF.

Sci STKE. 2005 Jul 26;2005(294):tr20.


Telomerase can act as a template- and RNA-independent terminal transferase.

Lue NF, Bosoy D, Moriarty TJ, Autexier C, Altman B, Leng S.

Proc Natl Acad Sci U S A. 2005 Jul 12;102(28):9778-83. Epub 2005 Jun 30.


A physical and functional constituent of telomerase anchor site.

Lue NF.

J Biol Chem. 2005 Jul 15;280(28):26586-91. Epub 2005 May 18.


Reverse transcriptase at bacterial telomeres.

Lue NF, Jiang S.

Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14307-8. Epub 2004 Sep 28. No abstract available.


Adding to the ends: what makes telomerase processive and how important is it?

Lue NF.

Bioessays. 2004 Sep;26(9):955-62. Review.


Homologous recombination in Candida albicans: role of CaRad52p in DNA repair, integration of linear DNA fragments and telomere length.

Ciudad T, Andaluz E, Steinberg-Neifach O, Lue NF, Gow NA, Calderone RA, Larriba G.

Mol Microbiol. 2004 Aug;53(4):1177-94. Erratum in: Mol Microbiol. 2005 Jun;56(5):1396.


Yeast telomerase is capable of limited repeat addition processivity.

Bosoy D, Lue NF.

Nucleic Acids Res. 2004 Jan 2;32(1):93-101. Print 2004.


Analysis of telomerase in Candida albicans: potential role in telomere end protection.

Singh SM, Steinberg-Neifach O, Mian IS, Lue NF.

Eukaryot Cell. 2002 Dec;1(6):967-77.


Conserved N-terminal motifs of telomerase reverse transcriptase required for ribonucleoprotein assembly in vivo.

Bosoy D, Peng Y, Mian IS, Lue NF.

J Biol Chem. 2003 Feb 7;278(6):3882-90. Epub 2002 Nov 27.


Functional analysis of the C-terminal extension of telomerase reverse transcriptase. A putative "thumb" domain.

Hossain S, Singh S, Lue NF.

J Biol Chem. 2002 Sep 27;277(39):36174-80. Epub 2002 Jul 31.

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